transforming-growth-factor-beta and Thyroid-Carcinoma--Anaplastic

transforming-growth-factor-beta has been researched along with Thyroid-Carcinoma--Anaplastic* in 2 studies

Other Studies

2 other study(ies) available for transforming-growth-factor-beta and Thyroid-Carcinoma--Anaplastic

Article	Year
EIF5A2 Is Highly Expressed in Anaplastic Thyroid Carcinoma and Is Associated With Tumor Growth by Modulating TGF- Signals. Oncology research, 2020, Sep-01, Volume: 28, Issue:4 Topics: Apoptosis; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Eukaryotic Translation Initiation Factor 5A; Humans; Peptide Initiation Factors; Reverse Transcriptase Polymerase Chain Reaction; RNA-Binding Proteins; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Transforming Growth Factor beta; Up-Regulation	2020
REGγ ablation impedes dedifferentiation of anaplastic thyroid carcinoma and accentuates radio-therapeutic response by regulating the Smad7-TGF-β pathway. Cell death and differentiation, 2020, Volume: 27, Issue:2 Anaplastic thyroid cancer (ATC) is the most aggressive human thyroid malignancy, characterized by dedifferentiation and resistance to radioiodine therapy. The underlying mechanisms regulating ATC dedifferentiation are largely unknown. Here, we show that REGγ, a noncanonical proteasome activator highly expressed in ATC, is an important regulator of differentiation in ATC cells. Ablation of REGγ significantly restored expression of thyroid-specific genes, enhanced iodine uptake, and improved the efficacy of Topics: Autoantigens; Cell Differentiation; Cell Line; Humans; Proteasome Endopeptidase Complex; Signal Transduction; Smad7 Protein; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Transforming Growth Factor beta	2020

Article

Year

EIF5A2 Is Highly Expressed in Anaplastic Thyroid Carcinoma and Is Associated With Tumor Growth by Modulating TGF- Signals.

Oncology research, 2020, Sep-01, Volume: 28, Issue:4

Topics: Apoptosis; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Eukaryotic Translation Initiation Factor 5A; Humans; Peptide Initiation Factors; Reverse Transcriptase Polymerase Chain Reaction; RNA-Binding Proteins; RNA, Messenger; RNA, Small Interfering; Signal Transduction; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Transforming Growth Factor beta; Up-Regulation

2020

REGγ ablation impedes dedifferentiation of anaplastic thyroid carcinoma and accentuates radio-therapeutic response by regulating the Smad7-TGF-β pathway.

Cell death and differentiation, 2020, Volume: 27, Issue:2

Anaplastic thyroid cancer (ATC) is the most aggressive human thyroid malignancy, characterized by dedifferentiation and resistance to radioiodine therapy. The underlying mechanisms regulating ATC dedifferentiation are largely unknown. Here, we show that REGγ, a noncanonical proteasome activator highly expressed in ATC, is an important regulator of differentiation in ATC cells. Ablation of REGγ significantly restored expression of thyroid-specific genes, enhanced iodine uptake, and improved the efficacy of

Topics: Autoantigens; Cell Differentiation; Cell Line; Humans; Proteasome Endopeptidase Complex; Signal Transduction; Smad7 Protein; Thyroid Carcinoma, Anaplastic; Thyroid Neoplasms; Transforming Growth Factor beta

2020