Page last updated: 2024-11-05

tranexamic acid and Osteoarthritis, Knee

tranexamic acid has been researched along with Osteoarthritis, Knee in 72 studies

Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.

Osteoarthritis, Knee: Noninflammatory degenerative disease of the knee joint consisting of three large categories: conditions that block normal synchronous movement, conditions that produce abnormal pathways of motion, and conditions that cause stress concentration resulting in changes to articular cartilage. (Crenshaw, Campbell's Operative Orthopaedics, 8th ed, p2019)

Research Excerpts

ExcerptRelevanceReference
" The purpose of this study was to compare the effects of intra-articular (IA) administration of tranexamic acid (TXA), an anti-fibrinolytic commonly used in TKA, and ALM chondroprotective solution on postoperative inflammation and joint tissue healing in a rat model of knee implant surgery."8.02Comparison of intra-articular administration of adenosine, lidocaine and magnesium solution and tranexamic acid for alleviating postoperative inflammation and joint fibrosis in an experimental model of knee arthroplasty. ( Biros, E; Dlaska, C; Dobson, GP; Hazratwala, K; Letson, HL; McEwen, P; Morris, JL; Wilkinson, M, 2021)
"The aim of this study was to evaluate the effects of a high initial-dose (60 mg/kg) intravenous tranexamic acid (IV-TXA) on fibrinolysis and inflammation after total knee arthroplasty (TKA)."5.34The antifibrinolytic and anti-inflammatory effects of a high initial-dose tranexamic acid in total knee arthroplasty: a randomized controlled trial. ( Huang, Q; Huang, W; Lei, YT; Pei, FX; Xie, JW, 2020)
" The purpose of this study was to compare the effects of intra-articular (IA) administration of tranexamic acid (TXA), an anti-fibrinolytic commonly used in TKA, and ALM chondroprotective solution on postoperative inflammation and joint tissue healing in a rat model of knee implant surgery."4.02Comparison of intra-articular administration of adenosine, lidocaine and magnesium solution and tranexamic acid for alleviating postoperative inflammation and joint fibrosis in an experimental model of knee arthroplasty. ( Biros, E; Dlaska, C; Dobson, GP; Hazratwala, K; Letson, HL; McEwen, P; Morris, JL; Wilkinson, M, 2021)
"Secondary outcome criteria were postoperative pain, intraarticular effusion (measured by ultrasound), range of motion (ROM) at discharge, peri- and postoperative complications and the KOOS PS (pre- and postoperatively at 1 year follow up)."3.11Use of tranexamic acid in medial open wedge high tibial osteotomy. ( Bentzin, M; Bierke, S; Häner, M; Park, HU; Petersen, W, 2022)
"Tranexamic acid (TXA) is an antifibrinolytic drug."2.90Comparison of Topical and Intravenous Tranexamic Acid for Total Knee Replacement: A Randomized Double-Blinded Controlled Study of Effects on Tranexamic Acid Levels and Thrombogenic and Inflammatory Marker Levels. ( Baaklini, LR; Cross, JR; Fields, KG; Jules-Elysee, KM; Mayman, DJ; McLawhorn, AS; Pickard, AJ; Qin, W; Sculco, TP; Su, EP; Tseng, A, 2019)
"To compare postoperative blood loss after intravenous and intraarticular tranexamic acid injection in patients of bilateral total knee arthroplasty."2.87Blood loss after intraarticular and intravenous tranexamic acid in total knee arthroplasty. ( Ahmad, S; Ahmed, A; Ahmed, S; Aziz, A; Javed, S, 2018)
"The combined (IV (intravenous) + topical) use of tranexamic acid (TXA) has been shown to be a safe method and more effective than single (IV or topical) application."2.84The combined use of oral and topical tranexamic acid is a safe, efficient and low-cost method in reducing blood loss and transfusion rates in total knee arthroplasty. ( Akkaya, M; Basaran, SH; Bozkurt, M; Cankaya, D; Dasar, U; Satilmis, AB, 2017)
"TXA treatment without drainage during TKA reduces the amount of blood transfusions required without increasing the rate of adverse events."2.80Safety and efficacy of intra-articular tranexamic acid injection without drainage on blood loss in total knee arthroplasty: A randomized clinical trial. ( Cao, JG; Li, ZJ; Liu, J; Sun, ZH; Wang, CG, 2015)
"Several methods reportedly reduce postoperative blood loss and avoid homologous blood transfusion with traditional TKA approaches, but it is unclear these reductions apply to a minimally invasive technique."2.76Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial. ( Charoencholvanich, K; Siriwattanasakul, P, 2011)
" In Group A, 1 g of tranexamic acid dissolved in 250 ml of normal saline was intravenously infused before deflation of the tourniquet; another intravenous administration of the same drug of the same dosage was given 3 hours later."2.73[Clinical comparative studies on effect of tranexamic acid on blood loss associated with total knee arthroplasty]. ( Gao, Z; Yu, J; Zhang, F, 2007)
"Tranexamic acid (TXA) has been shown to be effective in patients with total knee arthroplasty (TKA) in clinical studies with no consensus with regard to the most appropriate route of administration."2.58Tranexamic Acid in Total Knee Arthroplasty: Mixed Treatment Comparisons and Recursive Cumulative Meta-Analysis of Randomized, Controlled Trials and Cohort Studies. ( Sivaramakrishnan, G; Sridharan, K, 2018)
"The present meta-analysis indicated that intra-articular injection of TXA in patients undergoing TKA may reduce total blood loss and the need for blood transfusions, particularly when a high dosage of TXA is used (≥30 mg/ml), without any increase in the risk of post-operative DVT."2.50Reduced blood loss after intra-articular tranexamic acid injection during total knee arthroplasty: a meta-analysis of the literature. ( Wei, C; Yan, G; Ying-Ze, Z; Yuejv, L; Zhao-Yu, C, 2014)
"To investigate whether intravenous combined with topical administration of tranexamic acid (TXA) is superior to intravenous administration alone in terms of blood loss, incision complications, functional recovery, and pain relief in high tibial osteotomy (HTO)."1.56Intravenous Combined with Topical Tranexamic Acid Administration Has No Additional Benefits Compared with Intravenous Administration Alone in High Tibial Osteotomy: A Retrospective Case-Control Study. ( Guo, X; Li, S; Liu, P; Lu, Q; Luo, D; Miao, Z; Zhang, M, 2020)
" Previous studies have established the efficacy of TXA in TKA, however here are limited direct comparison studies available and the dosing regimens vary."1.56Higher doses of topical tranexamic acid safely improves immediate functional outcomes and reduces transfusion requirement in total knee arthroplasty. ( Tan, C; Wang, L; Wu, C, 2020)
"Thirty-four patients with haemophilia A undergoing 24 TKA and 18 THA were evaluated in this retrospective study (No."1.51Tranexamic acid may benefit patients undergoing total hip/knee arthroplasty because of haemophilia. ( Huang, Q; Huang, ZY; Ma, J; Pei, FX; Shen, B; Zeng, HJ; Zhou, ZK, 2019)
"The intravenous TXA would reduce postoperative blood loss and transfusion requirements without increasing thromboembolic complications in open-wedge HTO."1.48Tranexamic acid is effective for blood management in open-wedge high tibial osteotomy. ( Bae, SH; Kim, GB; Kim, HJ; Kim, KI, 2018)
"Male appeared to suffer more surgical blood loss than female."1.48Blood loss of total knee arthroplasty in osteoarthritis: an analysis of influential factors. ( Hu, Y; Li, Q; Shi, ZJ; Torsha, TT; Wei, BG; Xiao, J; Zhang, XS, 2018)
"This study aimed to compare the efficacy of intravenous administration of tranexamic acid for reducing blood loss in total knee arthroplasty at different dosage time."1.46The Efficacy Comparison of Tranexamic Acid for Reducing Blood Loss in Total Knee Arthroplasty at Different Dosage Time. ( Cai, M; Gong, J; Nie, X; Sun, Q; Yu, X, 2017)
"There were no deep venous thrombosis or thromboembolic complications in any group."1.43A comparative, retrospective study of peri-articular and intra-articular injection of tranexamic acid for the management of postoperative blood loss after total knee arthroplasty. ( Dai, K; Mao, Z; Wang, Y; Yan, M; Yue, B, 2016)
" However, few studies have reported the optimum timing and dosage for administration of TXA."1.39Repeat-dose intravenous tranexamic acid further decreases blood loss in total knee arthroplasty. ( Hamada, M; Hideki, Y; Iwai, T; Sugamoto, K; Tomita, T; Tsuji, S, 2013)
"Tranexamic acid (TA) is an inexpensive antifibrinolytic agent that is little used in orthopaedic surgery due to the absence of standardised optimal administration regimens."1.38Tranexamic acid reduces blood loss and financial cost in primary total hip and knee replacement surgery. ( Argenson, JN; Hémon, Y; Irisson, E; Kerbaul, F; Parratte, S; Pauly, V, 2012)

