Compounds > tranexamic acid
Page last updated: 2024-11-05

tranexamic acid and MODS

tranexamic acid has been researched along with MODS in 7 studies

Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.

Research Excerpts

ExcerptRelevanceReference
" The CRASH-2 trial aimed to determine the effect of the early administration of tranexamic acid on death and transfusion requirement in bleeding trauma patients."9.17The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. ( Balogun, E; Barnetson, L; Cairns, J; Coats, T; Cook, L; Guerriero, C; Hunt, B; Kawahara, T; Perel, P; Prieto-Merino, D; Ramos, M; Roberts, I; Shakur, H, 2013)
"Administration of TXA following traumatic injury was associated with MOF in the fibrinolysis shutdown and hyperfibrinolysis phenotypes and warrants continued evaluation."5.62Is Tranexamic Acid Associated With Mortality or Multiple Organ Failure Following Severe Injury? ( Betzold, RD; Chow, JH; Fedeles, BT; Grissom, TE; Koerner, K; Kozar, RA; Morrison, JJ; Renner, C; Richards, JE; Scalea, TM; Schlee, CS; Trinh, AT, 2021)
" The CRASH-2 trial aimed to determine the effect of the early administration of tranexamic acid on death and transfusion requirement in bleeding trauma patients."5.17The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. ( Balogun, E; Barnetson, L; Cairns, J; Coats, T; Cook, L; Guerriero, C; Hunt, B; Kawahara, T; Perel, P; Prieto-Merino, D; Ramos, M; Roberts, I; Shakur, H, 2013)
"Administration of TXA following traumatic injury was associated with MOF in the fibrinolysis shutdown and hyperfibrinolysis phenotypes and warrants continued evaluation."1.62Is Tranexamic Acid Associated With Mortality or Multiple Organ Failure Following Severe Injury? ( Betzold, RD; Chow, JH; Fedeles, BT; Grissom, TE; Koerner, K; Kozar, RA; Morrison, JJ; Renner, C; Richards, JE; Scalea, TM; Schlee, CS; Trinh, AT, 2021)
"MODS was compared between groups according to biomarker dynamics: persistently abnormal; abnormal to normal; and persistently normal."1.48Endotheliopathy of Trauma is an on-Scene Phenomenon, and is Associated with Multiple Organ Dysfunction Syndrome: A Prospective Observational Study. ( Belli, A; Bishop, J; Davies, DJ; Harrison, P; Hazeldine, J; Lord, JM; Midwinter, MJ; Naumann, DN, 2018)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19901 (14.29)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (57.14)24.3611
2020's2 (28.57)2.80

Authors

AuthorsStudies
Richards, JE1
Fedeles, BT1
Chow, JH1
Morrison, JJ1
Renner, C1
Trinh, AT1
Schlee, CS1
Koerner, K1
Grissom, TE1
Betzold, RD1
Scalea, TM1
Kozar, RA1
Li, SR1
Guyette, F1
Brown, J1
Zenati, M1
Reitz, KM1
Eastridge, B1
Nirula, R1
Vercruysse, GA1
O'Keeffe, T1
Joseph, B1
Neal, MD1
Zuckerbraun, BS1
Sperry, JL1
Naumann, DN1
Hazeldine, J1
Davies, DJ1
Bishop, J1
Midwinter, MJ1
Belli, A1
Harrison, P1
Lord, JM1
Roberts, I1
Shakur, H1
Coats, T1
Hunt, B1
Balogun, E1
Barnetson, L1
Cook, L1
Kawahara, T1
Perel, P1
Prieto-Merino, D1
Ramos, M1
Cairns, J1
Guerriero, C1
Schwameis, M1
Thaler, J1
Schober, A1
Schörgenhofer, C1
Kulinna-Cosentini, C1
Laggner, A1
Röggla, M1
Jilma, B1
Annecke, T1
Geisenberger, T1
Kürzl, R1
Penning, R1
Heindl, B1
Houwing, RH1
Leguit, P1

Clinical Trials (6)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Post-Injury Platelet Biology: Mechanisms and Outcomes[NCT03682757]367 participants (Actual)Observational2018-09-20Completed
Tranexamic Acid for Blood Loss Minimization in Endoscopic Pituitary Surgery: A Double-Blind Randomized Controlled Trial[NCT04863339]Phase 20 participants (Actual)Interventional2022-03-31Withdrawn (stopped due to Challenges in recruitment)
Randomized Study on the Topical Application of Tranexamic Acid to Wound Bed for Hemostasis in the Setting Granulating Wounds Following Mohs Micrographic Surgery[NCT04541303]Early Phase 162 participants (Anticipated)Interventional2020-10-08Recruiting
The Immunomodulatory Effect of Antrifibrinolytic (Tranexamic Acid) in Total Knee Arthroplasty[NCT03795649]80 participants (Anticipated)Interventional2018-12-18Recruiting
A Large Randomised Placebo Controlled Trial Among Trauma Patients With, or at Risk of, Significant Haemorrhage, of the Effects of Antifibrinolytic Treatment on Death and Transfusion Requirement[NCT00375258]Phase 320,211 participants (Actual)Interventional2005-05-31Completed
Tranexamic Acid to Prevent Bleeding After Endoscopic Resection of Large Colorectal Polyps: A Pilot Project[NCT04559880]Phase 425 participants (Actual)Interventional2020-09-10Active, not recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for tranexamic acid and MODS

ArticleYear
Early Prehospital Tranexamic Acid Following Injury Is Associated With a 30-day Survival Benefit: A Secondary Analysis of a Randomized Clinical Trial.
    Annals of surgery, 2021, 09-01, Volume: 274, Issue:3

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Double-Blind Method; Emergency Medical Services;

2021
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013
The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients.
    Health technology assessment (Winchester, England), 2013, Volume: 17, Issue:10

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Confidence Intervals; Craniocerebral Trauma; Fema

2013

Other Studies

5 other studies available for tranexamic acid and MODS

ArticleYear
Is Tranexamic Acid Associated With Mortality or Multiple Organ Failure Following Severe Injury?
    Shock (Augusta, Ga.), 2021, 01-01, Volume: 55, Issue:1

    Topics: Adult; Antifibrinolytic Agents; Female; Humans; Injury Severity Score; Male; Middle Aged; Multiple O

2021
Endotheliopathy of Trauma is an on-Scene Phenomenon, and is Associated with Multiple Organ Dysfunction Syndrome: A Prospective Observational Study.
    Shock (Augusta, Ga.), 2018, Volume: 49, Issue:4

    Topics: Adult; Endothelium, Vascular; Female; Humans; Male; Middle Aged; Multiple Organ Failure; Prospective

2018
Tranexamic acid and fibrinogen restore clotting in vitro and in vivo in cardiac thrombus associated hyperfibrinolysis with overt bleedings.
    Thrombosis and haemostasis, 2014, Volume: 112, Issue:5

    Topics: Adenocarcinoma; Aged; Anemia; Antifibrinolytic Agents; Antineoplastic Combined Chemotherapy Protocol

2014
Algorithm-based coagulation management of catastrophic amniotic fluid embolism.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 2010, Volume: 21, Issue:1

    Topics: Acidosis; Adult; Algorithms; Blood Coagulation Factors; Blood Component Transfusion; Cardiovascular

2010
[Skin necrosis following administration of vasopressin].
    Nederlands tijdschrift voor geneeskunde, 1987, Nov-21, Volume: 131, Issue:47

    Topics: Aged; Female; Hemoptysis; Humans; Multiple Organ Failure; Necrosis; Skin; Tranexamic Acid; Vasopress

1987