trazodone has been researched along with Bipolar Disorder in 31 studies
Trazodone: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
trazodone : An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.
Bipolar Disorder: A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The aim of the study was to evaluate trazodone efficiency and safety in comparison to venlafaxine treatments of depressive episode, recurrent depressive disorders and depressive episode in bipolar disorders." | 9.11 | [Trazodone and venlafaxine in treatment of depressive disorders]. ( Florkowski, A; Gałecki, P; Gruszczyński, W; Kołodziejska, I; Mikołajczyk, I; Zboralski, K, 2005) |
| "Early human pharmaco-EEG and subsequent sleep laboratory studies identified trazodone, a 5-HT(2) antagonist and 5-HT reuptake inhibitor (SARI), as an antidepressant with therapeutic effects on its target symptoms depressed mood, anxiety and insomnia." | 9.10 | Confirmation of the neurophysiologically predicted therapeutic effects of trazodone on its target symptoms depression, anxiety and insomnia by postmarketing clinical studies with a controlled-release formulation in depressed outpatients. ( Anderer, P; Arnold, O; Saletu, B; Saletu-Zyhlarz, GM, 2003) |
| "Trazodone is a multifunctional triazolopyridine drug with antidepressant, anxiolytic, sedative, and hypnotic properties." | 5.48 | Clinical effectiveness of parenteral trazodone for the management of psychomotor activation in patients with bipolar disorder. ( Ballerio, M; Crapanzano, C; Cuomo, A; Emanuele, E; Fagiolini, A; Goracci, A; Politi, P, 2018) |
| " The aim of the study was to evaluate trazodone efficiency and safety in comparison to venlafaxine treatments of depressive episode, recurrent depressive disorders and depressive episode in bipolar disorders." | 5.11 | [Trazodone and venlafaxine in treatment of depressive disorders]. ( Florkowski, A; Gałecki, P; Gruszczyński, W; Kołodziejska, I; Mikołajczyk, I; Zboralski, K, 2005) |
| "Early human pharmaco-EEG and subsequent sleep laboratory studies identified trazodone, a 5-HT(2) antagonist and 5-HT reuptake inhibitor (SARI), as an antidepressant with therapeutic effects on its target symptoms depressed mood, anxiety and insomnia." | 5.10 | Confirmation of the neurophysiologically predicted therapeutic effects of trazodone on its target symptoms depression, anxiety and insomnia by postmarketing clinical studies with a controlled-release formulation in depressed outpatients. ( Anderer, P; Arnold, O; Saletu, B; Saletu-Zyhlarz, GM, 2003) |
| "We describe a patient treated with trazodone, amitriptyline and lithium carbonate who developed anxiety, restlessness, tremor, myoclonus, hyperreflexia, diaphoresis, rigidity and hyperthermia." | 3.69 | A case of serotonin syndrome induced by concomitant treatment with low-dose trazodone and amitriptyline and lithium. ( Abe, T; Ishiguro, T; Nisijima, K; Shimizu, M, 1996) |
| "Case reports are presented of two depressed patients with probable bipolar disorder who did not respond to trazodone but developed mania when this drug was abruptly replaced with imipramine." | 3.67 | Mania following change from trazodone to imipramine. ( Haggerty, JJ; Jackson, R, 1985) |
| "Trazodone therapy was continued or reinstated shortly after the hypomanic episode without further evidence of hypomania." | 2.38 | Trazodone-induced transient hypomanic symptoms and their management. ( Fisher, CJ; Jabeen, S, 1991) |
| "Trazodone is a multifunctional triazolopyridine drug with antidepressant, anxiolytic, sedative, and hypnotic properties." | 1.48 | Clinical effectiveness of parenteral trazodone for the management of psychomotor activation in patients with bipolar disorder. ( Ballerio, M; Crapanzano, C; Cuomo, A; Emanuele, E; Fagiolini, A; Goracci, A; Politi, P, 2018) |
| "Previous reports document visual illusions resembling hallucinogen persisting perception disorder (HPPD) after risperidone treatment in patients with histories of previous LSD exposure." | 1.31 | Posthallucinogen-like visual illusions (palinopsia) with risperidone in a patient without previous hallucinogen exposure: possible relation to serotonin 5HT2a receptor blockade. ( Abdelhamid, A; Annandale, JB; Lauterbach, EC, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (48.39) | 18.7374 |