Research

Studies (72)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (2.78)29.6817
2010's57 (79.17)24.3611
2020's13 (18.06)2.80

Authors

AuthorsStudies
Cho, MR1
Jun, CM1
Song, SK1
Choi, WK1
Petersen, W1
Bentzin, M1
Bierke, S1
Park, HU1
Häner, M1
Wang, L4
Zhang, Z1
Xiong, W1
Fang, Q1
Tang, Y1
Wang, G1
Morris, JL1
Letson, HL1
McEwen, P1
Biros, E1
Dlaska, C1
Hazratwala, K1
Wilkinson, M1
Dobson, GP1
Moorthy, V3
Chen, JY5
Liow, MHL3
Pang, HN4
Tay, DK5
Chia, SL5
Lo, NN5
Yeo, SJ5
Iseki, T2
Kanto, R1
Onishi, S1
Yoshiya, S1
Tachibana, T1
Nakayama, H1
Huang, ZY1
Huang, Q3
Zeng, HJ1
Ma, J1
Shen, B2
Zhou, ZK2
Pei, FX3
Lostak, J1
Gallo, J1
Slavik, L1
Zapletalova, J1
Balaz, L1
Tsukada, S1
Kurosaka, K1
Nishino, M1
Maeda, T1
Yonekawa, Y1
Hirasawa, N1
Wang, HY1
Luo, ZY1
Wang, D1
Tang, X1
Jules-Elysee, KM1
Tseng, A1
Sculco, TP1
Baaklini, LR1
McLawhorn, AS1
Pickard, AJ1
Qin, W1
Cross, JR1
Su, EP1
Fields, KG1
Mayman, DJ1
Lei, YT1
Xie, JW1
Huang, W1
Li, S1
Lu, Q1
Guo, X1
Zhang, M1
Miao, Z1
Luo, D1
Liu, P1
Tandogan, RN1
Polat, M1
Beyzadeoglu, T1
Karabulut, E1
Yildirim, K1
Kayaalp, A1
Şahin, İG1
Akalin, Y1
Çevik, N1
Otuzbir, A1
Özkan, Y1
Öztürk, A1
Wu, C1
Tan, C1
Li, Z1
Wang, Y2
Cao, G2
An, S1
Feng, M1
Wang, X1
Yang, G1
Gao, G1
Wang, S1
Jiao, X1
Ding, L1
Zhang, S2
Wang, F1
Wang, C2
Chu, P1
Shi, L2
Xue, Q2
Liu, W1
Yang, C1
Huang, X1
Liu, R1
Eachempati, KK1
Gurava Reddy, AV1
Apsingi, S1
Sankineani, SR1
Shaheed, J1
Dannana, C1
Sridharan, K1
Sivaramakrishnan, G1
Lacko, M1
Cellar, R1
Schreierova, D1
Vasko, G1
Arora, M1
Singh, S1
Gupta, V1
Dongre, A1
Shetty, V1
Kim, KI2
Kim, HJ1
Kim, GB1
Bae, SH1
Lévy, Y1
Azar, M1
Tran, L1
Boileau, P1
Bronsard, N1
Trojani, C1
Ahmed, S1
Ahmed, A1
Ahmad, S1
Javed, S1
Aziz, A1
Hu, Y1
Li, Q1
Wei, BG1
Zhang, XS1
Torsha, TT1
Xiao, J1
Shi, ZJ1
Tzatzairis, T1
Drosos, GI2
Vogiatzaki, T1
Tilkeridis, K1
Ververidis, A1
Kazakos, K1
Laoruengthana, A1
Rattanaprichavej, P1
Chaibhuddanugul, N1
Varakornpipat, P1
Galassi, M1
Pongpirul, K1
Chen, G1
Huang, Z2
Alexander, PG1
Lin, H1
Xu, H1
Zhou, Z2
Pei, F2
Tille, E1
Mysliwietz, J1
Beyer, F1
Postler, A1
Lützner, J1
Forget, P1
Grosu, I1
Thienpont, E1
Iwai, T2
Tsuji, S2
Antinolfi, P1
Innocenti, B1
Caraffa, A1
Peretti, G1
Cerulli, G1
Dahuja, A1
Dahuja, G1
Jaswal, V1
Sandhu, K1
Zhao-Yu, C1
Yan, G1
Wei, C1
Yuejv, L1
Ying-Ze, Z1
Rikhraj, IS1
Chin, PL2
Panni, AS1
Cerciello, S1
Vasso, M1
Del Regno, C1
Jang, B1
Kao, M1
Bohm, MT1
Harris, IA1
Chen, DB1
MacDessi, SJ2
Upadhyay, S1
Raza, HK1
Kaplunov, OA1
Mikhin, IV1
Biriukov, SN1
Karaaslan, F1
Karaoğlu, S1
Mermerkaya, MU1
Baktir, A1
Hourlier, H1
Reina, N1
Fennema, P1
Wang, CG1
Sun, ZH1
Liu, J1
Cao, JG1
Li, ZJ1
Digas, G1
Koutsogiannis, I1
Meletiadis, G1
Antonopoulou, E1
Karamoulas, V1
Bikos, Ch1
Zhang, W1
Li, W1
Bai, G1
Zhang, C1
Lin, J1
Moo, IH1
Aggarwal, AK1
Singh, N1
Sudesh, P1
Rodriguez-Merchan, EC1
Ortega-Andreu, M1
Padilla-Eguiluz, NG1
Gomez-Cardero, P1
Martinez-Lloreda, Á1
Gomez-Barrena, E1
Uğurlu, M1
Aksekili, MA1
Çağlar, C1
Yüksel, K1
Şahin, E1
Akyol, M1
Nielsen, CS1
Jans, Ø1
Ørsnes, T1
Foss, NB1
Troelsen, A1
Husted, H1
Tzatzairis, TK1
Kotsios, SE1
Ververidis, AN1
Vogiatzaki, TD1
Kazakos, KI1
Sun, Q1
Yu, X1
Nie, X1
Gong, J1
Cai, M1
Pinsornsak, P1
Rojanavijitkul, S1
Chumchuen, S1
Guzel, Y1
Gurcan, OT1
Golge, UH1
Dulgeroglu, TC1
Metineren, H1
Song, EK1
Seon, JK1
Prakash, J1
Seol, YJ1
Park, YJ1
Jin, C1
Spanyer, J1
Patel, J1
Emberton, E1
Smith, LS1
Malkani, AL1
Mao, Z1
Yue, B1
Yan, M1
Dai, K1
Maniar, RN1
Singhi, T1
Patil, A1
Kumar, G1
Maniar, P1
Singh, J1
Cankaya, D1
Dasar, U1
Satilmis, AB1
Basaran, SH1
Akkaya, M1
Bozkurt, M1
Wu, Y1
Yang, T1
Zeng, Y1
Li, C1
Ishida, K1
Tsumura, N1
Kitagawa, A1
Hamamura, S1
Fukuda, K1
Dogaki, Y1
Kubo, S1
Matsumoto, T1
Matsushita, T1
Chin, T1
Iguchi, T1
Kurosaka, M1
Kuroda, R1
Charoencholvanich, K1
Siriwattanasakul, P1
Sepah, YJ1
Umer, M1
Ahmad, T1
Nasim, F1
Chaudhry, MU1
Umar, M1
Roy, SP1
Tanki, UF1
Dutta, A1
Jain, SK1
Nagi, ON1
Irisson, E1
Hémon, Y1
Pauly, V1
Parratte, S1
Argenson, JN1
Kerbaul, F1
Lee, SH1
Cho, KY1
Khurana, S1
Tomita, T1
Sugamoto, K1
Hideki, Y1
Hamada, M1
Good, L1
Peterson, E1
Lisander, B1
Zhang, F1
Gao, Z1
Yu, J1

