trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride has been researched along with Abnormalities, Drug-Induced in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (45.45) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dupuis, R; Horvath, C; Roux, C; Talbot, JN | 1 |
| Barbu, V; Dupuis, R; Gardette, J; Maziere, JC; Roux, C | 1 |
| Batta, AK; Salen, G | 1 |
| Chevy, F; Kolf-Clauw, M; Ponsart, C | 1 |
| Beachy, PA; Cooper, MK; Porter, JA; Young, KE | 1 |
| Chevy, F; Gaoua, W; Ilien, F; Roux, C; Wolf, C | 1 |
| Bourguignon, L; Gaoua, W; Gofflot, F; Picard, JJ; Roux, C | 1 |
| Dupuis, R; Horvath, C; Roux, C | 1 |
| Dupuis, R; Giroud, A; Horvath, C; Roux, C | 1 |
| Biade, S; Citadelle, D; Dupuis, R; Maziere, JC; Meier, M; Quiec, D; Repetto, M; Roux, C | 1 |
| Barbu, V; Dupuis, R; Elefant, E; Gardette, J; Lambert, D; Maziere, C; Maziere, JC; Polonovski, J; Roux, C | 1 |
1 review(s) available for trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Abnormal cholesterol biosynthesis produced by AY 9944 in the rat leads to skeletal deformities similar to the Smith-Lemli-Opitz syndrome.
Topics: Abnormalities, Drug-Induced; Animals; Anticholesteremic Agents; Bone and Bones; Bone Development; Cholesterol; Enzyme Inhibitors; Female; Holoprosencephaly; Humans; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pregnancy; Rats; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1998 |
10 other study(ies) available for trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Teratogenic effect of an inhibitor of cholesterol synthesis (AY 9944) in rats: correlation with maternal cholesterolemia.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Cholesterol; Cyclohexanes; Female; Maternal-Fetal Exchange; Pregnancy; Rats; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1980 |
Teratogenic effect of AY 9944 in rats: importance of the day of administration and maternal plasma cholesterol level.
Topics: Abnormalities, Drug-Induced; Animals; Cholesterol; Cyclohexanes; Female; Fetal Death; Gestational Age; Head; Pregnancy; Rats; Rats, Inbred Strains; Teratogens; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1984 |
Abnormal cholesterol biosynthesis as in Smith-Lemli-Opitz syndrome disrupts normal skeletal development in the rat.
Topics: Abnormalities, Drug-Induced; Animals; Anticholesteremic Agents; Body Weight; Bone and Bones; Bone Development; Cervical Vertebrae; Cholesterol; Dehydrocholesterols; Enzyme Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Male; Osteogenesis; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pregnancy; Rats; Rats, Wistar; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1998 |
Teratogen-mediated inhibition of target tissue response to Shh signaling.
Topics: Abnormalities, Drug-Induced; Animals; Cell Membrane; Central Nervous System; Chick Embryo; Cholesterol; Culture Techniques; DNA-Binding Proteins; Endoplasmic Reticulum; Hedgehog Proteins; Hepatocyte Nuclear Factor 3-beta; Holoprosencephaly; Homeodomain Proteins; LIM-Homeodomain Proteins; Membrane Proteins; Muscle Proteins; Nerve Tissue Proteins; Nuclear Proteins; Patched Receptors; PAX7 Transcription Factor; Proteins; Receptors, Cell Surface; Signal Transduction; Teratogens; Tomatine; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Trans-Activators; Transcription Factors; Triparanol; Veratrum Alkaloids | 1998 |
Cholesterol deficit but not accumulation of aberrant sterols is the major cause of the teratogenic activity in the Smith-Lemli-Opitz syndrome animal model.
Topics: Abnormalities, Drug-Induced; Animals; Cholesterol; Cholesterol, Dietary; Dehydrocholesterols; Disease Models, Animal; Embryo, Mammalian; Female; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pregnancy; Rats; Rats, Wistar; Smith-Lemli-Opitz Syndrome; Steroid Isomerases; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 2000 |
Expression of Sonic Hedgehog downstream genes is modified in rat embryos exposed in utero to a distal inhibitor of cholesterol biosynthesis.
Topics: Abnormalities, Drug-Induced; Animals; Anticholesteremic Agents; Cholesterol; Cholesterol, Dietary; Congenital Abnormalities; Dehydrocholesterols; Embryonic and Fetal Development; Embryonic Induction; Female; Gene Expression Regulation, Developmental; Hedgehog Proteins; Holoprosencephaly; Humans; In Situ Hybridization; Pregnancy; Proteins; Rats; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Trans-Activators | 2001 |
Teratogenic action and embryo lethality of AY 9944R. Prevention by a hypercholesterolemia-provoking diet.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Cholesterol; Cholesterol, Dietary; Cyclohexanes; Female; Fetal Death; Hypercholesterolemia; Male; Pregnancy; Rats; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Urogenital Abnormalities | 1979 |
Interpretation of isolated agenesis of the pituitary.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Cyclohexanes; Female; Humans; Pituitary Gland; Pregnancy; Rats; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Triparanol | 1979 |
Teratogenic effect of the cholesterol synthesis inhibitor AY 9944 on rat embryos in vitro.
Topics: Abnormalities, Drug-Induced; Animals; Cholesterol; Dehydrocholesterols; Embryonic and Fetal Development; Fetal Death; Holoprosencephaly; Morphogenesis; Organ Culture Techniques; Pituitary Gland; Rats; Rats, Inbred Strains; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1990 |
Cholesterol prevents the teratogenic action of AY 9944: importance of the timing of cholesterol supplementation to rats.
Topics: Abnormalities, Drug-Induced; Animals; Brain; Cholesterol; Cholesterol Esters; Cholesterol, Dietary; Cyclohexanes; Dehydrocholesterols; Dose-Response Relationship, Drug; Female; Fetal Death; Pituitary Gland; Pregnancy; Rats; Rats, Inbred Strains; Time Factors; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride | 1988 |