trazodone and Depression, Endogenous studies

Trazodone: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
trazodone : An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.

Research Excerpts

Excerpt	Relevance	Reference
" The aim of the study was to evaluate trazodone efficiency and safety in comparison to venlafaxine treatments of depressive episode, recurrent depressive disorders and depressive episode in bipolar disorders."	9.11	[Trazodone and venlafaxine in treatment of depressive disorders]. ( Florkowski, A; Gałecki, P; Gruszczyński, W; Kołodziejska, I; Mikołajczyk, I; Zboralski, K, 2005)
"Six middle aged subjects complaining of chronic insomnia associated with dysthymia were investigated in a 2-month single blind study: a 7-day placebo treatment period, followed by a 6-week phase with increasing doses of trazodone controlled release (CR) formulation (50 mg through days 8-10; 75 mg through days 11-13; 150 mg through days 14-49) and then a final 7-day withdrawal period under placebo."	9.07	Clinical and polysomnographic effects of trazodone CR in chronic insomnia associated with dysthymia. ( Boselli, M; Di Giovanni, G; Parrino, L; Spaggiari, MC; Terzano, MG, 1994)
"Forty-two women who met the new narrower criteria for bulimia nervosa of DSM-III-R completed a placebo-controlled double-blind study with trazodone."	9.06	A placebo-controlled study of trazodone in bulimia nervosa. ( Hudson, JI; Keck, PE; McElroy, SL; Pope, HG, 1989)
"This retrospective chart review examined the relative effectiveness of fluoxetine and trazodone in relieving insomnia associated with depressive disorders in adolescents (aged 13-17 years)."	7.69	Trazodone is only slightly faster than fluoxetine in relieving insomnia in adolescents with depressive disorders. ( Bhatara, VS; Fogas, BS; Kallepalli, BR; Misra, LK; Tervo, RC, 1997)
"Priapism occurred in ten patients undergoing treatment of depression with trazodone or impotence with papaverine."	7.68	Pharmacological priapism: comparison of trazodone- and papaverine-associated cases. ( Bardin, ED; Krieger, JN, 1990)
"Three bulimic patients with major depressive episodes developed delirium after trazodone administration."	7.67	Trazodone-induced delirium in bulimic patients. ( Damlouji, NF; Ferguson, JM, 1984)
"A case of priapism associated with trazodone is described."	7.67	Priapism associated with trazodone therapy: case report. ( Lansky, MR; Selzer, J, 1984)
"A 63-year-old woman with treatment-resistant depression was started on trazodone and subsequently developed erythema multiforme (EM), with lesions predominant on the distal parts of the limbs and involvement of the hands and feet, as well as her palms and soles."	7.67	Erythema multiforme associated with trazodone therapy: case report. ( Ford, HE; Jenike, MA, 1985)
"Ten depressed patients treated with trazodone developed edema and weight gain that was promptly reversed by reduction or discontinuation of trazodone."	7.67	Peripheral edema associated with trazodone: a report of ten cases. ( Barrnett, J; Brown, R; Frances, A; Kocsis, J; Mann, JJ, 1985)
"Two patients with severe obsessive-compulsive disorder with superimposed depression, who had failed to respond to a wide variety of antidepressants, were treated with trazodone hydrochloride."	7.67	Two cases of obsessive-compulsive disorder with depression responsive to trazodone. ( Baxter, LR, 1985)
"CR trazodone was effective in improving depressive and anxious symptomatology as well as in ameliorating the quality of sleep in 13 patients with a low incidence of side effects."	5.29	[Evaluation of therapeutic efficacy and pharmacokinetics of controlled release of trazodone in patients with major depressive disorder]. ( Delrio, G; Monteleone, P, 1994)
"Trazodone was associated with the occurrence of life-threatening premature ventricular contractions and angina in a 45-year-old white man who had no prior cardiovascular disease."	5.27	A case of trazodone-induced ventricular tachycardia. ( Aronson, MD; Hafez, H, 1986)
"To compare the therapeutic effects of insomnia accompanied with depressive disorders treated by acupuncture of relieving depression and regulating mind and oral administration of Trazodone."	5.14	[Effect of acupuncture treatment of relieving depression and regulating mind on insomnia accompanied with depressive disorders]. ( Lai, XS; Luo, WZ; Zhang, QZ, 2010)
" The aim of the study was to evaluate trazodone efficiency and safety in comparison to venlafaxine treatments of depressive episode, recurrent depressive disorders and depressive episode in bipolar disorders."	5.11	[Trazodone and venlafaxine in treatment of depressive disorders]. ( Florkowski, A; Gałecki, P; Gruszczyński, W; Kołodziejska, I; Mikołajczyk, I; Zboralski, K, 2005)
"Six middle aged subjects complaining of chronic insomnia associated with dysthymia were investigated in a 2-month single blind study: a 7-day placebo treatment period, followed by a 6-week phase with increasing doses of trazodone controlled release (CR) formulation (50 mg through days 8-10; 75 mg through days 11-13; 150 mg through days 14-49) and then a final 7-day withdrawal period under placebo."	5.07	Clinical and polysomnographic effects of trazodone CR in chronic insomnia associated with dysthymia. ( Boselli, M; Di Giovanni, G; Parrino, L; Spaggiari, MC; Terzano, MG, 1994)
"The effects of the antidepressant trazodone on clinical state and on EEG sleep in eight outpatients with a major depressive disorder were investigated in a single blind study."	5.07	Effects of trazodone on EEG sleep and clinical state in major depression. ( Havermans, RG; van Bemmel, AL; van Diest, R, 1992)
" For individual adverse events that developed or worsened during therapy, more fluoxetine-treated patients reported rhinitis and tremor (p less than or equal to ."	5.07	Fluoxetine versus trazodone: efficacy and activating-sedating effects. ( Beasley, CM; Bosomworth, JC; Dornseif, BE; Pultz, JA; Sayler, ME, 1991)
"To establish the differential indication of trazodone and to find the predictors of its efficacy, we conducted a study in which 45 patients with major depressive disorder and 75 patients with acute schizophrenia were randomly assigned under double-blind conditions to either 400 mg trazodone daily, 150 mg amitriptyline daily, 20 mg haloperidol daily, or placebo daily."	5.06	Experimental examination of trazodone. ( Klieser, E; Lehmann, E, 1989)
"Forty-two women who met the new narrower criteria for bulimia nervosa of DSM-III-R completed a placebo-controlled double-blind study with trazodone."	5.06	A placebo-controlled study of trazodone in bulimia nervosa. ( Hudson, JI; Keck, PE; McElroy, SL; Pope, HG, 1989)
"Fourteen out-patients with major depressive disorder completed a double-blind, randomized, parallel group study using trazodone (n = 6), amitriptyline (n = 5) and matching placebo (n = 3)."	5.05	Electrophysiological and haemodynamic changes with trazodone, amitriptyline and placebo in depressed out-patients. ( Ankier, SI; Silverstone, T; Van de Merwe, TJ, 1984)
"The FDA has approved the marketing of an extended-release formulation of trazodone (Oleptro--Angelini Labopharm) for treatment of major depressive disorder in adults."	4.86	Extended-release trazodone (Oleptro) for depression. ( , 2010)
"From this review, it is concluded that there are very few data to suggest that trazodone improves sleep in patients without mood disorder, though it does increase total sleep in patients with major depressive disorder."	4.82	The use of trazodone as a hypnotic: a critical review. ( James, SP; Mendelson, WB, 2004)
"Trazodone is an atypical antidepressant with additional anxiolytic effects."	3.76	Recent experience with trazodone. ( Lader, M, 1987)
"Trazodone has been shown to be at least as effective as standard antidepressants."	3.76	Overview of USA controlled trials of trazodone in clinical depression. ( Boyer, WF; Feighner, JP, 1988)
"Trazodone is a triazolopyridine derivative with antidepressant activity, that is chemically unrelated to other currently available antidepressants."	3.75	Trazodone: a review of its pharmacological properties and therapeutic use in depression and anxiety. ( Avery, GS; Brogden, RN; Heel, RC; Speight, TM, 1981)
" We report a case of severe protracted depression induced by IFN in a patient diagnosed with melanoma who responded rapidly to a course of methylphenidate using the Hamilton Depressive Rating Scale."	3.73	Methylphenidate for alpha-interferon induced depression. ( Camacho, A; Ng, B, 2006)
"The study consisted of evaluating 80 out-patients for DSM-IV diagnoses and giving 75 mg trazodone for four months to children aged 9-13 who fulfilled DSM-IV criteria for Major Depressive Disorder (n = 22); Major Depressive Disorder and Generalized Anxiety Disorder (n = 24), Major Depressive Disorder and Learning Disorder NOS (n = 24); Major Depressive Disorder and Oppositional Defiant Disorder (n = 10)."	3.69	Depressive disorder in pre-adolescence: comorbidity or different clinical subtypes? (A pharmacological contribution). ( Levi, G; Sogos, C, 1997)
"This retrospective chart review examined the relative effectiveness of fluoxetine and trazodone in relieving insomnia associated with depressive disorders in adolescents (aged 13-17 years)."	3.69	Trazodone is only slightly faster than fluoxetine in relieving insomnia in adolescents with depressive disorders. ( Bhatara, VS; Fogas, BS; Kallepalli, BR; Misra, LK; Tervo, RC, 1997)
"Priapism occurred in ten patients undergoing treatment of depression with trazodone or impotence with papaverine."	3.68	Pharmacological priapism: comparison of trazodone- and papaverine-associated cases. ( Bardin, ED; Krieger, JN, 1990)
"Nine of 10 consecutively evaluated men with DSM-III-R nonparaphilic sexual addictions or paraphilias noted improvement in sexual behaviors and depressive symptomatology while treated with fluoxetine, imipramine, or lithium."	3.68	Successful antidepressant treatment of nonparaphilic sexual addictions and paraphilias in men. ( Kafka, MP, 1991)
"Ten depressed patients treated with trazodone developed edema and weight gain that was promptly reversed by reduction or discontinuation of trazodone."	3.67	Peripheral edema associated with trazodone: a report of ten cases. ( Barrnett, J; Brown, R; Frances, A; Kocsis, J; Mann, JJ, 1985)
"We studied 14 patients with obsessive-compulsive disorder (OCD) by positron emission tomography and the fluorodeoxyglucose method, looking for abnormalities in local cerebral metabolic rates for glucose in brain structures that have been hypothesized to function abnormally in OCD."	3.67	Local cerebral glucose metabolic rates in obsessive-compulsive disorder. A comparison with rates in unipolar depression and in normal controls. ( Baxter, LR; Guze, BH; Mazziotta, JC; Phelps, ME; Schwartz, JM; Selin, CE, 1987)
"Three bulimic patients with major depressive episodes developed delirium after trazodone administration."	3.67	Trazodone-induced delirium in bulimic patients. ( Damlouji, NF; Ferguson, JM, 1984)
"A case of priapism associated with trazodone is described."	3.67	Priapism associated with trazodone therapy: case report. ( Lansky, MR; Selzer, J, 1984)
"A 63-year-old woman with treatment-resistant depression was started on trazodone and subsequently developed erythema multiforme (EM), with lesions predominant on the distal parts of the limbs and involvement of the hands and feet, as well as her palms and soles."	3.67	Erythema multiforme associated with trazodone therapy: case report. ( Ford, HE; Jenike, MA, 1985)
"Two patients with severe obsessive-compulsive disorder with superimposed depression, who had failed to respond to a wide variety of antidepressants, were treated with trazodone hydrochloride."	3.67	Two cases of obsessive-compulsive disorder with depression responsive to trazodone. ( Baxter, LR, 1985)
" As a result, trazodone at the dosage of 50-100 mg/day improved sleep disorders, particularly at the 100 mg/day dosage."	2.69	Effect of trazodone in a single dose before bedtime for sleep disorders accompanied by a depressive state: dose-finding study with no concomitant use of hypnotic agent. ( Horikoshi, R; Kaneko, Y; Kumashiro, H; Mashiko, H; Niwa, S; Numata, Y; Suzuki, S; Watanabe, Y, 1999)
"Mirtazapine was well tolerated, while the trazodone-treated patients experienced somnolence more frequently, particularly during the first 2 weeks of treatment."	2.68	Mirtazapine is more effective than trazodone: a double-blind controlled study in hospitalized patients with major depression. ( de Wilde, J; Dierick, M; Evrard, JL; Mendlewicz, J; van Moffaert, M; Vereecken, A; Wilmotte, J, 1995)
" The aim of the present study was to examine whether pindolol may increase the efficacy of a subtherapeutical dosage of trazodone in the treatment of major depression and TRD, defined according to the Thase and Rush criteria (1995)."	2.68	Efficacy of treatment with trazodone in combination with pindolol or fluoxetine in major depression. ( Desnyder, R; Maes, M; Vandoolaeghe, E, 1996)
"Haloperidol at 4 mg/day was coadministered for 1 week, and blood samplings were taken before and after the coadministration."	2.68	Increases in plasma concentration of m-chlorophenylpiperazine, but not trazodone, with low-dose haloperidol. ( Ishida, M; Kaneko, S; Mihara, K; Ohkubo, T; Osanai, T; Otani, K; Sugawara, K; Suzuki, A; Yasui, N, 1997)