Clinical Trials (22)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Extended Postoperative Tranexamic Acid Use in Primary Total Knee Arthroplasty: A Prospective, Randomized Controlled Trial[NCT05099276]Phase 446 participants (Actual)Interventional2021-12-07Active, not recruiting
Prospective, Multicenter, Randomized, Parallel Groups Study Comparing the Safety and the Efficacy of the Administration of One Intra-articular Injection of 4.8 ml (HO-1) or Three Intra-articular Injections of 2.2 ml (HS-3) of Pandora Gel to One Intra-arti[NCT05978180]252 participants (Anticipated)Interventional2023-10-18Recruiting
Prospective, Multicenter, Open Study Evaluating the Short-term Safety of Use of Pandora Administered in the Form of 1 Intra-articular Injection of Happyone or 3 Intra-articular Injections of Happysoft in Patients Suffering From Gonarthrosis[NCT05414617]20 participants (Actual)Interventional2022-06-08Completed
Tranexamic Acid Usage in Bilateral Mastectomy to Reduce Post-surgical Drainage[NCT05554211]Phase 230 participants (Anticipated)Interventional2022-07-12Recruiting
Effect of no Drainage Tube on Blood Loss and Recovery After High Tibial Osteotomy[NCT03954860]80 participants (Actual)Interventional2018-08-01Completed
Peri-articular Tranexamic Acid Injection in Total Knee Arthroplasty: A Randomized Controlled Trial[NCT02829346]Phase 260 participants (Actual)Interventional2012-10-31Completed
Evaluation of Efficacy and Safety of Perioperative Tranexamic Acid During Primary Total Knee Arthroplasty: A Randomized, Clinical Trial[NCT05919615]100 participants (Actual)Interventional2021-07-15Completed
Serial Use of Intravenous and Oral Tranexamic Acid in Primary Total Knee Arthroplasty Patients: A Randomized Controlled Study[NCT03109652]Phase 4144 participants (Anticipated)Interventional2017-07-10Recruiting
The Comparative Efficacy of Peri-articular and Intraarticular Tranexamic Acid in Total Knee Arthroplasty: A Prospective, Double-Blind Randomized, Controlled Trial[NCT03074994]Phase 2108 participants (Anticipated)Interventional2016-10-31Recruiting
Efficacy of Local Hemostatic Management in Implant Surgery in Anticoagulated Patients on Warfarin: a Randomized Clinical Study[NCT04846114]71 participants (Actual)Interventional2016-03-31Completed
Role of Topical Tranexamic Acid in Total Hip Arthroplasty[NCT01866943]Phase 241 participants (Actual)Interventional2011-11-30Terminated
Efficacy of Low-dose Intra-articular Tranexamic Acid in Total Knee Replacement; A Prospective Triple-blinded Randomized Controlled Trial.[NCT01850394]152 participants (Actual)Interventional2010-01-31Completed
Evaluation of the Pharmacokinetic Profile of Tranexamic Acid, After Injection in a Knee Neo-articulation.[NCT02319915]Early Phase 114 participants (Actual)Interventional2015-02-18Completed
Tranexamic Acid in Knee Joint Surgery - a Randomised Controlled Trial[NCT02278263]Phase 4150 participants (Actual)Interventional2014-12-31Completed
Efficacy of Tranexamic Acid in Femoral Shaft Fractures Osteosynthesis; A Double Blind Randomized Controlled Trial[NCT04803591]Phase 40 participants (Actual)Interventional2021-08-01Withdrawn (stopped due to Not approved by Ethics Commettee)
Evaluation of the Use of Tranexamic Acid in Tibial Osteotomies: a Randomised Controlled Clinical Trial.[NCT04785651]84 participants (Anticipated)Interventional2021-02-22Recruiting
Comparative Study of the Efficiency of Oral Tranexamic Tcid vs. Oral Tminocaproic Acid to Reduce Blood Loss and Transfusion After Total Knee Replacement. A Prospective, Randomized, Double Blinded Controlled Clinical Trial.[NCT03365999]Phase 292 participants (Actual)Interventional2017-10-15Completed
Single Versus Multi-Dose Oral and Intravenous Tranexamic Acid in Patients at High Risk for Blood Transfusion After Spine Surgery[NCT03849443]Early Phase 1604 participants (Anticipated)Interventional2019-08-26Recruiting
The Use of Tranexamic Acid to Reduce Blood Loss in Acetabular Surgery[NCT02684851]Phase 387 participants (Actual)Interventional2012-10-31Completed
Topical Tranexamic Acid and Acute Blood Loss in Total Knee Arthroplasty[NCT01370460]Phase 2101 participants (Actual)Interventional2011-06-30Completed
Intravenous Tranexamic Acid to Reduce Blood Loss in Reverse Total Shoulder Arthroplasty[NCT02043132]Phase 2/Phase 3116 participants (Actual)Interventional2013-09-30Completed
A Randomized Controlled Trial of Oral and Intravenous Tranexamic Acid in Lumbar Spine Surgery[NCT03037515]Phase 4120 participants (Anticipated)Interventional2017-02-15Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Estimated Blood Loss

Estimated Blood Loss defined as Pre Op Hgb mins the Post Op Day two Hgb. (NCT01866943)
Timeframe: Pre Op, Post Op Day 2

InterventionHemoglobin (grams/deciliter) (Mean)
Baseline Population2.93

Harris Hip Scores

Standardized questionnaire that measures clinical function related to the hip. Total potential range is from 4.0 - 96.0. A higher score indicates a more favorable clinical outcome. (NCT01866943)
Timeframe: 2 week

Interventionunits on a scale (Mean)
All Study Participants65.76

Harris Hip Scores

Standardized questionnaire that measures clinical function related to the hip. Total potential range is from 4.0 - 96.0. A higher score indicates a more favorable clinical outcome. (NCT01866943)
Timeframe: 6 week

Interventionunits on a scale (Mean)
All Study Participants81.77

Harris Hip Scores

Standardized questionnaire that measures clinical function related to the hip. Total potential range is from 4.0 - 96.0. A higher score indicates a more favorable clinical outcome. (NCT01866943)
Timeframe: Preoperative

Interventionunits on a scale (Mean)
All Study Participants58.34

Mid Thigh Circumference

Measurement of the thigh at the half way point between the prominence of the greater trochanter and the lateral epicondyle of the femur. No data recorded at 2 weeks or 6 weeks for this study population. (NCT01866943)
Timeframe: Pre Op

Interventioncentimeters (Mean)
Baseline Population52.99

Number of Patients Required Blood Transfusion

(NCT01850394)
Timeframe: postoperative period (5 days after surgery)

