tranilast has been researched along with Leukemia* in 1 studies
1 other study(ies) available for tranilast and Leukemia
| Article | Year |
|---|---|
Evaluation of cationic channel TRPV2 as a novel biomarker and therapeutic target in Leukemia-Implications concerning the resolution of pulmonary inflammation.
Patients treated during leukemia face the risk of complications including pulmonary dysfunction that may result from infiltration of leukemic blast cells (LBCs) into lung parenchyma and interstitium. In LBCs, we demonstrated that transient receptor potential vanilloid type 2 channel (TRPV2), reputed for its role in inflammatory processes, exhibited oncogenic activity associated with alteration of its molecular expression profile. TRPV2 was overexpressed in LBCs compared to normal human peripheral blood mononuclear cells (PBMCs). Additionally, functional full length isoform and nonfunctional short form pore-less variant of TRPV2 protein were up-regulated and down-regulated respectively in LBCs. However, the opposite was found in PBMCs. TRPV2 silencing or pharmacological targeting by Tranilast (TL) or SKF96365 (SKF) triggered caspace-mediated apoptosis and cell cycle arrest. TL and SKF inhibited chemotactic peptide fMLP-induced response linked to TRPV2 Ca Topics: ADP-ribosyl Cyclase 1; Apoptosis; Biomarkers; Calcium; Cell Cycle Checkpoints; Cell Line, Tumor; Down-Regulation; Humans; Imidazoles; Leukemia; Leukocytes, Mononuclear; Mitogen-Activated Protein Kinases; ortho-Aminobenzoates; Pneumonia; Protein Isoforms; RNA Interference; RNA, Small Interfering; Signal Transduction; TRPV Cation Channels; Up-Regulation | 2019 |