transforming-growth-factor-beta and Arthralgia

The authors report on a case of a patient who received recombinant human bone morphogenetic protein-2 (rhBMP-2) to augment spinal fusion for the first and third of 3 lumbosacral fusion surgeries. After receiving rhBMP-2 the first time, the patient became febrile and developed mild acute renal insufficiency and transient supraventricular tachycardia (SVT). The second operation was complicated only by perioperative fever. When the patient received rhBMP-2 again during the third operation, he developed fever, acute oliguric renal insufficiency, symptomatic SVT with hypoxemia, confusion, and joint pain. No clear cause of these problems was identified; however serum analysis revealed the presence of an antibody to rhBMP-2. The authors discuss potential mechanisms for the patient's putative reaction to rhBMP-2, as the findings from a literature review suggest this is the first such reaction to be reported.

Topics: Acute Kidney Injury; Antibodies; Arthralgia; Bone Morphogenetic Protein 2; Bone Morphogenetic Proteins; Confusion; Fever; Humans; Hypoxia; Immunoglobulin G; Lumbar Vertebrae; Male; Middle Aged; Recombinant Proteins; Sacrum; Spinal Fusion; Tachycardia, Supraventricular; Transforming Growth Factor beta