trazodone has been researched along with Chemical and Drug Induced Liver Injury in 16 studies
Trazodone: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
trazodone : An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.
Chemical and Drug Induced Liver Injury: A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Trazodone was initially started at that time due to severe separation anxiety while hospitalized (consistently 5 out of 7 days of the week, for a 6-week duration)." | 1.62 | Suspected hepatotoxicity secondary to trazodone therapy in a dog. ( Arnold, A; Davis, A; Lee, JA; Wismer, T, 2021) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| "Treatment with trazodone or nefazodone caused a dose-dependent decrease in serum nitric oxide levels compared with the CCl(4) control group." | 1.36 | Effect of trazodone and nefazodone on hepatic injury induced by carbon tetrachloride. ( Abdel Salam, OM; Shafee, N; Sleem, AA, 2010) |
| "Trazodone (Desyrel) is a second-generation, nontricyclic antidepressant that has been in use in North America since the early 1980s." | 1.31 | Trazodone-induced hepatotoxicity: a case report with comments on drug-induced hepatotoxicity. ( Fernandes, NF; Martin, RR; Schenker, S, 2000) |
| "Trazodone and clonidine were discontinued at that time." | 1.31 | Hepatotoxicity after short-term trazodone therapy. ( McClintock, C; Rettman, KS, 2001) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (12.50) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 8 (50.00) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 2 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Chen, Y | 1 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Aleo, MD | 1 |
| Luo, Y | 1 |
| Swiss, R | 1 |
| Bonin, PD | 1 |
| Potter, DM | 1 |
| Will, Y | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| Arnold, A | 1 |
| Davis, A | 1 |
| Wismer, T | 1 |
| Lee, JA | 1 |
| Abdel Salam, OM | 1 |
| Sleem, AA | 1 |
| Shafee, N | 1 |
| Sánchez Ruiz, JC | 1 |
| González López, E | 1 |
| Aparicio Tijeras, C | 1 |
| Ezquerra Gadea, J | 1 |
| Chu, AG | 1 |
| Gunsolly, BL | 1 |
| Summers, RW | 1 |
| Alexander, B | 1 |
| McChesney, C | 1 |
| Tanna, VL | 1 |
| Hull, M | 1 |
| Jones, R | 1 |
| Bendall, M | 1 |
| Beck, PL | 1 |
| Bridges, RJ | 1 |
| Demetrick, DJ | 1 |
| Kelly, JK | 1 |
| Lee, SS | 1 |
| Fernandes, NF | 1 |
| Martin, RR | 1 |
| Schenker, S | 1 |
| Rettman, KS | 1 |
| McClintock, C | 1 |
| Longstreth, GF | 1 |
| Hershman, J | 1 |
1 review available for trazodone and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
15 other studies available for trazodone and Chemical and Drug Induced Liver Injury
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2014 |
Suspected hepatotoxicity secondary to trazodone therapy in a dog.
Topics: Animals; Anti-Anxiety Agents; Chemical and Drug Induced Liver Injury; Dog Diseases; Dogs; Female; Tr | 2021 |
Effect of trazodone and nefazodone on hepatic injury induced by carbon tetrachloride.
Topics: Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; | 2010 |
[Hepatotoxicity due to trazodone].
Topics: Acute Disease; Antidepressive Agents, Second-Generation; Chemical and Drug Induced Liver Injury; Hum | 2004 |
Trazodone and liver toxicity.
Topics: Chemical and Drug Induced Liver Injury; Humans; Male; Middle Aged; Piperazines; Trazodone | 1983 |
Fatal hepatic necrosis associated with trazodone and neuroleptic drugs.
Topics: Aged; Antipsychotic Agents; Chemical and Drug Induced Liver Injury; Fatal Outcome; Female; Humans; N | 1994 |
Chronic active hepatitis associated with trazodone therapy.
Topics: Aged; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Injury, Chronic; Femal | 1993 |
Trazodone-induced hepatotoxicity: a case report with comments on drug-induced hepatotoxicity.
Topics: Adult; Anti-Inflammatory Agents; Antidepressive Agents, Second-Generation; Arthritis, Rheumatoid; Ch | 2000 |
Hepatotoxicity after short-term trazodone therapy.
Topics: Adult; Antidepressive Agents, Second-Generation; Chemical and Drug Induced Liver Injury; Comorbidity | 2001 |
Trazodone-induced hepatotoxicity and leukonychia.
Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Middle Aged; Nail Diseases; Piperazines; Tra | 1985 |