"Fluoxetine was significantly better tolerated than trazodone, with respective dropout rates of 7."	2.67	Long-term treatment of double depression: a preliminary study with serotonergic antidepressants. ( Hellerstein, DJ; Hemlock, C; Kasch, K; Rosenthal, J; Samstag, LW; Winston, A; Yanowitch, P, 1994)
"Trazodone is an effective hypnotic for patients with antidepressant-associated insomnia."	2.67	Trazodone for antidepressant-associated insomnia. ( Adler, LA; Nierenberg, AA; Peselow, E; Rosenthal, M; Zornberg, G, 1994)
"Trazodone was more effective against the sleep disturbance factor."	2.67	A comparison of venlafaxine, trazodone, and placebo in major depression. ( Borison, RL; Carman, JS; Chouinard, G; Crowder, JE; Cunningham, LA; Diamond, BI; Fischer, DE; Hearst, E, 1994)
"Bupropion and trazodone were compared in a two-center, double-blind clinical trial of outpatients with moderate to severe major depression."	2.67	Comparison of bupropion and trazodone for the treatment of major depression. ( Billow, AA; Branconnier, RJ; Johnston, JA; Lineberry, CG; Samara, B; Weisler, RH, 1994)
"Fluoxetine and trazodone were compared in a double-blind, randomized, parallel, 6-week trial in 43 outpatients with major depression after a 1-week single-blind placebo period."	2.66	Fluoxetine versus trazodone in the treatment of outpatients with major depression. ( Debus, JR; Himmel, C; Polatin, P; Rush, AJ; Tyler, D; Weissenburger, J, 1988)
" The authors hypothesize that fluoxetine 20 mg/day may be an ineffective dosage of the drug or that fluoxetine has a slower onset of antidepressant action than does trazodone."	2.66	A comparative trial of fluoxetine versus trazodone in outpatients with major depression. ( Cook, BL; Dunner, FJ; Garvey, MJ; Kelly, MW; Perry, PJ; Winokur, G, 1989)
" Significant improvement was recorded on all items in both groups, the only significant between-group difference being in relation to how tired the patient felt during the day, which was significantly better on night-time dosage at Weeks 1 and 2."	2.65	Trazodone: alternative dose regimens and sleep. ( Wheatley, D, 1984)
"Depression and dysphoria can follow the long-term use of cocaine."	2.65	Trazodone-oral cocaine interactions. ( Benowitz, NL; Jacob, P; Jones, RT; Rowbotham, MC, 1984)
" The results showed equivalent therapeutic efficacy for the two dosage regimens and tolerance was good in both groups."	2.65	Trazodone--a comparison of single night-time and divided daily dosage regimens. ( Ankier, SI; Bouras, N; Bridges, PK; Brooks, D; Jarman, CM; Prothero, W, 1984)
" Therapeutic effects were the same but once daily dosage produced drowsiness whilst thrice daily dosage did not."	2.65	Trazodone in depression. ( Wheatley, D, 1980)
"Trazodone was found to be equivalent in efficacy to imipramine and statistically significantly superior to placebo."	2.65	A controlled study of trazodone, imipramine, and placebo in outpatients with endogenous depression. ( Georgotas, A; Gershon, S; Mann, JJ; Newton, R, 1981)
"Trazodone was found to be significantly better than placebo on almost every rating scale, particularly on those items or factors related to depression and associated anxiety."	2.65	Trazodone in the treatment of neurotic depression. ( Finnerty, RJ; Goldberg, HL, 1980)
"Trazodone was less troublesome in respect of the persistent dry mouth and severe adverse psychiatric reactions which occurred with amitriptyline."	2.65	Trazodone. A comparative clinical and predictive study. ( Ankier, SI; Kerr, TA; McClelland, HA; Stephens, DA, 1984)
" The mean maintenance dosage of trazodone was 300 mg (range 200-350 mg) and of imipramine 160 mg (range 150-175 mg)."	2.65	A double blind comparison of the efficacy and safety of trazodone and imipramine in endogenous depression. ( Al-Yassiri, MM; Ankier, SI; Bridges, PK, 1983)
"Treatment with trazodone promises less risks according to the clinical experience described in the international literature."	2.65	Experiences with doxepin and trazodone in the therapy with outpatients suffering from depression. ( Pöldinger, W, 1984)
" However, the laboratory pharmacological characteristics of agents are a more reliable predictor of side effect profiles than they are of their therapeutic activities."	2.65	Comparative side effect profiles of trazodone and imipramine: special reference to the geriatric population. ( Gershon, S, 1984)
"Trazodone is an established antidepressant that is prescribed frequently as an off-label hypnotic with wide acceptance among psychiatrists."	2.47	Trazodone: properties and utility in multiple disorders. ( Mittur, A, 2011)
"As trazodone has been implicated in cardiac disorders, a further search was conducted using the term cardiac and trazodone."	2.43	A review of the evidence for the efficacy and safety of trazodone in insomnia. ( Mendelson, WB, 2005)
"Insomnia and daytime sleepiness are often associated with depression."	2.42	Daytime sleepiness and insomnia as correlates of depression. ( Fava, M, 2004)
"Trazodone therapy was continued or reinstated shortly after the hypomanic episode without further evidence of hypomania."	2.38	Trazodone-induced transient hypomanic symptoms and their management. ( Fisher, CJ; Jabeen, S, 1991)
"Trazodone has been shown to be safe in overdose, and the side effect profile is mild, with sedation the most common side effect."	2.38	Trazodone dosing regimen: experience with single daily administration. ( Fabre, LF, 1990)
"Severe orthostatic hypotension is more likely to develop in depressed patients with left ventricular impairment and/or in patients taking other drugs like diuretics or vasodilators."	2.38	Review of the cardiovascular effects of heterocyclic antidepressants. ( Glassman, AH; Preud'homme, XA, 1993)
" There are substantial pharmacokinetic differences among the five major classes."	2.38	Pharmacokinetics of antidepressants: why and how they are relevant to treatment. ( Preskorn, SH, 1993)
"Major depressive disorder is a major health concern."	2.38	Somatic therapy for major depressive disorder: selection of an antidepressant. ( Burke, M; Preskorn, SH, 1992)
"Trazodone is an atypical antidepressant drug that is commonly referred to as a serotonin (5-hydroxytryptamine; 5-HT) uptake inhibitor."	2.38	A comparison of trazodone and fluoxetine: implications for a serotonergic mechanism of antidepressant action. ( Marek, GJ; McDougle, CJ; Price, LH; Seiden, LS, 1992)
" In contrast, trazodone is relatively safe when taken in overdose; no deaths have been reported to the manufacturer when trazodone was the only agent taken."	2.37	The greater safety of trazodone over tricyclic antidepressant agents: 5-year experience in the United States. ( Rakel, RE, 1987)
"Trazodone has emerged as the antidepressant drug with the least risk of death in overdose, and as a useful alternative to the standard tricyclic antidepressant drugs in patients with preexisting conduction disease."	2.37	Cardiovascular toxicity of antidepressant medications. ( Glassman, AH; Jackson, WK; Roose, SP, 1987)
"Trazodone has been shown to demonstrate comparable efficacy to the other reuptake and monoamine oxidase inhibitors, but has the advantages of a low cardiovascular-risk profile, extremely low suicide toxicity, absence of anticholinergic side effects, and minimal effects on cognition."	2.37	Geriatric depression and treatment with trazodone. ( Gerner, RH, 1987)
"Trazodone appears to produce less cardiovascular toxicity than tricyclic antidepressants."	2.36	Trazodone (Desyrel, Mead-Johnson Pharmaceutical Division). ( Rawls, WN, 1982)
"Trazodone is a drug that was introduced in the clinic almost 40 years ago."	1.48	Evaluating the dose-dependent mechanism of action of trazodone by estimation of occupancies for different brain neurotransmitter targets. ( Settimo, L; Taylor, D, 2018)
" Greater clinical severity and low initial dosing may increase the risk of switching antidepressants."	1.35	Antidepressant switching among adherent patients treated for depression. ( Hassan, M; Marcus, SC; Olfson, M, 2009)
" The study is designated as semi-naturalistic due to the fact that, although the venlafaxine treatment regimen was strictly defined, the timing of the trazodone introduction and the dosage were determined by the clinicians."	1.33	Trazodone addition for insomnia in venlafaxine-treated, depressed inpatients: a semi-naturalistic study. ( Aït-Ameur, A; Bertschy, G; Ferrero, F; Muscionico, M; Osiek, C; Ragama-Pardos, E; Roth, L, 2005)
"Trazodone has been used widely to treat insomnia in depressed patients."	1.31	Electroconvulsive therapy and cardiovascular complications in patients taking trazodone for insomnia. ( Hanson, CA; Krahn, LE; Pileggi, TS; Rummans, TA, 2001)
"Despite the superior side effect profile of the newer antidepressants over the tricyclics and monoamine oxidase inhibitors, all newer antidepressants are associated with a wide array of side effects."	1.31	The pharmacologic management of SSRI-induced side effects: a survey of psychiatrists. ( Dording, CM; Fava, M; Gordon, J; Kornbluh, R; Mischoulon, D; Nierenberg, AA; Petersen, TJ; Rosenbaum, JE, 2002)
" For both trazodone and mCPP, significant linear relationships were found between plasma concentration after initial dosing and the average of 3 weeks' plasma concentrations."	1.30	Plasma concentrations of trazodone and m-chlorophenylpiperazine at steady state can be predicted from those after an initial dose of trazodone. ( Ishida, M; Kaneko, S; Kondo, T; Mihara, K; Ohkubo, T; Osanai, T; Otani, K; Sugawara, K; Tokinaga, N; Yasui, N, 1997)
"CR trazodone was effective in improving depressive and anxious symptomatology as well as in ameliorating the quality of sleep in 13 patients with a low incidence of side effects."	1.29	[Evaluation of therapeutic efficacy and pharmacokinetics of controlled release of trazodone in patients with major depressive disorder]. ( Delrio, G; Monteleone, P, 1994)
" In an effort to determine whether this discrepancy may be due to possible inappropriate dosing or use of trazodone for different patient subtypes, a retrospective chart review of 138 depressed inpatients treated with amitriptyline and of 42 depressed inpatients treated with trazodone was performed to compare their respective prescribing patterns."	1.28	A drug utilization review of prescribing patterns for trazodone versus amitriptyline. ( Brown, CS; Bryant, SG; Hokanson, JA, 1990)
"Both fluoxetine and trazodone were well tolerated in dysthymics, and showed similar short-term effectiveness in treating dysthymic symptoms."	1.28	A preliminary study of serotonergic antidepressants in treatment of dysthymia. ( Hellerstein, DJ; Hemlock, C; Kasch, K; Rosenthal, J; Samstag, L; Schupak, C; Winston, A; Yanowitch, P, 1992)
"Fluoxetine is an effective serotonin reuptake inhibitor antidepressant that can fail to alleviate either insomnia or major depression in a substantial minority of depressed patients."	1.28	Possible trazodone potentiation of fluoxetine: a case series. ( Cole, JO; Glass, L; Nierenberg, AA, 1992)
"Bilaterally olfactory bulbectomized rats were compared with intact rats in their responsiveness to the acute and chronic administration of nomifensine and trazodone in the learned immobility test of Porsolt."	1.27	Effect of bilateral olfactory bulbectomy in the rat, alone or in combination with antidepressants, on the learned immobility model of depression. ( Earley, B; Górka, Z; Leonard, BE, 1985)
"Trazodone was associated with the occurrence of life-threatening premature ventricular contractions and angina in a 45-year-old white man who had no prior cardiovascular disease."	1.27	A case of trazodone-induced ventricular tachycardia. ( Aronson, MD; Hafez, H, 1986)
"Trazodone tends to inhibit biochemical and pharmacological functions depending on the catecholaminergic system, whereas imipramine has a potentiating activity."	1.27	Trazodone, a new avenue in the treatment of depression. ( Silvestrini, B; Valeri, P, 1984)
"Trazodone has become a very popular second generation antidepressant."	1.27	A retrospective evaluation of plasma trazodone concentrations and clinical response in a primary care clinic. ( Garvey, MJ; Luxenberg, M; Saxena, S; Tollefson, GD, 1988)
"4 ng/ml and significantly correlated with dosage at r = 0."	1.27	Plasma trazodone concentrations in elderly depressed inpatients: cardiac effects and short-term efficacy. ( Spar, JE, 1987)
"Trazodone hydrochloride has a short half-life compared with other commercially available antidepressants."	1.27	A possible diurnal variation in trazodone clearance. ( Baxter, LR; Smith, GB; Wilkins, JN, 1986)
"Trazodone is a molecule which is already well known throughout the world for its antidepressant properties and its good global safety."	1.27	[Telematic multicenter study of Pragmarel 100 mg (trazodone)]. ( Benkelfat, C; Gay, C; Renardet, M, 1986)
"The antidepressant efficacy of trazodone has been studied during three weeks in 13 endogenously depressed patients, using a fixed dosage of 5/10 mg/kg bodyweight per day."	1.27	Trazodone in endogenous depressed patients: a negative report and a critical evaluation of the pertaining literature. ( Klein, HE; Müller, N, 1985)

