transforming-growth-factor-beta and Coronary-Stenosis

Topics: Adult; Aged; Arteriosclerosis; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Calcinosis; Calcium-Binding Proteins; Coronary Stenosis; Extracellular Matrix Proteins; Humans; Macrophages; Matrix Gla Protein; Middle Aged; Muscle, Smooth, Vascular; Neoplasm Proteins; Osteogenesis; Transcription Factors; Transforming Growth Factor beta; Tunica Intima

Vascular endothelial growth factor (VEGF) and transforming growth factor beta (TGF-beta1) play an important role in angiogenesis. We wanted to determine if concentrations of growth factors in the coronary sinus (CS) and right atrium (RA) are higher in coronary artery disease patients with total occlusions than in those with partial occlusions. Fifty-one patients scheduled for coronary artery angiography were evaluated for possible recruitment. A 6F Goodale-Lubin catheter was used to collect blood from the CS and RA. Data for all but four patients were gathered successfully, leaving 47 study patients. The reviewer was blinded to growth factor data when interpreting coronary angiographic findings. Of the 47 enrolled patients, 32 had at least one diseased vessel, seven of whom had at least one major total epicardial coronary occlusion. In all 32 patients, the concentrations of VEGF in the CS were higher than those in the RA (31.5 +/- 2.7 vs 27.1 +/- 1.8 pg/mL; p = 0.005). Patients with total occlusions had higher VEGF concentrations in the CS than those with non-total occlusions (38.9 +/- 8.0 vs 29.5 +/- 2.6 pg/mL; p = 0.037). The differences in TGF-beta1 in the two groups were not statistically significant. The higher CS VEGF concentrations in patients with total occlusion indicate that VEGF may play a part in the development of angiogenesis.

Topics: Aged; Arterial Occlusive Diseases; Coronary Angiography; Coronary Disease; Coronary Stenosis; Coronary Vessels; Enzyme-Linked Immunosorbent Assay; Female; Heart Atria; Humans; Hypertension; Male; Middle Aged; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A

To explore whether local growth factors concentration, including vascular endothelial growth factor (VEGF) and transforming growth factor beta one (TGF-beta(1)), influence the formation of coronary collaterals.. Thirty-six patients scheduled for coronary angiography received a 6F Goodale-Lubin catheterization to collect blood from the coronary sinus (CS) and right atrium (RA).. Patients with coronary collaterals had a higher number of diseased vessels (2.6+/-0.2 vs. 1.4+/-0.3, p = 0.005), higher percentage of severity of stenosis (93+/-2 vs. 48+/-8, P < 0.001) and higher VEGF concentrations in CS (38.9+/-3.9 pg/ml vs. 20.8+/-1.4 pg/ml, P < 0.001) and in RA (31.7+/-3.1 pg/ml vs. 22.0+/-2.3 pg/ml, p = 0.004). There was no significant relationship between coronary collateral formation and TGF-beta(1) concentration. By binary logistic regression analysis, VEGF concentrations in CS (p = 0.030) and stenosis severity (p = 0.042) are correlated positively with collateral formation.. The association between local, endogenous secretion of VEGF and coronary collateral formation is compatible with a paracrine role for this growth factor in pathophysiologic collateral formation.

Topics: Collateral Circulation; Coronary Artery Disease; Coronary Stenosis; Coronary Vessels; Female; Humans; Male; Middle Aged; Transforming Growth Factor beta; Transforming Growth Factor beta1; Vascular Endothelial Growth Factors