Interventionparticipants (Number)
Control Group10
TXA-250 Group6
TXA-500 Group0

Total Hemoglobin Loss

Total hemoglobin loos measured by difference between hemoglobin preoperatively and the fourth postoperative day (NCT01850394)
Timeframe: 5 days after surgery

Interventiong/dL (Mean)
Control Group2.9
TXA-250 Group2.2
TXA-500 Group2.2

Knee Function Scores

"Knee function score was measured with 2 methods, and were evaluated preoperatively and then postoperatively at 3-month, 6-month, and 1-year period.~Knee Society Knee Score using for rating knee function measurement and subdivided into two parts; knee score and function score 1.1. Knee score : calculated from pain, presence of deformity, total range of flexion, alignment, and stability. Total score is 100 (0-100), more score means better.~1.2. Function score : calculated from patient's ability to walk and climb stairs. The score ranges from 0-100, more score means better.~Western Ontario and McMaster Universities Arthritis Index or WOMAC score : a widely used, standardized questionnaires for evaluating the condition of patients with knee osteoarthritis, including pain (score = 0-20), stiffness (0-8), and functional limitation (0-68). Total score ranges from 0-68, lower score means better." (NCT01850394)
Timeframe: 1 year after surgery

,,
Interventionunits on a scale (Mean)
Knee Society Knee score at 1 yearWOMAC score at 1 year
Control Group148.915.5
TXA-250 Group151.215.1
TXA-500 Group150.914.5

Number of Patients Having Postoperative Complications

"Postoperative complications were measured as an incidence of the following complications;~wound hematoma~surgical site infection~systemic infection~deep vein thrombosis~pulmonary embolism~knee stiffness requiring manipulation~medical complication such as myocardial infarction, congestive hear failure" (NCT01850394)
Timeframe: postoperative 1-year period

,,
Interventionparticipants (Number)
Re-clamp incidenceRe-dressing incidenceVenous thromboembolic complicationCongestive heart failure
Control Group6340
TXA-250 Group1011
TXA-500 Group0020

Perioperative Blood Loss

"Drainage blood loss measured by accumulating total drainage volume postoperatively~Calculated total blood loss measured by using specific formula and difference between hematocrit preoperatively and the fourth postoperative day" (NCT01850394)
Timeframe: 5 days after surgery

,,
Interventionml (Median)
Drainage blood lossCalculated total blood loss
Control Group546.9329.2
TXA-250 Group475.0239.7
TXA-500 Group430.2217.2

Blood Loss

"The loss of haemoglobin (Hb) was then estimated according to the formula:~Hb(loss) = Blood volume (BV) x (Hbi-Hbe) x 0.001+Hbt~where Hb (loss) (g) is the amount of Hb lost, Hbi (g/L) the Hb concentration before surgery, Hbe (g/L) is the Hbe concentration on the third day after surgery, and Hbt (g) is the total amount of allogeneic Hb transfused. A unit of banked blood is considered to contain a minimum of 40g Hb (Blood component data sheet, New Zealand Blood Services [NZBS]). All units of blood are processed and stored in a nationally standardised manner. The blood loss (ml) was related to the patient's preoperative Hb value (g/L):~Blood loss =1000 x Hb(loss) /Hbi" (NCT02278263)
Timeframe: Post operative day 3

Interventionmls (Mean)
Control1090
Intraarticular716
Systemic746

Length of Stay (LOS)

Day of surgery is counted as Day 0. (NCT02278263)
Timeframe: Average length of stay is expected to be 3 to 5 days

Interventiondays (Median)
Control4
Topical4
Systemic4

Number of Participants Receiving Allogenic Blood Transfusion

"Those patients receiving blood products. Standardised protocol is as follows:~The criterion for transfusion of blood products will be a haemoglobin < 80g/L or a haemoglobin <100g/L in a patient with ischaemic heart disease or with significant symptomatology" (NCT02278263)
Timeframe: Participants will be followed for the duration of their hospital stay expected to be an average of 3-5 days

InterventionParticipants (Count of Participants)
Control2
Topical1
Systemic0

Perioperative Fluid Administration

Intravenous fluid (excluding blood transfusion) given during and first 24 hours after surgery (NCT02278263)
Timeframe: Day 1

Interventionmls (Mean)
Control1765
Topical1613
Systemic1807

Number of Participants Experiencing Symptomatic Venothromboembolic (VTE) Disease

Rates of deep vein thrombosis (DVT) and pulmonary embolus (PE) in each group recorded as a percentage (NCT02278263)
Timeframe: Postoperatively within 30 days after surgery

,,
InterventionParticipants (Count of Participants)
DVTPE
Control00
Systemic01
Topical02

Range of Active Flexion

Range of motion measured in degrees on postoperative days 1-3 (NCT02278263)
Timeframe: Days 1-3

,,
Interventiondegrees (Mean)
Day 1Day 2Day 3
Control577175
Systemic587278
Topical657582

Range of Passive Flexion

Range of motion measured in degrees for postoperative days 1 to 3 (NCT02278263)
Timeframe: Days 1-3

,,
Interventiondegrees (Mean)
Day 1Day 2Day 3
Control657682
Systemic688087
Topical748187

Allogenic Blood Transfusion Rates

Number of participant received allogenic blood transfusions. (NCT02684851)
Timeframe: post-operative

InterventionParticipants (Count of Participants)
Tranexamic21
Placebo13

Estimate Blood Loss

To measure average estimate perioperative blood loss (NCT02684851)
Timeframe: perioperative

InterventionmL (Mean)
Tranexamic727.6
Placebo560.1

Number of Participants With a Thromboembolic Event

Do patients undergoing acetabular ORIF who receive tranexamic acid have a higher risk for thromboembolic events than patients who receive placebo? (NCT02684851)
Timeframe: 30 days

InterventionParticipants (Count of Participants)
Tranexamic1
Placebo0

Units of Packed Red Blood Cells Transfused

Average units packed red blood cells transfused among participants (NCT02684851)
Timeframe: perioperative

InterventionUnits of packed red blood cells (Mean)
Tranexamic2.65
Placebo2.36

Blood Loss

Preoperative and lowest postoperative hemoglobin. Blood loss was calculated taking change in hemoglobin as described (units g/dL) and converting to blood loss (mL) according to the formulas included in the papers cited in this entry (Good 2003 Br J Anesthesia; Nadler 1962 Surgery, http://www.ncbi.nlm.nih.gov/pubmed/21936146). (NCT01370460)
Timeframe: participants will be followed for the duration of hospital stay, an expected average of 3 days

InterventionmL (Mean)
Placebo1293.1
Tranexamic Acid940.2

Postoperative Transfusion Rate

Number of patients with symptomatic (tachycardia, hypotension, presyncope) anemia of < 8.0g/dL hemoglobin, or any hemoglobin <7.0 g/dL, precipitated transfusion. (NCT01370460)
Timeframe: participants will be followed for the duration of hospital stay, an expected average of 3 days

Interventionparticipants (Number)
Tranexamic Acid0
Placebo4

Number of Participants Experiencing Deep Vein Thrombosis

"The occurrence of the following systemic and surgical site complications within 6 weeks of surgery will be recorded. Data will be obtained from EMR and from patient at standard of care 2 week and 6 week follow-up appointment.~Deep venous thrombosis" (NCT02043132)
Timeframe: up to 6-weeks post-operatively

InterventionParticipants (Count of Participants)
Tranexamic Acid0
Normal Saline0

Number of Participants Experiencing Hematoma as a Surgical Site Complication

"The occurrence of the following systemic and surgical site complications within 6 weeks of surgery will be recorded. Data will be obtained from EMR and from patient at standard of care 2 week and 6 week follow-up appointment.~Hematoma" (NCT02043132)
Timeframe: up to 6-weeks post-operatively

