trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride has been researched along with Disease Models, Animal in 39 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (7.69) | 18.7374 |
| 1990's | 9 (23.08) | 18.2507 |
| 2000's | 17 (43.59) | 29.6817 |
| 2010's | 10 (25.64) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Perescis, MFJ; van Luijtelaar, G; van Rijn, CM | 1 |
| Fliesler, SJ; Keiko, U; Más Gómez, N; Mitchell, CH; Pfeffer, BA; Ramachandra Rao, S; Rowsam, AM; Skelton, LA; Sparrow, JR | 1 |
| Ferrington, DA; Fliesler, SJ; Kapphahn, RJ; Richards, MJ | 1 |
| Fliesler, SJ; Xu, L | 1 |
| Jeon, D; Jeong, Y; Jung, S | 1 |
| Bercovici, E; Cortez, MA; Snead, OC; Wang, X | 1 |
| Cortez, MA; Huo, JZ; Snead, OC | 1 |
| Ahmed, M; Burnham, WM; Chan, KF; Chieverton, L; Liu, RR; Scott, BW; Wong, G; Wood, J | 1 |
| Fliesler, SJ; Liu, W; Porter, NA; Sheflin, LG; Xu, L | 1 |
| Fliesler, SJ; Porter, NA; Sheflin, LG; Xu, L | 1 |
| Cortez, MA; Snead, OC; Stewart, LS | 1 |
| Fliesler, SJ; Goulah, CC; Keller, RK; Mitchell, DA | 1 |
| Cortez, MA; Persad, V; Snead, OC; Ting Wong, CG; Wang, YT | 1 |
| Fliesler, SJ; Nagel, BA; Peachey, NS; Richards, MJ; Vaughan, DK | 1 |
| Cortez, MA; McKerlie, C; Serbanescu, I; Snead, OC | 1 |
| El-Beheiry, M; Khokhotva, V; Kokarovtseva, L; Leshchenko, Y; Perez Velazquez, JL; Proulx, E; Snead, OC | 1 |
| Burnham, WM; Chan, KF; Cortez, MA; Jia, Z; Snead, OC | 1 |
| Bercovici, E; Cortez, MA; Mistry, N; Persad, V; Serbanescu, I; Shukla, R; Snead, OC; Stewart, LS | 1 |
| Fisher, RS; Huguenard, JR; Li, H | 1 |
| Fliesler, SJ; Jenewein, EC; Nagel, BA; Peachey, NS; Richards, MJ; Vaughan, DK | 1 |
| Dominguez, LG; Huo, JZ; Leshchenko, Y; Snead, OC; Velazquez, JL | 1 |
| Anderson, RE; Brush, RS; Fliesler, SJ; Ford, DA; Monda, JK; Richards, MJ | 1 |
| Anderson, RE; Boesze-Battaglia, K; Brush, RS; Damek-Poprawa, M; Fliesler, SJ; Greeley, L; Mitchell, DC; Richards, MJ | 1 |
| Chevy, F; Citadelle, D; Kolf-Clauw, M; Mulliez, N; Pham, J; Roux, C; Wolf, C | 1 |
| Fisher, RS; Smith, KA | 1 |
| Chevy, F; Citadelle, D; Kolf-Clauw, M; Roux, C; Siliart, B; Wolf, C | 1 |
| Chambers, CM; McLean, MP; Ness, GC | 1 |
| Clayton, PT | 1 |
| Chevy, F; Gaoua, W; Roux, C; Wolf, C | 1 |
| Clotman, F; Gofflot, F; Kolf-Clauw, M; Picard, JJ; Roux, C | 1 |
| Chevy, F; Gaoua, W; Ilien, F; Roux, C; Wolf, C | 1 |
| Chevy, F; Citadelle, D; Cormier, V; Gaoua, W; Mulliez, N; Roux, C; Wolf, C | 1 |
| Cortez, MA; Persad, V; Snead, OC | 1 |
| Cortez, MA; Cunnane, SC; Snead, OC | 1 |
| Sakuragawa, M | 1 |
| Barranger, JA; Brady, RO; Kuwabara, T; Pentchev, PG; Sakuragaw, M; Sakuragawa, N | 1 |
| Lüllmann, H; Lüllmann-Rauch, R | 1 |
| Snead, OC | 1 |
| Bierkamper, GG; Smith, KA | 1 |
4 review(s) available for trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride and Disease Models, Animal
| Article | Year |
|---|---|
Oxysterols and Retinal Degeneration in a Rat Model of Smith-Lemli-Opitz Syndrome: Implications for an Improved Therapeutic Intervention.
