tranexamic acid has been researched along with Injuries, Multiple in 18 studies
Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the mechanism of action of tranexamic acid (TXA) in bleeding trauma patients, we examined the timing of its effect on mortality." | 9.19 | Mechanism of action of tranexamic acid in bleeding trauma patients: an exploratory analysis of data from the CRASH-2 trial. ( Manno, D; Prieto-Merino, D; Roberts, I, 2014) |
| " Tranexamic Acid (TXA) is used as an anti-fibrinolytic agent to reduce surgical bleeding if administered prior to or during surgery, and to improve survival in trauma if given early after trauma." | 7.91 | Effect of tranexamic acid administration on acute traumatic coagulopathy in rats with polytrauma and hemorrhage. ( Benov, A; Cap, AP; Darlington, DN; Keesee, JD; Liu, B; Wu, X, 2019) |
| "Sprague-Dawley rats were subjected to polytrauma (laparotomy, and trauma to intestines, liver, right leg skeletal muscle, and right femur fracture), then bled 40% of their blood volume." | 5.46 | Tranexamic Acid Attenuates The Loss of Lung Barrier Function in a Rat Model of Polytrauma And Hemorrhage With Resuscitation. ( Cap, AP; Darlington, DN; Dubick, MA; Schwacha, MG; Wu, X, 2017) |
| "To investigate the mechanism of action of tranexamic acid (TXA) in bleeding trauma patients, we examined the timing of its effect on mortality." | 5.19 | Mechanism of action of tranexamic acid in bleeding trauma patients: an exploratory analysis of data from the CRASH-2 trial. ( Manno, D; Prieto-Merino, D; Roberts, I, 2014) |
| " There have been many changes in the management of massive hemorrhage, for example, the administration of the tranexamic acid and the use of balanced transfusion ratio." | 4.93 | [Management of bleeding and coagulopathy following major trauma]. ( Etxaniz, A; Pita, E, 2016) |
| " One such protocol governs the use of tranexamic acid (TXA), which is used to control bleeding." | 4.89 | Tranexamic acid in patients with major injuries and blood loss. ( Livingstone, C, 2013) |
| "Several studies have demonstrated the clinical utility of tranexamic acid (TXA) for use in trauma patients presenting with significant hemorrhage." | 4.31 | EFFECTS OF TRANEXAMIC ACID ON NEUROPATHOLOGY, ELECTROENCEPHALOGRAPHY, AND CEREBRAL FIBRIN DEPOSITION IN A RAT MODEL OF POLYTRAUMA WITH CONCOMITANT PENETRATING TRAUMATIC BRAIN INJURY. ( Bailey, ZS; Cao, Y; Cardiff, K; Gilsdorf, J; Houchins, M; Lu, XC; Scultetus, A; Shear, D; Wang, P; Yang, X, 2023) |
| "Tranexamic acid (TXA) has shown to be beneficial in selected patients with hemorrhagic shock." | 4.12 | The effect of prehospital tranexamic acid on outcome in polytrauma patients with associated severe brain injury. ( Jochems, D; Leenen, LPH; van Wessem, KJP, 2022) |
| " Tranexamic Acid (TXA) is used as an anti-fibrinolytic agent to reduce surgical bleeding if administered prior to or during surgery, and to improve survival in trauma if given early after trauma." | 3.91 | Effect of tranexamic acid administration on acute traumatic coagulopathy in rats with polytrauma and hemorrhage. ( Benov, A; Cap, AP; Darlington, DN; Keesee, JD; Liu, B; Wu, X, 2019) |
| "Tranexamic acid (TXA) was administered in 164 patients (23%) and tourniquets were used in 575 (80%)." | 1.46 | Patients with multiple traumatic amputations: An analysis of operation enduring freedom joint theatre trauma registry data. ( Chestovich, PJ; Godfrey, BW; Ingalls, NK; Lee, GH; Martin, A; Saldanha, V, 2017) |
| "Sprague-Dawley rats were subjected to polytrauma (laparotomy, and trauma to intestines, liver, right leg skeletal muscle, and right femur fracture), then bled 40% of their blood volume." | 1.46 | Tranexamic Acid Attenuates The Loss of Lung Barrier Function in a Rat Model of Polytrauma And Hemorrhage With Resuscitation. ( Cap, AP; Darlington, DN; Dubick, MA; Schwacha, MG; Wu, X, 2017) |
