Page last updated: 2024-11-05

tranexamic acid and Postoperative Nausea and Vomiting

tranexamic acid has been researched along with Postoperative Nausea and Vomiting in 6 studies

Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.

Postoperative Nausea and Vomiting: Emesis and queasiness occurring after anesthesia.

Research Excerpts

ExcerptRelevanceReference
"In this meta-analysis, the combination of TXA and DEX has positive impacts on the usage of oxycodone and metoclopramide, postoperative range of motion, postoperative nausea and vomiting and reduces the length of hospital stay."5.41Effects of combined dexamethasone and tranexamic acid in lower limb total arthroplasty: a systematic review and meta-analysis of randomized clinical trials. ( Gopal Subramaniam, A; Hau, R; Tan, TK, 2023)
"To evaluate the efficacy and safety of dexamethasone (DEXA) combined with tranexamic acid (TXA) in the perioperative period of total hip arthroplasty."3.11Application of dexamethasone combined with tranexamic acid in perioperative period of total hip arthroplasty. ( Huang, W; Huang, X; Li, F; Liu, W; Wang, C; Yin, D, 2022)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's3 (50.00)24.3611
2020's2 (33.33)2.80

Authors

AuthorsStudies
Li, F1
Huang, X1
Liu, W1
Huang, W1
Wang, C1
Yin, D1
Tan, TK1
Gopal Subramaniam, A1
Hau, R1
Yu, Y1
Lin, H1
Wu, Z1
Xu, P1
Lei, Z1
Kim, DH1
Kim, S1
Kang, H1
Jin, HJ1
Hwang, SH1
Sculco, PK1
Pagnano, MW1
Veien, M1
Juelsgaard, P1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Tranexamic Acid on Postoperative Bleeding Following Sinus and Nasal Surgery[NCT04754230]Phase 440 participants (Actual)Interventional2021-06-17Completed
Do Peri-operative High Doses of Intravenous Glucocorticoids Improve Short-term Functional Outcome After Direct Anterior Total Hip Arthroplasty? A Randomized, Single Surgeon, Placebo Controlled, Double Blind Study[NCT04317872]70 participants (Anticipated)Interventional2020-07-01Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Bleeding VAS - POD1

Patient-reported Visual Analog Scale - Bleeding Score Day 1. Score range: 0 (no bleeding) to 10 (uncontrolled bleeding). (NCT04754230)
Timeframe: Postoperative Day 1 (assessed within first 24 hours following surgery)

Interventionscore on a scale (Mean)
Normal Saline5.03
1,000mg IV Tranexamic Acid4.82

Bleeding VAS - POD2

Patient-reported Visual Analog Scale - Bleeding Score Day 2. Score range: 0 (no bleeding) to 10 (uncontrolled bleeding). (NCT04754230)
Timeframe: Postoperative Day 2

Interventionscore on a scale (Mean)
Normal Saline4.47
1,000mg IV Tranexamic Acid3.89

Bleeding VAS - POD3

Patient-reported Visual Analog Scale - Bleeding Score Day 3. Score range: 0 (no bleeding) to 10 (uncontrolled bleeding). (NCT04754230)
Timeframe: Postoperative Day 3

Interventionscore on a scale (Mean)
Normal Saline2.93
1,000mg IV Tranexamic Acid2.29

Bleeding VAS - POD4

Patient-reported Visual Analog Scale - Bleeding Score Day 4. Score range: 0 (no bleeding) to 10 (uncontrolled bleeding). (NCT04754230)
Timeframe: Postoperative Day 4

Interventionscore on a scale (Mean)
Normal Saline2.12
1,000mg IV Tranexamic Acid1.44

Bleeding VAS - POD5

Patient-reported Visual Analog Scale - Bleeding Score Day 5. Score range: 0 (no bleeding) to 10 (uncontrolled bleeding). (NCT04754230)
Timeframe: Postoperative Day 5

Interventionscore on a scale (Mean)
Normal Saline1.32
1,000mg IV Tranexamic Acid1.15