InterventionParticipants (Count of Participants)
Tranexamic Acid0
Normal Saline0

Number of Participants Experiencing Infection as a Surgical Site Complication

"The occurrence of the following systemic and surgical site complications within 6 weeks of surgery will be recorded. Data will be obtained from EMR and from patient at standard of care 2 week and 6 week follow-up appointment.~Infection" (NCT02043132)
Timeframe: up to 6-weeks post-operatively

InterventionParticipants (Count of Participants)
Tranexamic Acid0
Normal Saline0

Number of Participants Experiencing Myocardial Infarction

"The occurrence of the following systemic and surgical site complications within 6 weeks of surgery will be recorded. Data will be obtained from EMR and from patient at standard of care 2 week and 6 week follow-up appointment.~Myocardial infarction" (NCT02043132)
Timeframe: up to 6-weeks post-operatively

InterventionParticipants (Count of Participants)
Tranexamic Acid0
Normal Saline1

Number of Participants Experiencing Pulmonary Embolism

"The occurrence of the following systemic and surgical site complications within 6 weeks of surgery will be recorded. Data will be obtained from EMR and from patient at standard of care 2 week and 6 week follow-up appointment.~Pulmonary Embolism" (NCT02043132)
Timeframe: up to 6-weeks post-operatively

InterventionParticipants (Count of Participants)
Tranexamic Acid0
Normal Saline0

Total Blood Loss

Total Blood Loss as calculated according to method as described by Good et al. Total Blood Loss (mL) = 1000 X Hb(loss)/Hb(initial) (NCT02043132)
Timeframe: Preoperative through Postoperative Days 1 and 2

InterventionTotal Blood Loss (mL) (Mean)
Tranexamic Acid1122.4
Normal Saline1472

Total Drain Output

Total Drain Output as measured postoperatively 0-48 hours (NCT02043132)
Timeframe: 0-48 hours postoperatively

InterventionmL (Mean)
Tranexamic Acid221
Normal Saline372

Total Hemoglobin Loss

Total hemoglobin loss estimated using the formula for total blood volume described by Nadler et al Hb(loss) = blood volume (L) x [Hb(initial)(g/L) - Hb(final)(g/L)] + Hb(transfused) (NCT02043132)
Timeframe: Preoperative through Postoperative Days 1 and 2

Interventiong (Mean)
Tranexamic Acid154.6
Normal Saline200.1

Reviews

2 reviews available for tranexamic acid and Osteoarthritis, Knee

ArticleYear
Tranexamic Acid in Total Knee Arthroplasty: Mixed Treatment Comparisons and Recursive Cumulative Meta-Analysis of Randomized, Controlled Trials and Cohort Studies.
    Basic & clinical pharmacology & toxicology, 2018, Volume: 122, Issue:1

    Topics: Administration, Intravenous; Administration, Oral; Administration, Topical; Antifibrinolytic Agents;

2018
Reduced blood loss after intra-articular tranexamic acid injection during total knee arthroplasty: a meta-analysis of the literature.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2014, Volume: 22, Issue:12

    Topics: Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Blood Transfusion; H

2014

Trials

42 trials available for tranexamic acid and Osteoarthritis, Knee

ArticleYear
Use of tranexamic acid in medial open wedge high tibial osteotomy.
    Archives of orthopaedic and trauma surgery, 2022, Volume: 142, Issue:9

    Topics: Hemoglobins; Humans; Osteoarthritis, Knee; Osteotomy; Pain, Postoperative; Postoperative Complicatio

2022
Efficacy of intravenous tranexamic acid administration in medial opening-wedge distal tibial tuberosity osteotomy (MOWDTO) for varus knee osteoarthritis: a randomized control trial.
    Journal of orthopaedic surgery and research, 2023, Mar-08, Volume: 18, Issue:1

    Topics: Administration, Intravenous; Antifibrinolytic Agents; Blood Loss, Surgical; Humans; Osteoarthritis,

2023
Monitoring of fibrinolytic system activity with plasminogen, D-dimers and FDP in primary total knee arthroplasty (TKA) after topical, intravenous or combined administration of tranexamic acid.
    Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia, 2020, Volume: 164, Issue:2

    Topics: Administration, Intravenous; Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, R

2020
Intra-articular tranexamic acid as an adjunct to intravenous tranexamic acid for simultaneous bilateral total knee arthroplasty: a randomized double-blind, placebo-controlled trial.
    BMC musculoskeletal disorders, 2019, Oct-22, Volume: 20, Issue:1

    Topics: Administration, Intravenous; Aged; Aged, 80 and over; Arthroplasty, Replacement, Knee; Chemotherapy,

2019
Intravenous and subsequent long-term oral tranexamic acid in enhanced-recovery primary total knee arthroplasty without the application of a tourniquet: a randomized placebo-controlled trial.
    BMC musculoskeletal disorders, 2019, Oct-25, Volume: 20, Issue:1

    Topics: Administration, Intravenous; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood L

2019
Comparison of Topical and Intravenous Tranexamic Acid for Total Knee Replacement: A Randomized Double-Blinded Controlled Study of Effects on Tranexamic Acid Levels and Thrombogenic and Inflammatory Marker Levels.
    The Journal of bone and joint surgery. American volume, 2019, Dec-04, Volume: 101, Issue:23

    Topics: Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blin

2019
Comparison of Topical and Intravenous Tranexamic Acid for Total Knee Replacement: A Randomized Double-Blinded Controlled Study of Effects on Tranexamic Acid Levels and Thrombogenic and Inflammatory Marker Levels.
    The Journal of bone and joint surgery. American volume, 2019, Dec-04, Volume: 101, Issue:23

    Topics: Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blin

2019
Comparison of Topical and Intravenous Tranexamic Acid for Total Knee Replacement: A Randomized Double-Blinded Controlled Study of Effects on Tranexamic Acid Levels and Thrombogenic and Inflammatory Marker Levels.
    The Journal of bone and joint surgery. American volume, 2019, Dec-04, Volume: 101, Issue:23

    Topics: Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blin

2019
Comparison of Topical and Intravenous Tranexamic Acid for Total Knee Replacement: A Randomized Double-Blinded Controlled Study of Effects on Tranexamic Acid Levels and Thrombogenic and Inflammatory Marker Levels.
    The Journal of bone and joint surgery. American volume, 2019, Dec-04, Volume: 101, Issue:23

    Topics: Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blin

2019
Comparison of Topical and Intravenous Tranexamic Acid for Total Knee Replacement: A Randomized Double-Blinded Controlled Study of Effects on Tranexamic Acid Levels and Thrombogenic and Inflammatory Marker Levels.
    The Journal of bone and joint surgery. American volume, 2019, Dec-04, Volume: 101, Issue:23

    Topics: Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blin

2019
Comparison of Topical and Intravenous Tranexamic Acid for Total Knee Replacement: A Randomized Double-Blinded Controlled Study of Effects on Tranexamic Acid Levels and Thrombogenic and Inflammatory Marker Levels.
    The Journal of bone and joint surgery. American volume, 2019, Dec-04, Volume: 101, Issue:23

    Topics: Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blin

2019
Comparison of Topical and Intravenous Tranexamic Acid for Total Knee Replacement: A Randomized Double-Blinded Controlled Study of Effects on Tranexamic Acid Levels and Thrombogenic and Inflammatory Marker Levels.
    The Journal of bone and joint surgery. American volume, 2019, Dec-04, Volume: 101, Issue:23

    Topics: Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blin

2019
Comparison of Topical and Intravenous Tranexamic Acid for Total Knee Replacement: A Randomized Double-Blinded Controlled Study of Effects on Tranexamic Acid Levels and Thrombogenic and Inflammatory Marker Levels.
    The Journal of bone and joint surgery. American volume, 2019, Dec-04, Volume: 101, Issue:23