| "Massive hemorrhage is the leading cause of death in the first few hours following multiple trauma, therefore, early and aggressive treatment of clotting disorders and surgical intervention to stop the bleeding are of utmost importance." | 1.38 | [Coagulation management of trauma patients with unstabile circulation : establishment of a hemoglobin-oriented standard operating procedure]. ( Hilbert, P; Hofmann, GO; Jakubetz, J; Stuttmann, R; Teichmann, J; zur Nieden, K, 2012) |
| "We report the case of a patient with multiple trauma who developed pronounced anaphylactic shock, and was successfully treated with 1000 mg tranexamic acid intravenously (Exacyl)." | 1.28 | Tranexamic acid in the treatment of anaphylactic shock. ( Hoste, S; Stevens, E; Van Aken, H, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 13 (72.22) | 24.3611 |
| 2020's | 4 (22.22) | 2.80 |
| Authors | Studies |
|---|---|
| van Wessem, KJP | 1 |
| Jochems, D | 1 |
| Leenen, LPH | 1 |
| Bailey, ZS | 1 |
| Yang, X | 1 |
| Cardiff, K | 1 |
| Wang, P | 1 |
| Houchins, M | 1 |
| Lu, XC | 1 |
| Cao, Y | 1 |
| Gilsdorf, J | 1 |
| Scultetus, A | 1 |
| Shear, D | 1 |
| Wu, X | 2 |
| Benov, A | 1 |
| Darlington, DN | 2 |
| Keesee, JD | 1 |
| Liu, B | 1 |
| Cap, AP | 2 |
| Brenner, A | 1 |
| Belli, A | 1 |
| Chaudhri, R | 1 |
| Coats, T | 1 |
| Frimley, L | 1 |
| Jamaluddin, SF | 1 |
| Jooma, R | 1 |
| Mansukhani, R | 1 |
| Sandercock, P | 1 |
| Shakur-Still, H | 1 |
| Shokunbi, T | 1 |
| Roberts, I | 3 |
| King, KL | 1 |
| Balogh, ZJ | 1 |
| David, JS | 1 |
| Godier, A | 1 |
| Dargaud, Y | 1 |
| Inaba, K | 1 |
| Livingstone, C | 1 |
| Mitra, B | 1 |
| Mazur, S | 1 |
| Cameron, PA | 1 |
| Bernard, S | 1 |
| Burns, B | 1 |
| Smith, A | 1 |
| Rashford, S | 1 |
| Fitzgerald, M | 1 |
| Smith, K | 1 |
| Gruen, RL | 1 |
| Prieto-Merino, D | 1 |
| Manno, D | 1 |
| Honickel, M | 1 |
| Treutler, S | 1 |
| van Ryn, J | 1 |
| Tillmann, S | 1 |
| Rossaint, R | 1 |
| Grottke, O | 1 |
| Etxaniz, A | 1 |
| Pita, E | 1 |
| Panteli, M | 1 |
| Pountos, I | 1 |
| Giannoudis, PV | 1 |
| Godfrey, BW | 1 |
| Martin, A | 1 |
| Chestovich, PJ | 1 |
| Lee, GH | 1 |
| Ingalls, NK | 1 |
| Saldanha, V | 1 |
| Dubick, MA | 1 |
| Schwacha, MG | 1 |
| Kunze-Szikszay, N | 1 |
| Krack, LA | 1 |
| Wildenauer, P | 1 |
| Wand, S | 1 |
| Heyne, T | 1 |
| Walliser, K | 1 |
| Spering, C | 1 |
| Bauer, M | 1 |
| Quintel, M | 1 |
| Roessler, M | 1 |
| Hilbert, P | 1 |
| Hofmann, GO | 1 |
| zur Nieden, K | 1 |
| Teichmann, J | 1 |
| Jakubetz, J | 1 |
| Stuttmann, R | 1 |
| Hoste, S | 1 |
| Van Aken, H | 1 |
| Stevens, E | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Tranexamic Acid for the Treatment of Significant Traumatic Brain Injury: an International Randomised, Double Blind Placebo Controlled Trial[NCT01402882] | Phase 3 | 12,737 participants (Actual) | Interventional | 2012-07-31 | Completed | ||
| Single Centre Randomised Controlled Trial to Assess the Effect of the Addition of Twenty-four Hours of Oral Tranexamic Acid Post-operatively to a Single Intra-operative Intravenous Dose of Tranexamic Acid on Calculated Blood Loss Following Primary Hip and[NCT03690037] | Phase 4 | 1,089 participants (Actual) | Interventional | 2016-07-07 | Completed | ||
| A Multi-centre Randomised, Double-blinded, Placebo-controlled Trial of Pre-hospital Treatment With Tranexamic Acid for Severely Injured Patients at Risk of Acute Traumatic Coagulopathy.[NCT02187120] | Phase 3 | 1,310 participants (Actual) | Interventional | 2014-07-28 | Completed | ||
| A Large Randomised Placebo Controlled Trial Among Trauma Patients With, or at Risk of, Significant Haemorrhage, of the Effects of Antifibrinolytic Treatment on Death and Transfusion Requirement[NCT00375258] | Phase 3 | 20,211 participants (Actual) | Interventional | 2005-05-31 | Completed | ||
| [NCT01938768] | 110 participants (Actual) | Observational | 2013-11-30 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for tranexamic acid and Injuries, Multiple
| Article | Year |
|---|---|
Tranexamic acid in patients with major injuries and blood loss.