Topics: Animals; Cholesterol; Dehydrocholesterols; Disease Models, Animal; Lipid Metabolism; Oxysterols; Rats; Retina; Retinal Degeneration; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2018 |
Disorders of cholesterol biosynthesis.
Topics: Anticholesteremic Agents; Cholesterol; Desmosterol; Disease Models, Animal; Humans; Infant, Newborn; Lanosterol; Metabolism, Inborn Errors; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1998 |
Role of cholesterol in embryonic development.
Topics: Animals; Anticholesteremic Agents; Cholesterol; Dehydrocholesterols; Disease Models, Animal; Embryonic and Fetal Development; Fetus; Piperazines; Rats; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Triparanol | 2000 |
Pharmacological models of generalized absence seizures in rodents.
Topics: Animals; Disease Models, Animal; Epilepsy, Absence; Isoxazoles; Penicillins; Pentylenetetrazole; Rodentia; Sodium Oxybate; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1992 |
35 other study(ies) available for trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride and Disease Models, Animal
| Article | Year |
|---|---|
Neonatal exposure to AY-9944 increases typical spike and wave discharges in WAG/Rij and Wistar rats.
Topics: Animals; Brain Waves; Cerebral Cortex; Disease Models, Animal; Electroencephalography; Hippocampus; Male; Rats; Rats, Wistar; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2019 |
Compromised phagosome maturation underlies RPE pathology in cell culture and whole animal models of Smith-Lemli-Opitz Syndrome.
Topics: Animals; Biomarkers; Cathepsin D; Cattle; Cell Culture Techniques; Dehydrocholesterols; Disease Models, Animal; Humans; Lysosomes; Membrane Fusion; Phagocytosis; Phagosomes; Protein Biosynthesis; Rats; Retinal Pigment Epithelium; Retinoids; Rod Cell Outer Segment; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Transcription, Genetic; Ubiquitinated Proteins | 2018 |
Lipid-derived and other oxidative modifications of retinal proteins in a rat model of Smith-Lemli-Opitz syndrome.
Topics: Aldehydes; Animals; Blotting, Western; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Female; Opsins; Oxidative Stress; Pregnancy; Proteomics; Rats; Rats, Sprague-Dawley; Retina; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Transducin | 2019 |
Epileptic activity during early postnatal life in the AY-9944 model of atypical absence epilepsy.
Topics: Animals; Animals, Newborn; CA1 Region, Hippocampal; Calcium Channels, T-Type; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Female; In Vitro Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons; Patch-Clamp Techniques; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Voltage-Gated Sodium Channels | 2015 |
Monoamine variability in the chronic model of atypical absence seizures.
Topics: Animals; Animals, Newborn; Biogenic Monoamines; Brain; Chromatography, High Pressure Liquid; Disease Models, Animal; Electrochemistry; Electroencephalography; Epilepsy, Absence; Male; Neurotransmitter Agents; Rats; Rats, Long-Evans; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2009 |
GABA receptor proteins within lipid rafts in the AY-9944 model of atypical absence seizures.
Topics: Age Factors; Analysis of Variance; Animals; Animals, Newborn; Brain; Cholesterol; Disease Models, Animal; Epilepsy, Absence; Gene Expression Regulation, Developmental; Male; Membrane Microdomains; Membrane Proteins; Protein Subunits; Protein Transport; Rats; Rats, Long-Evans; Receptors, GABA; Receptors, N-Methyl-D-Aspartate; Time Factors; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2009 |
Cytogenesis in the adult rat dentate gyrus is increased following kindled seizures but is unaltered in pharmacological models of absence seizures.
