trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride has been researched along with Pregnancy in 31 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (38.71) | 18.7374 |
| 1990's | 5 (16.13) | 18.2507 |
| 2000's | 11 (35.48) | 29.6817 |
| 2010's | 3 (9.68) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ferrington, DA; Fliesler, SJ; Kapphahn, RJ; Richards, MJ | 1 |
| Fliesler, SJ; Porter, NA; Sheflin, LG; Xu, L | 1 |
| Cortez, MA; Snead, OC; Stewart, LS | 1 |
| Cortez, MA; Persad, V; Snead, OC; Ting Wong, CG; Wang, YT | 1 |
| Andersen, CY; Bo, S; Byskov, AG; Tao, Y; Xia, G; Xie, H | 1 |
| Fliesler, SJ; Nagel, BA; Peachey, NS; Richards, MJ; Vaughan, DK | 1 |
| Cortez, MA; McKerlie, C; Serbanescu, I; Snead, OC | 1 |
| Fliesler, SJ; Jenewein, EC; Nagel, BA; Peachey, NS; Richards, MJ; Vaughan, DK | 1 |
| Arenillas, JF; Dávalos, A; de la Ossa, NP; Gasull, T; Hurtado, O; Millan, M; Ponce, J | 1 |
| Anastasia, M; Bernini, F; Fiecchi, A; Fumagalli, R; Galli, G | 1 |
| Dupuis, R; Horvath, C; Roux, C; Talbot, JN | 1 |
| Dupuis, R; Marmor, D; Prédine, J; Roux, C; Youssef, S | 1 |
| Cenedella, RJ; Sarkar, CP | 1 |
| Barbu, V; Dupuis, R; Gardette, J; Maziere, JC; Roux, C | 1 |
| Chevy, F; Citadelle, D; Kolf-Clauw, M; Mulliez, N; Pham, J; Roux, C; Wolf, C | 1 |
| Batta, AK; Salen, G | 1 |
| Chevy, F; Kolf-Clauw, M; Ponsart, C | 1 |
| Fliesler, SJ; Miller, C; Peachey, NS; Richards, MJ | 1 |
| Clotman, F; Gofflot, F; Kolf-Clauw, M; Picard, JJ; Roux, C | 1 |
| Chevy, F; Gaoua, W; Ilien, F; Roux, C; Wolf, C | 1 |
| Bourguignon, L; Gaoua, W; Gofflot, F; Picard, JJ; Roux, C | 1 |
| Batta, A; Dyer, CA; Kendler, A; O'Brien, WT; Salen, G; Servatius, RJ; Tint, GS; Xu, G | 1 |
| Cortez, MA; Persad, V; Snead, OC | 1 |
| Cortez, MA; Cunnane, SC; Snead, OC | 1 |
| Kim, SU | 1 |
| Aubry, MM; Dupuis, R; Rapin, J; Roux, C | 1 |
| Aubry, MM; Dupuis, R; Horvath, H; Roux, C | 1 |
| Dupuis, R; Horvath, C; Roux, C | 1 |
| Dupuis, R; Giroud, A; Horvath, C; Roux, C | 1 |
| Barbu, V; Dupuis, R; Elefant, E; Gardette, J; Lambert, D; Maziere, C; Maziere, JC; Polonovski, J; Roux, C | 1 |
| Kacew, S; Reasor, MJ | 1 |
1 review(s) available for trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride and Pregnancy
| Article | Year |
|---|---|
Abnormal cholesterol biosynthesis produced by AY 9944 in the rat leads to skeletal deformities similar to the Smith-Lemli-Opitz syndrome.
Topics: Abnormalities, Drug-Induced; Animals; Anticholesteremic Agents; Bone and Bones; Bone Development; Cholesterol; Enzyme Inhibitors; Female; Holoprosencephaly; Humans; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pregnancy; Rats; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1998 |
30 other study(ies) available for trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride and Pregnancy
| Article | Year |
|---|---|
Lipid-derived and other oxidative modifications of retinal proteins in a rat model of Smith-Lemli-Opitz syndrome.