Bleeding VAS - POD6

Patient-reported Visual Analog Scale - Bleeding Score Day 6. Score range: 0 (no bleeding) to 10 (uncontrolled bleeding). (NCT04754230)
Timeframe: Postoperative Day 6

Interventionscore on a scale (Mean)
Normal Saline1.36
1,000mg IV Tranexamic Acid0.76

Bleeding VAS - POD7

Patient-reported Visual Analog Scale - Bleeding Score Day 7. Score range: 0 (no bleeding) to 10 (uncontrolled bleeding). (NCT04754230)
Timeframe: Postoperative Day 7

Interventionscore on a scale (Mean)
Normal Saline0.97
1,000mg IV Tranexamic Acid0.72

Frequency of Participant Follow-up

Number of patients in each arm requiring evaluation by the resident service for bleeding concerns expressed by the recovery nurse (in PACU), had any follow-up visit or phone call outside of regularly scheduled follow-up (NCT04754230)
Timeframe: Day of surgery through 1 week

,
InterventionParticipants (Count of Participants)
PACUFollow-up visitFollow-up phone call
1,000mg IV Tranexamic Acid012
Normal Saline002

Guaze Saturation VAS Though POD7

Patient-reported Visual Analog Scale - Guaze Saturation Score through Postoperative Day 7. Score range: 0 (not at all) to 10 (dripping blood). (NCT04754230)
Timeframe: Postoperative Day 2 through Postoperative Day 7

,
Interventionscore on a scale (Mean)
Postoperative day 2Postoperative day 3Postoperative day 4Postoperative day 5Postoperative day 6Postoperative day 7
1,000mg IV Tranexamic Acid4.562.090.760.400.290.28
Normal Saline5.163.031.741.110.990.80

Reviews

2 reviews available for tranexamic acid and Postoperative Nausea and Vomiting

ArticleYear
Effects of combined dexamethasone and tranexamic acid in lower limb total arthroplasty: a systematic review and meta-analysis of randomized clinical trials.
    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2023, Volume: 33, Issue:8

    Topics: Administration, Intravenous; Antifibrinolytic Agents; Arthroplasty, Replacement, Hip; Arthroplasty,

2023
Efficacy of tranexamic acid on operative bleeding in endoscopic sinus surgery: A meta-analysis and systematic review.
    The Laryngoscope, 2019, Volume: 129, Issue:4

    Topics: Adult; Antifibrinolytic Agents; Blood Loss, Surgical; Endoscopy; Female; Humans; Incidence; Male; Mi

2019

Trials

3 trials available for tranexamic acid and Postoperative Nausea and Vomiting

ArticleYear
Application of dexamethasone combined with tranexamic acid in perioperative period of total hip arthroplasty.
    Medicine, 2022, Oct-21, Volume: 101, Issue:42

    Topics: Analgesics; Antiemetics; Arthroplasty, Replacement, Hip; C-Reactive Protein; Dexamethasone; Drug The

2022
Perioperative combined administration of tranexamic acid and dexamethasone in total knee arthroplasty-benefit versus harm?
    Medicine, 2019, Volume: 98, Issue:34

    Topics: Aged; Analgesics; Anti-Inflammatory Agents; Antiemetics; Antifibrinolytic Agents; Arthroplasty, Repl

2019
[A dose-response study of tranexamic acid. The effect on nausea and blood loss after total knee replacement].
    Ugeskrift for laeger, 2005, Apr-04, Volume: 167, Issue:14

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Dose-Response

2005

Other Studies

1 other study available for tranexamic acid and Postoperative Nausea and Vomiting

ArticleYear
Perioperative solutions for rapid recovery joint arthroplasty: get ahead and stay ahead.
    The Journal of arthroplasty, 2015, Volume: 30, Issue:4

    Topics: Antifibrinolytic Agents; Arthroplasty, Replacement; Clinical Protocols; Fluid Therapy; Hemorrhage; H

2015