Research

Studies (259)

Authors

Clinical Trials (6)

Trial Overview

Trial Outcomes

Change in Beck Depression Inventory II (BDI-II)

Timeframe	Studies, this research(%)	All Research%
pre-1990	156 (60.23)	18.7374
1990's	77 (29.73)	18.2507
2000's	19 (7.34)	29.6817
2010's	6 (2.32)	24.3611
2020's	1 (0.39)	2.80

Authors	Studies
Digala, LP	1
Lucchese, S	1
Settimo, L	1
Taylor, D	1
Chen, HM	1
Yang, YH	1
Chen, KJ	1
Lee, Y	1
McIntyre, RS	1
Lu, ML	1
Lee, YC	1
Hsieh, MC	1
Chen, VC	1
Marcus, SC	1
Hassan, M	1
Olfson, M	1
Brass, SD	1
Auerbach, S	1
Luo, WZ	1
Zhang, QZ	1
Lai, XS	1
Mittur, A	1
Marinescu, IP	1
Predescu, A	1
Udriştoiu, T	1
Marinescu, D	1
Kem, DL	1
Posey, DJ	1
McDougle, CJ	2
Mihara, K	4
Yasui-Furukori, N	1
Kondo, T	2
Ishida, M	4
Ono, S	1
Ohkubo, T	6
Osanai, T	5
Sugawara, K	6
Otani, K	6
Kaneko, S	6
Dording, CM	1
Mischoulon, D	1
Petersen, TJ	1
Kornbluh, R	1
Gordon, J	1
Nierenberg, AA	4
Rosenbaum, JE	1
Fava, M	2
Taylor, MJ	1
Carney, SM	1
Goodwin, GM	1
Geddes, JR	1
James, SP	1
Mendelson, WB	2
Bertschy, G	1
Ragama-Pardos, E	1
Muscionico, M	1
Aït-Ameur, A	1
Roth, L	1
Osiek, C	1
Ferrero, F	1
Zivanović, O	1
Till, E	1
Florkowski, A	1
Gruszczyński, W	1
Gałecki, P	1
Zboralski, K	1
Kołodziejska, I	1
Mikołajczyk, I	1
Camacho, A	1
Ng, B	1
Howes, OD	1
Ayd, FJ	1
Settle, EC	2
Burchinskiĭ, SG	1
Silvestrini, B	3
Valeri, P	1
Leonard, BE	6
Loeb, DC	1
Roccatagliata, G	3
Albano, C	2
Abbruzzese, G	1
Janowsky, D	2
Curtis, G	2
Zisook, S	2
Kuhn, K	2
Resovsky, K	2
Le Winter, M	2
Himmelhoch, JM	1
Schechtman, K	1
Auchenbach, R	1
Gershon, S	6
Georgotas, A	3
Newton, R	2
Bush, D	1
Kelwala, S	1
Stanley, M	1
Al-Yassiri, MM	1
Ankier, SI	8
Bridges, PK	2
Healy, D	4
Carney, PA	4
Fabre, LF	3
Feighner, JP	4
Dominguez, RA	1
Hayes, RL	1
Gerner, RH	2
Fairbanks, L	1
Moran, M	1
Waltuch, L	1
Beaumont, G	1
Gringras, M	1
Pöldinger, W	1
van de Merwe, TJ	3
Silverstone, T	2
Warrington, SJ	1
Turner, P	1
Agnoli, A	2
De Gregorio, M	1
Dionisio, A	1
Wheatley, D	2
Lydiard, RB	1
Pottash, AL	1
Gold, MS	1
Rowbotham, MC	1
Jones, RT	1
Benowitz, NL	1
Jacob, P	1
Bennie, EH	1
Khan, MC	1
Tyrer, SP	1
Siddiqui, U	1
Kerr, TA	1
McClelland, HA	1
Stephens, DA	1
Birkhimer, LJ	1
Alderman, AA	1
Schmitt, CE	1
Ednie, KJ	1
Brooks, D	1
Prothero, W	1
Bouras, N	1
Jarman, CM	1
Warren, M	1
Bick, PA	1
Jones, SD	1
Rausch, JL	1
Pavlinac, DM	1
Newman, PE	1
McCracken, J	1
Kosanin, R	1
Wold, P	1
Damlouji, NF	1
Ferguson, JM	1
Erickson, J	1
Fisher, A	1
Scher, M	1
Krieger, JN	2
Juergens, S	1
Lippmann, S	1
Bedford, P	1
Manshadi, M	1
Mather, S	1
Kraft, TB	1
Pellettier, JR	1
Bartolucci, G	1
Zetin, M	1
Zimmer, B	1
Daly, F	1
Benjamin, L	1
Lansky, MR	1
Selzer, J	1
Doweiko, J	1
Fogel, BS	1
Goldberg, RJ	1
Kieback, DG	1
Bowdan, ND	1
Irwin, M	1
Spar, JE	2
Shopsin, B	1
Brogden, RN	1
Heel, RC	1
Speight, TM	1
Avery, GS	1
Moises, HW	1
Kasper, S	2
Beckmann, H	1
Mann, JJ	3
Rawls, WN	1
Rickels, K	1
Case, WG	1
Cassano, GB	1
Conti, L	1
Dell'Osso, L	1
Massimetti, G	1
Scardigli, G	1
Jans, G	1
Vencovský, E	3
Peterová, E	3
Kieback, D	1
Murialdo, G	1
Giovale, M	1
Zauli, C	1
Polleri, A	1
Cavanagh, P	1
Pohlmeier, H	1
Friedman, E	1
Lange, E	1
Riedel, C	1
König, L	1
Liefke, T	1
Kursawe, H	1
Shader, RI	1
Greenblatt, DJ	1
Pisl, I	1
Goldberg, HL	1
Finnerty, RJ	1
Purcell, P	1
Ghurye, R	1
van Moffaert, M	1
de Wilde, J	1
Vereecken, A	1
Dierick, M	1
Evrard, JL	1
Wilmotte, J	1
Mendlewicz, J	1
Yasui, N	5
Fukushima, Y	1
Parrino, L	1
Spaggiari, MC	1
Boselli, M	1
Di Giovanni, G	1
Terzano, MG	1
Nemeroff, CB	3
Bodner, RA	1
Lynch, T	1
Lewis, L	1
Kahn, D	1
Monteleone, P	3
Delrio, G	2
Fernandez, F	1
Levy, JK	1
Katkov, YA	1
Otmakhova, NA	1
Gurevich, EV	1
Nesterova, IV	1
Bobkova, NV	1
Forster, P	1
King, J	1
Adler, LA	1
Peselow, E	1
Zornberg, G	1
Rosenthal, M	1
Weisler, RH	1
Johnston, JA	1
Lineberry, CG	1
Samara, B	1
Branconnier, RJ	1
Billow, AA	1
Bystritsky, A	1
Waikar, SV	1
Hellerstein, DJ	2
Yanowitch, P	2
Rosenthal, J	2
Hemlock, C	2
Kasch, K	2
Samstag, LW	1
Winston, A	2
Cunningham, LA	1
Borison, RL	1
Carman, JS	1
Chouinard, G	1
Crowder, JE	1
Diamond, BI	1
Fischer, DE	1
Hearst, E	1
Fisher, S	1
Bryant, SG	2
Kent, TA	1
Van der Klauw, MM	1
Janssen, JC	1
Stricker, BH	1
Preskorn, SH	2
Workman, EA	2
Short, DD	1
Lanes, T	1
Ravaris, CL	1
Glassman, AH	2
Preud'homme, XA	1
Salzman, C	2
Terao, T	2
Van Bemmel, AL	2
Beersma, DG	1
Van den Hoofdakker, RH	1
Rothschild, AJ	1
Robillard, M	1
Lieff, S	1
George, TP	1
Godleski, LS	1
Little, KY	1
Gay, TL	1
Maes, M	3
Van de Vyvere, J	1
Vandoolaeghe, E	3
Bril, T	1
Demedts, P	2
Wauters, A	2
Neels, H	2
Pecknold, JC	1
Langer, SF	1
Desnyder, R	1
Lewis, CF	1
DeQuardo, JR	1
Tandon, R	1
Van Hunsel, F	1
Suzuki, A	2
Tokinaga, N	1
Hrdina, PD	1
Bakish, D	2
Ravindran, A	1
Chudzik, J	1
Cavazzoni, P	1
Lapierre, YD	1
Patterson, DE	1
Braverman, SE	1
Belandres, PV	1
Levi, G	1
Sogos, C	1
Kallepalli, BR	1
Bhatara, VS	1
Fogas, BS	1
Tervo, RC	1
Misra, LK	1
Nakano, H	1
Meng, X	1
Nagasaki, T	1
Tsuchida, S	1
Gonzalez, FJ	1
Croghan, TW	1
Lair, TJ	1
Engelhart, L	1
Crown, WE	1
Copley-Merriman, C	1
Melfi, CA	1
Obenchain, RL	1
Buesching, DP	1
Mirassou, MM	1
Lennkh, C	1
Fischer, P	1
Küfferle, B	1
Evans, CL	1
Ha, Y	1
Saisch, S	1
Ellison, Z	1
Fombonne, E	1
Mashiko, H	1
Niwa, S	1
Kumashiro, H	1
Kaneko, Y	1
Suzuki, S	1
Numata, Y	1
Horikoshi, R	1
Watanabe, Y	1
Romero, AS	1
Delgado, RG	1
Peña, MF	1
Magder, DM	1
Aleksic, I	1
Kennedy, SH	1
Michael, A	1
O'Donnell, EA	1
Krahn, LE	1
Hanson, CA	1
Pileggi, TS	1
Rummans, TA	1
Peschina, W	1
Conca, A	1
König, P	1
Fritzsche, H	1
Beraus, W	1
McCue, RE	1
Joseph, M	1
Saletu-Zyhlarz, GM	1
Abu-Bakr, MH	1
Anderer, P	1
Gruber, G	1
Mandl, M	1
Strobl, R	1
Gollner, D	1
Prause, W	1
Saletu, B	1
Loeb, C	1
Besio, G	1
Marek, GJ	1
Price, LH	2
Seiden, LS	1
White, K	1
Kando, J	1
Park, T	1
Waternaux, C	1
Brown, WA	1
Schupak, C	1
Samstag, L	1
Burke, M	1
Patten, SB	1
Cole, JO	4
Glass, L	1
Tellian, F	1
Short, D	1
Havermans, RG	1
van Diest, R	1
Mück-Seler, D	1
Jakovljević, M	1
Deanović, Z	1
Kafka, MP	1
Jabeen, S	1
Fisher, CJ	1
Sullivan, M	1
Beasley, CM	1
Dornseif, BE	1
Pultz, JA	1
Bosomworth, JC	1
Sayler, ME	1
Solomon, RL	1
Rich, CL	1
Darko, DF	1
Fudge, JL	1
Perry, PJ	2
Garvey, MJ	3
Kelly, MW	2
Scharf, MB	1
Sachais, BA	1
Hokanson, JA	1
Brown, CS	1
Catapano, F	1
Galderisi, S	1
Bardin, ED	1
Jacobsen, FM	1
Gnocchi, G	2
Browne, JL	1
Rice, JL	1
Evans, DL	2
Prange, AJ	1
Silver, JM	1
Hales, RE	1
Yudofsky, SC	1
Górka, Z	1
Earley, B	1
Aronson, MD	1
Hafez, H	1
Pohl, R	1
Bridges, M	1
Rainey, JM	1
Boudoulas, H	1
Yeragani, VK	2
Figiel, GS	1
Krishnan, KR	1
Breitner, JC	1
Katasonow, AB	1
Brusow, OS	1
Beljaew, BS	1
Slobina, GP	1
Faktor, MI	2
Larionowa, TB	1
Trunte, K	1
Lidemann, RR	1
Giannelli, A	1
Rabboni, M	1
Zarattini, F	1
Malgeri, C	1
Magnolfi, G	1
Altamura, AC	2
Mauri, MC	2
Rudas, N	2
Carpiniello, B	1
Montanini, R	2
Perini, M	2
Scapicchio, PL	2
Hadjchristos, C	2
Carucci, G	2
Minervini, M	2
Bayer, AJ	1
Pathy, MS	1
Cameron, A	1
Venkateswalu, T	1
Ather, SA	1
Mankikar, GD	1
Ghosh, AK	1
Cook, BL	1
Dunner, FJ	1
Winokur, G	1
Pope, HG	1
Keck, PE	2
McElroy, SL	1
Hudson, JI	1
Botros, WA	1
Priest, RG	1
McManus, IC	1
Steinert, J	1
Samir, ZY	1
Spivak, B	2

Trial	Phase	Enrollment	Study Type	Start Date	Status
Music to Improve Sleep Quality in Adults With Depression and Insomnia: a Randomized Controlled Trial Using Mixed Methods[NCT03676491]		112 participants (Actual)	Interventional	2018-05-23	Completed
Study of Antidepressants in Parkinson's Disease[NCT00086190]	Phase 3	115 participants (Actual)	Interventional	2005-06-30	Completed
Treatment Strategy to Prevent Mood Disorders Following Traumatic Brain Injury[NCT00704379]	Phase 2/Phase 3	94 participants (Actual)	Interventional	2008-06-30	Completed
[NCT05753943]		0 participants	Expanded Access		No longer available
Tolcapone Treatment of Obsessive Compulsive Disorder: A Double-Blind, Placebo-Controlled, Cross-Over Pilot Study[NCT03348930]	Phase 2/Phase 3	20 participants (Actual)	Interventional	2018-03-20	Completed
Stimulation magnétique transcrânienne répétitive Dans le Traitement Des Troubles Obsessionnels Compulsifs[NCT02884674]		56 participants (Anticipated)	Interventional	2015-05-31	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Beck Depression Inventory II ranges from 0-63. Higher score indicates more severe depression. 0-13 minimal depression, 14-19 mild depression, 20-28 moderate depression, 29-63 severe depression. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

Change in Brief Psychiatric Rating Scale (BPRS)

Intervention	Change in BDI-II score (Mean)
Paroxetine	-9.7
Venlafaxine Extended Release	-9.6
Placebo	-5.2

Brief Psychiatric Rating Scale. Maximum score 126. Higher score indicates greater psychiatric difficulties. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

Change in Geriatric Depression Rating Scale (GDS)

Intervention	Change in BPRS score (Mean)
Paroxetine	-9.0
Venlafaxine Extended Release	-9.8
Placebo	-4.4

Geriatric Depression Scale ranges from 0-30. Higher score indicates more severe depression. 0-9 normal, 10-19 mild depression, 20-30 severe depression. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

Change in Hamilton Depression Rating Scale (HAM-D) Scores

Intervention	Change in GDS score (Mean)
Paroxetine	-6.9
Venlafaxine Extended Release	-6.9
Placebo	-2.8

Change in Hamilton Rating Scale for Depression over 12 weeks. Hamilton Depression Rating Scale ranges from 0-50. Higher scores represent more significant depression. Mild depression ranges from 8-13, moderate depression from 14-18, severe 19-22 and very severe any score over 23. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

Change in Montgomery-Asberg Depression Rating Scale (MADRS)

Intervention	Change in HAM-D score (Mean)
Paroxetine	-13.0
Venlafaxine Extended Release	-11.0
Placebo	-6.8

Montgomery-Asberg Depression Rating Scale ranges from 0-60. Higher score indicates more severe depression. 0-6 normal, 7-19 mild depression, 20-34 moderate depression, greater than 34 severe depression. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

Change in Parkinson's Disease Questionnaire (PDQ) - 39 - Emotional Well-Being

Intervention	Change in MADRS score (Mean)
Paroxetine	-13.6
Venlafaxine Extended Release	-10.9
Placebo	-6.6

Parkinson's Disease Questionnaire (PDQ-39) - Emotional Well-Being maximum score 24, minimum score of 0.Lower score indicates a better perceived health status. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

Change in Parkinson's Disease Questionnaire (PDQ) - 39 - Overall

Intervention	Change in PDQ-39 Emotional score (Mean)
Paroxetine	-21.4
Venlafaxine Extended Release	-20.7
Placebo	-10.9

Parkinson's Disease Questionnaire (PDQ-39) Total. Range 0-100. Lower score indicates a better perceived health status. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

Change in Pittsburgh Sleep Quality Index (PSQI)

Intervention	Change in PDQ-39 score (Mean)
Paroxetine	-8.0
Venlafaxine Extended Release	-8.4
Placebo	-5.3

Pittsburgh Sleep Quality Index scores range from 0-21, with higher scores indicating severe sleep difficulties. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

Change in Short Form 36 Health Survey - Mental Component Summary

Intervention	Change in PQSI score (Mean)
Paroxetine	-2.1
Venlafaxine Extended Release	-2.6
Placebo	-1.1

Short Form 36 Health Survey. Range 0-100. Higher score indicates a better perceived quality of life. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

Change in Short Form 36 Health Survey - Mental Health

Intervention	Change in SF-36 mental score (Mean)
Paroxetine	11.4
Venlafaxine Extended Release	9.5
Placebo	4.8

Short Form 36 Health Survey - Mental Health subscale ranges from 0-100. Higher score indicates a better perceived quality of life. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

Change in Short Form 36 Health Survey - Role-Emotional

Intervention	Change in SF-36 Mental Health score (Mean)
Paroxetine	16.7
Venlafaxine Extended Release	17.4
Placebo	9.7

Short Form 36 Health Survey - Emotional subscale ranges from 0-100. Higher score indicates a better perceived quality of life. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

Change in Short Form 36 Health Survey - Vitality

Intervention	Change in SF-36 Role score (Mean)
Paroxetine	39.5
Venlafaxine Extended Release	26.9
Placebo	12.7

Short Form 36 Health Survey - Vitality subscale ranges from 0-100. Higher score indicates a better perceived quality of life. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

Change in Snaith Clinical Anxiety Scale (CAS)

Intervention	Change in SF-36 vitality score (Mean)
Paroxetine	13.5
Venlafaxine Extended Release	9.1
Placebo	4.7

Snaith Clinical Anxiety Scale. Range 0-21. Higher scores indicate increased anxiety. Score greater than 8 indicates clinical anxiety. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

Change in Unified Parkinson's Disease Rating Scale (UPDRS)

Intervention	Change in CAS score (Mean)
Paroxetine	-3.6
Venlafaxine Extended Release	-3.2
Placebo	-2.4

Unified Parkinson's Disease Rating Scale. Higher score indicates more severe Parkinson's disease symptoms. Total maximum = 176. Mental maximum = 52, Activities of Daily Living maximum = 52, Motor maximum = 72. Minimum = 0. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

Change in Unified Parkinson's Disease Rating Scale (UPDRS) - Bulbar

Intervention	Change in UPDRS score (Mean)
Paroxetine	-8.7
Venlafaxine Extended Release	-7.0
Placebo	-4.3

Unified Parkinson's Disease Rating Scale - Bulbar maximum score 24, minimum score of 0. Higher score indicates more severe Parkinson's disease symptoms. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

Change in Unified Parkinson's Disease Rating Scale (UPDRS) - Motor

Intervention	Change in UPDRS-Bulbar score (Mean)
Paroxetine	-1.4
Venlafaxine Extended Release	-1.4
Placebo	-0.5

Unified Parkinson's Disease Rating Scale - Motor has a maximum score of 72, minimum score of 0. Higher score indicates more severe Parkinson's disease symptoms. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

Change in Unified Parkinson's Disease Rating Scale (UPDRS) - Tremor

Intervention	Change in UPDRS-motor score (Mean)
Paroxetine	-4.3
Venlafaxine Extended Release	-2.0
Placebo	-1.0

Unified Parkinson's Disease Rating Scale - Tremor subscale ranges from 0-23. Higher score indicates more severe Parkinson's disease symptoms. (NCT00086190)
Timeframe: from the beginning (0 weeks) to end (12 weeks) of the double-blind phase

Iowa Gambling Task Score

Intervention	Change in UPDRS-tremor score (Mean)
Paroxetine	0.4
Venlafaxine Extended Release	0.5
Placebo	-0.6

The Iowa Gambling Task (IGT) evaluates decision making ability. During IGT subjects have to choose between decks of cards which yield high immediate gain but larger future loss (i.e., long term loss), and decks which yield lower immediate gain but a smaller future loss (i.e., a long term gain). The task consists of four decks of cards: A, B, C, and D. The goal in the task is to maximize profit. Subjects are required to make a series of card selections. The decks A and B are long term loss decks and the decks C and D are long term gain decks. The IGT Score reported is the combination of the raw score for each deck combined in the following way: (C+D) - (A+B). The range for this score is: -100 to 100. Higher values of this score indicate better decision making ability. (NCT00704379)
Timeframe: 6 months after TBI