Topics: Aldehydes; Animals; Blotting, Western; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Female; Opsins; Oxidative Stress; Pregnancy; Proteomics; Rats; Rats, Sprague-Dawley; Retina; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Transducin | 2019 |
7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome.
Topics: Animals; Animals, Newborn; Cholesterol; Chromatography, High Pressure Liquid; Dehydrocholesterols; Disease Models, Animal; Female; Humans; Ketocholesterols; Male; Mass Spectrometry; Molecular Structure; Pregnancy; Rats; Rats, Sprague-Dawley; Retina; Retinal Degeneration; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2012 |
Environmental enrichment improves behavioral outcome in the AY-9944 model of childhood atypical absence epilepsy.
Topics: Animals; Anticholesteremic Agents; Anxiety; Behavior, Animal; Brain Waves; Disease Models, Animal; Electroencephalography; Environment; Epilepsy, Absence; Exploratory Behavior; Female; Male; Maze Learning; Mice; Mice, Inbred C3H; Odorants; Pregnancy; Recognition, Psychology; Smell; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2012 |
Hormonal regulation of atypical absence seizures.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anticholesteremic Agents; Blotting, Western; Cell Line; Disease Models, Animal; Electroencephalography; Embryo, Mammalian; Epilepsy, Absence; Estrous Cycle; Female; Functional Laterality; Hormones; Humans; Kidney; Male; Organophosphorus Compounds; Pregnancy; Protein Binding; Rats; Rats, Long-Evans; Receptors, GABA-B; Sex Characteristics; Time Factors; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Transfection; Tritium | 2004 |
Roles of gonadotropins and meiosis-activating sterols in meiotic resumption of cultured follicle-enclosed mouse oocytes.
Topics: Aniline Compounds; Animals; Chorionic Gonadotropin; Culture Media, Serum-Free; Culture Techniques; Female; Follicle Stimulating Hormone; Meiosis; Mice; Oocytes; Ovarian Follicle; Pregnancy; Sterols; Sulfides; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2004 |
Retinal degeneration in a rodent model of Smith-Lemli-Opitz syndrome: electrophysiologic, biochemical, and morphologic features.
Topics: Animals; Anticholesteremic Agents; Cholesterol; Dark Adaptation; Dehydrocholesterols; Disease Models, Animal; Electrophysiology; Electroretinography; Female; Pigment Epithelium of Eye; Pregnancy; Rats; Rats, Sprague-Dawley; Retina; Retinal Degeneration; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2004 |
Refractory atypical absence seizures in rat: a two hit model.
Topics: Animals; Anticholesteremic Agents; Brain; Disease Models, Animal; Drug Resistance; Electroencephalography; Epilepsy, Absence; Female; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Protein Synthesis Inhibitors; Rats; Rats, Long-Evans; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2004 |
Partial rescue of retinal function and sterol steady-state in a rat model of Smith-Lemli-Opitz syndrome.
Topics: Animals; Cholesterol, Dietary; Disease Models, Animal; Female; Humans; Photoreceptor Cells, Vertebrate; Pregnancy; Rats; Retina; Smith-Lemli-Opitz Syndrome; Sterols; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2007 |
Simvastatin reduces the association of NMDA receptors to lipid rafts: a cholesterol-mediated effect in neuroprotection.
Topics: Animals; Anticholesteremic Agents; Cell Death; Cells, Cultured; Cerebral Cortex; Cholesterol; Female; Membrane Microdomains; Neurons; Neuroprotective Agents; Neurotoxins; Pregnancy; Rats; Receptors, N-Methyl-D-Aspartate; Simvastatin; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2008 |
The identification of a novel C27 diene, cholesta-5,8-dien-3 beta-OL, in tissues of rats given AY-9944 (trans-1,4-bis(2-dichlorobenzylaminoethyl)cyclohexane) in pregnancy.
