trazodone has been researched along with Arrhythmia in 16 studies
Trazodone: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
trazodone : An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.
| Excerpt | Relevance | Reference |
|---|---|---|
| "From this review, it is concluded that there are very few data to suggest that trazodone improves sleep in patients without mood disorder, though it does increase total sleep in patients with major depressive disorder." | 4.82 | The use of trazodone as a hypnotic: a critical review. ( James, SP; Mendelson, WB, 2004) |
| " One drug, trazodone, caused arrhythmia consistent with blockade of the hERG (human ether-a-go-go related gene) potassium channel." | 3.78 | Antidepressants cause bradycardia and heart block in GD 13 rat embryos in vitro. ( Ababneh, D; Ritchie, H; Webster, WS, 2012) |
| "Severe orthostatic hypotension is more likely to develop in depressed patients with left ventricular impairment and/or in patients taking other drugs like diuretics or vasodilators." | 2.38 | Review of the cardiovascular effects of heterocyclic antidepressants. ( Glassman, AH; Preud'homme, XA, 1993) |
| "Trazodone has emerged as the antidepressant drug with the least risk of death in overdose, and as a useful alternative to the standard tricyclic antidepressant drugs in patients with preexisting conduction disease." | 2.37 | Cardiovascular toxicity of antidepressant medications. ( Glassman, AH; Jackson, WK; Roose, SP, 1987) |
| "Seizures were more common in the amoxapine (24." | 1.27 | Relative toxicity of cyclic antidepressants. ( Gorman, RL; Klein-Schwartz, W; Oderda, GM; Wedin, GP, 1986) |
| " In part this is due to generally exaggerated fears that primary care physicians have regarding these medications, especially the anticholinegic effects of recommended dosage levels and sudden cardiac death." | 1.27 | Update on some of the older and newer antidepressants. ( Thompson, TL, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (68.75) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 2 (12.50) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Ryan, K | 1 |
| Benz, P | 1 |
| Zosel, A | 1 |
| Farkas, A | 1 |
| Theobald, J | 1 |
| Ababneh, D | 1 |
| Ritchie, H | 1 |
| Webster, WS | 1 |
| James, SP | 1 |
| Mendelson, WB | 1 |
| Winkler, D | 1 |
| Ortner, R | 1 |
| Pjrek, E | 1 |
| Aschauer, H | 1 |
| Kasper, S | 1 |
| Janowsky, D | 1 |
| Curtis, G | 1 |
| Zisook, S | 1 |
| Kuhn, K | 1 |
| Resovsky, K | 1 |
| Le Winter, M | 1 |
| Himmelhoch, JM | 1 |
| Schechtman, K | 1 |
| Auchenbach, R | 1 |
| van de Merwe, TJ | 1 |
| Silverstone, T | 1 |
| Ankier, SI | 1 |
| Warrington, SJ | 1 |
| Turner, P | 1 |
| Lippmann, S | 1 |
| Bedford, P | 1 |
| Manshadi, M | 1 |
| Mather, S | 1 |
| Pellettier, JR | 1 |
| Bartolucci, G | 1 |
| Glassman, AH | 2 |
| Preud'homme, XA | 1 |
| Pohl, R | 1 |
| Bridges, M | 1 |
| Rainey, JM | 1 |
| Boudoulas, H | 1 |
| Yeragani, VK | 1 |
| Ostow, M | 1 |
| Jackson, WK | 1 |
| Roose, SP | 1 |
| Wedin, GP | 1 |
| Oderda, GM | 1 |
| Klein-Schwartz, W | 1 |
| Gorman, RL | 1 |
| Thompson, TL | 1 |
| Johnson, BA | 1 |
3 reviews available for trazodone and Arrhythmia
| Article | Year |
|---|---|
The use of trazodone as a hypnotic: a critical review.
Topics: Aged; Arrhythmias, Cardiac; Clinical Trials as Topic; Comorbidity; Depressive Disorder; Humans; Hypn | 2004 |
Review of the cardiovascular effects of heterocyclic antidepressants.
Topics: Amoxapine; Antidepressive Agents; Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Bupropion; | 1993 |
Cardiovascular toxicity of antidepressant medications.
Topics: Antidepressive Agents; Arrhythmias, Cardiac; Depressive Disorder; Humans; Hypotension, Orthostatic; | 1987 |
1 trial available for trazodone and Arrhythmia
| Article | Year |
|---|---|
A double-blind non-crossover placebo-controlled study between group comparison of trazodone and amitriptyline on cardiovascular function in major depressive disorder.
Topics: Adult; Amitriptyline; Arrhythmias, Cardiac; Clinical Trials as Topic; Depressive Disorder; Double-Bl | 1984 |
12 other studies available for trazodone and Arrhythmia
| Article | Year |
|---|---|
QTc Prolongation in Poison Center Exposures to CredibleMeds List of Substances with "Known Risk of Torsades de Pointes".
Topics: Amitriptyline; Arrhythmias, Cardiac; Diphenhydramine; Electrocardiography; Flecainide; Humans; Long | 2022 |
Antidepressants cause bradycardia and heart block in GD 13 rat embryos in vitro.
Topics: Animals; Antidepressive Agents; Arrhythmias, Cardiac; Bradycardia; Calcium Channels; Female; Heart; | 2012 |
Trazodone-induced cardiac arrhythmias: a report of two cases.
Topics: Aged; Antidepressive Agents, Second-Generation; Arrhythmias, Cardiac; Depression; Female; Humans; Ma | 2006 |
Ventricular arrhythmias possibly aggravated by trazodone.
Topics: Adult; Arrhythmia, Sinus; Arrhythmias, Cardiac; Cardiac Complexes, Premature; Depressive Disorder; H | 1983 |
The role of trazodone in the treatment of depressed cardiac patients.
Topics: Aged; Anxiety Disorders; Arrhythmias, Cardiac; Bipolar Disorder; Cardiac Complexes, Premature; Depre | 1984 |
Trazodone cardiotoxicity.
Topics: Arrhythmias, Cardiac; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; Middle | 1983 |
Trazodone and cardiovascular side effects.
Topics: Aged; Arrhythmias, Cardiac; Depressive Disorder; Humans; Male; Piperazines; Trazodone | 1984 |
Effects of trazodone and desipramine on cardiac rate and rhythm in a patient with preexisting cardiovascular disease.
Topics: Arrhythmias, Cardiac; Cardiac Complexes, Premature; Depressive Disorder; Desipramine; Female; Heart | 1986 |
Pharmacologic treatment of manic and depressive illness.
Topics: Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Bipolar Disorder; Central Nervous System Sti | 1985 |
Relative toxicity of cyclic antidepressants.
Topics: Adolescent; Adult; Aged; Amoxapine; Anthracenes; Antidepressive Agents, Tricyclic; Arrhythmias, Card | 1986 |
Update on some of the older and newer antidepressants.
Topics: Aged; Amoxapine; Antidepressive Agents; Arrhythmias, Cardiac; Humans; Maprotiline; Parasympathetic N | 1985 |
Trazodone toxicity.
Topics: Antidepressive Agents, Tricyclic; Arrhythmias, Cardiac; Humans; Male; Middle Aged; Piperazines; Traz | 1985 |