Memory Function Composite

Intervention	units on a scale (Mean)
Placebo	16.67
Sertraline	-0.77

This outcome measures memory function and is a composite of five standardized scores: Brief Visuospatial Memory Test - Revised, Delayed Recall and California Verbal Learning Test, Short Delay Free Recall Number Correct and Discriminability, and Long Delay Free Recall Number Correct and Discriminability. Standardized scores (i.e., z-scores) for each test of this composite were obtained by subtracting the mean raw score of all participants to the raw score of each participant and dividing the result by the standard deviation of the raw scores of all participants. The composite score was obtained by averaging the z-scores of the four memory tests mentioned previously. Range: -3 to 3. Higher scores represent better memory function. (NCT00704379)
Timeframe: 6 months following traumatic brain injury

Neuroimaging Variables (i.e., Fractional Anisotropy [FA] of Frontal White Matter Such as the Cingulate Gyrus)

Intervention	z-scores (Mean)
Placebo	-0.08
Sertraline	0.07

"FA is a measured obtained from Diffusion Tensor Imaging, an image modality of Magnetic Resonance Imaging (MRI). FA is a unitless index. Range: 0 to 1. FA describes the degree of anisotropy of a diffusion process. A value of zero means that diffusion is unrestricted or equally restricted in all directions. A value of one means that diffusion occurs only along one axis and is fully restricted along all other directions. In the context of this study, FA measures the integrity of the cingulate gyrus white matter. Higher FA values reflect higher integrity of the cingulate gyrus white matter tract. Average FA values for the right and left cingulate gyri were summed.~One aim of this project was to identify predictors of the occurrence of mood disturbances during the first 6 months following TBI. The hypothesis for this aim was that patients who develop a mood or anxiety disorder six months after TBI present at baseline with lower FA of the cingulate gyrus than those who do not." (NCT00704379)
Timeframe: Baseline

Social Functioning Examination Total Score

Intervention	unitless index (Mean)
Patients Who Developped a Mood or Anxiety Disorder	0.91
Patients Who Did Not Developped a Mood or Anxiety Disorder	0.94

The Social Functioning Examination (SFE) is a semi-structured interview that measures social functioning in areas such as interpersonal relationships, work adjustment, use of community resources and satisfaction with living environment. Range: 0 to 1. Higher scores denote lower levels of social functioning. (NCT00704379)
Timeframe: 6 months after TBI

Time to Onset of Diagnostic and Statistical Manual (DSM) IV Defined Mood and Anxiety Disorders Associated With Traumatic Brain Injury (TBI)

Intervention	units on a scale (Mean)
Placebo	0.04
Sertraline	0.04

"Following the DSM-IV (now updated by the DSM-5), depressive disorders associated with TBI are categorized as Mood Disorder Due to Another Medical Condition with subtypes: 1) With major depressive-like episode (if the full criteria for a major depressive episode [MDE] are met) or 2) With depressive features (prominent depressed mood but full criteria for a MDE are not met); and 3) with mixed features (e.g. significant irritability, pressured speech and formal thought disorder).~On the other hand, bipolar and related disorders due to TBI are subdivided in: 1) with manic or hypomanic like episode; 2) with manic features; and 3) with mixed features.~A similar conceptual framework has been used to define Anxiety Disorder due to another Medical Condition, in this case, TBI. According to DSM-IV/DSM-5, such diagnosis can be made when, besides an evident pathophysiological relationship with TBI, panic attacks or generalized anxiety are the prominent features of the clinical presentation." (NCT00704379)
Timeframe: 6 months after TBI

Total Community Integration Questionnaire Scores

Intervention	weeks (Mean)
Placebo	21.4264
Sertraline	15.7833

The Community Integration Questionnaire (CIQ) is intended as a brief, reliable measure of an individual's level of integration into the home and community following traumatic brain injury. Total CIQ scores were used as the outcome measure. Range: 0 to 25. Higher scores indicate higher levels of integration into the home and community following TBI. (NCT00704379)
Timeframe: 6 months after TBI

Clinical Global Impression- Severity and Improvement (CGI)

Intervention	units on a scale (Mean)
Placebo	16.77
Sertraline	17.67

"The entire study for the subject will last 5 weeks. Every two weeks and after the one week washout period the subject will complete the CGI. The change in scores from baseline to after 5 weeks will be assessed. The scale itself assesses overall disorder severity on a scale from 1 to 7 with 1 being not at all and 7 being among the most severe cases" (NCT03348930)
Timeframe: 2 weeks (start of study to washout period OR two weeks following washout period)

Hamilton Anxiety Rating Scale (HAM-A)

Intervention	score on a scale (Mean)
Tolcapone	3.78
Placebo	3.5

Every study visit, the subject will complete the HAM-A. The change in scores from baseline to after 5 weeks will be assessed. The scale itself assesses level of anxiety. Higher scores indicate higher levels of anxiety, with 0 being no symptoms of anxiety and 30 being severe anxiety. (NCT03348930)
Timeframe: 2 weeks (start of study to washout period OR two weeks following washout period)

Hamilton Depression Rating Scale (HAM-D)

Intervention	mean change in HAM-A score (Mean)
Tolcapone	-1.90
Placebo	-1.60

The entire study for the subject will last 5 weeks. The HAM-D will be administered at every study visit. The change in scores from baseline to after the end of the 2-week active treatment period will be assessed and the change in scores from baseline to the end of the 2-week placebo period. The scale itself assesses level of depression. The minimum score is 0 and indicates no depressive symptoms, while the highest possible score is 50. Higher total scores indicate high levels of depression. Higher scores indicate a worse outcome. Higher total scored (14-50) indicate higher levels of depression, while a score between 0-7 is considered normal. (NCT03348930)
Timeframe: 2 weeks (start of study to washout period OR two weeks following washout period)

Sheehan Disability Scale (SDS)

Intervention	mean change in HAM-D score (Mean)
Tolcapone	-1.65
Placebo	-2.00

The entire study for the subject will last 5 weeks. Every two weeks and after the one week washout period the subject will complete the SDS. The change in scores from baseline to after 5 weeks will be assessed. The scale itself assesses the level of disability from obsessive compulsive disorder (or target disorder). The SDS is a brief, 5-item self-report tool that assesses functional impairment in work/school, social life, and family life. Work/school scores range from 0 to 10, Social life scores range from 0 to 10, Family life/home responsibilities scores range from 0 to 10). Total scores are calculated by adding the scores for work/school, social life, and family life. Total scores range from a minimum of 0 to a maximum of 30 (0 unimpaired, 30 highly impaired). (NCT03348930)
Timeframe: 2 weeks (start of study to washout period OR two weeks following washout period)

Yale Brown Obsessive Compulsive Scale (Y-BOCS)

Intervention	mean change in SDS score (Mean)
Tolcapone	-2.68
Placebo	-1.97

The entire study for the subject will last 5 weeks. Every 2 weeks and after the one week washout period the subject will take the YBOCS. The change in scores from baseline to after 5 weeks will be assessed. The scale itself assesses severity of OCD symptoms. The YBOCS scale ranges from 0 to 40, with 0 being no symptoms and 40 being severe. (NCT03348930)
Timeframe: 2 weeks (start of study to washout period OR two weeks following washout period)

Article	Year
Extended-release trazodone (Oleptro) for depression. The Medical letter on drugs and therapeutics, 2010, Nov-15, Volume: 52, Issue:1351 Topics: Animals; Antidepressive Agents, Second-Generation; Delayed-Action Preparations; Depressive Disorder;	2010
Trazodone: properties and utility in multiple disorders. Expert review of clinical pharmacology, 2011, Volume: 4, Issue:2 Topics: Animals; Anxiety Disorders; Chronic Pain; Cognition Disorders; Depressive Disorder; Humans; Mental D	2011
Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials. Journal of psychopharmacology (Oxford, England), 2004, Volume: 18, Issue:2 Topics: Administration, Oral; Aged; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Drug Ad	2004
The use of trazodone as a hypnotic: a critical review. The Journal of clinical psychiatry, 2004, Volume: 65, Issue:6 Topics: Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Comorbidity; Depressive Disorder; Humans; Hypn	2004
Daytime sleepiness and insomnia as correlates of depression. The Journal of clinical psychiatry, 2004, Volume: 65 Suppl 16 Topics: Antidepressive Agents; Benzhydryl Compounds; Bupropion; Comorbidity; Depressive Disorder; Disorders	2004
A review of the evidence for the efficacy and safety of trazodone in insomnia. The Journal of clinical psychiatry, 2005, Volume: 66, Issue:4 Topics: Adult; Age Factors; Aged; Antidepressive Agents, Second-Generation; Clinical Trials as Topic; Depres	2005
Trazodone: a novel, broad-spectrum antidepressant. Modern problems of pharmacopsychiatry, 1982, Volume: 18 Topics: Animals; Anxiety Disorders; Depressive Disorder; Hemodynamics; Humans; Neurotransmitter Agents; Para	1982
[Biochemical aspects of using antidepressants in late middle age and the elderly (review)]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1983, Volume: 83, Issue:4 Topics: Age Factors; Aged; Aging; Antidepressive Agents; Catechol O-Methyltransferase; Depression; Depressiv	1983
History of antidepressants: successes and failures. The Journal of clinical psychiatry, 1983, Volume: 44, Issue:5 Pt 2 Topics: Albuterol; Animals; Antidepressive Agents; Brompheniramine; Bupropion; Clinical Trials as Topic; Dep	1983
Trazodone: a review of its pharmacological properties and therapeutic use in depression and anxiety. Drugs, 1981, Volume: 21, Issue:6 Topics: Aged; Animals; Anxiety Disorders; Brain; Cardiovascular System; Clinical Trials as Topic; Depressive	1981
Trazodone (Desyrel, Mead-Johnson Pharmaceutical Division). Drug intelligence & clinical pharmacy, 1982, Volume: 16, Issue:1 Topics: Animals; Depressive Disorder; Drug Interactions; Half-Life; Humans; Piperazines; Tissue Distribution	1982
Four new atypical antidepressants (trazodone, mianserin, nomifensine, caroxazone): results of controlled trials. Advances in biochemical psychopharmacology, 1982, Volume: 32 Topics: Antidepressive Agents; Benzeneacetamides; Clinical Trials as Topic; Depressive Disorder; Drug Therap	1982
Evolutionary trends in the pharmacotherapeutic management of depression. The Journal of clinical psychiatry, 1994, Volume: 55 Suppl Topics: Adolescent; Adult; Age Factors; Aged; Animals; Antidepressive Agents; Antidepressive Agents, Tricycl	1994
Psychopharmacology in HIV spectrum disorders. The Psychiatric clinics of North America, 1994, Volume: 17, Issue:1 Topics: Acquired Immunodeficiency Syndrome; AIDS Dementia Complex; Anti-Anxiety Agents; Antipsychotic Agents	1994
Definitive treatment of patients with serious mental disorders in an emergency service, Part I. Hospital & community psychiatry, 1994, Volume: 45, Issue:9 Topics: Antidepressive Agents; Anxiety Disorders; Depressive Disorder; Emergency Services, Psychiatric; Hosp	1994
Pharmacokinetics of antidepressants: why and how they are relevant to treatment. The Journal of clinical psychiatry, 1993, Volume: 54 Suppl Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Biological Availability; Bupropion; Depress	1993
Atypical antidepressants versus imipramine in the treatment of major depression: a meta-analysis. The Journal of clinical psychiatry, 1993, Volume: 54, Issue:1 Topics: Antidepressive Agents; Bupropion; Depressive Disorder; Fluoxetine; Humans; Imipramine; Trazodone	1993
Review of the cardiovascular effects of heterocyclic antidepressants. The Journal of clinical psychiatry, 1993, Volume: 54 Suppl Topics: Amoxapine; Antidepressive Agents; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Bupropion;	1993
Pharmacologic treatment of depression in the elderly. The Journal of clinical psychiatry, 1993, Volume: 54 Suppl Topics: Age Factors; Aged; Antidepressive Agents; Antidepressive Agents, Tricyclic; Bupropion; Depressive Di	1993
The diagnosis and treatment of late-life depression. The Journal of clinical psychiatry, 1996, Volume: 57 Suppl 5 Topics: Age Factors; Aged; Antidepressive Agents; Anxiety Disorders; Bupropion; Cyclohexanols; Depressive Di	1996
A comparison of trazodone and fluoxetine: implications for a serotonergic mechanism of antidepressant action. Psychopharmacology, 1992, Volume: 109, Issue:1-2 Topics: Animals; Antidepressive Agents; Depressive Disorder; Fluoxetine; Humans; Serotonin; Trazodone	1992
Somatic therapy for major depressive disorder: selection of an antidepressant. The Journal of clinical psychiatry, 1992, Volume: 53 Suppl Topics: 1-Naphthylamine; Antidepressive Agents; Bupropion; Depressive Disorder; Humans; Nortriptyline; Sertr	1992
The comparative efficacy of trazodone and imipramine in the treatment of depression. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 1992, Apr-01, Volume: 146, Issue:7 Topics: Clinical Trials as Topic; Confidence Intervals; Depressive Disorder; Humans; Imipramine; Meta-Analys	1992
Monoamine oxidase inhibitors and atypical antidepressants. Clinics in geriatric medicine, 1992, Volume: 8, Issue:2 Topics: Aged; Antidepressive Agents; Bupropion; Depressive Disorder; Fluoxetine; Humans; Methylphenidate; Mo	1992
Trazodone-induced transient hypomanic symptoms and their management. The British journal of psychiatry : the journal of mental science, 1991, Volume: 158 Topics: Adult; Aged; Bipolar Disorder; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans	1991
Trazodone dosing regimen: experience with single daily administration. The Journal of clinical psychiatry, 1990, Volume: 51 Suppl Topics: Circadian Rhythm; Depressive Disorder; Drug Administration Schedule; Half-Life; Humans; Sleep; Sleep	1990
The paradoxical stress response: a possible common basis for depression and other conditions. The Journal of clinical psychiatry, 1990, Volume: 51 Suppl Topics: Animals; Depressive Disorder; Rabbits; Rats; Stress, Physiological; Sympathetic Nervous System; Traz	1990
Depression and cerebral stroke. The Journal of clinical psychiatry, 1990, Volume: 51 Suppl Topics: Cerebrovascular Disorders; Depressive Disorder; Humans; Trazodone	1990
Psychopharmacology of depression in neurologic disorders. The Journal of clinical psychiatry, 1990, Volume: 51 Suppl Topics: Amitriptyline; Antidepressive Agents; Depressive Disorder; Electroconvulsive Therapy; Humans; Nervou	1990
United States experience and perspectives with trazodone. Clinical neuropharmacology, 1989, Volume: 12 Suppl 1 Topics: Aged; Bulimia; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Female; Humans; Male;	1989
Therapeutic effects of serotonin uptake inhibitors in depression. The Journal of clinical psychiatry, 1986, Volume: 47 Suppl Topics: 5-Hydroxytryptophan; Alanine; Citalopram; Depressive Disorder; Fluoxetine; Fluvoxamine; Humans; Imip	1986
Recent studies on selective serotonergic antidepressants: trazodone, fluoxetine, and fluvoxamine. Journal of clinical psychopharmacology, 1987, Volume: 7, Issue:6 Suppl Topics: Animals; Antidepressive Agents; Depressive Disorder; Fluoxetine; Fluvoxamine; Humans; Oximes; Seroto	1987
Overview of USA controlled trials of trazodone in clinical depression. Psychopharmacology, 1988, Volume: 95 Suppl Topics: Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Humans; Random Allocation; Trazo	1988
The drug treatment of anxiety and depression. The Medical clinics of North America, 1988, Volume: 72, Issue:4 Topics: Antidepressive Agents, Tricyclic; Anxiety Disorders; Benzodiazepines; Depressive Disorder; Humans; M	1988
United States experience with trazodone: a literature review. Psychopathology, 1987, Volume: 20 Suppl 1 Topics: Depressive Disorder; Humans; Trazodone	1987
Recent experience with trazodone. Psychopathology, 1987, Volume: 20 Suppl 1 Topics: Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Humans; Trazodone	1987
Trazodone: a 5-year review of antidepressant efficacy. Psychopathology, 1987, Volume: 20 Suppl 1 Topics: Depressive Disorder; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Trazodo	1987
The greater safety of trazodone over tricyclic antidepressant agents: 5-year experience in the United States. Psychopathology, 1987, Volume: 20 Suppl 1 Topics: Antidepressive Agents, Tricyclic; Depressive Disorder; Humans; Trazodone	1987
Cardiovascular toxicity of antidepressant medications. Psychopathology, 1987, Volume: 20 Suppl 1 Topics: Antidepressive Agents; Arrhythmias, Cardiac; Depressive Disorder; Humans; Hypotension, Orthostatic;	1987
Geriatric depression and treatment with trazodone. Psychopathology, 1987, Volume: 20 Suppl 1 Topics: Adjustment Disorders; Aged; Depressive Disorder; Humans; Trazodone	1987

