tranexamic acid has been researched along with Spinal Stenosis in 8 studies
Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.
Spinal Stenosis: Narrowing of the spinal canal.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the effectiveness and safety of intravenous tranexamic acid for reducing perioperative blood loss in patients with multilevel thoracic spinal stenosis (TSS)." | 7.88 | The efficacy and safety of tranexamic acid in reducing perioperative blood loss in patients with multilevel thoracic spinal stenosis: A retrospective observational study. ( Huang, X; Huang, Y; Liu, T; Qiao, F; Xu, X; Xue, P; Yang, J, 2018) |
| "Sixty eight patients with multilevel thoracic spine stenosis were randomized into the tranexamic acid group receiving 15 mg/kg body weight before the skin incision was made and 1 mg/kg body weight per hour during operation or the control group receiving the same dose of placebo (0." | 5.51 | The efficacy and safety of intravenous tranexamic acid in patients with posterior operation of multilevel thoracic spine stenosis: a prospective randomized controlled trial. ( Bingtao, W; Lei, T; Xin, L; Zhaoqing, G; Zhongqiang, C, 2022) |
| "To investigate the effectiveness and safety of intravenous tranexamic acid for reducing perioperative blood loss in patients with multilevel thoracic spinal stenosis (TSS)." | 3.88 | The efficacy and safety of tranexamic acid in reducing perioperative blood loss in patients with multilevel thoracic spinal stenosis: A retrospective observational study. ( Huang, X; Huang, Y; Liu, T; Qiao, F; Xu, X; Xue, P; Yang, J, 2018) |
| "v, a maintenance dosage of 2 mg/kg/h TA, or an equivalent volume of normal saline." | 2.84 | Tranexamic acid reduces perioperative blood loss of posterior lumbar surgery for stenosis or spondylolisthesis: A randomized trial. ( Jiang, D; Ou, Y; Quan, Z; Shi, H; Zhao, Z; Zhu, Y, 2017) |
| "Intraoperative and postoperative blood loss were compared between the two groups." | 2.78 | Tranexamic acid reduces postoperative blood loss of degenerative lumbar instability with stenosis in posterior approach lumbar surgery: a randomized controlled trial. ( Bi, Y; Chen, Y; Fan, R; Guo, M; Hua, Z; Liu, J; Piao, M; Ren, W; Wang, Q; Xiang, L; Yu, H, 2013) |
| "Patients suffered from acute spinal cord compression caused by spinal tumor manifestation (n = 5), empyema (n = 4), degenerative spinal stenosis (n = 1), hematoma (n = 1), and vertebral body fracture/dislocation (n = 2)." | 1.51 | Management of Spinal Emergencies in Patients on Direct Oral Anticoagulants. ( Beynon, C; Gumbinger, C; Olivares, A; Unterberg, AW; Younsi, A; Zweckberger, K, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 7 (87.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Lei, T | 1 |
| Bingtao, W | 1 |
| Zhaoqing, G | 1 |
| Zhongqiang, C | 1 |
| Xin, L | 1 |
| Beynon, C | 1 |
| Olivares, A | 1 |
| Gumbinger, C | 1 |
| Younsi, A | 1 |
| Zweckberger, K | 1 |
| Unterberg, AW | 1 |
| Bai, J | 1 |
| Zhang, P | 1 |
| Liang, Y | 1 |
| Wang, J | 2 |
| Wang, Y | 1 |
| Xue, P | 1 |
| Yang, J | 1 |
| Xu, X | 1 |
| Liu, T | 1 |
| Huang, Y | 1 |
| Qiao, F | 1 |
| Huang, X | 1 |
| Sun, H | 1 |
| Deng, L | 1 |
| Deng, J | 1 |
| Zhang, H | 1 |
| Chen, K | 1 |
| Li, H | 1 |
| Ning, X | 1 |
| Yang, H | 1 |
| Wang, Q | 1 |
| Liu, J | 1 |
| Fan, R | 1 |
| Chen, Y | 1 |
| Yu, H | 1 |
| Bi, Y | 1 |
| Hua, Z | 1 |
| Piao, M | 1 |
| Guo, M | 1 |
| Ren, W | 1 |
| Xiang, L | 1 |
| Shi, H | 1 |
| Ou, Y | 1 |
| Jiang, D | 1 |
| Quan, Z | 1 |
| Zhao, Z | 1 |
| Zhu, Y | 1 |
| Endres, S | 1 |
| Heinz, M | 1 |
| Wilke, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Use of Tranexamic Acid to Reduce Perioperative Blood Loss During High Risk Spine Fusion Surgery[NCT01728636] | Phase 2 | 61 participants (Actual) | Interventional | 2013-01-15 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Total additional blood products (fresh frozen plasma, cryoprecipitate, and platelets) transfused in the perioperative period measured in units. (NCT01728636)
