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trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride and Abnormalities, Drug-Induced

trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride has been researched along with Abnormalities, Drug-Induced in 11 studies

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19905 (45.45)18.7374
1990's4 (36.36)18.2507
2000's2 (18.18)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Dupuis, R; Horvath, C; Roux, C; Talbot, JN1
Barbu, V; Dupuis, R; Gardette, J; Maziere, JC; Roux, C1
Batta, AK; Salen, G1
Chevy, F; Kolf-Clauw, M; Ponsart, C1
Beachy, PA; Cooper, MK; Porter, JA; Young, KE1
Chevy, F; Gaoua, W; Ilien, F; Roux, C; Wolf, C1
Bourguignon, L; Gaoua, W; Gofflot, F; Picard, JJ; Roux, C1
Dupuis, R; Horvath, C; Roux, C1
Dupuis, R; Giroud, A; Horvath, C; Roux, C1
Biade, S; Citadelle, D; Dupuis, R; Maziere, JC; Meier, M; Quiec, D; Repetto, M; Roux, C1
Barbu, V; Dupuis, R; Elefant, E; Gardette, J; Lambert, D; Maziere, C; Maziere, JC; Polonovski, J; Roux, C1

Reviews

1 review(s) available for trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride and Abnormalities, Drug-Induced

ArticleYear
Abnormal cholesterol biosynthesis produced by AY 9944 in the rat leads to skeletal deformities similar to the Smith-Lemli-Opitz syndrome.
    The Journal of laboratory and clinical medicine, 1998, Volume: 131, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Anticholesteremic Agents; Bone and Bones; Bone Development; Cholesterol; Enzyme Inhibitors; Female; Holoprosencephaly; Humans; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pregnancy; Rats; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride

1998

Other Studies

10 other study(ies) available for trans-1,4-bis(2-chlorobenzaminomethyl)cyclohexane dihydrochloride and Abnormalities, Drug-Induced

ArticleYear
Teratogenic effect of an inhibitor of cholesterol synthesis (AY 9944) in rats: correlation with maternal cholesterolemia.
    The Journal of nutrition, 1980, Volume: 110, Issue:11

    Topics: Abnormalities, Drug-Induced; Animals; Brain; Cholesterol; Cyclohexanes; Female; Maternal-Fetal Exchange; Pregnancy; Rats; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride

1980
Teratogenic effect of AY 9944 in rats: importance of the day of administration and maternal plasma cholesterol level.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1984, Volume: 176, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Cholesterol; Cyclohexanes; Female; Fetal Death; Gestational Age; Head; Pregnancy; Rats; Rats, Inbred Strains; Teratogens; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride

1984
Abnormal cholesterol biosynthesis as in Smith-Lemli-Opitz syndrome disrupts normal skeletal development in the rat.
    The Journal of laboratory and clinical medicine, 1998, Volume: 131, Issue:3

    Topics: Abnormalities, Drug-Induced; Animals; Anticholesteremic Agents; Body Weight; Bone and Bones; Bone Development; Cervical Vertebrae; Cholesterol; Dehydrocholesterols; Enzyme Inhibitors; Female; Gas Chromatography-Mass Spectrometry; Male; Osteogenesis; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pregnancy; Rats; Rats, Wistar; Smith-Lemli-Opitz Syndrome; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride

1998
Teratogen-mediated inhibition of target tissue response to Shh signaling.
    Science (New York, N.Y.), 1998, Jun-05, Volume: 280, Issue:5369

    Topics: Abnormalities, Drug-Induced; Animals; Cell Membrane; Central Nervous System; Chick Embryo; Cholesterol; Culture Techniques; DNA-Binding Proteins; Endoplasmic Reticulum; Hedgehog Proteins; Hepatocyte Nuclear Factor 3-beta; Holoprosencephaly; Homeodomain Proteins; LIM-Homeodomain Proteins; Membrane Proteins; Muscle Proteins; Nerve Tissue Proteins; Nuclear Proteins; Patched Receptors; PAX7 Transcription Factor; Proteins; Receptors, Cell Surface; Signal Transduction; Teratogens; Tomatine; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Trans-Activators; Transcription Factors; Triparanol; Veratrum Alkaloids

1998
Cholesterol deficit but not accumulation of aberrant sterols is the major cause of the teratogenic activity in the Smith-Lemli-Opitz syndrome animal model.
    Journal of lipid research, 2000, Volume: 41, Issue:4

    Topics: Abnormalities, Drug-Induced; Animals; Cholesterol; Cholesterol, Dietary; Dehydrocholesterols; Disease Models, Animal; Embryo, Mammalian; Female; Oxidoreductases; Oxidoreductases Acting on CH-CH Group Donors; Pregnancy; Rats; Rats, Wistar; Smith-Lemli-Opitz Syndrome; Steroid Isomerases; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride

2000
Expression of Sonic Hedgehog downstream genes is modified in rat embryos exposed in utero to a distal inhibitor of cholesterol biosynthesis.
    Developmental dynamics : an official publication of the American Association of Anatomists, 2001, Volume: 220, Issue:2

    Topics: Abnormalities, Drug-Induced; Animals; Anticholesteremic Agents; Cholesterol; Cholesterol, Dietary; Congenital Abnormalities; Dehydrocholesterols; Embryonic and Fetal Development; Embryonic Induction; Female; Gene Expression Regulation, Developmental; Hedgehog Proteins; Holoprosencephaly; Humans; In Situ Hybridization; Pregnancy; Proteins; Rats; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Trans-Activators

2001
Teratogenic action and embryo lethality of AY 9944R. Prevention by a hypercholesterolemia-provoking diet.
    Teratology, 1979, Volume: 19, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Brain; Cholesterol; Cholesterol, Dietary; Cyclohexanes; Female; Fetal Death; Hypercholesterolemia; Male; Pregnancy; Rats; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Urogenital Abnormalities

1979
Interpretation of isolated agenesis of the pituitary.
    Teratology, 1979, Volume: 19, Issue:1

    Topics: Abnormalities, Drug-Induced; Animals; Brain; Cyclohexanes; Female; Humans; Pituitary Gland; Pregnancy; Rats; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride; Triparanol

1979
Teratogenic effect of the cholesterol synthesis inhibitor AY 9944 on rat embryos in vitro.
    Teratology, 1990, Volume: 42, Issue:6

    Topics: Abnormalities, Drug-Induced; Animals; Cholesterol; Dehydrocholesterols; Embryonic and Fetal Development; Fetal Death; Holoprosencephaly; Morphogenesis; Organ Culture Techniques; Pituitary Gland; Rats; Rats, Inbred Strains; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride

1990
Cholesterol prevents the teratogenic action of AY 9944: importance of the timing of cholesterol supplementation to rats.
    The Journal of nutrition, 1988, Volume: 118, Issue:6

    Topics: Abnormalities, Drug-Induced; Animals; Brain; Cholesterol; Cholesterol Esters; Cholesterol, Dietary; Cyclohexanes; Dehydrocholesterols; Dose-Response Relationship, Drug; Female; Fetal Death; Pituitary Gland; Pregnancy; Rats; Rats, Inbred Strains; Time Factors; trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride

1988