Article	Year
[Effect of acupuncture treatment of relieving depression and regulating mind on insomnia accompanied with depressive disorders]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion, 2010, Volume: 30, Issue:11 Topics: Acupuncture Therapy; Adult; Depressive Disorder; Female; Humans; Male; Middle Aged; Sleep Initiation	2010
Relationship between plasma concentrations of trazodone and its active metabolite, m-chlorophenylpiperazine, and its clinical effect in depressed patients. Therapeutic drug monitoring, 2002, Volume: 24, Issue:4 Topics: Adult; Antidepressive Agents, Second-Generation; Chromatography, High Pressure Liquid; Depressive Di	2002
Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials. Journal of psychopharmacology (Oxford, England), 2004, Volume: 18, Issue:2 Topics: Administration, Oral; Aged; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Drug Ad	2004
[Trazodone and venlafaxine in treatment of depressive disorders]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego, 2005, Volume: 18, Issue:107 Topics: Adult; Antidepressive Agents, Second-Generation; Bipolar Disorder; Cyclohexanols; Depressive Disorde	2005
Clinical evaluation of two new antidepressants. Advances in biochemical psychopharmacology, 1982, Volume: 32 Topics: Adolescent; Adult; Aged; Antidepressive Agents; Brompheniramine; Clinical Trials as Topic; Depressiv	1982
History of antidepressants: successes and failures. The Journal of clinical psychiatry, 1983, Volume: 44, Issue:5 Pt 2 Topics: Albuterol; Animals; Antidepressive Agents; Brompheniramine; Bupropion; Clinical Trials as Topic; Dep	1983
A double blind comparison of the efficacy and safety of trazodone and imipramine in endogenous depression. Journal of affective disorders, 1983, Volume: 5, Issue:4 Topics: Adult; Clinical Trials as Topic; Depressive Disorder; Desipramine; Double-Blind Method; Female; Huma	1983
Biochemical correlates of antidepressant response. Results of a trazodone versus amitriptyline trial. Psychopathology, 1984, Volume: 17 Suppl 2 Topics: Amitriptyline; Blood Platelets; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method;	1984
Long-term therapy for depression with trazodone. The Journal of clinical psychiatry, 1983, Volume: 44, Issue:1 Topics: Ambulatory Care; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Humans; Imipram	1983
Evaluating the effectiveness of the new antidepressants. Hospital & community psychiatry, 1983, Volume: 34, Issue:5 Topics: Amoxapine; Antidepressive Agents; Clinical Trials as Topic; Depressive Disorder; Humans; Maprotiline	1983
ECG findings in geriatric depressives given trazodone, placebo, or imipramine. The Journal of clinical psychiatry, 1983, Volume: 44, Issue:5 Topics: Aged; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Electrocardiography; Femal	1983
Trazodone and mianserin in general practice. Psychopathology, 1984, Volume: 17 Suppl 2 Topics: Adult; Anxiety Disorders; Clinical Trials as Topic; Depressive Disorder; Dibenzazepines; Double-Blin	1984
Experiences with doxepin and trazodone in the therapy with outpatients suffering from depression. Psychopathology, 1984, Volume: 17 Suppl 2 Topics: Adult; Ambulatory Care; Clinical Trials as Topic; Depressive Disorder; Dibenzazepines; Dose-Response	1984
A double-blind study to compare trazodone with amitriptyline in depressed patients. Psychopathology, 1984, Volume: 17 Suppl 2 Topics: Adult; Amitriptyline; Anxiety Disorders; Clinical Trials as Topic; Depressive Disorder; Dose-Respons	1984
Comparative side effect profiles of trazodone and imipramine: special reference to the geriatric population. Psychopathology, 1984, Volume: 17 Suppl 2 Topics: Aged; Clinical Trials as Topic; Depressive Disorder; Humans; Imipramine; Mental Recall; Piperazines;	1984
A double-blind non-crossover placebo-controlled study between group comparison of trazodone and amitriptyline on cardiovascular function in major depressive disorder. Psychopathology, 1984, Volume: 17 Suppl 2 Topics: Adult; Amitriptyline; Arrhythmias, Cardiac; Clinical Trials as Topic; Depressive Disorder; Double-Bl	1984
Trazodone, a review of clinical literature and personal experience. Psychopathology, 1984, Volume: 17 Suppl 2 Topics: Clinical Trials as Topic; Depressive Disorder; Drug Tolerance; Electrocardiography; Electroencephalo	1984
Trazodone: alternative dose regimens and sleep. Pharmatherapeutica, 1984, Volume: 3, Issue:9 Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Drug Ad	1984
Speed of onset of action of the newer antidepressants. Psychopharmacology bulletin, 1984,Spring, Volume: 20, Issue:2 Topics: Amitriptyline; Amoxapine; Antidepressive Agents; Clinical Trials as Topic; Depression; Depressive Di	1984
Trazodone-oral cocaine interactions. Archives of general psychiatry, 1984, Volume: 41, Issue:9 Topics: Administration, Oral; Adult; Blood Pressure; Clinical Trials as Topic; Cocaine; Depressive Disorder;	1984
Comparison of trazodone and mianserin in depressive illness. Current medical research and opinion, 1984, Volume: 9, Issue:4 Topics: Adult; Aged; Clinical Trials as Topic; Depressive Disorder; Dibenzazepines; Double-Blind Method; Fem	1984
Trazodone. A comparative clinical and predictive study. Acta psychiatrica Scandinavica, 1984, Volume: 70, Issue:6 Topics: Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Female; Humans; Male; Mid	1984
Trazodone in major affective disorders. Psychopathology, 1984, Volume: 17 Suppl 2 Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female;	1984
Trazodone--a comparison of single night-time and divided daily dosage regimens. Psychopharmacology, 1984, Volume: 84, Issue:1 Topics: Adolescent; Adult; Aged; Blood Pressure; Depressive Disorder; Drug Administration Schedule; Female;	1984
Electrophysiological and haemodynamic changes with trazodone, amitriptyline and placebo in depressed out-patients. Current medical research and opinion, 1984, Volume: 9, Issue:5 Topics: Adult; Ambulatory Care; Amitriptyline; Blood Pressure; Depressive Disorder; Double-Blind Method; Ele	1984
[Psychological test methods in pharmacopsychiatry]. Pharmacopsychiatria, 1982, Volume: 15, Issue:5 Topics: Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Humans; Piperazin	1982
Trazodone: a review of its pharmacological properties and therapeutic use in depression and anxiety. Drugs, 1981, Volume: 21, Issue:6 Topics: Aged; Animals; Anxiety Disorders; Brain; Cardiovascular System; Clinical Trials as Topic; Depressive	1981
Trazodone in depression. International pharmacopsychiatry, 1980, Volume: 15, Issue:4 Topics: Adult; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Humans; Imipramin	1980
Trazodone and amitriptyline in treatment of depressed inpatients. A double-blind study. Pharmacopsychiatria, 1981, Volume: 14, Issue:5 Topics: Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Electroencephalog	1981
A controlled study of trazodone, imipramine, and placebo in outpatients with endogenous depression. Journal of clinical psychopharmacology, 1981, Volume: 1, Issue:2 Topics: Adult; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Humans; Imipramin	1981
Trazodone in depressed outpatients. The American journal of psychiatry, 1982, Volume: 139, Issue:6 Topics: Adult; Ambulatory Care; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Double-Blind M	1982
Four new atypical antidepressants (trazodone, mianserin, nomifensine, caroxazone): results of controlled trials. Advances in biochemical psychopharmacology, 1982, Volume: 32 Topics: Antidepressive Agents; Benzeneacetamides; Clinical Trials as Topic; Depressive Disorder; Drug Therap	1982
Comparative double-blind study on efficacy and side-effects of trazodone, nomifensine, mianserin in elderly patients. Advances in biochemical psychopharmacology, 1982, Volume: 32 Topics: Aged; Clinical Trials as Topic; Depressive Disorder; Dibenzazepines; Double-Blind Method; Female; Hu	1982
[Comparison of the Hamilton Depression Rating Scale and the Self Rating Scale BS (v. Zerssen) within a double blind study on the antidepressant effects of trazodone verus amitriptyline (author's transl)]. Pharmacopsychiatria, 1982, Volume: 15, Issue:3 Topics: Administration, Oral; Adult; Amitriptyline; Depressive Disorder; Female; Humans; Male; Middle Aged;	1982
Trazodone in the treatment of neurotic depression. The Journal of clinical psychiatry, 1980, Volume: 41, Issue:12 Pt 1 Topics: Adolescent; Adult; Amitriptyline; Depressive Disorder; Female; Humans; Male; Middle Aged; Piperazine	1980
Mirtazapine is more effective than trazodone: a double-blind controlled study in hospitalized patients with major depression. International clinical psychopharmacology, 1995, Volume: 10, Issue:1 Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Depressive Disorder; Double-Blind Method; Female; Hum	1995
Clinical and polysomnographic effects of trazodone CR in chronic insomnia associated with dysthymia. Psychopharmacology, 1994, Volume: 116, Issue:4 Topics: Adult; Chronic Disease; Delayed-Action Preparations; Depressive Disorder; Female; Humans; Male; Midd	1994
Trazodone for antidepressant-associated insomnia. The American journal of psychiatry, 1994, Volume: 151, Issue:7 Topics: Adult; Bupropion; Confidence Intervals; Depressive Disorder; Dose-Response Relationship, Drug; Doubl	1994
Comparison of bupropion and trazodone for the treatment of major depression. Journal of clinical psychopharmacology, 1994, Volume: 14, Issue:3 Topics: Adult; Bupropion; Depressive Disorder; Double-Blind Method; Drug Administration Schedule; Female; Hu	1994
Inert placebo versus active medication. Patient blindability in clinical pharmacological trials. The Journal of nervous and mental disease, 1994, Volume: 182, Issue:9 Topics: Clinical Trials as Topic; Clomipramine; Depressive Disorder; Double-Blind Method; Humans; Obsessive-	1994
Long-term treatment of double depression: a preliminary study with serotonergic antidepressants. Progress in neuro-psychopharmacology & biological psychiatry, 1994, Volume: 18, Issue:1 Topics: Adult; Depressive Disorder; Female; Fluoxetine; Humans; Infant, Newborn; Male; Middle Aged; Psychiat	1994
A comparison of venlafaxine, trazodone, and placebo in major depression. Journal of clinical psychopharmacology, 1994, Volume: 14, Issue:2 Topics: Adult; Antidepressive Agents; Blood Pressure; Cyclohexanols; Depressive Disorder; Double-Blind Metho	1994
Comparison of manic switch onset during fluoxetine and trazodone treatment. Biological psychiatry, 1993, Mar-15, Volume: 33, Issue:6 Topics: Adult; Bipolar Disorder; Depressive Disorder; Double-Blind Method; Female; Fluoxetine; Humans; Male;	1993
Changes in EEG power density of non-REM sleep in depressed patients during treatment with trazodone. Journal of affective disorders, 1995, Oct-09, Volume: 35, Issue:1-2 Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder; Dose-Response Relationship, Dr	1995
Acute stimulant response prediction of chronic trazodone effects. Progress in neuro-psychopharmacology & biological psychiatry, 1996, Volume: 20, Issue:5 Topics: Adult; Antidepressive Agents, Second-Generation; Central Nervous System Stimulants; Depressive Disor	1996
Alterations in iron metabolism and the erythron in major depression: further evidence for a chronic inflammatory process. Journal of affective disorders, 1996, Sep-09, Volume: 40, Issue:1-2 Topics: Acute-Phase Reaction; Adrenergic beta-Antagonists; Adult; Aged; Antidepressive Agents, Second-Genera	1996
Efficacy of treatment with trazodone in combination with pindolol or fluoxetine in major depression. Journal of affective disorders, 1996, Dec-16, Volume: 41, Issue:3 Topics: Adult; Aged; Antidepressive Agents, Second-Generation; Depressive Disorder; Double-Blind Method; Dru	1996
Lower total serum protein, albumin, and beta- and gamma-globulin in major and treatment-resistant depression: effects of antidepressant treatments. Psychiatry research, 1996, Dec-20, Volume: 65, Issue:3 Topics: Acute-Phase Proteins; Adrenergic beta-Antagonists; Adult; Aged; Alpha-Globulins; Antidepressive Agen	1996
Increases in plasma concentration of m-chlorophenylpiperazine, but not trazodone, with low-dose haloperidol. Therapeutic drug monitoring, 1997, Volume: 19, Issue:1 Topics: Adult; Antidepressive Agents, Second-Generation; Antipsychotic Agents; Cytochrome P-450 CYP2D6 Inhib	1997
Effect of trazodone in a single dose before bedtime for sleep disorders accompanied by a depressive state: dose-finding study with no concomitant use of hypnotic agent. Psychiatry and clinical neurosciences, 1999, Volume: 53, Issue:2 Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder; Dose-Response Relationship, Dr	1999
Tolerability and efficacy of high-dose moclobemide alone and in combination with lithium and trazodone. Journal of clinical psychopharmacology, 2000, Volume: 20, Issue:3 Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder; Humans; Lithium; Male; Moclobe	2000
Insomnia in depression: differences in objective and subjective sleep and awakening quality to normal controls and acute effects of trazodone. Progress in neuro-psychopharmacology & biological psychiatry, 2002, Volume: 26, Issue:2 Topics: Adult; Aged; Antidepressive Agents; Cross-Over Studies; Depressive Disorder; Female; Humans; Male; M	2002
Effects of trazodone on EEG sleep and clinical state in major depression. Psychopharmacology, 1992, Volume: 107, Issue:4 Topics: Adult; Depressive Disorder; Electroencephalography; Female; Humans; Male; Middle Aged; Psychiatric S	1992
Effect of antidepressant treatment on platelet 5-HT content and relation to therapeutic outcome in unipolar depressive patients. Journal of affective disorders, 1991, Volume: 23, Issue:3 Topics: Adult; Aged; Amitriptyline; Antidepressive Agents; Blood Platelets; Depressive Disorder; Double-Blin	1991
Fluoxetine versus trazodone: efficacy and activating-sedating effects. The Journal of clinical psychiatry, 1991, Volume: 52, Issue:7 Topics: Adult; Akathisia, Drug-Induced; Ambulatory Care; Anxiety; Depressive Disorder; Dizziness; Double-Bli	1991
A comparison of the effect of fluoxetine and trazodone on the cognitive functioning of depressed outpatients. Journal of affective disorders, 1990, Volume: 18, Issue:4 Topics: Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Sche	1990
A combination of hypothalamic phospholipid liposomes with trazodone for treatment of depression. An open controlled study. Acta psychiatrica Scandinavica, 1989, Volume: 79, Issue:1 Topics: Adult; Aged; Arousal; Clinical Trials as Topic; Combined Modality Therapy; Depressive Disorder; Fema	1989
United States experience and perspectives with trazodone. Clinical neuropharmacology, 1989, Volume: 12 Suppl 1 Topics: Aged; Bulimia; Chronic Disease; Clinical Trials as Topic; Depressive Disorder; Female; Humans; Male;	1989
Clinical activity and tolerability of trazodone, mianserin, and amitriptyline in elderly subjects with major depression: a controlled multicenter trial. Clinical neuropharmacology, 1989, Volume: 12 Suppl 1 Topics: Aged; Amitriptyline; Depressive Disorder; Double-Blind Method; Female; Humans; Male; Mianserin; Midd	1989
A comparative study of conventional and controlled-release formulations of trazodone in elderly depressed patients. Clinical neuropharmacology, 1989, Volume: 12 Suppl 1 Topics: Aged; Aged, 80 and over; Delayed-Action Preparations; Depressive Disorder; Double-Blind Method; Fema	1989
A comparative trial of fluoxetine versus trazodone in outpatients with major depression. The Journal of clinical psychiatry, 1989, Volume: 50, Issue:8 Topics: Adult; Ambulatory Care; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female;	1989
A placebo-controlled study of trazodone in bulimia nervosa. Journal of clinical psychopharmacology, 1989, Volume: 9, Issue:4 Topics: Adult; Bulimia; Clinical Trials as Topic; Depressive Disorder; Dose-Response Relationship, Drug; Dou	1989
Clinical assessment and performance tasks in depression: a comparison of amitriptyline and trazodone. The British journal of psychiatry : the journal of mental science, 1989, Volume: 155 Topics: Adolescent; Adult; Aged; Amitriptyline; Depressive Disorder; Double-Blind Method; Female; Humans; Ma	1989
Experimental examination of trazodone. Clinical neuropharmacology, 1989, Volume: 12 Suppl 1 Topics: Adult; Amitriptyline; Anxiety; Depression; Depressive Disorder; Double-Blind Method; Female; Haloper	1989
The new generation antidepressants: promising innovations or disappointments? The Journal of clinical psychiatry, 1985, Volume: 46, Issue:10 Pt 2 Topics: Alprazolam; Antidepressive Agents; Benzodiazepines; Bupropion; Citalopram; Clinical Trials as Topic;	1985
Fluoxetine versus trazodone in the treatment of outpatients with major depression. The Journal of clinical psychiatry, 1988, Volume: 49, Issue:11 Topics: Ambulatory Care; Clinical Trials as Topic; Depressive Disorder; Dizziness; Double-Blind Method; Fluo	1988
Trazodone for treatment of older depressed patients: comment. Journal of clinical psychopharmacology, 1988, Volume: 8, Issue:6 Topics: Aged; Aged, 80 and over; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Humans;	1988
Experimental comparison between the effect of standardized trazodone-amitriptyline and placebo treatment in vitalized depressive patients. Psychopharmacology, 1988, Volume: 95 Suppl Topics: Adult; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Female; Hu	1988
Clinical experience with antidepressive infusion therapy: trazodone. Psychopharmacology, 1988, Volume: 95 Suppl Topics: Adult; Aged; Ambulatory Care; Blood Pressure; Clinical Trials as Topic; Depressive Disorder; Drug To	1988
Trazodone in late life depressive states: a double-blind multicenter study versus amitriptyline and mianserin. Psychopharmacology, 1988, Volume: 95 Suppl Topics: Aged; Aged, 80 and over; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Double-Blind	1988
Overview of USA controlled trials of trazodone in clinical depression. Psychopharmacology, 1988, Volume: 95 Suppl Topics: Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Humans; Random Allocation; Trazo	1988
Recent experience with trazodone. Psychopathology, 1987, Volume: 20 Suppl 1 Topics: Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Humans; Trazodone	1987
Differential dosing of trazodone in elderly depressed patients: a study to investigate optimal dosing. The Journal of international medical research, 1986, Volume: 14, Issue:5 Topics: Aged; Clinical Trials as Topic; Depressive Disorder; Double-Blind Method; Drug Tolerance; Female; Hu	1986
The dexamethasone suppression test and antidepressant response in major depression. Journal of psychiatric research, 1987, Volume: 21, Issue:3 Topics: Adolescent; Adult; Aged; Anthracenes; Depressive Disorder; Dexamethasone; Dose-Response Relationship	1987
Weight changes in antidepressants: a comparison of amitriptyline and trazodone. Neuropsychobiology, 1986, Volume: 15 Suppl 1 Topics: Adolescent; Adult; Amitriptyline; Body Weight; Depressive Disorder; Humans; Middle Aged; Trazodone	1986
[Review of studies of trazodone at the Feighner Research Institute in ambulatory and hospitalized patients]. L'Encephale, 1986, Volume: 12 Spec No Topics: Adolescent; Adult; Aged; Ambulatory Care; Depressive Disorder; Double-Blind Method; Female; Hospital	1986
Self-rating data as a selecting factor in clinical trials of psychotropic drugs. European archives of psychiatry and neurological sciences, 1985, Volume: 235, Issue:2 Topics: Adolescent; Adult; Aged; Amitriptyline; Clinical Trials as Topic; Depressive Disorder; Double-Blind	1985