    Topics: Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blin

2019
Comparison of Topical and Intravenous Tranexamic Acid for Total Knee Replacement: A Randomized Double-Blinded Controlled Study of Effects on Tranexamic Acid Levels and Thrombogenic and Inflammatory Marker Levels.
    The Journal of bone and joint surgery. American volume, 2019, Dec-04, Volume: 101, Issue:23

    Topics: Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blin

2019
The antifibrinolytic and anti-inflammatory effects of a high initial-dose tranexamic acid in total knee arthroplasty: a randomized controlled trial.
    International orthopaedics, 2020, Volume: 44, Issue:3

    Topics: Administration, Intravenous; Aged; Anti-Inflammatory Agents; Antifibrinolytic Agents; Arthroplasty,

2020
Topical co-delivery of platelet rich fibrin and tranexamic acid does not decrease blood loss in primary total knee arthroplasty compared to the standard of care: a prospective, randomized, controlled trial.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2021, Volume: 29, Issue:2

    Topics: Administration, Intravenous; Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, R

2021
Tranexamic acid in total knee replacement which protocol? which application form? A prospective randomised study.
    Acta orthopaedica Belgica, 2019, Volume: 85, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss

2019
Are The Applications of Tranexamic Acid in Reverse Hybrid Total Knee Arthroplasty (TKA) The Same as Those in Fully Cemented TKA?: A Randomized Controlled Trial.
    Advances in therapy, 2021, Volume: 38, Issue:5

    Topics: Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Blood Transfusion; H

2021
Tranexamic Acid Reduces Occult Blood Loss, Blood Transfusion, and Improves Recovery of Knee Function after Total Knee Arthroplasty: A Comparative Study.
    The journal of knee surgery, 2018, Volume: 31, Issue:3

    Topics: Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Blood Transfusion; F

2018
A comparative analysis of the role of Tranexamic acid as an independent variable in reducing intraoperative blood loss in patients undergoing conventional total knee arthroplasty versus computer-assisted total knee arthroplasty.
    Musculoskeletal surgery, 2017, Volume: 101, Issue:3

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Female; Hemogl

2017
Comparison of intravenous and intra-articular tranexamic acid in reducing blood loss in primary total knee replacement.
    Eklem hastaliklari ve cerrahisi = Joint diseases & related surgery, 2017, Volume: 28, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgi

2017
Comparing the efficacy of intravenous or intra-articular tranexamic acid in reducing blood loss in simultaneous bilateral knee replacement surgery without the use of tourniquet.
    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2018, Volume: 28, Issue:7

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Blood Transfus

2018
Blood loss after intraarticular and intravenous tranexamic acid in total knee arthroplasty.
    JPMA. The Journal of the Pakistan Medical Association, 2018, Volume: 68, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Dose-Response Relationship, Drug; F

2018
Multiple intravenous tranexamic acid doses in total knee arthroplasty without tourniquet: a randomized controlled study.
    Archives of orthopaedic and trauma surgery, 2019, Volume: 139, Issue:6

    Topics: Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Transfusion; Hemoglobins; Humans; Os

2019
Blood loss reduction: effect of different knee prosthesis designs and use of tranexamic acid-a randomized controlled trial.
    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2019, Volume: 29, Issue:7

    Topics: Administration, Intravenous; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood L

2019
Multi-route applications of tranexamic acid to reduce blood loss after total knee arthroplasty: a randomized controlled trial.
    Medicine, 2019, Volume: 98, Issue:30

    Topics: Age Factors; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; B

2019
Post-operative blood loss in total knee arthroplasty: knee flexion versus pharmacological techniques.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2014, Volume: 22, Issue:11

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Female; Humans; K

2014
Knee flexion after total knee arthroplasty reduces blood loss.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2014, Volume: 22, Issue:8

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Transfusion; Female; Humans; K

2014
Reducing blood loss in simultaneous bilateral total knee arthroplasty: combined intravenous-intra-articular tranexamic acid administration. A prospective randomized controlled trial.
    The Knee, 2015, Volume: 22, Issue:2

    Topics: Aged; Analgesics; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Do

2015
Single dose intravenous tranexamic acid as effective as continuous infusion in primary total knee arthroplasty: a randomised clinical trial.
    Archives of orthopaedic and trauma surgery, 2015, Volume: 135, Issue:4

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Transfusion; Dose-Response Rel

2015
Safety and efficacy of intra-articular tranexamic acid injection without drainage on blood loss in total knee arthroplasty: A randomized clinical trial.
    International journal of surgery (London, England), 2015, Volume: 20

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Blood Transfus

2015
Intra-articular injection of tranexamic acid reduce blood loss in cemented total knee arthroplasty.
    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2015, Volume: 25, Issue:7

    Topics: Administration, Intravenous; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood L

2015
[A PROSPECTIVE RANDOMIZED SELF-CONTROLLED STUDY ON EFFECT OF TRANEXAMIC ACID IN REDUCING BLOOD LOSS IN TOTAL KNEE ARTHROPLASTY].
    Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2015, Volume: 29, Issue:3

    Topics: Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Blood Transfusion; H

2015
Intravenous versus intra-articular tranexamic acid in total knee arthroplasty: A double-blinded randomised controlled noninferiority trial.
    The Knee, 2016, Volume: 23, Issue:1

    Topics: Administration, Intravenous; Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replace

2016
Topical vs Intravenous Tranexamic Acid in Reducing Blood Loss After Bilateral Total Knee Arthroplasty: A Prospective Study.
    The Journal of arthroplasty, 2016, Volume: 31, Issue:7

    Topics: Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss,

2016
Effect of Topical and Intravenously Applied Tranexamic Acid Compared to Control Group on Bleeding in Primary Unilateral Total Knee Arthroplasty.
    The journal of knee surgery, 2017, Volume: 30, Issue:2

    Topics: Administration, Intravenous; Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, R

2017
Combined Intra-Articular and Intravenous Tranexamic Acid Reduces Blood Loss in Total Knee Arthroplasty: A Randomized, Double-Blind, Placebo-Controlled Trial.
    The Journal of bone and joint surgery. American volume, 2016, May-18, Volume: 98, Issue:10

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Blood Transfus

2016
Combined Intra-Articular and Intravenous Tranexamic Acid Reduces Blood Loss in Total Knee Arthroplasty: A Randomized, Double-Blind, Placebo-Controlled Trial.
    The Journal of bone and joint surgery. American volume, 2016, May-18, Volume: 98, Issue:10

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Blood Transfus

2016
Combined Intra-Articular and Intravenous Tranexamic Acid Reduces Blood Loss in Total Knee Arthroplasty: A Randomized, Double-Blind, Placebo-Controlled Trial.
    The Journal of bone and joint surgery. American volume, 2016, May-18, Volume: 98, Issue:10

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Blood Transfus

2016
Combined Intra-Articular and Intravenous Tranexamic Acid Reduces Blood Loss in Total Knee Arthroplasty: A Randomized, Double-Blind, Placebo-Controlled Trial.
    The Journal of bone and joint surgery. American volume, 2016, May-18, Volume: 98, Issue:10

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Blood Transfus

2016
Intravenous vs Topical Tranexamic Acid in Total Knee Arthroplasty Without Tourniquet Application: A Randomized Controlled Study.
    The Journal of arthroplasty, 2016, Volume: 31, Issue:11

    Topics: Administration, Intravenous; Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, R

2016
Peri-articular tranexamic acid injection in total knee arthroplasty: a randomized controlled trial.
    BMC musculoskeletal disorders, 2016, 07-26, Volume: 17

    Topics: Administration, Intravenous; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood T

2016
Peri-articular tranexamic acid injection in total knee arthroplasty: a randomized controlled trial.
    BMC musculoskeletal disorders, 2016, 07-26, Volume: 17

    Topics: Administration, Intravenous; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood T