Timeframe: 24 hours after skin incision
| Intervention | Units (Mean) |
|---|---|
| Tranexamic Acid | 1 |
| Placebo | 2 |
Estimated Intraoperative blood loss in milliliters (mLs) (NCT01728636)
Timeframe: Incision to skin closure (approximately 10 hours)
| Intervention | Milliliters (Mean) |
|---|---|
| Tranexamic Acid | 1550 |
| Placebo | 1600 |
Number of participants who experienced arterial or venous thromboembolism, neurologic complications (including stroke, seizure,and delirium), infections, and pulmonary renal or cardiac adverse outcomes (demand ischemia, myocardial infarction or new arrhythmia) before another operative procedure or hospital discharge. (NCT01728636)
Timeframe: Time of surgery to date of discharge from hospital (average 7 days)
| Intervention | Participants (Count of Participants) |
|---|---|
| Tranexamic Acid | 9 |
| Placebo | 9 |
Total operating room time from incision to closure of incision in minutes. (NCT01728636)
Timeframe: Minutes
| Intervention | Minutes (Median) |
|---|---|
| Tranexamic Acid | 602 |
| Placebo | 576 |
Total red blood cells transfused in the intraoperative period in (mL). Total RBC equal packed red blood cells and cell saver infusion. (NCT01728636)
Timeframe: Intraoperative period (approximately 12 hours)
| Intervention | milliliters (Median) |
|---|---|
| Tranexamic Acid | 1140 |
| Placebo | 1460 |
Total milligrams of intravenous tranexamic acid administered during the surgical procedure. (NCT01728636)
Timeframe: Intraoperative period
| Intervention | milligrams (Median) |
|---|---|
| Tranexamic Acid | 1408 |
| Placebo | 0 |
1 review available for tranexamic acid and Spinal Stenosis
| Article | Year |
|---|---|
Efficacy and safety of tranexamic acid usage in patients undergoing posterior lumbar fusion: a meta-analysis.
Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Blood Transfusion; Hemoglobins; Humans; Intervertebra | 2019 |
3 trials available for tranexamic acid and Spinal Stenosis
| Article | Year |
|---|---|
The efficacy and safety of intravenous tranexamic acid in patients with posterior operation of multilevel thoracic spine stenosis: a prospective randomized controlled trial.
Topics: Antifibrinolytic Agents; Body Weight; Constriction, Pathologic; Humans; Prospective Studies; Spinal | 2022 |
Tranexamic acid reduces postoperative blood loss of degenerative lumbar instability with stenosis in posterior approach lumbar surgery: a randomized controlled trial.
Topics: Aged; Antifibrinolytic Agents; Blood Coagulation Tests; Decompression, Surgical; Female; Humans; Int | 2013 |
Tranexamic acid reduces perioperative blood loss of posterior lumbar surgery for stenosis or spondylolisthesis: A randomized trial.
Topics: Adult; Aged; Antifibrinolytic Agents; Blood Loss, Surgical; Decompression, Surgical; Double-Blind Me | 2017 |
4 other studies available for tranexamic acid and Spinal Stenosis
| Article | Year |
|---|---|
Management of Spinal Emergencies in Patients on Direct Oral Anticoagulants.
Topics: Acute Disease; Aged; Aged, 80 and over; Anticoagulants; Antithrombins; Blood Coagulation Factors; Bl | 2019 |
The efficacy and safety of tranexamic acid in reducing perioperative blood loss in patients with multilevel thoracic spinal stenosis: A retrospective observational study.
Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Blood Transfusion; Bone Transplantation; China; Decom | 2018 |
The Efficacy and Safety of Prophylactic Intravenous Tranexamic Acid on Perioperative Blood Loss in Patients Treated with Posterior Lumbar Interbody Fusion.
Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Blood Transfusion, Autologous; Body Mass Index; Bone | 2019 |
Efficacy of tranexamic acid in reducing blood loss in posterior lumbar spine surgery for degenerative spinal stenosis with instability: a retrospective case control study.
Topics: Aged; Antifibrinolytic Agents; Blood Loss, Surgical; Decompression, Surgical; Dose-Response Relation | 2011 |