Article	Year
IV Lidocaine Infusion Leading to the Toxic Levels in Serum Causing Asystole - A Case Report. Headache, 2020, Volume: 60, Issue:1 Topics: Anesthetics; Depressive Disorder; Drug Interactions; Female; Headache Disorders; Heart Arrest; Human	2020
Evaluating the dose-dependent mechanism of action of trazodone by estimation of occupancies for different brain neurotransmitter targets. Journal of psychopharmacology (Oxford, England), 2018, Volume: 32, Issue:1 Topics: Animals; Antidepressive Agents; Brain; Dementia; Depression; Depressive Disorder; Humans; Hypnotics	2018
Antidepressants Reduced Risk of Mortality in Patients With Diabetes Mellitus: A Population-Based Cohort Study in Taiwan. The Journal of clinical endocrinology and metabolism, 2019, 10-01, Volume: 104, Issue:10 Topics: Adolescent; Adult; Aged; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cohort Studies; Co	2019
Antidepressant switching among adherent patients treated for depression. Psychiatric services (Washington, D.C.), 2009, Volume: 60, Issue:5 Topics: Adolescent; Adult; Aged; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cyclohexanols; Dep	2009
A sleepy patient with REM rebound. Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2009, Aug-15, Volume: 5, Issue:4 Topics: Adult; Antidepressive Agents; Depressive Disorder; Diagnosis, Differential; Humans; Male; Narcolepsy	2009
Comparative study of neuroprotective effect of tricyclics vs. trazodone on animal model of depressive disorder. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie, 2012, Volume: 53, Issue:2 Topics: Animals; Antidepressive Agents, Tricyclic; Depressive Disorder; Dexamethasone; Disease Models, Anima	2012
Priapism associated with trazodone in an adolescent with autism. Journal of the American Academy of Child and Adolescent Psychiatry, 2002, Volume: 41, Issue:7 Topics: Adolescent; Autistic Disorder; Depressive Disorder; Humans; Male; Priapism; Selective Serotonin Reup	2002
The pharmacologic management of SSRI-induced side effects: a survey of psychiatrists. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 2002, Volume: 14, Issue:3 Topics: Akathisia, Drug-Induced; Antidepressive Agents, Second-Generation; Bupropion; Critical Pathways; Dat	2002
Trazodone addition for insomnia in venlafaxine-treated, depressed inpatients: a semi-naturalistic study. Pharmacological research, 2005, Volume: 51, Issue:1 Topics: Adult; Chi-Square Distribution; Cyclohexanols; Depressive Disorder; Drug Therapy, Combination; Femal	2005
[Serotonin syndrome--a case account]. Medicinski pregled, 1992, Volume: 45, Issue:3-4 Topics: Antidepressive Agents; Depressive Disorder; Humans; Male; Middle Aged; Moclobemide; Monoamine Oxidas	1992
Methylphenidate for alpha-interferon induced depression. Journal of psychopharmacology (Oxford, England), 2006, Volume: 20, Issue:5 Topics: Affect; Aged; Antineoplastic Agents; Central Nervous System Stimulants; Depressive Disorder; Humans;	2006
Compulsions in depression: stalking by text message. The American journal of psychiatry, 2006, Volume: 163, Issue:9 Topics: Adult; Behavior Therapy; Combined Modality Therapy; Communication Aids for Disabled; Compulsive Beha	2006
Trazodone, a new avenue in the treatment of depression. Psychopathology, 1984, Volume: 17 Suppl 2 Topics: Alcohol Withdrawal Delirium; Brain; Depressive Disorder; Humans; Imipramine; Neurotransmitter Agents	1984
Pharmacology of new antidepressants. Progress in neuro-psychopharmacology & biological psychiatry, 1984, Volume: 8, Issue:1 Topics: Animals; Antidepressive Agents; Brain; Depressive Disorder; Disease Models, Animal; Dopamine; Humans	1984
[Cerebrospinal HVA and 5-HIAA in patients with endogenous depression in the course of treatment]. Schweizer Archiv fur Neurologie, Neurochirurgie und Psychiatrie = Archives suisses de neurologie, neurochirurgie et de psychiatrie, 1980, Volume: 126, Issue:1 Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Bromocriptine; Depressive Disorder; Electroconvulsive	1980
Ventricular arrhythmias possibly aggravated by trazodone. The American journal of psychiatry, 1983, Volume: 140, Issue:6 Topics: Adult; Arrhythmia, Sinus; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Depressive Disorder; H	1983
Trazodone-aggravated ventricular arrhythmias. Journal of clinical psychopharmacology, 1983, Volume: 3, Issue:6 Topics: Adult; Angina Pectoris; Cardiac Complexes, Premature; Depressive Disorder; Humans; Hypertension; Mal	1983
The role of trazodone in the treatment of depressed cardiac patients. Psychopathology, 1984, Volume: 17 Suppl 2 Topics: Aged; Anxiety Disorders; Arrhythmias, Cardiac; Bipolar Disorder; Cardiac Complexes, Premature; Depre	1984
Combined trazodone-lithium therapy for refractory depression. The American journal of psychiatry, 1983, Volume: 140, Issue:10 Topics: Depressive Disorder; Drug Therapy, Combination; Humans; Lithium; Lithium Carbonate; Male; Middle Age	1983
Two case reports of trazodone-induced mania. The American journal of psychiatry, 1984, Volume: 141, Issue:9 Topics: Adult; Bipolar Disorder; Depressive Disorder; Female; Humans; Middle Aged; Piperazines; Psychoses, S	1984
Ejaculatory inhibition with trazodone. Journal of clinical psychopharmacology, 1984, Volume: 4, Issue:5 Topics: Depressive Disorder; Ejaculation; Humans; Male; Middle Aged; Piperazines; Trazodone	1984
Complete heart block following a single dose of trazodone. The American journal of psychiatry, 1984, Volume: 141, Issue:11 Topics: Aged; Depressive Disorder; Dose-Response Relationship, Drug; Heart Block; Humans; Male; Piperazines;	1984
Trazodone administration during ECT associated with cardiac conduction abnormality. The American journal of psychiatry, 1984, Volume: 141, Issue:11 Topics: Depressive Disorder; Electroconvulsive Therapy; Female; Heart Block; Humans; Middle Aged; Piperazine	1984
Trazodone in the treatment of bulimia. The Journal of clinical psychiatry, 1983, Volume: 44, Issue:7 Topics: Depressive Disorder; Feeding and Eating Disorders; Humans; Hyperphagia; Piperazines; Trazodone	1983
Trazodone-induced delirium in bulimic patients. The American journal of psychiatry, 1984, Volume: 141, Issue:3 Topics: Adolescent; Adult; Delirium; Depressive Disorder; Feeding and Eating Disorders; Female; Hallucinatio	1984
Myalgia associated with trazodone. The American journal of psychiatry, 1983, Volume: 140, Issue:9 Topics: Depressive Disorder; Humans; Male; Middle Aged; Muscles; Obsessive-Compulsive Disorder; Pain; Pipera	1983
Trazodone and priapism. The American journal of psychiatry, 1983, Volume: 140, Issue:10 Topics: Combined Modality Therapy; Depressive Disorder; Dose-Response Relationship, Drug; Humans; Male; Midd	1983
Trazodone cardiotoxicity. The American journal of psychiatry, 1983, Volume: 140, Issue:10 Topics: Arrhythmias, Cardiac; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; Middle	1983
Psychoses following trazodone administration. The American journal of psychiatry, 1983, Volume: 140, Issue:10 Topics: Depressive Disorder; Female; Humans; Middle Aged; Piperazines; Psychoses, Substance-Induced; Trazodo	1983
Trazodone and cardiovascular side effects. Journal of clinical psychopharmacology, 1984, Volume: 4, Issue:2 Topics: Aged; Arrhythmias, Cardiac; Depressive Disorder; Humans; Male; Piperazines; Trazodone	1984
Combined use of trazodone and phenelzine in depression: case report. The Journal of clinical psychiatry, 1984, Volume: 45, Issue:4 Topics: Adult; Depressive Disorder; Drug Administration Schedule; Drug Therapy, Combination; Humans; Male; P	1984
More on combination antidepressant therapy. Archives of general psychiatry, 1984, Volume: 41, Issue:5 Topics: Adult; Aged; Depressive Disorder; Drug Therapy, Combination; Female; Humans; Male; Phenelzine; Piper	1984
Priapism associated with trazodone therapy: case report. The Journal of clinical psychiatry, 1984, Volume: 45, Issue:5 Topics: Adult; Depressive Disorder; Humans; Male; Piperazines; Priapism; Trazodone	1984
Trazodone and hemodialysis. The Journal of clinical psychiatry, 1984, Volume: 45, Issue:8 Topics: Aged; Depressive Disorder; Humans; Kidney Failure, Chronic; Male; Piperazines; Renal Dialysis; Trazo	1984
Trazodone hydrochloride in depressive illness. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1983, Feb-05, Volume: 63, Issue:6 Topics: Depressive Disorder; Humans; Piperazines; Trazodone	1983
Seizure possibly caused by trazodone HCl. The American journal of psychiatry, 1983, Volume: 140, Issue:5 Topics: Adult; Depressive Disorder; Female; Humans; Piperazines; Seizures; Trazodone	1983
Reversible cardiac conduction abnormality associated with trazodone administration. The American journal of psychiatry, 1983, Volume: 140, Issue:7 Topics: Aged; Depressive Disorder; Heart Block; Humans; Male; Piperazines; Trazodone	1983
Second generation antidepressants. The Journal of clinical psychiatry, 1980, Volume: 41, Issue:12 Pt 2 Topics: Antidepressive Agents, Tricyclic; Catecholamines; Depressive Disorder; Double-Blind Method; Fluoxeti	1980
Trazodone (Desyrel), a new non-tricyclic antidepressant. The Medical letter on drugs and therapeutics, 1982, May-14, Volume: 24, Issue:609 Topics: Depressive Disorder; Humans; Piperazines; Trazodone	1982
[Therapeutic effects of trazodone in endogenous depressions (author's transl)]. Ceskoslovenska psychiatrie, 1982, Volume: 78, Issue:2 Topics: Adult; Aged; Depressive Disorder; Female; Humans; Male; Middle Aged; Piperazines; Trazodone	1982
Recently introduced antidepressants: their place in clinical practice. Postgraduate medicine, 1982, Volume: 72, Issue:3 Topics: Amoxapine; Antidepressive Agents; Bundle of His; Chemical Phenomena; Chemistry; Depressive Disorder;	1982
Neuroendocrinological and clinical data upon trazodone treatment in depressed patients. Neuropsychobiology, 1982, Volume: 8, Issue:5 Topics: Adult; Aged; Circadian Rhythm; Depressive Disorder; Growth Hormone; Humans; Male; Middle Aged; Piper	1982
Trazodone hydrochloride in depressive illness. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde, 1982, Oct-23, Volume: 62, Issue:18 Topics: Adjustment Disorders; Adult; Depressive Disorder; Humans; Male; Piperazines; Trazodone	1982
[Contribution to a discussion on the importance of the non-tricyclic antidepressives for the development of a theory of depression (author's transl)]. Pharmacopsychiatria, 1981, Volume: 14, Issue:2 Topics: Antidepressive Agents; Depressive Disorder; Humans; Middle Aged; Trazodone; Tremor	1981
The antidepressant effects of trazodone and inhibition of platelet serotonin reuptake. Communications in psychopharmacology, 1980, Volume: 4, Issue:4 Topics: Antidepressive Agents; Blood Platelets; Depressive Disorder; Double-Blind Method; Humans; Imipramine	1980
[Clinical investigation comparing trazodone and clomipramine]. Psychiatrie, Neurologie, und medizinische Psychologie, 1980, Volume: 32, Issue:12 Topics: Clomipramine; Depressive Disorder; Humans; Piperazines; Trazodone	1980
Antidepressants: the second harvest and DSM-III. Journal of clinical psychopharmacology, 1981, Volume: 1, Issue:2 Topics: Amoxapine; Antidepressive Agents; Depressive Disorder; Humans; Trazodone	1981
The therapeutic effect of Trazodon with endogenous depressions. Agressologie: revue internationale de physio-biologie et de pharmacologie appliquees aux effets de l'agression, 1981, Volume: 22, Issue:E Topics: Adult; Aged; Depressive Disorder; Female; Humans; Male; Middle Aged; Piperazines; Psychiatric Status	1981
[Comparison of antidepressant action of trazodon and imipramine (author's transl)]. Ceskoslovenska psychiatrie, 1980, Volume: 76, Issue:3 Topics: Adult; Depressive Disorder; Humans; Imipramine; Middle Aged; Piperazines; Trazodone	1980
Trazodone and spontaneous orgasms in an elderly postmenopausal woman: a case report. Journal of clinical psychopharmacology, 1995, Volume: 15, Issue:4 Topics: Aged; Antidepressive Agents, Second-Generation; Depressive Disorder; Female; Humans; Orgasm; Sexual	1995
Trazodone treatment increases plasma prolactin concentrations in depressed patients. International clinical psychopharmacology, 1995, Volume: 10, Issue:2 Topics: Adult; Depressive Disorder; Female; Follow-Up Studies; Humans; Male; Middle Aged; Piperazines; Prola	1995
Serotonin syndrome. Neurology, 1995, Volume: 45, Issue:2 Topics: Depressive Disorder; Humans; Isocarboxazid; Male; Methylphenidate; Middle Aged; Nervous System Disea	1995
[Evaluation of therapeutic efficacy and pharmacokinetics of controlled release of trazodone in patients with major depressive disorder]. Minerva psichiatrica, 1994, Volume: 35, Issue:4 Topics: Adult; Aged; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; Male; Middle Age	1994