| 1990's | 7 (22.58) | 18.2507 |
| 2000's | 5 (16.13) | 29.6817 |
| 2010's | 4 (12.90) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Vijay, A | 1 |
| Becker, JE | 1 |
| Ross, JS | 1 |
| Ballerio, M | 1 |
| Politi, P | 1 |
| Crapanzano, C | 1 |
| Emanuele, E | 1 |
| Cuomo, A | 1 |
| Goracci, A | 1 |
| Fagiolini, A | 1 |
| Steelman, BC | 1 |
| Waldo, SW | 1 |
| Treit, K | 1 |
| Goldschlager, N | 1 |
| Saletu-Zyhlarz, GM | 1 |
| Anderer, P | 1 |
| Arnold, O | 1 |
| Saletu, B | 1 |
| Florkowski, A | 1 |
| Gruszczyński, W | 1 |
| Gałecki, P | 1 |
| Zboralski, K | 1 |
| Kołodziejska, I | 1 |
| Mikołajczyk, I | 1 |
| Preskorn, SH | 1 |
| Klier, CM | 1 |
| Mossaheb, N | 1 |
| Saria, A | 1 |
| Schloegelhofer, M | 1 |
| Zernig, G | 1 |
| Himmelhoch, JM | 1 |
| Schechtman, K | 1 |
| Auchenbach, R | 1 |
| Warren, M | 1 |
| Bick, PA | 1 |
| Soucek, K | 1 |
| Zatecka, I | 1 |
| Vencovsky, E | 1 |
| Terao, T | 1 |
| Young, C | 1 |
| Nisijima, K | 1 |
| Shimizu, M | 1 |
| Abe, T | 1 |
| Ishiguro, T | 1 |
| Lennkh, C | 1 |
| Fischer, P | 1 |
| Küfferle, B | 1 |
| Kasper, S | 1 |
| Lauterbach, EC | 1 |
| Abdelhamid, A | 1 |
| Annandale, JB | 1 |
| Jabeen, S | 1 |
| Fisher, CJ | 1 |
| Solomon, RL | 1 |
| Rich, CL | 1 |
| Darko, DF | 1 |
| Jacobsen, FM | 1 |
| Patterson, BD | 1 |
| Srisopark, MM | 1 |
| Katasonov, AB | 1 |
| Beliaev, BS | 1 |
| Zlobina, GP | 1 |
| Faktor, MI | 1 |
| Brusov, OS | 1 |
| Ostow, M | 1 |
| Sullivan, G | 1 |
| Zubenko, GS | 1 |
| Cohen, BM | 1 |
| Lipinski, JF | 1 |
| Lennhoff, M | 1 |
| Zmitek, A | 1 |
| Kramer, MS | 1 |
| Marcus, DJ | 1 |
| DiFerdinando, J | 1 |
| Dewey, D | 1 |
| Theilman, SB | 1 |
| Christenbury, MM | 1 |
| Knobler, HY | 1 |
| Itzchaky, S | 1 |
| Emanuel, D | 1 |
| Mester, R | 1 |
| Maizel, S | 1 |
| Arana, GW | 1 |
| Kaplan, GB | 1 |
| Haggerty, JJ | 1 |
| Jackson, R | 1 |
1 review available for trazodone and Bipolar Disorder
| Article | Year |
|---|---|
Trazodone-induced transient hypomanic symptoms and their management.
Topics: Adult; Aged; Bipolar Disorder; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans | 1991 |
3 trials available for trazodone and Bipolar Disorder
| Article | Year |
|---|---|
Confirmation of the neurophysiologically predicted therapeutic effects of trazodone on its target symptoms depression, anxiety and insomnia by postmarketing clinical studies with a controlled-release formulation in depressed outpatients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents, Second-Generation; Anxiety; Bipol | 2003 |
[Trazodone and venlafaxine in treatment of depressive disorders].
Topics: Adult; Antidepressive Agents, Second-Generation; Bipolar Disorder; Cyclohexanols; Depressive Disorde | 2005 |
Comparison of manic switch onset during fluoxetine and trazodone treatment.
Topics: Adult; Bipolar Disorder; Depressive Disorder; Double-Blind Method; Female; Fluoxetine; Humans; Male; | 1993 |
27 other studies available for trazodone and Bipolar Disorder
| Article | Year |
|---|---|
Patterns and predictors of off-label prescription of psychiatric drugs.
Topics: Adult; Aged; Antipsychotic Agents; Bipolar Disorder; Citalopram; Cross-Sectional Studies; Drug Presc | 2018 |
Clinical effectiveness of parenteral trazodone for the management of psychomotor activation in patients with bipolar disorder.
Topics: Adult; Aged; Bipolar Disorder; Female; Humans; Injections, Intramuscular; Injections, Intravenous; L | 2018 |
Bipolar II disorder case study.
Topics: Bipolar Disorder; Female; Humans; Middle Aged; Psychiatric Status Rating Scales; Selective Serotonin | 2018 |
Possible acute myocardial infarction in a hypothermic patient.
Topics: Acute Disease; Anticonvulsants; Antimanic Agents; Benzodiazepines; Bipolar Disorder; Drug Overdose; | 2011 |
Neuroleptic malignant syndrome resulting from a complex drug-drug interaction: "I don't see 'em!".