2016
Peri-articular tranexamic acid injection in total knee arthroplasty: a randomized controlled trial.
    BMC musculoskeletal disorders, 2016, 07-26, Volume: 17

    Topics: Administration, Intravenous; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood T

2016
Peri-articular tranexamic acid injection in total knee arthroplasty: a randomized controlled trial.
    BMC musculoskeletal disorders, 2016, 07-26, Volume: 17

    Topics: Administration, Intravenous; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood T

2016
Topical tranexamic acid versus autotransfusion after total knee arthroplasty.
    Journal of orthopaedic surgery (Hong Kong), 2016, Volume: 24, Issue:2

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Transfusion, Autologous; Cost-

2016
Combined Administration of IV and Topical Tranexamic Acid is Not Superior to Either Individually in Primary Navigated TKA.
    The Journal of arthroplasty, 2017, Volume: 32, Issue:1

    Topics: Administration, Intravenous; Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, R

2017
Optimizing effectivity of tranexamic acid in bilateral knee arthroplasty - A prospective randomized controlled study.
    The Knee, 2017, Volume: 24, Issue:1

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Blood Transfus

2017
The combined use of oral and topical tranexamic acid is a safe, efficient and low-cost method in reducing blood loss and transfusion rates in total knee arthroplasty.
    Journal of orthopaedic surgery (Hong Kong), 2017, Volume: 25, Issue:1

    Topics: Administration, Oral; Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, Replacem

2017
The combined use of oral and topical tranexamic acid is a safe, efficient and low-cost method in reducing blood loss and transfusion rates in total knee arthroplasty.
    Journal of orthopaedic surgery (Hong Kong), 2017, Volume: 25, Issue:1

    Topics: Administration, Oral; Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, Replacem

2017
The combined use of oral and topical tranexamic acid is a safe, efficient and low-cost method in reducing blood loss and transfusion rates in total knee arthroplasty.
    Journal of orthopaedic surgery (Hong Kong), 2017, Volume: 25, Issue:1

    Topics: Administration, Oral; Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, Replacem

2017
The combined use of oral and topical tranexamic acid is a safe, efficient and low-cost method in reducing blood loss and transfusion rates in total knee arthroplasty.
    Journal of orthopaedic surgery (Hong Kong), 2017, Volume: 25, Issue:1

    Topics: Administration, Oral; Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, Replacem

2017
The combined use of oral and topical tranexamic acid is a safe, efficient and low-cost method in reducing blood loss and transfusion rates in total knee arthroplasty.
    Journal of orthopaedic surgery (Hong Kong), 2017, Volume: 25, Issue:1

    Topics: Administration, Oral; Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, Replacem

2017
The combined use of oral and topical tranexamic acid is a safe, efficient and low-cost method in reducing blood loss and transfusion rates in total knee arthroplasty.
    Journal of orthopaedic surgery (Hong Kong), 2017, Volume: 25, Issue:1

    Topics: Administration, Oral; Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, Replacem

2017
The combined use of oral and topical tranexamic acid is a safe, efficient and low-cost method in reducing blood loss and transfusion rates in total knee arthroplasty.
    Journal of orthopaedic surgery (Hong Kong), 2017, Volume: 25, Issue:1

    Topics: Administration, Oral; Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, Replacem

2017
The combined use of oral and topical tranexamic acid is a safe, efficient and low-cost method in reducing blood loss and transfusion rates in total knee arthroplasty.
    Journal of orthopaedic surgery (Hong Kong), 2017, Volume: 25, Issue:1

    Topics: Administration, Oral; Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, Replacem

2017
The combined use of oral and topical tranexamic acid is a safe, efficient and low-cost method in reducing blood loss and transfusion rates in total knee arthroplasty.
    Journal of orthopaedic surgery (Hong Kong), 2017, Volume: 25, Issue:1

    Topics: Administration, Oral; Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, Replacem

2017
Clamping drainage is unnecessary after minimally invasive total knee arthroplasty in patients with tranexamic acid: A randomized, controlled trial.
    Medicine, 2017, Volume: 96, Issue:7

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Constriction;

2017
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Intra-articular injection of tranexamic acid reduces not only blood loss but also knee joint swelling after total knee arthroplasty.
    International orthopaedics, 2011, Volume: 35, Issue:11

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Edema; Female;

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Tranexamic acid reduces blood loss and blood transfusion after TKA: a prospective randomized controlled trial.
    Clinical orthopaedics and related research, 2011, Volume: 469, Issue:10

    Topics: Administration, Oral; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Biomarkers; Bl

2011
Efficacy of intra-articular tranexamic acid in blood loss reduction following primary unilateral total knee arthroplasty.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2012, Volume: 20, Issue:12

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Transfusion; Double-Blind Meth

2012
Efficacy of intra-articular tranexamic acid in blood loss reduction following primary unilateral total knee arthroplasty.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2012, Volume: 20, Issue:12

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Transfusion; Double-Blind Meth

2012
Efficacy of intra-articular tranexamic acid in blood loss reduction following primary unilateral total knee arthroplasty.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2012, Volume: 20, Issue:12

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Transfusion; Double-Blind Meth

2012
Efficacy of intra-articular tranexamic acid in blood loss reduction following primary unilateral total knee arthroplasty.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2012, Volume: 20, Issue:12

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Transfusion; Double-Blind Meth

2012
Efficacy of intra-articular tranexamic acid in blood loss reduction following primary unilateral total knee arthroplasty.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2012, Volume: 20, Issue:12

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Transfusion; Double-Blind Meth

2012
Efficacy of intra-articular tranexamic acid in blood loss reduction following primary unilateral total knee arthroplasty.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2012, Volume: 20, Issue:12

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Transfusion; Double-Blind Meth

2012
Efficacy of intra-articular tranexamic acid in blood loss reduction following primary unilateral total knee arthroplasty.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2012, Volume: 20, Issue:12

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Transfusion; Double-Blind Meth

2012
Efficacy of intra-articular tranexamic acid in blood loss reduction following primary unilateral total knee arthroplasty.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2012, Volume: 20, Issue:12

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Transfusion; Double-Blind Meth

2012
Efficacy of intra-articular tranexamic acid in blood loss reduction following primary unilateral total knee arthroplasty.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2012, Volume: 20, Issue:12

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Transfusion; Double-Blind Meth

2012
Less blood loss under concomitant administration of tranexamic acid and indirect factor Xa inhibitor following total knee arthroplasty: a prospective randomized controlled trial.
    Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2013, Volume: 21, Issue:11

    Topics: Aged; Anticoagulants; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical

2013
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
Tranexamic acid decreases external blood loss but not hidden blood loss in total knee replacement.
    British journal of anaesthesia, 2003, Volume: 90, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Double-Blind Meth

2003
[Clinical comparative studies on effect of tranexamic acid on blood loss associated with total knee arthroplasty].
    Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2007, Volume: 21, Issue:12

    Topics: Aged; Antifibrinolytic Agents; Arthritis; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Bl

2007

Other Studies

28 other studies available for tranexamic acid and Osteoarthritis, Knee

ArticleYear
Natural course of hemoglobin level after total knee arthroplasty and the benefit of tranexamic acid injection in the joint.
    Medicine, 2021, Sep-03, Volume: 100, Issue:35

    Topics: Aged; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Female; Hemoglobins; Humans; Injections

2021
Impact of tourniquet on short-term outcomes in opening wedge high tibial osteotomy with modern tranexamic acid protocols: a retrospective cohort study.
    BMC musculoskeletal disorders, 2021, Nov-08, Volume: 22, Issue:1

    Topics: Humans; Osteoarthritis, Knee; Osteotomy; Retrospective Studies; Tibia; Tourniquets; Tranexamic Acid