Antidepressants suppress bulbectomy-induced augmentation of voluntary alcohol consumption in C57B1/6j but not in DBA/2j mice. Physiology & behavior, 1994, Volume: 56, Issue:3 Topics: Alcohol Drinking; Amitriptyline; Animals; Antidepressive Agents; Arousal; Depressive Disorder; Disea	1994
Postmarketing surveillance by patient self-monitoring: trazodone versus fluoxetine. Journal of clinical psychopharmacology, 1993, Volume: 13, Issue:4 Topics: Adult; Adverse Drug Reaction Reporting Systems; Data Collection; Depressive Disorder; Female; Fluoxe	1993
Agranulocytosis probably induced by trazodone. The American journal of psychiatry, 1993, Volume: 150, Issue:10 Topics: Adult; Agranulocytosis; Depressive Disorder; Humans; Male; Trazodone	1993
Prolonged ECT seizure duration in a patient taking trazodone. The American journal of psychiatry, 1993, Volume: 150, Issue:3 Topics: Aged; Depressive Disorder; Electroconvulsive Therapy; Female; Humans; Seizures; Trazodone	1993
Augmentation of antidepressant therapy by buspirone: three geriatric case histories. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1995, Volume: 40, Issue:10 Topics: Aged; Aged, 80 and over; Antidepressive Agents; Buspirone; Depressive Disorder; Dose-Response Relati	1995
Possible serotonin syndrome with trazodone addition to fluoxetine. Biological psychiatry, 1996, Mar-01, Volume: 39, Issue:5 Topics: Adult; Antidepressive Agents, Second-Generation; Depressive Disorder; Drug Therapy, Combination; Epi	1996
Carbamazepine augmentation therapy in three patients with trazodone-resistant unipolar depression. International clinical psychopharmacology, 1996, Volume: 11, Issue:1 Topics: Aged; Anticonvulsants; Carbamazepine; Depressive Disorder; Drug Resistance; Drug Therapy, Combinatio	1996
Rapid synergistic effects of lithium and antidepressants. Psychopharmacology, 1995, Volume: 122, Issue:2 Topics: Adult; Antidepressive Agents; Antidepressive Agents, Second-Generation; Clomipramine; Depressive Dis	1995
Priapism: trazodone versus nefazodone. The Journal of clinical psychiatry, 1996, Volume: 57, Issue:11 Topics: Antidepressive Agents, Second-Generation; Depressive Disorder; Humans; Male; Middle Aged; Piperazine	1996
Dystonia associated with trazodone and sertraline. Journal of clinical psychopharmacology, 1997, Volume: 17, Issue:1 Topics: 1-Naphthylamine; Adult; Antidepressive Agents, Second-Generation; Depressive Disorder; Dose-Response	1997
Plasma concentrations of trazodone and m-chlorophenylpiperazine at steady state can be predicted from those after an initial dose of trazodone. Progress in neuro-psychopharmacology & biological psychiatry, 1997, Volume: 21, Issue:1 Topics: Adult; Aged; Depressive Disorder; Female; Humans; Male; Middle Aged; Piperazines; Trazodone	1997
Platelet serotonergic indices in major depression: up-regulation of 5-HT2A receptors unchanged by antidepressant treatment. Psychiatry research, 1997, Feb-07, Volume: 66, Issue:2-3 Topics: Adolescent; Adult; Aged; Amitriptyline; Antidepressive Agents; Blood Platelets; Carrier Proteins; De	1997
Speech dysfunction due to trazodone--fluoxetine combination in traumatic brain injury. Brain injury, 1997, Volume: 11, Issue:4 Topics: Adult; Brain Injuries; Depressive Disorder; Dysarthria; Fluoxetine; Humans; Male; Selective Serotoni	1997
Depressive disorder in pre-adolescence: comorbidity or different clinical subtypes? (A pharmacological contribution). The Israel journal of psychiatry and related sciences, 1997, Volume: 34, Issue:3 Topics: Adolescent; Antidepressive Agents; Anxiety Disorders; Child; Depressive Disorder; Female; Humans; Le	1997
Trazodone is only slightly faster than fluoxetine in relieving insomnia in adolescents with depressive disorders. Journal of child and adolescent psychopharmacology, 1997,Summer, Volume: 7, Issue:2 Topics: Adolescent; Antidepressive Agents, Second-Generation; Depressive Disorder; Female; Fluoxetine; Human	1997
Relationship between the CYP2D6 genotype and the steady-state plasma concentrations of trazodone and its active metabolite m-chlorophenylpiperazine. Psychopharmacology, 1997, Volume: 133, Issue:1 Topics: Adult; Antidepressive Agents, Second-Generation; Cytochrome P-450 CYP2D6; Depressive Disorder; Femal	1997
Effect of antidepressant therapy on health care utilization and costs in primary care. Psychiatric services (Washington, D.C.), 1997, Volume: 48, Issue:11 Topics: Adult; Antidepressive Agents; Antidepressive Agents, Tricyclic; Cohort Studies; Depressive Disorder;	1997
Rectal antidepressant medication in the treatment of depression. The Journal of clinical psychiatry, 1998, Volume: 59, Issue:1 Topics: Adult; Depressive Disorder; Humans; Male; Postoperative Complications; Pyloric Stenosis; Recurrence;	1998
Occurrence of trazodone-induced delirium. International clinical psychopharmacology, 1998, Volume: 13, Issue:5 Topics: Adult; Antidepressive Agents, Second-Generation; Bipolar Disorder; Cerebrovascular Disorders; Deliri	1998
Tricyclic antidepressants in adolescent depression. A case report. European child & adolescent psychiatry, 1998, Volume: 7, Issue:3 Topics: Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Child; De	1998
Interaction between trazodone and carbamazepine. The Annals of pharmacotherapy, 1999, Volume: 33, Issue:12 Topics: Anticonvulsants; Antidepressive Agents, Second-Generation; Carbamazepine; Depressive Disorder; Epile	1999
Fluoxetine-induced sexual dysfunction reversed by trazodone. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2000, Volume: 45, Issue:9 Topics: Adult; Depressive Disorder; Female; Fluoxetine; Humans; Sexual Dysfunctions, Psychological; Trazodon	2000
Electroconvulsive therapy and cardiovascular complications in patients taking trazodone for insomnia. The Journal of clinical psychiatry, 2001, Volume: 62, Issue:2 Topics: Adult; Cardiovascular Diseases; Case-Control Studies; Comorbidity; Confidence Intervals; Depressive	2001
Low frequency rTMS as an add-on antidepressive strategy: heterogeneous impact on 99mTc-HMPAO and 18 F-FDG uptake as measured simultaneously with the double isotope SPECT technique. Pilot study. Nuclear medicine communications, 2001, Volume: 22, Issue:8 Topics: Adult; Antidepressive Agents; Brain; Brain Mapping; Citalopram; Depressive Disorder; Female; Fluorod	2001
Venlafaxine- and trazodone-induced serotonin syndrome. The American journal of psychiatry, 2001, Volume: 158, Issue:12 Topics: Cyclohexanols; Depressive Disorder; Drug Interactions; Drug Therapy, Combination; Humans; Male; Midd	2001
[Variations in the urinary level of MHPG in depressive syndromes]. Schweizer Archiv fur Neurologie, Neurochirurgie und Psychiatrie = Archives suisses de neurologie, neurochirurgie et de psychiatrie, 1979, Volume: 125, Issue:2 Topics: Adult; Age Factors; Aged; Antidepressive Agents, Tricyclic; Anxiety; Depression; Depressive Disorder	1979
Side effects and the "blindability" of clinical drug trials. The American journal of psychiatry, 1992, Volume: 149, Issue:12 Topics: Ambulatory Care; Antidepressive Agents; Bias; Clinical Trials as Topic; Depressive Disorder; Double-	1992
A preliminary study of serotonergic antidepressants in treatment of dysthymia. Progress in neuro-psychopharmacology & biological psychiatry, 1992, Volume: 16, Issue:6 Topics: Adult; Antidepressive Agents; Depressive Disorder; Female; Fluoxetine; Humans; Male; Middle Aged; Ps	1992
Possible trazodone potentiation of fluoxetine: a case series. The Journal of clinical psychiatry, 1992, Volume: 53, Issue:3 Topics: Adult; Depressive Disorder; Drug Synergism; Drug Therapy, Combination; Female; Fluoxetine; Humans; M	1992
Trazodone induction of migraine headache through mCPP. The American journal of psychiatry, 1992, Volume: 149, Issue:5 Topics: Adult; Depressive Disorder; Humans; Male; Migraine Disorders; Piperazines; Trazodone	1992
Fluoxetine potentiation by buspirone: three case histories. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1991, Volume: 36, Issue:10 Topics: Adult; Buspirone; Clonazepam; Depressive Disorder; Dose-Response Relationship, Drug; Drug Synergism;	1991
Successful antidepressant treatment of nonparaphilic sexual addictions and paraphilias in men. The Journal of clinical psychiatry, 1991, Volume: 52, Issue:2 Topics: Adult; Antidepressive Agents; Depressive Disorder; Fluoxetine; Humans; Imipramine; Lithium; Male; Ma	1991
Integrated treatment of a woman with chronic hand pain. Hospital & community psychiatry, 1991, Volume: 42, Issue:5 Topics: Adult; Combined Modality Therapy; Depressive Disorder; Female; Fluoxetine; Hand; Hand Injuries; Huma	1991
Antidepressant treatment and the occurrence of mania in bipolar patients admitted for depression. Journal of affective disorders, 1990, Volume: 18, Issue:4 Topics: Antidepressive Agents, Tricyclic; Bipolar Disorder; Combined Modality Therapy; Depressive Disorder;	1990
Sleep laboratory evaluation of the effects and efficacy of trazodone in depressed insomniac patients. The Journal of clinical psychiatry, 1990, Volume: 51 Suppl Topics: Adult; Depressive Disorder; Female; Humans; Male; Psychiatric Status Rating Scales; Single-Blind Met	1990
A drug utilization review of prescribing patterns for trazodone versus amitriptyline. The Journal of clinical psychiatry, 1990, Volume: 51 Suppl Topics: Adult; Age Factors; Amitriptyline; Depressive Disorder; Drug Prescriptions; Drug Utilization; Female	1990
Insights in the use of trazodone in depressed patients. The Journal of clinical psychiatry, 1990, Volume: 51 Suppl Topics: Depressive Disorder; Humans; Trazodone	1990
Pharmacological priapism: comparison of trazodone- and papaverine-associated cases. International urology and nephrology, 1990, Volume: 22, Issue:2 Topics: Depressive Disorder; Erectile Dysfunction; Humans; Male; Papaverine; Priapism; Trazodone	1990
Low-dose trazodone as a hypnotic in patients treated with MAOIs and other psychotropics: a pilot study. The Journal of clinical psychiatry, 1990, Volume: 51, Issue:7 Topics: Administration, Oral; Adult; Bipolar Disorder; Depressive Disorder; Female; Humans; Male; Middle Age	1990
Evidence for a linear relationship between plasma trazodone levels and clinical response in depression in the elderly. Clinical neuropharmacology, 1990, Volume: 13 Suppl 1 Topics: Administration, Oral; Aged; Chromatography, High Pressure Liquid; Depressive Disorder; Dose-Response	1990
Triiodothyronine augmentation of the antidepressant effect of the nontricyclic antidepressant trazodone. The Journal of nervous and mental disease, 1990, Volume: 178, Issue:9 Topics: Depressive Disorder; Drug Synergism; Drug Therapy, Combination; Female; Humans; Middle Aged; Trazodo	1990
Effect of bilateral olfactory bulbectomy in the rat, alone or in combination with antidepressants, on the learned immobility model of depression. Neuropsychobiology, 1985, Volume: 13, Issue:1-2 Topics: Amygdala; Animals; Depressive Disorder; Disease Models, Animal; Humans; Hydroxyindoleacetic Acid; Is	1985
A case of trazodone-induced ventricular tachycardia. The Journal of clinical psychiatry, 1986, Volume: 47, Issue:7 Topics: Angina Pectoris; Cardiac Complexes, Premature; Depressive Disorder; Electrocardiography; Heart Ventr	1986
Effects of trazodone and desipramine on cardiac rate and rhythm in a patient with preexisting cardiovascular disease. Journal of clinical psychopharmacology, 1986, Volume: 6, Issue:6 Topics: Arrhythmias, Cardiac; Cardiac Complexes, Premature; Depressive Disorder; Desipramine; Female; Heart	1986
Radiologic correlates of antidepressant-induced delirium: the possible significance of basal-ganglia lesions. The Journal of neuropsychiatry and clinical neurosciences, 1989,Spring, Volume: 1, Issue:2 Topics: Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Basal Ganglia; Basal Ganglia Diseases	1989
[The effect of imipramine and trazodone on the re-uptake of (3H) serotonin by thrombocytes in patients with endogenous depression: changes in antidepressive therapy]. Psychiatrie, Neurologie, und medizinische Psychologie, 1989, Volume: 41, Issue:4 Topics: Adolescent; Adult; Blood Platelets; Carrier Proteins; Depressive Disorder; Female; Humans; Imipramin	1989
Management of monoamine oxidase inhibitor-associated insomnia with trazodone. Journal of clinical psychopharmacology, 1989, Volume: 9, Issue:1 Topics: Adult; Aged; Depressive Disorder; Dose-Response Relationship, Drug; Drug Therapy, Combination; Femal	1989
Side effects of trazodone in a geriatric population. Journal of clinical psychopharmacology, 1989, Volume: 9, Issue:1 Topics: Aged; Depressive Disorder; Female; Humans; Male; Risk Factors; Trazodone	1989
