tranilast has been researched along with Stomach-Ulcer* in 1 studies
1 other study(ies) available for tranilast and Stomach-Ulcer
| Article | Year |
|---|---|
Studies on antiulcer agents. II. Antiulcer properties of N-(1H-tetrazol-5-yl)-2-anilino-5-pyrimidinecarboxamides inhibiting release of histamine from passively sensitized rat peritoneal mast cells.
With the aim of applying mast cell-stabilizing agents as antiulcer agents, N-(1H-tetrazol-5-yl)-2-anilino-5-pyrimidinecarboxamides were synthesized, and initially evaluated pharmacologically for activity in the rat passive cutaneous anaphylaxis test by oral administration. The most active compound 6 was proved to inhibit potently the release of histamine from passively sensitized rat peritoneal mast cells in vitro. When compared with other mast cell-stabilizing agents and an antiulcer agent, compound 6 was found to show excellent gastric mucosal protection and gastric antisecretion activities. Furthermore, compound 6 revealed good activity against acidified aspirin ulcer in rats and water-immersion stress ulcer in rats. Topics: Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Cromolyn Sodium; Ethanol; Histamine H1 Antagonists; Histamine Release; Mast Cells; ortho-Aminobenzoates; Passive Cutaneous Anaphylaxis; Peritoneal Cavity; Pyrimidines; Rats; Stomach Ulcer; Tetrazoles | 1995 |