transforming-growth-factor-beta and Guillain-Barre-Syndrome

transforming-growth-factor-beta has been researched along with Guillain-Barre-Syndrome* in 2 studies

Other Studies

2 other study(ies) available for transforming-growth-factor-beta and Guillain-Barre-Syndrome

Article	Year
Elevated number of cells secreting transforming growth factor beta in Guillain-Barré syndrome. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2003, Volume: 111, Issue:12 We used ELISPOT and cell ELISA to study secretion of IL-4, IFN-gamma, TGF-beta, IL-6, and TNF-alpha by circulating mononuclear cells during the course of Guillain-Barré syndrome (GBS). Compared to healthy controls, patients with GBS had higher numbers of TGF-beta-secreting cells and the number of individuals with myelin-peptide-induced IL-4 and TGF-beta secretion was higher in the GBS group. No significant differences were seen concerning the predominantly pro-inflammatory cytokines IFN-gamma, IL-6 or TNF-alpha. Our findings indicate a down-regulatory role for TGF-beta and IL-4 in GBS. Topics: Adolescent; Adult; Aged; Female; Guillain-Barre Syndrome; Humans; Interferon-gamma; Interleukin-4; Interleukin-6; Leukocytes, Mononuclear; Lymphocyte Count; Male; Middle Aged; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha	2003
Expression of TNFalpha and TGFbeta1 in Guillain-Barré syndrome: correlation of a low TNFalpha-/TGFbeta1-mRNA ratio with good recovery and signs for immunoregulation within the cerebrospinal fluid compartment. European journal of neurology, 2000, Volume: 7, Issue:1 In the pathogenesis of Guillain-Barré syndrome (GBS) a dysregulation of cytokines is supposed. The protein concentration and mRNA expression of TNFalpha and TGFbeta1 were investigated in cerebrospinal fluid (CSF) and blood in 10 patients with GBS. TNFalpha-mRNA was increased at the beginning of the disease and demonstrated a decline during the time course (P = 0.001). The level of TNFalpha protein was elevated in only a few patients. TGFbeta1-mRNA (P = 0.001) and the active TGFbeta1 protein (P < 0.05) increased during the course of GBS, and the level of total TGFbeta1 protein was temporarily elevated (P = 0.005). A low ratio of TNFalpha-/TGFbeta-mRNA expression correlated to a good clinical course (P < 0.05). The results indicate an association of TNFalpha with disease activity. TGFbeta1 seems to terminate and limit the inflammatory reactions and to promote the healing course of GBS. In addition the investigations show that in GBS immunoregulatory mechanisms also take place in the CSF compartment itself and that CSF cells are involved in the production of pro-inflammatory as well as immunosuppressive cytokines. Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cerebrospinal Fluid; Enzyme-Linked Immunosorbent Assay; Female; Guillain-Barre Syndrome; Humans; In Situ Hybridization; Leukocytes, Mononuclear; Middle Aged; Predictive Value of Tests; RNA, Messenger; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha	2000

Article

Year

Elevated number of cells secreting transforming growth factor beta in Guillain-Barré syndrome.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 2003, Volume: 111, Issue:12

We used ELISPOT and cell ELISA to study secretion of IL-4, IFN-gamma, TGF-beta, IL-6, and TNF-alpha by circulating mononuclear cells during the course of Guillain-Barré syndrome (GBS). Compared to healthy controls, patients with GBS had higher numbers of TGF-beta-secreting cells and the number of individuals with myelin-peptide-induced IL-4 and TGF-beta secretion was higher in the GBS group. No significant differences were seen concerning the predominantly pro-inflammatory cytokines IFN-gamma, IL-6 or TNF-alpha. Our findings indicate a down-regulatory role for TGF-beta and IL-4 in GBS.

Topics: Adolescent; Adult; Aged; Female; Guillain-Barre Syndrome; Humans; Interferon-gamma; Interleukin-4; Interleukin-6; Leukocytes, Mononuclear; Lymphocyte Count; Male; Middle Aged; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

2003

Expression of TNFalpha and TGFbeta1 in Guillain-Barré syndrome: correlation of a low TNFalpha-/TGFbeta1-mRNA ratio with good recovery and signs for immunoregulation within the cerebrospinal fluid compartment.

European journal of neurology, 2000, Volume: 7, Issue:1

In the pathogenesis of Guillain-Barré syndrome (GBS) a dysregulation of cytokines is supposed. The protein concentration and mRNA expression of TNFalpha and TGFbeta1 were investigated in cerebrospinal fluid (CSF) and blood in 10 patients with GBS. TNFalpha-mRNA was increased at the beginning of the disease and demonstrated a decline during the time course (P = 0.001). The level of TNFalpha protein was elevated in only a few patients. TGFbeta1-mRNA (P = 0.001) and the active TGFbeta1 protein (P < 0.05) increased during the course of GBS, and the level of total TGFbeta1 protein was temporarily elevated (P = 0.005). A low ratio of TNFalpha-/TGFbeta-mRNA expression correlated to a good clinical course (P < 0.05). The results indicate an association of TNFalpha with disease activity. TGFbeta1 seems to terminate and limit the inflammatory reactions and to promote the healing course of GBS. In addition the investigations show that in GBS immunoregulatory mechanisms also take place in the CSF compartment itself and that CSF cells are involved in the production of pro-inflammatory as well as immunosuppressive cytokines.

Topics: Adolescent; Adult; Aged; Aged, 80 and over; Cerebrospinal Fluid; Enzyme-Linked Immunosorbent Assay; Female; Guillain-Barre Syndrome; Humans; In Situ Hybridization; Leukocytes, Mononuclear; Middle Aged; Predictive Value of Tests; RNA, Messenger; Transforming Growth Factor beta; Tumor Necrosis Factor-alpha

2000