Topics: 4-Butyrolactone; Animals; Animals, Newborn; Anticholesteremic Agents; Bromodeoxyuridine; Cell Count; Dentate Gyrus; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Gene Expression Regulation; Kindling, Neurologic; Male; Nerve Tissue Proteins; Neurogenesis; Rats; Rats, Long-Evans; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2010 |
Novel oxysterols observed in tissues and fluids of AY9944-treated rats: a model for Smith-Lemli-Opitz syndrome.
Topics: Animals; Anticholesteremic Agents; Cholestenones; Cholesterol; Chromatography, High Pressure Liquid; Dehydrocholesterols; Disease Models, Animal; Hydroxycholesterols; Ketocholesterols; Lipid Peroxidation; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Rats; Rats, Sprague-Dawley; Smith-Lemli-Opitz Syndrome; Spectrophotometry, Ultraviolet; Sterols; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2011 |
7-Dehydrocholesterol-derived oxysterols and retinal degeneration in a rat model of Smith-Lemli-Opitz syndrome.
Topics: Animals; Animals, Newborn; Cholesterol; Chromatography, High Pressure Liquid; Dehydrocholesterols; Disease Models, Animal; Female; Humans; Ketocholesterols; Male; Mass Spectrometry; Molecular Structure; Pregnancy; Rats; Rats, Sprague-Dawley; Retina; Retinal Degeneration; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2012 |
Environmental enrichment improves behavioral outcome in the AY-9944 model of childhood atypical absence epilepsy.
Topics: Animals; Anticholesteremic Agents; Anxiety; Behavior, Animal; Brain Waves; Disease Models, Animal; Electroencephalography; Environment; Epilepsy, Absence; Exploratory Behavior; Female; Male; Maze Learning; Mice; Mice, Inbred C3H; Odorants; Pregnancy; Recognition, Psychology; Smell; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2012 |
Hepatic isoprenoid metabolism in a rat model of Smith-Lemli-Opitz Syndrome.
Topics: Animals; Anticholesteremic Agents; Cholesterol; Dehydrocholesterols; Disease Models, Animal; Dolichols; Humans; Liver; Oxidoreductases Acting on CH-CH Group Donors; Rats; Rats, Sprague-Dawley; Smith-Lemli-Opitz Syndrome; Terpenes; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Ubiquinone | 2013 |
Hormonal regulation of atypical absence seizures.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anticholesteremic Agents; Blotting, Western; Cell Line; Disease Models, Animal; Electroencephalography; Embryo, Mammalian; Epilepsy, Absence; Estrous Cycle; Female; Functional Laterality; Hormones; Humans; Kidney; Male; Organophosphorus Compounds; Pregnancy; Protein Binding; Rats; Rats, Long-Evans; Receptors, GABA-B; Sex Characteristics; Time Factors; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Transfection; Tritium | 2004 |
Retinal degeneration in a rodent model of Smith-Lemli-Opitz syndrome: electrophysiologic, biochemical, and morphologic features.
Topics: Animals; Anticholesteremic Agents; Cholesterol; Dark Adaptation; Dehydrocholesterols; Disease Models, Animal; Electrophysiology; Electroretinography; Female; Pigment Epithelium of Eye; Pregnancy; Rats; Rats, Sprague-Dawley; Retina; Retinal Degeneration; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2004 |
Refractory atypical absence seizures in rat: a two hit model.
Topics: Animals; Anticholesteremic Agents; Brain; Disease Models, Animal; Drug Resistance; Electroencephalography; Epilepsy, Absence; Female; Methylazoxymethanol Acetate; Pregnancy; Prenatal Exposure Delayed Effects; Protein Synthesis Inhibitors; Rats; Rats, Long-Evans; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2004 |
Functional contribution of specific brain areas to absence seizures: role of thalamic gap-junctional coupling.
Topics: Animals; Animals, Newborn; Brain Mapping; Carbenoxolone; Disease Models, Animal; Electrodes; Electroencephalography; Epilepsy, Absence; Evoked Potentials; Functional Laterality; Gap Junctions; Methylamines; Rats; Rats, Long-Evans; Spectrum Analysis; Thalamus; Time Factors; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2006 |
GABAB receptor antagonism abolishes the learning impairments in rats with chronic atypical absence seizures.
