tranilast and Granuloma

Topics: Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Fatal Outcome; Granuloma; Humans; Male; Myelodysplastic Syndromes; ortho-Aminobenzoates; Skin Diseases

We report our experience of a case in which a combination of conjunctival symblepharon detachment, conjunctival granuloma excision, and conjunctival free flap transplantation was performed for the treatment of symblepharon after pterygium surgery, with satisfactory outcomes. The patient was referred to our hospital with pterygium recurrence, symblepharon and granuloma formation after pterygium surgery in the right eye at another hospital. We performed conjunctival symblepharon detachment along with conjunctival autograft transplantation, and started instillation of tranilast ophthalmic solution immediately after the surgery, to inhibit proliferation and adhesion formation. During the 6 months' follow-up of the patient at our hospital, the postoperative course was satisfactory, and no recurrence of symblepharon, pterygium or granuloma was observed. There were no adverse drug reactions associated with the instillation of tranilast ophthalmic solution. Tranilast ophthalmic solution may be effective not only for prevention of pterygium recurrence, but also for inhibition of symblepharon and granuloma formation.

Topics: Conjunctiva; Conjunctival Diseases; Granuloma; Humans; Instillation, Drug; Male; Middle Aged; Ophthalmic Solutions; ortho-Aminobenzoates; Pterygium; Secondary Prevention; Treatment Outcome

Topics: Anti-Allergic Agents; Antineoplastic Agents; Biopsy; Drug Eruptions; Face; Female; Granuloma; Humans; Interferon-gamma; Middle Aged; Mycosis Fungoides; ortho-Aminobenzoates; Skin; Treatment Outcome

Topics: Aged, 80 and over; Anti-Allergic Agents; Female; Granuloma; Herpes Zoster; Humans; ortho-Aminobenzoates; Skin Diseases

Merkersson-Rosenthal syndrome (MRS) is characterized by cheilitis or pareitis granulomatosa, facial palsy, and fissured tongue. Sometimes the forehead, eyelids and chin are involved, and occasionally genital lesions are present. A vulval lesion of MRS is named vulvitis granulomatosa. Tranilast has been described as an effective treatment for cases of MRS, granulomatous cheilitis, and granulomatous blepharitis. Herein we report a successful treatment with tranilast of an adult female patient with vulvitis granulomatosa.

Topics: Female; Granuloma; Humans; Melkersson-Rosenthal Syndrome; Middle Aged; ortho-Aminobenzoates; Vulvitis

Topics: Aged; Anti-Allergic Agents; Anti-Inflammatory Agents, Non-Steroidal; Blepharitis; Granuloma; Humans; Male; Melkersson-Rosenthal Syndrome; ortho-Aminobenzoates

We examined the effects of tranilast, an anti-allergic agent, on hypersensitive inflammation and on morphology and functions of fibroblasts. In vivo, tranilast suppressed the content of collagen in granulation tissue of hypersensitive granulomatous inflammation induced by methylated bovine serum albumin (m-BSA) in rats. In culture, tranilast inhibited the TGF-beta-independent inflammatory exudate-induced stimulation of morphological changes of fibroblasts to myofibroblast-like cells and their proliferation. Collagen gel contraction by myofibroblast-like cells and fibroblasts was also inhibited by tranilast. Flow cytometric analysis revealed that tranilast suspended the cell cycle of fibroblasts at the G0/G1 phase. These results suggest that tranilast modulates the fibrosis and contraction of granulation tissue by inhibiting the growth of myofibroblast-like cells and fibroblasts.

Topics: Administration, Oral; Animals; Cell Division; Cells, Cultured; Collagen; Fibroblasts; Granuloma; Hypersensitivity; Inflammation; Male; ortho-Aminobenzoates; Rats; Rats, Sprague-Dawley; Specific Pathogen-Free Organisms

We report two cases of patients with cheilitis granulomatosis treated successfully with tranilast and ketotifen, both of which are known to be potent inhibitors or mediator release from mast cells. In one patient, complete resolution of the lesion occurred after 1 year of therapy. In another patient, the lesion also showed consistent, if not complete, improvement during the course of therapy. Because of the mechanism of the action, these agents have been widely used as therapeutic modalities for mast-cell-related diseases. We therefore measured numbers of mast cells in the lesions of cheilitis granulomatosis, in comparison with those in mucous cyst and lichen planus. Light microscopy of toluidine-blue-stained sections showed that mast cells, particularly those with ongoing degranulation, increased in number in the reticular dermis of the lesions of cheilitis granulomatosis. These findings suggest that mediators released from mast cells may be critical for the granulomatous inflammation in cheilitis granulomatosis.

Topics: Adolescent; Adult; Biological Factors; Cell Count; Cheilitis; Female; Granuloma; Humans; Ketotifen; Male; Mast Cells; Middle Aged; ortho-Aminobenzoates