trazodone has been researched along with Aging in 6 studies
Trazodone: A serotonin uptake inhibitor that is used as an antidepressive agent. It has been shown to be effective in patients with major depressive disorders and other subsets of depressive disorders. It is generally more useful in depressive disorders associated with insomnia and anxiety. This drug does not aggravate psychotic symptoms in patients with schizophrenia or schizoaffective disorders. (From AMA Drug Evaluations Annual, 1994, p309)
trazodone : An N-arylpiperazine in which one nitrogen is substituted by a 3-chlorophenyl group, while the other is substituted by a 3-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)propyl group.
Aging: The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Absolute bioavailability of oral trazodone averaged 70% to 90% and was unrelated to age or sex." | 6.66 | Trazodone kinetics: effect of age, gender, and obesity. ( Blyden, GT; Burstein, ES; Friedman, H; Greenblatt, DJ; Harmatz, JS; Miller, LG; Ochs, HR; Scavone, JM; Shader, RI, 1987) |
| " Absolute bioavailability of oral trazodone averaged 70% to 90% and was unrelated to age or sex." | 2.66 | Trazodone kinetics: effect of age, gender, and obesity. ( Blyden, GT; Burstein, ES; Friedman, H; Greenblatt, DJ; Harmatz, JS; Miller, LG; Ochs, HR; Scavone, JM; Shader, RI, 1987) |
| "This article will review the causes of insomnia in the elderly, the approach to patient evaluation, and the nonpharmacologic and pharmacologic treatment of insomnia." | 2.43 | Insomnia in the elderly: cause, approach, and treatment. ( Gammack, JK; Kamel, NS, 2006) |
| "The pharmacokinetic and some pharmacodynamic characteristics of a single oral dose of 100 mg trazodone were compared in young and elderly volunteers." | 1.27 | Pharmacokinetic and pharmacodynamic characteristics of trazodone in the elderly. ( Ankier, SI; Bayer, AJ; Pathy, MS, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (66.67) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Tunc-Ozcan, E | 1 |
| Brooker, SM | 1 |
| Bonds, JA | 1 |
| Tsai, YH | 1 |
| Rawat, R | 1 |
| McGuire, TL | 1 |
| Peng, CY | 1 |
| Kessler, JA | 1 |
| Kamel, NS | 1 |
| Gammack, JK | 1 |
| Burchinskiĭ, SG | 1 |
| Bayer, AJ | 1 |
| Pathy, MS | 1 |
| Ankier, SI | 1 |
| Greenblatt, DJ | 1 |
| Friedman, H | 1 |
| Burstein, ES | 1 |
| Scavone, JM | 1 |
| Blyden, GT | 1 |
| Ochs, HR | 1 |
| Miller, LG | 1 |
| Harmatz, JS | 1 |
| Shader, RI | 1 |
| Ravizza, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of the Benefits of Individualized Advice Administration on Quality of Sleep for the Elderly Living at Home Prospective, Monocentric and Open Study[NCT03594851] | 45 participants (Actual) | Interventional | 2018-01-08 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for trazodone and Aging
| Article | Year |
|---|---|
Insomnia in the elderly: cause, approach, and treatment.
Topics: Acetamides; Aged; Aging; Antidepressive Agents; Azabicyclo Compounds; Behavior Therapy; Benzodiazepi | 2006 |
[Biochemical aspects of using antidepressants in late middle age and the elderly (review)].
Topics: Age Factors; Aged; Aging; Antidepressive Agents; Catechol O-Methyltransferase; Depression; Depressiv | 1983 |
1 trial available for trazodone and Aging
| Article | Year |
|---|---|
Trazodone kinetics: effect of age, gender, and obesity.
Topics: Adult; Aged; Aging; Biotransformation; Female; Half-Life; Humans; Kinetics; Male; Middle Aged; Obesi | 1987 |
3 other studies available for trazodone and Aging
| Article | Year |
|---|---|
Hippocampal BMP signaling as a common pathway for antidepressant action.
Topics: Aging; Animals; Anti-Anxiety Agents; Antidepressive Agents; Behavior, Animal; Bone Morphogenetic Pro | 2021 |
Pharmacokinetic and pharmacodynamic characteristics of trazodone in the elderly.
Topics: Adult; Aged; Aging; Female; Flicker Fusion; Half-Life; Humans; Hypnotics and Sedatives; Kinetics; Ma | 1983 |
Diagnostic and therapeutic problems in the psychopharmacological treatment of the elderly patient.
Topics: Aged; Aging; Depressive Disorder; Diagnosis, Differential; Humans; Kinetics; Mental Disorders; Neuro | 1986 |