Page last updated: 2024-11-05

tranexamic acid and Spinal Stenosis

tranexamic acid has been researched along with Spinal Stenosis in 8 studies

Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.

Spinal Stenosis: Narrowing of the spinal canal.

Research Excerpts

ExcerptRelevanceReference
"To investigate the effectiveness and safety of intravenous tranexamic acid for reducing perioperative blood loss in patients with multilevel thoracic spinal stenosis (TSS)."7.88The efficacy and safety of tranexamic acid in reducing perioperative blood loss in patients with multilevel thoracic spinal stenosis: A retrospective observational study. ( Huang, X; Huang, Y; Liu, T; Qiao, F; Xu, X; Xue, P; Yang, J, 2018)
"Sixty eight patients with multilevel thoracic spine stenosis were randomized into the tranexamic acid group receiving 15 mg/kg body weight before the skin incision was made and 1 mg/kg body weight per hour during operation or the control group receiving the same dose of placebo (0."5.51The efficacy and safety of intravenous tranexamic acid in patients with posterior operation of multilevel thoracic spine stenosis: a prospective randomized controlled trial. ( Bingtao, W; Lei, T; Xin, L; Zhaoqing, G; Zhongqiang, C, 2022)
"To investigate the effectiveness and safety of intravenous tranexamic acid for reducing perioperative blood loss in patients with multilevel thoracic spinal stenosis (TSS)."3.88The efficacy and safety of tranexamic acid in reducing perioperative blood loss in patients with multilevel thoracic spinal stenosis: A retrospective observational study. ( Huang, X; Huang, Y; Liu, T; Qiao, F; Xu, X; Xue, P; Yang, J, 2018)
"v, a maintenance dosage of 2 mg/kg/h TA, or an equivalent volume of normal saline."2.84Tranexamic acid reduces perioperative blood loss of posterior lumbar surgery for stenosis or spondylolisthesis: A randomized trial. ( Jiang, D; Ou, Y; Quan, Z; Shi, H; Zhao, Z; Zhu, Y, 2017)
"Intraoperative and postoperative blood loss were compared between the two groups."2.78Tranexamic acid reduces postoperative blood loss of degenerative lumbar instability with stenosis in posterior approach lumbar surgery: a randomized controlled trial. ( Bi, Y; Chen, Y; Fan, R; Guo, M; Hua, Z; Liu, J; Piao, M; Ren, W; Wang, Q; Xiang, L; Yu, H, 2013)
"Patients suffered from acute spinal cord compression caused by spinal tumor manifestation (n = 5), empyema (n = 4), degenerative spinal stenosis (n = 1), hematoma (n = 1), and vertebral body fracture/dislocation (n = 2)."1.51Management of Spinal Emergencies in Patients on Direct Oral Anticoagulants. ( Beynon, C; Gumbinger, C; Olivares, A; Unterberg, AW; Younsi, A; Zweckberger, K, 2019)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (87.50)24.3611
2020's1 (12.50)2.80

Authors

AuthorsStudies
Lei, T1
Bingtao, W1
Zhaoqing, G1
Zhongqiang, C1
Xin, L1
Beynon, C1
Olivares, A1
Gumbinger, C1
Younsi, A1
Zweckberger, K1
Unterberg, AW1
Bai, J1
Zhang, P1
Liang, Y1
Wang, J2
Wang, Y1
Xue, P1
Yang, J1
Xu, X1
Liu, T1
Huang, Y1
Qiao, F1
Huang, X1
Sun, H1
Deng, L1
Deng, J1
Zhang, H1
Chen, K1
Li, H1
Ning, X1
Yang, H1
Wang, Q1
Liu, J1
Fan, R1
Chen, Y1
Yu, H1
Bi, Y1
Hua, Z1
Piao, M1
Guo, M1
Ren, W1
Xiang, L1
Shi, H1
Ou, Y1
Jiang, D1
Quan, Z1
Zhao, Z1
Zhu, Y1
Endres, S1
Heinz, M1
Wilke, A1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Use of Tranexamic Acid to Reduce Perioperative Blood Loss During High Risk Spine Fusion Surgery[NCT01728636]Phase 261 participants (Actual)Interventional2013-01-15Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Additional Blood Products Transfused

Total additional blood products (fresh frozen plasma, cryoprecipitate, and platelets) transfused in the perioperative period measured in units. (NCT01728636)
Timeframe: 24 hours after skin incision