2021
Comparison of intra-articular administration of adenosine, lidocaine and magnesium solution and tranexamic acid for alleviating postoperative inflammation and joint fibrosis in an experimental model of knee arthroplasty.
    Journal of orthopaedic surgery and research, 2021, Dec-20, Volume: 16, Issue:1

    Topics: Adenosine; Administration, Intravenous; Animals; Antifibrinolytic Agents; Arthroplasty, Replacement,

2021
The effect of topical tranexamic acid on functional outcomes and quality of life in patients undergoing unicompartmental knee arthroplasty.
    Archives of orthopaedic and trauma surgery, 2023, Volume: 143, Issue:7

    Topics: Administration, Topical; Arthroplasty, Replacement, Knee; Humans; Knee Joint; Osteoarthritis, Knee;

2023
The effect of topical tranexamic acid on functional outcomes and quality of life in patients undergoing unicompartmental knee arthroplasty.
    Archives of orthopaedic and trauma surgery, 2023, Volume: 143, Issue:7

    Topics: Administration, Topical; Arthroplasty, Replacement, Knee; Humans; Knee Joint; Osteoarthritis, Knee;

2023
The effect of topical tranexamic acid on functional outcomes and quality of life in patients undergoing unicompartmental knee arthroplasty.
    Archives of orthopaedic and trauma surgery, 2023, Volume: 143, Issue:7

    Topics: Administration, Topical; Arthroplasty, Replacement, Knee; Humans; Knee Joint; Osteoarthritis, Knee;

2023
The effect of topical tranexamic acid on functional outcomes and quality of life in patients undergoing unicompartmental knee arthroplasty.
    Archives of orthopaedic and trauma surgery, 2023, Volume: 143, Issue:7

    Topics: Administration, Topical; Arthroplasty, Replacement, Knee; Humans; Knee Joint; Osteoarthritis, Knee;

2023
Tranexamic acid may benefit patients undergoing total hip/knee arthroplasty because of haemophilia.
    BMC musculoskeletal disorders, 2019, Sep-04, Volume: 20, Issue:1

    Topics: Administration, Intravenous; Adult; Antifibrinolytic Agents; Arthralgia; Arthroplasty, Replacement,

2019
Intravenous Combined with Topical Tranexamic Acid Administration Has No Additional Benefits Compared with Intravenous Administration Alone in High Tibial Osteotomy: A Retrospective Case-Control Study.
    Orthopaedic surgery, 2020, Volume: 12, Issue:2

    Topics: Administration, Intravenous; Administration, Topical; Aged; Antifibrinolytic Agents; Case-Control St

2020
Higher doses of topical tranexamic acid safely improves immediate functional outcomes and reduces transfusion requirement in total knee arthroplasty.
    Archives of orthopaedic and trauma surgery, 2020, Volume: 140, Issue:12

    Topics: Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss,

2020
Does the correction angle affect hidden blood loss in HTO?
    Journal of orthopaedic surgery and research, 2020, Nov-11, Volume: 15, Issue:1

    Topics: Aged; Blood Loss, Surgical; Female; Humans; Knee Joint; Male; Middle Aged; Osteoarthritis, Knee; Ost

2020
Tranexamic acid is effective for blood management in open-wedge high tibial osteotomy.
    Orthopaedics & traumatology, surgery & research : OTSR, 2018, Volume: 104, Issue:7

    Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Blood Transfusion; Blood Volume; Case-Control Studies

2018
Early morbidity and mortality after single-stage bilateral total knee replacement.
    Orthopaedics & traumatology, surgery & research : OTSR, 2018, Volume: 104, Issue:8

    Topics: Adult; Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss

2018
Blood loss of total knee arthroplasty in osteoarthritis: an analysis of influential factors.
    Journal of orthopaedic surgery and research, 2018, Dec-22, Volume: 13, Issue:1

    Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Antifibrinolytic Agents; Arthroplasty, Replacement,

2018
The efficacy and safety of tranexamic acid for reducing blood loss following simultaneous bilateral total knee arthroplasty: a multicenter retrospective study.
    BMC musculoskeletal disorders, 2019, Jul-12, Volume: 20, Issue:1

    Topics: Administration, Intravenous; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood L

2019
Intraarticular use of tranexamic acid reduces blood loss and transfusion rate after primary total knee arthroplasty.
    BMC musculoskeletal disorders, 2019, Jul-27, Volume: 20, Issue:1

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Blood Transfus

2019
Inadequate methodology renders results on the use of tranexamic acid inconclusive.
    International orthopaedics, 2013, Volume: 37, Issue:7

    Topics: Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Female; Humans; Male

2013
Reply to Letter to the Editor: Inadequate methodology renders results on the use of tranexamic acid inconclusive.
    International orthopaedics, 2013, Volume: 37, Issue:8

    Topics: Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Female; Humans; Male

2013
A prospective study on role of tranexamic acid in reducing postoperative blood loss in total knee arthroplasty and its effect on coagulation profile.
    The Journal of arthroplasty, 2014, Volume: 29, Issue:4

    Topics: Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Coagulation; Case-Control Studies; D

2014
Can tranexamic acid and hydrogen peroxide reduce blood loss in cemented total knee arthroplasty?
    Archives of orthopaedic and trauma surgery, 2014, Volume: 134, Issue:7

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgi

2014
Intra-articular injection of tranexamic acid to reduce blood loss after total knee arthroplasty.
    Journal of orthopaedic surgery (Hong Kong), 2014, Volume: 22, Issue:2

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Transfusion; Dose-Response Rel

2014
Letter to the Editor: Intra-articular injection of tranexamic acid to reduce blood loss after total knee arthroplasty.
    Journal of orthopaedic surgery (Hong Kong), 2014, Volume: 22, Issue:3

    Topics: Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Female; Humans; Male; Osteoarthritis, Knee

2014
[Blood loss during total knee-joint replacement: a combination of anticoagulant and hemostatic techniques].
    Khirurgiia, 2014, Issue:12

    Topics: Anticoagulants; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Etha

2014
Authors' reply.
    Journal of orthopaedic surgery (Hong Kong), 2014, Volume: 22, Issue:3

    Topics: Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Female; Humans; Male; Osteoarthritis, Knee

2014
Low-volume formulation of intra-articular tranexamic acid, 25-ml tranexamic acid (2.5 g) plus 20-ml saline, is effective in decreasing blood transfusion rate in primary total knee replacement even without preoperative haemoglobin optimization.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2016, Volume: 27, Issue:6

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgi

2016
The Efficacy Comparison of Tranexamic Acid for Reducing Blood Loss in Total Knee Arthroplasty at Different Dosage Time.
    The Journal of arthroplasty, 2017, Volume: 32, Issue:1

    Topics: Administration, Intravenous; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood L

2017
Topical Tranexamic Acid in Total Knee Arthroplasty Patients with Increased Thromboembolic Risk.
    The journal of knee surgery, 2017, Volume: 30, Issue:5

    Topics: Administration, Topical; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss,

2017
A comparative, retrospective study of peri-articular and intra-articular injection of tranexamic acid for the management of postoperative blood loss after total knee arthroplasty.
    BMC musculoskeletal disorders, 2016, 10-19, Volume: 17, Issue:1

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Transfusion; Drainage; Female;

2016
Use of tranexamic acid is a cost effective method in preventing blood loss during and after total knee replacement.
    Journal of orthopaedic surgery and research, 2011, May-21, Volume: 6

    Topics: Antifibrinolytic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgica

2011
Tranexamic acid reduces blood loss and financial cost in primary total hip and knee replacement surgery.
    Orthopaedics & traumatology, surgery & research : OTSR, 2012, Volume: 98, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Antifibrinolytic Agents; Arthroplasty, Replacement, Hip; Arthroplast

2012
Repeat-dose intravenous tranexamic acid further decreases blood loss in total knee arthroplasty.
    International orthopaedics, 2013, Volume: 37, Issue:3

    Topics: Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Blood Transfus

2013