Topics: Animals; Brain; Chemical Phenomena; Chemistry; Cholestadienols; Cholesterol; Cyclohexanes; Female; Gas Chromatography-Mass Spectrometry; Liver; Magnetic Resonance Spectroscopy; Maternal-Fetal Exchange; Pregnancy; Rats; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1980 |
Teratogenic effect of an inhibitor of cholesterol synthesis (AY 9944) in rats: correlation with maternal cholesterolemia.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Cholesterol; Cyclohexanes; Female; Maternal-Fetal Exchange; Pregnancy; Rats; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1980 |
[Pituitary agenesis in the rat: synthesis of testosterone in fatal testes].
Topics: Animals; Female; Male; Pituitary Gland; Pregnancy; Rats; Rats, Inbred Strains; Testis; Testosterone; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1981 |
Reactivity of key metabolic sterols in standard colorimetric assays for cholesterol.
Topics: Animals; Brain; Brain Chemistry; Cholesterol; Colorimetry; Dehydrocholesterols; Desmosterol; False Positive Reactions; Female; Lanosterol; Pregnancy; Rats; Rats, Inbred Strains; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1982 |
Teratogenic effect of AY 9944 in rats: importance of the day of administration and maternal plasma cholesterol level.
Topics: Abnormalities, Drug-Induced; Animals; Cholesterol; Cyclohexanes; Female; Fetal Death; Gestational Age; Head; Pregnancy; Rats; Rats, Inbred Strains; Teratogens; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1984 |
Changes in serum sterols of rats treated with 7-dehydrocholesterol-delta 7-reductase inhibitors: comparison to levels in humans with Smith-Lemli-Opitz syndrome.
Topics: Animals; Child; Cholestadienols; Cholesterol; Dehydrocholesterols; Disease Models, Animal; Enzyme Inhibitors; Female; Heterozygote; Humans; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Piperazines; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Smith-Lemli-Opitz Syndrome; Sterols; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1996 |
Abnormal cholesterol biosynthesis as in Smith-Lemli-Opitz syndrome disrupts normal skeletal development in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Anticholesteremic Agents; Body Weight; Bone and Bones; Bone Development; Cervical Vertebrae; Cholesterol; Dehydrocholesterols; Enzyme Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Male; Osteogenesis; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pregnancy; Rats; Rats, Wistar; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1998 |
Marked alteration of sterol metabolism and composition without compromising retinal development or function.
Topics: Animals; Animals, Newborn; Anticholesteremic Agents; Cholesterol; Chromatography, High Pressure Liquid; Dehydrocholesterols; Electroretinography; Female; Pregnancy; Rats; Rats, Sprague-Dawley; Retina; Smith-Lemli-Opitz Syndrome; Sterols; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1999 |
Absence of ventral cell populations in the developing brain in a rat model of the Smith-Lemli-Opitz syndrome.
Topics: Animals; Brain; Cholesterol; Disease Models, Animal; DNA-Binding Proteins; Embryonic and Fetal Development; Enzyme Inhibitors; Eye Proteins; Female; Fetal Diseases; Fetal Proteins; Gestational Age; Hedgehog Proteins; Homeodomain Proteins; In Situ Hybridization; Male; Nerve Tissue Proteins; Neural Tube Defects; Neurons; Otx Transcription Factors; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Paired Box Transcription Factors; PAX6 Transcription Factor; Pregnancy; Prosencephalon; Protein Biosynthesis; Proteins; Rats; Rats, Wistar; Repressor Proteins; Rhombencephalon; Signal Transduction; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Trans-Activators | 1999 |
Cholesterol deficit but not accumulation of aberrant sterols is the major cause of the teratogenic activity in the Smith-Lemli-Opitz syndrome animal model.