InterventionUnits (Mean)
Tranexamic Acid1
Placebo2

Estimated Intraoperative Blood Loss

Estimated Intraoperative blood loss in milliliters (mLs) (NCT01728636)
Timeframe: Incision to skin closure (approximately 10 hours)

InterventionMilliliters (Mean)
Tranexamic Acid1550
Placebo1600

Post Operative Major Morbidity

Number of participants who experienced arterial or venous thromboembolism, neurologic complications (including stroke, seizure,and delirium), infections, and pulmonary renal or cardiac adverse outcomes (demand ischemia, myocardial infarction or new arrhythmia) before another operative procedure or hospital discharge. (NCT01728636)
Timeframe: Time of surgery to date of discharge from hospital (average 7 days)

InterventionParticipants (Count of Participants)
Tranexamic Acid9
Placebo9

Total Operating Room Time

Total operating room time from incision to closure of incision in minutes. (NCT01728636)
Timeframe: Minutes

InterventionMinutes (Median)
Tranexamic Acid602
Placebo576

Total Red Blood Cells Transfused in the Intraoperative Period

Total red blood cells transfused in the intraoperative period in (mL). Total RBC equal packed red blood cells and cell saver infusion. (NCT01728636)
Timeframe: Intraoperative period (approximately 12 hours)

Interventionmilliliters (Median)
Tranexamic Acid1140
Placebo1460

Total Tranexamic Acid Dose (mg)

Total milligrams of intravenous tranexamic acid administered during the surgical procedure. (NCT01728636)
Timeframe: Intraoperative period

Interventionmilligrams (Median)
Tranexamic Acid1408
Placebo0

Reviews

1 review available for tranexamic acid and Spinal Stenosis

ArticleYear
Efficacy and safety of tranexamic acid usage in patients undergoing posterior lumbar fusion: a meta-analysis.
    BMC musculoskeletal disorders, 2019, Aug-31, Volume: 20, Issue:1

    Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Blood Transfusion; Hemoglobins; Humans; Intervertebra

2019

Trials

3 trials available for tranexamic acid and Spinal Stenosis

ArticleYear
The efficacy and safety of intravenous tranexamic acid in patients with posterior operation of multilevel thoracic spine stenosis: a prospective randomized controlled trial.
    BMC musculoskeletal disorders, 2022, May-02, Volume: 23, Issue:1

    Topics: Antifibrinolytic Agents; Body Weight; Constriction, Pathologic; Humans; Prospective Studies; Spinal

2022
Tranexamic acid reduces postoperative blood loss of degenerative lumbar instability with stenosis in posterior approach lumbar surgery: a randomized controlled trial.
    European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2013, Volume: 22, Issue:9

    Topics: Aged; Antifibrinolytic Agents; Blood Coagulation Tests; Decompression, Surgical; Female; Humans; Int

2013
Tranexamic acid reduces perioperative blood loss of posterior lumbar surgery for stenosis or spondylolisthesis: A randomized trial.
    Medicine, 2017, Volume: 96, Issue:1

    Topics: Adult; Aged; Antifibrinolytic Agents; Blood Loss, Surgical; Decompression, Surgical; Double-Blind Me

2017

Other Studies

4 other studies available for tranexamic acid and Spinal Stenosis

ArticleYear
Management of Spinal Emergencies in Patients on Direct Oral Anticoagulants.
    World neurosurgery, 2019, Volume: 131

    Topics: Acute Disease; Aged; Aged, 80 and over; Anticoagulants; Antithrombins; Blood Coagulation Factors; Bl

2019
The efficacy and safety of tranexamic acid in reducing perioperative blood loss in patients with multilevel thoracic spinal stenosis: A retrospective observational study.
    Medicine, 2018, Volume: 97, Issue:50

    Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Blood Transfusion; Bone Transplantation; China; Decom

2018
The Efficacy and Safety of Prophylactic Intravenous Tranexamic Acid on Perioperative Blood Loss in Patients Treated with Posterior Lumbar Interbody Fusion.
    World neurosurgery, 2019, Volume: 125

    Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Blood Transfusion, Autologous; Body Mass Index; Bone

2019
Efficacy of tranexamic acid in reducing blood loss in posterior lumbar spine surgery for degenerative spinal stenosis with instability: a retrospective case control study.
    BMC surgery, 2011, Nov-03, Volume: 11

    Topics: Aged; Antifibrinolytic Agents; Blood Loss, Surgical; Decompression, Surgical; Dose-Response Relation

2011