tranexamic acid and Transfusion Reaction studies

Transfusion Reaction: Complications of BLOOD TRANSFUSION. Included adverse reactions are common allergic and febrile reactions; hemolytic (delayed and acute) reactions; and other non-hemolytic adverse reactions such as infections and adverse immune reactions related to immunocompatibility.

Research Excerpts

Excerpt	Relevance	Reference
" There have been many changes in the management of massive hemorrhage, for example, the administration of the tranexamic acid and the use of balanced transfusion ratio."	4.93	[Management of bleeding and coagulopathy following major trauma]. ( Etxaniz, A; Pita, E, 2016)
" The ongoing trials create six new comparisons: tranexamic acid (tablet + injection) versus placebo; intravenous tranexamic acid versus oral tranexamic acid; topical tranexamic acid versus oral tranexamic acid; different intravenous tranexamic acid dosing regimes; topical tranexamic acid versus topical fibrin glue; and fibrinogen (injection) versus placebo."	3.01	Pharmacological interventions for the prevention of bleeding in people undergoing definitive fixation or joint replacement for hip, pelvic and long bone fractures. ( Brunskill, SJ; Champaneria, R; Dorée, C; Estcourt, LJ; Geneen, LJ; Gibbs, VN; Novak, A; Palmer, AJ; Raval, P, 2023)
"Several methods reportedly reduce postoperative blood loss and avoid homologous blood transfusion with traditional TKA approaches, but it is unclear these reductions apply to a minimally invasive technique."	2.76	Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. ( Charoencholvanich, K; Siriwattanasakul, P, 2011)
"Tranexamic acid (TXA) is an antifibrinolytic agent that reduces bleeding and transfusion in a broad number of adult and pediatric surgeries, as well as in trauma and obstetrics."	2.61	Tranexamic acid and perioperative bleeding in children: what do we still need to know? ( Faraoni, D; Goobie, SM, 2019)
"Tranexamic acid was introduced during these procedures in 2006."	1.43	Use of Tranexamic Acid Is Associated with Reduced Blood Product Transfusion in Complex Skull Base Neurosurgical Procedures: A Retrospective Cohort Study. ( Akagami, R; Flexman, AM; Mebel, D, 2016)
"The incidence of symptomatic deep vein thrombosis and pulmonary embolism was evaluated."	1.43	Tranexamic Acid Can Be Administered to Arthroplasty Patients Who Receive Aspirin for Venous Thromboembolic Prophylaxis. ( Chen, AF; Heller, S; Parvizi, J; Secrist, E; Shahi, A, 2016)
"Blood conservation; the area of greatest clinical variability was seen in dosing regimes for Tranexamic acid."	1.37	Blood conservation and pain control in scoliosis corrective surgery: an online survey of UK practice. ( Bird, S; McGill, N, 2011)

Research

Studies (22)

Authors

Clinical Trials (9)

Trial Overview

Trial Outcomes

Estimated Blood Loss

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (13.64)	29.6817
2010's	18 (81.82)	24.3611
2020's	1 (4.55)	2.80

