transforming-growth-factor-beta and Peptic-Ulcer-Perforation

Omental implantation, a surgical procedure in which a perforated gastric or duodenal ulcer is repaired by drawing and implanting a portion of the omentum into the digestive tract, accelerates ulcer healing and inhibits ulcer recurrence. However, the mechanisms underlying these beneficial effects are largely unknown. To clarify these mechanisms, we investigated ulcer healing in two groups of rats in which acetic acid-induced gastric ulcers were perforated. Omental implantation was used for repair in one group and simple suturing was employed in the other group. Greater anti-inflammatory and angiogenic activity and accelerated collagen synthesis were seen in the omental implantation group. Basic fibroblast growth factor (bFGF)-mediated angiogenesis was noted in this group, as well as transforming growth factor-beta 1 (TGF-beta 1) activity within and around the omentum, resulting in abundant collagen production. It was confirmed that omental implantation accelerated ulcer healing and inhibited ulcer recurrence, and the presence of bFGF and TGF-beta 1 played a significant role in both these phenomena.

Topics: Animals; Blood Flow Velocity; Cell Count; Disease Models, Animal; Endothelium, Vascular; Fibroblast Growth Factor 2; Fibroblasts; Gastric Mucosa; Immunohistochemistry; Macrophages; Male; Omentum; Peptic Ulcer Perforation; Postoperative Complications; Rats; Rats, Wistar; Recurrence; Stomach Ulcer; Transforming Growth Factor beta