Topics: Animals; Anticholesteremic Agents; Anticonvulsants; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Epilepsy, Absence; Ethosuximide; Female; GABA Antagonists; GABA-B Receptor Antagonists; Hippocampus; Learning Disabilities; Maze Learning; Memory Disorders; Organophosphorus Compounds; Rats; Time Factors; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2006 |
Daily rhythms of seizure activity and behavior in a model of atypical absence epilepsy.
Topics: Animals; Anticholesteremic Agents; Behavior, Animal; Cerebral Cortex; Circadian Rhythm; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Male; Mice; Mice, Inbred C3H; Movement; Rats; Rats, Long-Evans; Seizures; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2006 |
Gender and age differences in expression of GABAA receptor subunits in rat somatosensory thalamus and cortex in an absence epilepsy model.
Topics: Age Factors; Animals; Anticholesteremic Agents; Disease Models, Animal; Epilepsy, Absence; Female; Gene Expression Regulation, Developmental; Intralaminar Thalamic Nuclei; Male; Protein Subunits; Rats; Rats, Long-Evans; Receptors, GABA-A; RNA, Messenger; Sex Characteristics; Somatosensory Cortex; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Ventral Thalamic Nuclei | 2007 |
Partial rescue of retinal function and sterol steady-state in a rat model of Smith-Lemli-Opitz syndrome.
Topics: Animals; Cholesterol, Dietary; Disease Models, Animal; Female; Humans; Photoreceptor Cells, Vertebrate; Pregnancy; Rats; Retina; Smith-Lemli-Opitz Syndrome; Sterols; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2007 |
Typical versus atypical absence seizures: network mechanisms of the spread of paroxysms.
Topics: 4-Butyrolactone; Action Potentials; Animals; Cerebral Cortex; Cortical Spreading Depression; Cortical Synchronization; Disease Models, Animal; Electrodes, Implanted; Electroencephalography; Epilepsy, Absence; Hippocampus; Models, Neurological; Neural Inhibition; Neural Pathways; Rats; Rats, Long-Evans; Recruitment, Neurophysiological; Synaptic Transmission; Thalamus; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2007 |
Lipidomic analysis of the retina in a rat model of Smith-Lemli-Opitz syndrome: alterations in docosahexaenoic acid content of phospholipid molecular species.
Topics: Animals; Cholesterol; Disease Models, Animal; Docosahexaenoic Acids; Neurochemistry; Neurons; Phosphatidylcholines; Phosphatidylethanolamines; Phospholipids; Rats; Retina; Retinal Degeneration; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2008 |
Alteration of retinal rod outer segment membrane fluidity in a rat model of Smith-Lemli-Opitz syndrome.
Topics: Animals; Disease Models, Animal; Fatty Acids; Female; Proteins; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rod Cell Outer Segment; Smith-Lemli-Opitz Syndrome; Sterols; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2008 |
Changes in serum sterols of rats treated with 7-dehydrocholesterol-delta 7-reductase inhibitors: comparison to levels in humans with Smith-Lemli-Opitz syndrome.
Topics: Animals; Child; Cholestadienols; Cholesterol; Dehydrocholesterols; Disease Models, Animal; Enzyme Inhibitors; Female; Heterozygote; Humans; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Piperazines; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Smith-Lemli-Opitz Syndrome; Sterols; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1996 |
The selective GABAB antagonist CGP-35348 blocks spike-wave bursts in the cholesterol synthesis rat absence epilepsy model.
Topics: Animals; Cholesterol; Disease Models, Animal; Dose-Response Relationship, Drug; Electrocardiography; Epilepsy, Absence; GABA Antagonists; Male; Organophosphorus Compounds; Rats; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1996 |
Inhibition of 7-dehydrocholesterol reductase by the teratogen AY9944: a rat model for Smith-Lemli-Opitz syndrome.
Topics: Animals; Cholesterol; Disease Models, Animal; Estradiol; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Progesterone; Rats; Rats, Wistar; Smith-Lemli-Opitz Syndrome; Teratogens; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1996 |
Smith-Lemli-Opitz syndrome produced in rats with AY 9944 treated by intravenous injection of lipoprotein cholesterol.