Authors	Studies
Gibbs, VN	1
Geneen, LJ	1
Champaneria, R	1
Raval, P	1
Dorée, C	1
Brunskill, SJ	1
Novak, A	1
Palmer, AJ	1
Estcourt, LJ	1
Cybulska, P	1
Goss, C	1
Tew, WP	1
Parameswaran, R	1
Sonoda, Y	1
Goobie, SM	1
Faraoni, D	1
Muñoz Gómez, M	2
Páramo Fernández, JA	2
Engelbrecht, S	1
Wood, EM	1
Cole-Sinclair, MF	1
Maciel, JD	1
Gifford, E	1
Plurad, D	1
de Virgilio, C	1
Bricker, S	1
Bongard, F	1
Neville, A	1
Smith, J	1
Putnam, B	1
Kim, D	1
Gao, F	1
Sun, W	1
Guo, W	1
Li, Z	1
Wang, W	1
Cheng, L	1
Etxaniz, A	1
Pita, E	1
Bisbe Vives, E	1
Basora Macaya, M	1
García Erce, JA	1
Gómez Luque, A	1
Leal-Noval, SR	1
Colomina, MJ	1
Comin Colet, J	1
Contreras Barbeta, E	1
Cuenca Espiérrez, J	1
Garcia de Lorenzo Y Mateos, A	1
Gomollón García, F	1
Izuel Ramí, M	1
Moral García, MV	1
Montoro Ronsano, JB	1
Pereira Saavedra, A	1
Quintana Diaz, M	1
Remacha Sevilla, Á	1
Salinas Argente, R	1
Sánchez Pérez, C	1
Tirado Anglés, G	1
Torrabadella de Reinoso, P	1
Bagsby, DT	1
Samujh, CA	1
Vissing, JL	1
Empson, JA	1
Pomeroy, DL	1
Malkani, AL	1
Mebel, D	1
Akagami, R	1
Flexman, AM	1
Kopanidis, P	1
Hardidge, A	1
McNicol, L	1
Tay, S	1
McCall, P	1
Weinberg, L	1
Heller, S	1
Secrist, E	1
Shahi, A	1
Chen, AF	1
Parvizi, J	1
Tzatzairis, TK	1
Drosos, GI	1
Kotsios, SE	1
Ververidis, AN	1
Vogiatzaki, TD	1
Kazakos, KI	1
Soroceanu, A	1
Oren, JH	1
Smith, JS	1
Hostin, R	1
Shaffrey, CI	1
Mundis, GM	1
Ames, CP	1
Burton, DC	1
Bess, S	1
Gupta, MC	1
Deviren, V	1
Schwab, FJ	1
Lafage, V	1
Errico, TJ	1
Rosencher, N	1
Bellamy, L	1
Chabbouh, T	1
Arnaout, L	1
Ozier, Y	1
Bird, S	1
McGill, N	1
Anderson, L	1
Charoencholvanich, K	1
Siriwattanasakul, P	1
Watts, CD	1
Pagnano, MW	1
Pleym, H	1
Katz, E	1
Gaitini, L	1
Samri, M	1
Egoz, N	1
Fergusson, D	1
Laupacis, A	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Tranexamic Acid for Blood Loss Minimization in Endoscopic Pituitary Surgery: A Double-Blind Randomized Controlled Trial[NCT04863339]	Phase 2	0 participants (Actual)	Interventional	2022-03-31	Withdrawn (stopped due to Challenges in recruitment)
Efficacy of Tranexamic Acid in Femoral Shaft Fractures Osteosynthesis; A Double Blind Randomized Controlled Trial[NCT04803591]	Phase 4	0 participants (Actual)	Interventional	2021-08-01	Withdrawn (stopped due to Not approved by Ethics Commettee)
Role of Topical Tranexamic Acid in Total Hip Arthroplasty[NCT01866943]	Phase 2	41 participants (Actual)	Interventional	2011-11-30	Terminated
Peri-articular Tranexamic Acid Injection in Total Knee Arthroplasty: A Randomized Controlled Trial[NCT02829346]	Phase 2	60 participants (Actual)	Interventional	2012-10-31	Completed
Evaluation of Efficacy and Safety of Perioperative Tranexamic Acid During Primary Total Knee Arthroplasty: A Randomized, Clinical Trial[NCT05919615]		100 participants (Actual)	Interventional	2021-07-15	Completed
Serial Use of Intravenous and Oral Tranexamic Acid in Primary Total Knee Arthroplasty Patients: A Randomized Controlled Study[NCT03109652]	Phase 4	144 participants (Anticipated)	Interventional	2017-07-10	Recruiting
Evaluation of the Pharmacokinetic Profile of Tranexamic Acid, After Injection in a Knee Neo-articulation.[NCT02319915]	Early Phase 1	14 participants (Actual)	Interventional	2015-02-18	Completed
Evaluation of the Use of Tranexamic Acid in Tibial Osteotomies: a Randomised Controlled Clinical Trial.[NCT04785651]		84 participants (Anticipated)	Interventional	2021-02-22	Recruiting
Efficacy and Safety of Erythropoietin And/Or Intravenous Iron Sucrose For Treatment of Anemia In Hip and Knee Arthroplasty: A Single-center Retrospective Study[NCT03917394]		780 participants (Anticipated)	Observational	2019-04-24	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Estimated Blood Loss defined as Pre Op Hgb mins the Post Op Day two Hgb. (NCT01866943)
Timeframe: Pre Op, Post Op Day 2

