tranilast has been researched along with Cognitive-Dysfunction* in 2 studies
2 other study(ies) available for tranilast and Cognitive-Dysfunction
| Article | Year |
|---|---|
Tranilast, a Transient Receptor Potential Vanilloid 2 Channel (TRPV2) Inhibitor Attenuates Amyloid β-Induced Cognitive Impairment: Possible Mechanisms.
Alzheimer's disease (AD) is associated with the accumulation of β-amyloid and leads to cognitive impairment. Numerous studies have established that neuronal calcium homeostasis is perturbed in AD. Recently, transient receptor potential vanilloid 2 (TRPV2) channels, a non-selective calcium-permeable channel, have been investigated in several diseases. However, the role of the TRPV2 channel has not been investigated in AD yet. In this study, intracerebroventricular administration of β-amyloid (10 μg) to Sprague Dawley rats resulted in cognitive impairment which was evident from the assessment of cognitive tests. Also, TRPV2 mRNA and protein expression were found to be upregulated, while the expression of Ca Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcineurin; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calsequestrin; Cognitive Dysfunction; Glycogen Synthase Kinase 3 beta; ortho-Aminobenzoates; Parvalbumins; Rats; Rats, Sprague-Dawley; RNA, Messenger; TRPV Cation Channels | 2022 |
Amelioration of diabetes-induced cognitive impairment by Transient Receptor Potential Vanilloid 2 (TRPV2) channel inhibitor: Behavioral and mechanistic study.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Cognitive Dysfunction; Diabetes Mellitus, Experimental; Dose-Response Relationship, Drug; Male; Maze Learning; ortho-Aminobenzoates; Rats; Rats, Sprague-Dawley; TRPV Cation Channels | 2020 |