Topics: Animals; Anticholesteremic Agents; Cholesterol; Cholesterol, Dietary; Combined Modality Therapy; Dehydrocholesterols; Disease Models, Animal; Enzyme Inhibitors; Injections, Intravenous; Lipoproteins; Male; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Rats; Rats, Sprague-Dawley; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1997 |
Oxidized derivatives of 7-dehydrocholesterol induce growth retardation in cultured rat embryos: a model for antenatal growth retardation in the Smith-Lemli-Opitz syndrome.
Topics: Animals; Antioxidants; Cholesterol; Dehydrocholesterols; Disease Models, Animal; Embryo, Mammalian; Embryonic and Fetal Development; Female; Growth; Organ Culture Techniques; Oxidation-Reduction; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Rats; Rats, Wistar; Smith-Lemli-Opitz Syndrome; Teratogens; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Ultraviolet Rays; Vitamin E | 1999 |
Absence of ventral cell populations in the developing brain in a rat model of the Smith-Lemli-Opitz syndrome.
Topics: Animals; Brain; Cholesterol; Disease Models, Animal; DNA-Binding Proteins; Embryonic and Fetal Development; Enzyme Inhibitors; Eye Proteins; Female; Fetal Diseases; Fetal Proteins; Gestational Age; Hedgehog Proteins; Homeodomain Proteins; In Situ Hybridization; Male; Nerve Tissue Proteins; Neural Tube Defects; Neurons; Otx Transcription Factors; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Paired Box Transcription Factors; PAX6 Transcription Factor; Pregnancy; Prosencephalon; Protein Biosynthesis; Proteins; Rats; Rats, Wistar; Repressor Proteins; Rhombencephalon; Signal Transduction; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Trans-Activators | 1999 |
Cholesterol deficit but not accumulation of aberrant sterols is the major cause of the teratogenic activity in the Smith-Lemli-Opitz syndrome animal model.
Topics: Abnormalities, Drug-Induced; Animals; Cholesterol; Cholesterol, Dietary; Dehydrocholesterols; Disease Models, Animal; Embryo, Mammalian; Female; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pregnancy; Rats; Rats, Wistar; Smith-Lemli-Opitz Syndrome; Steroid Isomerases; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2000 |
A chronic model of atypical absence seizures: studies of developmental and gender sensitivity.
Topics: Animals; Animals, Newborn; Anticholesteremic Agents; Disease Models, Animal; Epilepsy, Absence; Female; Male; Pregnancy; Rats; Rats, Long-Evans; Sex Characteristics; Sexual Maturation; Time Factors; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2002 |
Brain sterols in the AY-9944 rat model of atypical absence seizures.
Topics: Animals; Anticholesteremic Agents; Brain Chemistry; Cholesterol; Dehydrocholesterols; Disease Models, Animal; Electroencephalography; Epilepsy, Absence; Female; Male; Phospholipids; Pregnancy; Rats; Rats, Long-Evans; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2002 |
Niemann-Pick disease-like inclusions caused by a hypocholesteremic agent.
Topics: Animals; Cyclohexanes; Disease Models, Animal; Eye Diseases; Humans; Inclusion Bodies; Niemann-Pick Diseases; Optic Nerve; Optic Nerve Diseases; Rats; Retina; Retinal Diseases; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1976 |
Niemann-Pick disease experimental model: sphingomyelinase reduction induced by AY-9944.
Topics: Animals; Body Weight; Cholesterol; Cyclohexanes; Depression, Chemical; Disease Models, Animal; Humans; Inclusion Bodies; Liver; Lysosomes; Niemann-Pick Diseases; Phospholipids; Phosphoric Diester Hydrolases; Rats; Sphingomyelin Phosphodiesterase; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1977 |
Niemann-Pick disease experimental model.
Topics: Animals; Cyclohexanes; Disease Models, Animal; Humans; Niemann-Pick Diseases; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1978 |
Paradoxical role of GABA in a chronic model of petit mal (absence)-like epilepsy in the rat.
Topics: Animals; Anticonvulsants; Chronic Disease; Disease Models, Animal; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Epilepsy, Absence; GABA Antagonists; gamma-Aminobutyric Acid; Male; Picrotoxin; Rats; Seizures; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1990 |