transforming-growth-factor-beta and Fibrous-Dysplasia-of-Bone

The Fifth Biennial Research Summit of the American Association of Oral and Maxillofacial Surgeons and its Committee on Research Planning and Technology Assessment was held in Rosemont, Illinois on May 6 and 7, 2015. The goal of the symposium is to provide a forum for the most recent clinical and scientific advances to be brought to the specialty. The proceedings of the events of that summit are presented in this report.

Topics: Ameloblastoma; Bone Morphogenetic Protein 2; Bone Regeneration; Carcinogenesis; Congresses as Topic; Dental Research; Fibrous Dysplasia of Bone; Humans; Imaging, Three-Dimensional; Nerve Growth Factor; Odontogenic Tumors; Osteolysis; Patient Care Planning; Plastic Surgery Procedures; Printing, Three-Dimensional; Recombinant Proteins; Regenerative Medicine; Registries; Societies, Dental; Surgery, Computer-Assisted; Surgery, Oral; Tissue Engineering; Transforming Growth Factor beta; Translational Research, Biomedical; User-Computer Interface

Osteofibrous dysplasia (OFD) and fibrous dysplasia (FD) are both benign bone lesions which comprise the proliferation of fibroblast-like cells with bone formation, and these fibroblast-like cells have the phenotype of osteoprogenitor cells. The roentgenograph of OFD shows a heterogeneous osteolytic lesion with surrounding osteosclerosis, whereas FD is typically characterized by a rather homogeneous osteolytic lesion, or 'ground-glass appearance', with a smaller amount of surrounding osteosclerosis. Growth factors of transforming growth factor-beta1 (TGF-beta1), fibroblast growth factor-2 (FGF-2) and bone morphogenetic protein-2 (BMP-2) modulate bone differentiation. Expression of these growth factors was examined in the fibroblast-like cells of 16 cases of OFD and 16 cases of FD, immunohistochemically. TGF-beta1 in fibroblast-like cells was frequently expressed both in the OFD (16/16) and the FD (15/16) cases. The frequency of FGF-2 (16/16) expression and BMP-2 (13/16) expression in the fibroblast-like cells of OFD was higher than that of those [FGF-2 (8/16) and BMP-2 (6/16)] in the fibroblast-like cells of FD, with a statistical significance. These results seem to suggest that fibroblast-like cells of OFD have greater bone-forming ability than those of FD, and may explain the roentgenographic difference between OFD and FD and a difference in the nature of fibroblast-like cells between these two types of lesions.

Topics: Adolescent; Adult; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Child; Child, Preschool; Fibroblast Growth Factor 2; Fibroblasts; Fibrous Dysplasia of Bone; Humans; Immunohistochemistry; Middle Aged; Transforming Growth Factor beta