Harris Hip Scores

Intervention	Hemoglobin (grams/deciliter) (Mean)
Baseline Population	2.93

Standardized questionnaire that measures clinical function related to the hip. Total potential range is from 4.0 - 96.0. A higher score indicates a more favorable clinical outcome. (NCT01866943)
Timeframe: 2 week

Harris Hip Scores

Intervention	units on a scale (Mean)
All Study Participants	65.76

Intervention	units on a scale (Mean)
All Study Participants	81.77

Mid Thigh Circumference

Intervention	units on a scale (Mean)
All Study Participants	58.34

Measurement of the thigh at the half way point between the prominence of the greater trochanter and the lateral epicondyle of the femur. No data recorded at 2 weeks or 6 weeks for this study population. (NCT01866943)
Timeframe: Pre Op

Article	Year
Pharmacological interventions for the prevention of bleeding in people undergoing definitive fixation or joint replacement for hip, pelvic and long bone fractures. The Cochrane database of systematic reviews, 2023, 06-05, Volume: 6 Topics: Arthroplasty, Replacement; Fibrinogen; Fractures, Bone; Hemorrhage; Hemostatics; Humans; Myocardial	2023
Indications for and complications of transfusion and the management of gynecologic malignancies. Gynecologic oncology, 2017, Volume: 146, Issue:2 Topics: Acute Lung Injury; Anemia; Antifibrinolytic Agents; Blood Loss, Surgical; Erythrocyte Transfusion; F	2017
Tranexamic acid and perioperative bleeding in children: what do we still need to know? Current opinion in anaesthesiology, 2019, Volume: 32, Issue:3 Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Blood Transfusion; Child; Dose-Response Relationship,	2019
[Management of bleeding and coagulopathy following major trauma]. Revista espanola de anestesiologia y reanimacion, 2016, Volume: 63, Issue:5 Topics: Blood Coagulation Disorders; Hemorrhage; Humans; Multiple Trauma; Tranexamic Acid; Transfusion React	2016
[Blood conservation approaches in orthopedic surgery]. Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine, 2008, Volume: 15, Issue:5 Topics: Anemia; Aprotinin; Blood Loss, Surgical; Blood Transfusion; Blood Transfusion, Autologous; Drug Admi	2008
Minimising blood loss and transfusion in contemporary hip and knee arthroplasty. The Journal of bone and joint surgery. British volume, 2012, Volume: 94, Issue:11 Suppl A Topics: Anemia; Antifibrinolytic Agents; Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Bl	2012

Article	Year
Topical Administration of Tranexamic Acid Plus Diluted-Epinephrine in Primary Total Knee Arthroplasty: A Randomized Double-Blinded Controlled Trial. The Journal of arthroplasty, 2015, Volume: 30, Issue:8 Topics: Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blin	2015
Intravenous vs Topical Tranexamic Acid in Total Knee Arthroplasty Without Tourniquet Application: A Randomized Controlled Study. The Journal of arthroplasty, 2016, Volume: 31, Issue:11 Topics: Administration, Intravenous; Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, R	2016
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10 Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl	2011