Topics: Benztropine; Bipolar Disorder; Cytochrome P-450 CYP2D6 Inhibitors; Drug Interactions; Drug Therapy, | 2007 |
Pharmacokinetics and elimination of quetiapine, venlafaxine, and trazodone during pregnancy and postpartum.
Topics: Adolescent; Antipsychotic Agents; Bipolar Disorder; Cyclohexanols; Dibenzothiazepines; Female; Human | 2007 |
The role of trazodone in the treatment of depressed cardiac patients.
Topics: Aged; Anxiety Disorders; Arrhythmias, Cardiac; Bipolar Disorder; Cardiac Complexes, Premature; Depre | 1984 |
Two case reports of trazodone-induced mania.
Topics: Adult; Bipolar Disorder; Depressive Disorder; Female; Humans; Middle Aged; Piperazines; Psychoses, S | 1984 |
The use of the antidepressant tradozone in outpatient psychiatric practice.
Topics: Adult; Aged; Bipolar Disorder; Female; Humans; Male; Middle Aged; Piperazines; Psychiatric Status Ra | 1981 |
A case of neuroleptic malignant syndrome and serotonin disturbance.
Topics: Akathisia, Drug-Induced; Benztropine; Bipolar Disorder; Dose-Response Relationship, Drug; Drug Admin | 1997 |
A case of serotonin syndrome induced by concomitant treatment with low-dose trazodone and amitriptyline and lithium.
Topics: Amitriptyline; Anxiety; Bipolar Disorder; Humans; Lithium; Male; Middle Aged; Trazodone | 1996 |
Occurrence of trazodone-induced delirium.
Topics: Adult; Antidepressive Agents, Second-Generation; Bipolar Disorder; Cerebrovascular Disorders; Deliri | 1998 |
Posthallucinogen-like visual illusions (palinopsia) with risperidone in a patient without previous hallucinogen exposure: possible relation to serotonin 5HT2a receptor blockade.
Topics: Antidepressive Agents, Second-Generation; Antipsychotic Agents; Bipolar Disorder; Clonazepam; Female | 2000 |
Antidepressant treatment and the occurrence of mania in bipolar patients admitted for depression.
Topics: Antidepressive Agents, Tricyclic; Bipolar Disorder; Combined Modality Therapy; Depressive Disorder; | 1990 |
Low-dose trazodone as a hypnotic in patients treated with MAOIs and other psychotropics: a pilot study.
Topics: Administration, Oral; Adult; Bipolar Disorder; Depressive Disorder; Female; Humans; Male; Middle Age | 1990 |
Severe anorexia and possible psychosis or hypomania after trazodone-tryptophan treatment of aggression.
Topics: Adult; Aggression; Anorexia Nervosa; Bipolar Disorder; Drug Therapy, Combination; Female; Humans; Ps | 1989 |
[Sensitivity of the retrograde uptake of H3-serotonin to imipramine and trazodone in patients with endogenous depression treated with antidepressive drugs].
Topics: Adolescent; Adult; Antidepressive Agents; Bipolar Disorder; Blood Platelets; Culture Media; Depressi | 1989 |
Pharmacologic treatment of manic and depressive illness.
Topics: Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Bipolar Disorder; Central Nervous System Sti | 1985 |
Increased libido with trazodone.
Topics: Adult; Bipolar Disorder; Humans; Libido; Male; Trazodone | 1987 |
Antidepressant-related akathisia.
Topics: Adult; Akathisia, Drug-Induced; Antidepressive Agents; Bipolar Disorder; Depressive Disorder; Female | 1987 |
Trazodone-induced mania.
Topics: Alcoholism; Bipolar Disorder; Depressive Disorder; Doxepin; Humans; Male; Middle Aged; Trazodone | 1987 |
Trazodone-induced mania.
Topics: Bipolar Disorder; Depressive Disorder; Female; Humans; Middle Aged; Trazodone | 1987 |
Atypical acute dystonia associated with trazodone treatment.
Topics: Acute Disease; Bipolar Disorder; Dystonia; Humans; Male; Middle Aged; Trazodone | 1986 |
Hypomania following withdrawal of trazodone.
Topics: Adult; Bipolar Disorder; Depressive Disorder; Female; Humans; Substance Withdrawal Syndrome; Trazodo | 1986 |
Trazodone-induced mania.
Topics: Adult; Aged; Bipolar Disorder; Depressive Disorder; Female; Humans; Male; Trazodone | 1986 |
Trazodone-induced mania following desipramine-induced mania in major depressive disorders.
Topics: Aged; Bipolar Disorder; Depressive Disorder; Desipramine; Female; Humans; Male; Middle Aged; Piperaz | 1985 |
Mania following change from trazodone to imipramine.
Topics: Adult; Bipolar Disorder; Depression; Female; Humans; Imipramine; Middle Aged; Trazodone | 1985 |