trans-sodium-crocetinate has been researched along with Sleep-Initiation-and-Maintenance-Disorders* in 2 studies
2 trial(s) available for trans-sodium-crocetinate and Sleep-Initiation-and-Maintenance-Disorders
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Effect of crocetin on quality of sleep: A randomized, double-blind, placebo-controlled, crossover study.
The aim of the present study was to investigate the effect of crocetin on sleep architecture and subjective sleep parameters in healthy adult participants with mild sleep complaints.. A randomized, double-blind, placebo-controlled, crossover study with two intervention periods of 14 days each, separated by a 14-day wash-out period.. Thirty participants were randomly assigned to one of two sequence groups. Each group was given crocetin at 7.5 mg/day, or placebo. We measured objective sleep parameters using single-channel electroencephalography and assessed subjective sleep parameters using the Oguri-Shirakawa-Azumi Sleep Inventory, Middle-age and Aged version (OSA-MA).. Differences between crocetin and placebo in an objective sleep parameter (delta power), and OSA-MA scores.. Delta power was significantly increased with crocetin compared with placebo. There were no significant differences in the other sleep parameters, including sleep latency, sleep efficiency, total sleep time, and wake after sleep onset. Subjective scores for sleepiness on rising and feeling refreshed were significantly improved with crocetin compared with placebo.. The findings of the present study suggest that crocetin supplementation contributes to sleep maintenance, leading to improved subjective sleep quality. Topics: Adult; Carotenoids; Crocus; Cross-Over Studies; Dietary Supplements; Double-Blind Method; Electroencephalography; Female; Gardenia; Humans; Hypnotics and Sedatives; Male; Middle Aged; Plant Extracts; Sleep; Sleep Initiation and Maintenance Disorders; Vitamin A; Wakefulness | 2018 |
Effect of crocetin from Gardenia jasminoides Ellis on sleep: a pilot study.
Crocetin is a pharmacologically active carotenoid compound of Gardenia jasminoides Ellis used as a traditional herbal medicine and natural colorant. The present pilot study investigated the effect of crocetin on sleep. The clinical trial comprised a double-blind, placebo-controlled, crossover trial of 21 healthy adult men with a mild sleep complaint. It included two intervention periods of 2 weeks each, separated by a 2-week washout period. We measured objective sleep quality using an actigraph, and assessed the subjective symptoms using St Mary's Hospital Sleep Questionnaire. Actigraph data showed that after administration of crocetin, the number of wakening episodes was reduced compared to that of the placebo (p=0.025). Subjective data from St Mary's Hospital Sleep Questionnaire showed that crocetin tended to improve the quality of sleep compared to sleep before its intake. Additionally, no side effects from crocetin intake were observed. The results suggest that crocetin may contribute to improving the quality of sleep. Topics: Adult; Carotenoids; Cross-Over Studies; Double-Blind Method; Fruit; Gardenia; Humans; Male; Middle Aged; Phytotherapy; Pilot Projects; Plant Extracts; Sleep; Sleep Initiation and Maintenance Disorders; Vitamin A | 2010 |