tranilast has been researched along with Rhinitis--Allergic--Seasonal* in 2 studies
1 trial(s) available for tranilast and Rhinitis--Allergic--Seasonal
| Article | Year |
|---|---|
Clinical and pathophysiological evaluation of tranilast in patients with pollinosis: the effects of pre-seasonal treatment.
Tranilast is an orally effective anti-allergic agent evaluated for clinical activity in prevention of symptoms of allergic rhinitis. It was investigated in a randomized, pre-seasonal, and in-seasonal treatment of tranilast to test the clinical efficacy and pathophysiological changes on the onset of nasal symptoms in season. Thirty-eight patients with a history of Sugi pollinosis and positive allergic tests were treated with tranilast 300 mg daily 6 to 7 weeks before the onset of the pollen season and continuously during the season or no medication including tranilast until the onset of clinical symptoms in season. The number of sneezing and the grade of stuffiness at the onset of pollen season were inhibited significantly in pre-seasonal treatment. The number of mast cells and eosinophils in season increased compared with off-season and the threshold of nasal hypersensitivity in season decreased compared with off-season in inseasonal treatment, but not in pre-seasonal treatment. This study indicates that tranilast may have the prophylactic effect for Sugi pollinosis. Topics: Adolescent; Adult; Aged; Eosinophils; Epithelium; Female; Histamine H1 Antagonists; Humans; Hypersensitivity; Male; Middle Aged; Nasal Mucosa; Nasal Provocation Tests; ortho-Aminobenzoates; Rhinitis, Allergic, Seasonal; Treatment Outcome | 1993 |
1 other study(ies) available for tranilast and Rhinitis--Allergic--Seasonal
| Article | Year |
|---|---|
Seasonal facial erythema in a patient with allergic rhinitis treated using a combination of tranilast and roxithromycin.
A competitive effect with suppression of Th2 immune responses of the tranilast and roxithromycin combination is examined in an allergic rhinitis patient.. A 42-year-old female patient with allergic rhinitis caused by cedar pollen, which is one of the most common allergies during the spring, exhibited facial erythema with itching, particularly on both cheeks, and rhinitis symptoms, such as nasal discharge, and 200 mg/day of tranilast (original) and 300 mg/day of roxithromycin were administered.. After 2 weeks, the patient's skin lesions were mostly eliminated, with the skin appearing almost normal; itching was nearly absent; and rhinitis symptoms disappeared.. This combination may be a promising new therapeutic strategy for allergic rhinitis. Topics: Adult; Erythema; Female; Humans; Pruritus; Rhinitis; Rhinitis, Allergic; Rhinitis, Allergic, Seasonal; Roxithromycin; Seasons | 2023 |