Article	Year
[Intravenous administration of tranexamic acid to decrease bleeding and transfusion in knee and hip prosthetic surgery: is it safe and cost-effective?]. Medicina clinica, 2013, Sep-07, Volume: 141, Issue:5 Topics: Arthroplasty, Replacement, Hip; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Cost-Benefit	2013
Clinical transfusion practice update: haemovigilance, complications, patient blood management and national standards. The Medical journal of Australia, 2013, Sep-16, Volume: 199, Issue:6 Topics: Acute Lung Injury; Anticoagulants; Antifibrinolytic Agents; Australia; Blood Transfusion; Clinical P	2013
The impact of a massive transfusion protocol on outcomes among patients with abdominal aortic injuries. Annals of vascular surgery, 2015, Volume: 29, Issue:4 Topics: Abdominal Injuries; Accidents, Traffic; Adolescent; Adult; Antifibrinolytic Agents; Aorta, Abdominal	2015
Forum for debate: Safety of allogeneic blood transfusion alternatives in the surgical/critically ill patient. Medicina intensiva, 2015, Volume: 39, Issue:9 Topics: Anemia; Antifibrinolytic Agents; Aprotinin; Blood Coagulation Factors; Blood Transfusion; Clinical T	2015
Tranexamic Acid Decreases Incidence of Blood Transfusion in Simultaneous Bilateral Total Knee Arthroplasty. The Journal of arthroplasty, 2015, Volume: 30, Issue:12 Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Blood Transfus	2015
Use of Tranexamic Acid Is Associated with Reduced Blood Product Transfusion in Complex Skull Base Neurosurgical Procedures: A Retrospective Cohort Study. Anesthesia and analgesia, 2016, Volume: 122, Issue:2 Topics: Antifibrinolytic Agents; Blood Transfusion; Cohort Studies; Erythrocyte Transfusion; Female; Hemoglo	2016
Perioperative blood management programme reduces the use of allogenic blood transfusion in patients undergoing total hip and knee arthroplasty. Journal of orthopaedic surgery and research, 2016, Feb-29, Volume: 11 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anemia; Antifibrinolytic Agents; Arthroplasty, Replaceme	2016
Tranexamic Acid Can Be Administered to Arthroplasty Patients Who Receive Aspirin for Venous Thromboembolic Prophylaxis. The Journal of arthroplasty, 2016, Volume: 31, Issue:7 Topics: Aged; Antifibrinolytic Agents; Arthroplasty; Aspirin; Blood Loss, Surgical; Cohort Studies; Female;	2016
Effect of Antifibrinolytic Therapy on Complications, Thromboembolic Events, Blood Product Utilization, and Fusion in Adult Spinal Deformity Surgery. Spine, 2016, Jul-15, Volume: 41, Issue:14 Topics: Adult; Aged; Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Female; Humans; Male;	2016
Blood conservation and pain control in scoliosis corrective surgery: an online survey of UK practice. Paediatric anaesthesia, 2011, Volume: 21, Issue:1 Topics: Adolescent; Analgesia, Epidural; Analgesics, Opioid; Anesthesia; Anticoagulants; Antifibrinolytic Ag	2011
Blood conservation in cardiac surgery. Journal of perioperative practice, 2010, Volume: 20, Issue:12 Topics: Algorithms; Aprotinin; Blood Loss, Surgical; Blood Substitutes; Blood Transfusion; Cardiac Surgical	2010
[Drugs to reduce transfusion needs during surgery]. Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2008, Apr-03, Volume: 128, Issue:7 Topics: Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Blood Transfusion; Blood Transfusion, Auto	2008
The use of technologies to decrease peri-operative allogenic blood transfusion: results of practice variation in Israel. The Israel Medical Association journal : IMAJ, 2001, Volume: 3, Issue:11 Topics: Aprotinin; Attitude of Health Personnel; Biomedical Technology; Blood Loss, Surgical; Blood Transfus	2001

tranexamic acid and Transfusion Reaction

Research Excerpts

Research

Studies (22)

Authors

Clinical Trials (9)

Trial Overview

Trial Outcomes

Estimated Blood Loss

Harris Hip Scores

Harris Hip Scores

Harris Hip Scores

Mid Thigh Circumference

Reviews

Trials

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