tranilast and Conjunctivitis--Allergic

We evaluated the efficacy and safety of long-term management of patients with vernal keratoconjunctivitis (VKC) with bromfenac sodium eye drops in combination with corticosteroids and anti-allergic eye drops.. Twenty-two patients with VKC were randomly assigned to receive two test eye drops, either bromfenac sodium 0.1% (group A) or placebo eye drops (normal saline; group B) for a mean observation period of 20.9 months. Topical corticosteroids and mast cell stabilizers were continued during the observation period.. The mean 2-year recurrence rate was 90.9% in group A and 11.3% in group B, with a significant difference. No serious side effect was observed in group A.. These results suggest that bromfenac sodium eye drops can be used as baseline local treatment in patients with VKC.

Topics: Adolescent; Adult; Anti-Allergic Agents; Anti-Inflammatory Agents, Non-Steroidal; Benzophenones; Bromobenzenes; Child; Child, Preschool; Conjunctiva; Conjunctivitis, Allergic; Cornea; Drug Administration Schedule; Drug Therapy, Combination; Female; Follow-Up Studies; Glucocorticoids; Humans; Male; Ophthalmic Solutions; ortho-Aminobenzoates; Severity of Illness Index; Time Factors; Treatment Outcome

The effect of the ophthalmic solution of tranilast, an anti-allergic agent, on allergic conjunctivitis was studied in passively sensitized guinea pigs. We determined the content of uranine dye and histamine in tears and histopathologically examined palpebral conjunctiva. After instillation of antigen into the conjunctival sac, inflammation of the palpebral conjunctiva, an increase in leaked dye and the release of histamine were found. In the histopathological study, tranilast (1.0%) suppressed the appearance of edema and infiltration of inflammatory cells. Tranilast suppressed the leakage of uranine in a dose-dependent manner. A 0.5% solution of diphenhydramine also showed the inhibitory effect on the leakage of uranine. The inhibitory effect of 0.5% tranilast on antigen-induced dye leakage and histamine release lasted for 6 hr. These results suggest that topically applied tranilast is effective for allergic conjunctivitis.

Topics: Animals; Conjunctiva; Conjunctivitis, Allergic; Cromolyn Sodium; Diphenhydramine; Fluorescein; Fluoresceins; Guinea Pigs; Histamine; Histamine H1 Antagonists; Male; Ophthalmic Solutions; ortho-Aminobenzoates; Tears