Topics: Abnormalities, Drug-Induced; Animals; Cholesterol; Cholesterol, Dietary; Dehydrocholesterols; Disease Models, Animal; Embryo, Mammalian; Female; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pregnancy; Rats; Rats, Wistar; Smith-Lemli-Opitz Syndrome; Steroid Isomerases; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2000 |
Expression of Sonic Hedgehog downstream genes is modified in rat embryos exposed in utero to a distal inhibitor of cholesterol biosynthesis.
Topics: Abnormalities, Drug-Induced; Animals; Anticholesteremic Agents; Cholesterol; Cholesterol, Dietary; Congenital Abnormalities; Dehydrocholesterols; Embryonic and Fetal Development; Embryonic Induction; Female; Gene Expression Regulation, Developmental; Hedgehog Proteins; Holoprosencephaly; Humans; In Situ Hybridization; Pregnancy; Proteins; Rats; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Trans-Activators | 2001 |
Developmental sensitivity of associative learning to cholesterol synthesis inhibitors.
Topics: Aging; Animals; Association Learning; Brain Chemistry; Cholesterol; Conditioning, Classical; Enzyme Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Male; Motor Activity; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Piperazines; Pregnancy; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Reaction Time; Reflex, Startle; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2002 |
A chronic model of atypical absence seizures: studies of developmental and gender sensitivity.
Topics: Animals; Animals, Newborn; Anticholesteremic Agents; Disease Models, Animal; Epilepsy, Absence; Female; Male; Pregnancy; Rats; Rats, Long-Evans; Sex Characteristics; Sexual Maturation; Time Factors; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2002 |
Brain sterols in the AY-9944 rat model of atypical absence seizures.
Topics: Animals; Anticholesteremic Agents; Brain Chemistry; Cholesterol; Dehydrocholesterols; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Female; Male; Phospholipids; Pregnancy; Rats; Rats, Long-Evans; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2002 |
Effects of the cholesterol biosynthesis inhibitor ay9944 on organotypic cultures ofmouse spinal cord. Retarded myelinogenesis and induction of cytoplasmic inclusions.
Topics: Animals; Astrocytes; Axons; Cholesterol; Culture Media; Cyclohexanes; Dendrites; Female; Fetus; Inclusion Bodies; Mice; Microscopy, Electron; Myelin Sheath; Neurons; Oligodendroglia; Organ Culture Techniques; Pregnancy; Spinal Cord; Time Factors; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1975 |
[Incorporation of 3H-thymidine in Wistar rat embryos treated with AY 9944].
Topics: Animals; Body Weight; Cyclohexanes; Embryo, Mammalian; Female; Pregnancy; Rats; Thymidine; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1975 |
[Teratogenic action of an inhibitor of cholesterol synthesis in Wistar and Sprague-Dawley rats].
Topics: Animals; Cholesterol; Cyclohexanes; Female; Fetus; Pregnancy; Rats; Species Specificity; Teratogens; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1977 |
Teratogenic action and embryo lethality of AY 9944R. Prevention by a hypercholesterolemia-provoking diet.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Cholesterol; Cholesterol, Dietary; Cyclohexanes; Female; Fetal Death; Hypercholesterolemia; Male; Pregnancy; Rats; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Urogenital Abnormalities | 1979 |
Interpretation of isolated agenesis of the pituitary.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Cyclohexanes; Female; Humans; Pituitary Gland; Pregnancy; Rats; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Triparanol | 1979 |
Cholesterol prevents the teratogenic action of AY 9944: importance of the timing of cholesterol supplementation to rats.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Cholesterol; Cholesterol Esters; Cholesterol, Dietary; Cyclohexanes; Dehydrocholesterols; Dose-Response Relationship, Drug; Female; Fetal Death; Pituitary Gland; Pregnancy; Rats; Rats, Inbred Strains; Time Factors; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1988 |
Newborn response to cationic amphiphilic drugs.
Topics: Animals; Animals, Newborn; Chlorphentermine; Dexamethasone; Drug Interactions; Female; Fetus; Gentamicins; Lipidoses; Lung; Phenobarbital; Phentermine; Phospholipids; Piperazines; Pregnancy; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Triparanol | 1985 |