[Sensitivity of the retrograde uptake of H3-serotonin to imipramine and trazodone in patients with endogenous depression treated with antidepressive drugs]. Zhurnal nevropatologii i psikhiatrii imeni S.S. Korsakova (Moscow, Russia : 1952), 1989, Volume: 89, Issue:2 Topics: Adolescent; Adult; Antidepressive Agents; Bipolar Disorder; Blood Platelets; Culture Media; Depressi	1989
Trazodone: an antidepressant with adrenolytic activity. Based on a symposium to the Collegium Internationale Neuro-Psychopharmalogicum 16th C.I.N.P. congress. Munich, F.R.G., August 15, 1988. Clinical neuropharmacology, 1989, Volume: 12 Suppl 1 Topics: Depressive Disorder; Humans; Trazodone	1989
Plasma trazodone concentrations and clinical response in elderly depressed patients: a preliminary study. Journal of clinical psychopharmacology, 1989, Volume: 9, Issue:4 Topics: Administration, Oral; Aged; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; M	1989
Pharmacologic treatment of manic and depressive illness. Comprehensive therapy, 1985, Volume: 11, Issue:7 Topics: Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Bipolar Disorder; Central Nervous System Sti	1985
[History and pharmacology of trazodone]. L'Encephale, 1986, Volume: 12 Spec No Topics: Analgesics; Animals; Brain; Depressive Disorder; Drug Therapy, Combination; Humans; Imipramine; Neur	1986
Peripheral adrenoceptors and serotonin receptors in depression. Changes associated with response to treatment with trazodone or amitriptyline. Journal of affective disorders, 1985, Volume: 9, Issue:3 Topics: Adolescent; Adult; Aged; Amitriptyline; Blood Platelets; Depressive Disorder; Double-Blind Method; H	1985
New antidepressants--the serotonin reuptake inhibitors. Psychiatric journal of the University of Ottawa : Revue de psychiatrie de l'Universite d'Ottawa, 1987, Volume: 12, Issue:1 Topics: Brain; Depressive Disorder; Fluoxetine; Humans; Propylamines; Receptors, Serotonin; Trazodone; Zimel	1987
Trazodone and the mental pain hypothesis of depression. Neuropsychobiology, 1986, Volume: 15 Suppl 1 Topics: Depressive Disorder; Ethanol; Humans; Receptors, Serotonin; Serotonin; Substance Withdrawal Syndrome	1986
Effects of trazodone treatment on alpha-2 adrenoceptor function in depressed patients. Psychopharmacology, 1986, Volume: 89, Issue:1 Topics: Adult; Aged; Antidepressive Agents; Blood Pressure; Clonidine; Depressive Disorder; Female; Growth H	1986
Symposium on trazodone. Recent advances in psychiatric treatment. Berlin, April 1987. Proceedings. Psychopharmacology, 1988, Volume: 95 Suppl Topics: Depressive Disorder; Humans; Trazodone	1988
Effects of trazodone on the sleep of depressed subjects--a polygraphic study. Psychopharmacology, 1988, Volume: 95 Suppl Topics: Adult; Depressive Disorder; Electroencephalography; Female; Half-Life; Humans; Male; Middle Aged; Sl	1988
A retrospective evaluation of plasma trazodone concentrations and clinical response in a primary care clinic. The Hillside journal of clinical psychiatry, 1988, Volume: 10, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Depressive Disorder; Dose-Response Relationship, Drug; Humans; Middl	1988
Increased libido in three men treated with trazodone. The Journal of clinical psychiatry, 1988, Volume: 49, Issue:5 Topics: Adult; Depressive Disorder; Humans; Libido; Male; Middle Aged; Sexual Dysfunctions, Psychological; T	1988
Trazodone and anorgasmia. The American journal of psychiatry, 1988, Volume: 145, Issue:7 Topics: Depressive Disorder; Female; Humans; Middle Aged; Orgasm; Sexual Dysfunctions, Psychological; Trazod	1988
Treatment of self abusive behavior with trazodone. Canadian journal of psychiatry. Revue canadienne de psychiatrie, 1988, Volume: 33, Issue:4 Topics: Adult; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; Self Mutilation; Trazo	1988
Plasma trazodone concentrations in elderly depressed inpatients: cardiac effects and short-term efficacy. Journal of clinical psychopharmacology, 1987, Volume: 7, Issue:6 Topics: Aged; Aged, 80 and over; Depressive Disorder; Dose-Response Relationship, Drug; Electrocardiography;	1987
A possible diurnal variation in trazodone clearance. Journal of clinical psychopharmacology, 1986, Volume: 6, Issue:4 Topics: Adolescent; Adult; Aged; Circadian Rhythm; Depressive Disorder; Feeding and Eating Disorders; Female	1986
Local cerebral glucose metabolic rates in obsessive-compulsive disorder. A comparison with rates in unipolar depression and in normal controls. Archives of general psychiatry, 1987, Volume: 44, Issue:3 Topics: Adult; Brain; Caudate Nucleus; Cerebral Cortex; Deoxyglucose; Depressive Disorder; Diagnosis, Differ	1987
Local cerebral glucose metabolic rates in obsessive-compulsive disorder. A comparison with rates in unipolar depression and in normal controls. Archives of general psychiatry, 1987, Volume: 44, Issue:3 Topics: Adult; Brain; Caudate Nucleus; Cerebral Cortex; Deoxyglucose; Depressive Disorder; Diagnosis, Differ	1987
Local cerebral glucose metabolic rates in obsessive-compulsive disorder. A comparison with rates in unipolar depression and in normal controls. Archives of general psychiatry, 1987, Volume: 44, Issue:3 Topics: Adult; Brain; Caudate Nucleus; Cerebral Cortex; Deoxyglucose; Depressive Disorder; Diagnosis, Differ	1987
Local cerebral glucose metabolic rates in obsessive-compulsive disorder. A comparison with rates in unipolar depression and in normal controls. Archives of general psychiatry, 1987, Volume: 44, Issue:3 Topics: Adult; Brain; Caudate Nucleus; Cerebral Cortex; Deoxyglucose; Depressive Disorder; Diagnosis, Differ	1987
Trazodone withdrawal and formication. The Journal of clinical psychiatry, 1987, Volume: 48, Issue:9 Topics: Aged; Depressive Disorder; Humans; Male; Paresthesia; Substance Withdrawal Syndrome; Trazodone	1987
Antidepressant-related akathisia. Journal of clinical psychopharmacology, 1987, Volume: 7, Issue:4 Topics: Adult; Akathisia, Drug-Induced; Antidepressive Agents; Bipolar Disorder; Depressive Disorder; Female	1987
Trazodone-induced mania. The Journal of clinical psychiatry, 1987, Volume: 48, Issue:10 Topics: Alcoholism; Bipolar Disorder; Depressive Disorder; Doxepin; Humans; Male; Middle Aged; Trazodone	1987
Postural hypotension with syncope possibly precipitated by trazodone. The American journal of psychiatry, 1987, Volume: 144, Issue:11 Topics: Aged; Antihypertensive Agents; Depressive Disorder; Drug Therapy, Combination; Female; Humans; Hypot	1987
Trazodone-induced mania. The British journal of psychiatry : the journal of mental science, 1987, Volume: 151 Topics: Bipolar Disorder; Depressive Disorder; Female; Humans; Middle Aged; Trazodone	1987
Response of tardive and L-dopa-induced dyskinesias to antidepressants. The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques, 1987, Volume: 14, Issue:4 Topics: Aged; Antidepressive Agents; Depressive Disorder; Desipramine; Dyskinesia, Drug-Induced; Humans; Lev	1987
Complex partial seizures in a patient receiving trazodone. The Journal of clinical psychiatry, 1986, Volume: 47, Issue:6 Topics: Carbamazepine; Depressive Disorder; Epilepsy, Temporal Lobe; Erectile Dysfunction; Humans; Male; Mid	1986
Increased libido in women receiving trazodone. The American journal of psychiatry, 1986, Volume: 143, Issue:6 Topics: Adult; Depressive Disorder; Female; Humans; Libido; Trazodone	1986
Symposium on trazodone. New clinical applications and safety considerations for a third generation antidepressant. IVth World Congress of Biological Psychiatry. Philadelphia, September 1985. Neuropsychobiology, 1986, Volume: 15 Suppl 1 Topics: Depressive Disorder; Humans; Trazodone	1986
Use of interactive computer technology in open clinical trials. Study with trazodone in depressed patients. Neuropsychobiology, 1986, Volume: 15 Suppl 1 Topics: Adolescent; Adult; Aged; Clinical Trials as Topic; Computers; Depressive Disorder; Dizziness; Female	1986
Diagnostic and therapeutic problems in the psychopharmacological treatment of the elderly patient. Neuropsychobiology, 1986, Volume: 15 Suppl 1 Topics: Aged; Aging; Depressive Disorder; Diagnosis, Differential; Humans; Kinetics; Mental Disorders; Neuro	1986
Withdrawal syndrome in a depressed patient treated with trazodone. The American journal of psychiatry, 1986, Volume: 143, Issue:9 Topics: Adult; Anxiety Disorders; Depersonalization; Depressive Disorder; Dreams; Humans; Male; Sleep Initia	1986
Increased seizure duration during ECT with trazodone administration. The American journal of psychiatry, 1986, Volume: 143, Issue:10 Topics: Aged; Depressive Disorder; Electroconvulsive Therapy; Female; Humans; Time Factors; Trazodone	1986
Hypomania following withdrawal of trazodone. The American journal of psychiatry, 1986, Volume: 143, Issue:11 Topics: Adult; Bipolar Disorder; Depressive Disorder; Female; Humans; Substance Withdrawal Syndrome; Trazodo	1986
Trazodone-induced mania. The British journal of psychiatry : the journal of mental science, 1986, Volume: 149 Topics: Adult; Aged; Bipolar Disorder; Depressive Disorder; Female; Humans; Male; Trazodone	1986
Libido in women receiving trazodone. The American journal of psychiatry, 1987, Volume: 144, Issue:1 Topics: Depressive Disorder; Female; Humans; Libido; Trazodone	1987
Variations in platelet 5-hydroxytryptamine in control and depressed populations. Journal of psychiatric research, 1986, Volume: 20, Issue:4 Topics: Adult; Aged; Blood Platelets; Combined Modality Therapy; Depressive Disorder; Dothiepin; Electroconv	1986
[Telematic multicenter study of Pragmarel 100 mg (trazodone)]. L'Encephale, 1986, Volume: 12 Spec No Topics: Adult; Computer Communication Networks; Depressive Disorder; Humans; Middle Aged; Trazodone	1986
Antidepressant drug therapy: the role of the new antidepressants. Hospital & community psychiatry, 1985, Volume: 36, Issue:5 Topics: Amoxapine; Antidepressive Agents; Bupropion; Cardiovascular Diseases; Depressive Disorder; Drug Eval	1985
Consistent reversal of abnormal DSTs after different antidepressant therapies in a patient with dementia. The American journal of psychiatry, 1985, Volume: 142, Issue:1 Topics: Amitriptyline; Antidepressive Agents; Dementia; Depressive Disorder; Dexamethasone; Humans; Hydrocor	1985
Trazodone and priapism. The American journal of psychiatry, 1985, Volume: 142, Issue:1 Topics: Adult; Depressive Disorder; Dose-Response Relationship, Drug; Humans; Male; Piperazines; Priapism; T	1985
Trazodone-induced mania following desipramine-induced mania in major depressive disorders. The American journal of psychiatry, 1985, Volume: 142, Issue:3 Topics: Aged; Bipolar Disorder; Depressive Disorder; Desipramine; Female; Humans; Male; Middle Aged; Piperaz	1985
Unusual erectile activity as a side effect of trazodone. Hospital & community psychiatry, 1985, Volume: 36, Issue:3 Topics: Depressive Disorder; Humans; Male; Middle Aged; Piperazines; Priapism; Trazodone	1985
Seizures and trazodone therapy. Archives of general psychiatry, 1985, Volume: 42, Issue:5 Topics: Depressive Disorder; Female; Humans; Middle Aged; Piperazines; Seizures; Trazodone	1985
Peripheral edema associated with trazodone: a report of ten cases. Journal of clinical psychopharmacology, 1985, Volume: 5, Issue:3 Topics: Adult; Aged; Blood Pressure; Body Weight; Depressive Disorder; Dose-Response Relationship, Drug; Ede	1985
Trazodone in endogenous depressed patients: a negative report and a critical evaluation of the pertaining literature. Progress in neuro-psychopharmacology & biological psychiatry, 1985, Volume: 9, Issue:2 Topics: Adult; Aged; Depressive Disorder; Drug Evaluation; Electroencephalography; Female; Follow-Up Studies	1985
More on trazodone and priapism. The American journal of psychiatry, 1985, Volume: 142, Issue:6 Topics: Depressive Disorder; Humans; Male; Middle Aged; Piperazines; Priapism; Trazodone	1985
Erythema multiforme associated with trazodone therapy: case report. The Journal of clinical psychiatry, 1985, Volume: 46, Issue:7 Topics: Depressive Disorder; Erythema Multiforme; Extremities; Female; Humans; Middle Aged; Piperazines; Tra	1985
Two cases of obsessive-compulsive disorder with depression responsive to trazodone. The Journal of nervous and mental disease, 1985, Volume: 173, Issue:7 Topics: Adult; Depressive Disorder; Drug Therapy, Combination; Humans; Male; Obsessive-Compulsive Disorder;	1985
The elicitation of a movement disorder by trazodone: case report. The Journal of clinical psychiatry, 1985, Volume: 46, Issue:12 Topics: Aged; Depressive Disorder; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Huma	1985

trazodone and Depression, Endogenous