tranexamic acid and Liver Dysfunction

tranexamic acid has been researched along with Liver Dysfunction in 5 studies

Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.

Research

Studies (5)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Trial Feasibility

Trial accrual (NCT02548910)
Timeframe: through study completion, an average of 2 years

Blood Product Transfusion Rates

(NCT02548910)
Timeframe: Will be measured in the operating room and in the first postoperative week

Change in Physiologic Parameters (Cardiac Index)

(NCT02548910)
Timeframe: Will be measured in the operating room

Changes in Physiologic Parameters (CVP)

(NCT02548910)
Timeframe: Will be measured in the operating room

Perioperative Morbidity (Dindo-Clavien Grade 3b of Higher) and Mortality

(NCT02548910)
Timeframe: Postoperative setting up to 30 days following surgery

Total Intraoperative Blood Loss, by Measurement of Change in Hemoglobin Levels

Intraoperative blood loss is notoriously difficult to measure. It is suggested that calculation of blood loss using preoperative and postoperative hemoglobin levels in most consistently accurate. In order to minimize the risk of bias associated with any one method of intraoperative measurement of blood loss, three methods will be used independently. In the operating room, all blood and fluid aspirated from the abdomen will be measured accurately using graduated suction containers. As well, the amount of irrigation fluid will be carefully monitored and recorded. Finally, the weight of all surgical sponges will be measured. This information will be used by the surgeon and anesthesiologist to independently visually estimate blood loss, as is commonly done in clinical practice. In parallel, intraoperative blood loss will also be calculated based on an equation. (NCT02548910)
Timeframe: 1 week prior to surgery (hemoglobin level), and day two of post-op (hemoglobin again).

Other Studies

5 other studies available for tranexamic acid and Liver Dysfunction