Topics: Antifibrinolytic Agents; Hemorrhage; Humans; Multiple Trauma; Time Factors; Tranexamic Acid; United | 2013 |
[Management of bleeding and coagulopathy following major trauma].
Topics: Blood Coagulation Disorders; Hemorrhage; Humans; Multiple Trauma; Tranexamic Acid; Transfusion React | 2016 |
Pharmacological adjuncts to stop bleeding: options and effectiveness.
Topics: Acidosis; Antifibrinolytic Agents; Blood Coagulation Disorders; Blood Coagulation Tests; Blood Trans | 2016 |
2 trials available for tranexamic acid and Injuries, Multiple
| Article | Year |
|---|---|
Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial.
Topics: Antifibrinolytic Agents; Brain Injuries; Humans; Multiple Trauma; Neuroprotective Agents; Protective | 2020 |
Mechanism of action of tranexamic acid in bleeding trauma patients: an exploratory analysis of data from the CRASH-2 trial.
Topics: Antifibrinolytic Agents; Cause of Death; Exsanguination; Female; Hemorrhage; Humans; Male; Mortality | 2014 |
13 other studies available for tranexamic acid and Injuries, Multiple
| Article | Year |
|---|---|
The effect of prehospital tranexamic acid on outcome in polytrauma patients with associated severe brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Female; Humans; Male; Middle Age | 2022 |
EFFECTS OF TRANEXAMIC ACID ON NEUROPATHOLOGY, ELECTROENCEPHALOGRAPHY, AND CEREBRAL FIBRIN DEPOSITION IN A RAT MODEL OF POLYTRAUMA WITH CONCOMITANT PENETRATING TRAUMATIC BRAIN INJURY.
Topics: Animals; Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Electroencephalography; | 2023 |
Effect of tranexamic acid administration on acute traumatic coagulopathy in rats with polytrauma and hemorrhage.
Topics: Animals; Antifibrinolytic Agents; Biomarkers; Blood Coagulation; Blood Coagulation Disorders; Diseas | 2019 |
Invited Commentary: A Decade Older Polytrauma Patients Do As Well Without As the Younger Ones with Tranexamic Acid.
Topics: Humans; Multiple Trauma; Tranexamic Acid | 2021 |
Case scenario: management of trauma-induced coagulopathy in a severe blunt trauma patient.
Topics: Accidents, Traffic; Adult; Anticoagulants; Antifibrinolytic Agents; Blood Coagulation Disorders; Ear | 2013 |
Tranexamic acid for trauma: filling the 'GAP' in evidence.
Topics: Antifibrinolytic Agents; Evidence-Based Medicine; Hemorrhage; Humans; Multiple Trauma; Resuscitation | 2014 |
Tranexamic acid for trauma: filling the 'GAP' in evidence.
Topics: Antifibrinolytic Agents; Evidence-Based Medicine; Hemorrhage; Humans; Multiple Trauma; Resuscitation | 2014 |
Tranexamic acid for trauma: filling the 'GAP' in evidence.
Topics: Antifibrinolytic Agents; Evidence-Based Medicine; Hemorrhage; Humans; Multiple Trauma; Resuscitation | 2014 |
Tranexamic acid for trauma: filling the 'GAP' in evidence.
Topics: Antifibrinolytic Agents; Evidence-Based Medicine; Hemorrhage; Humans; Multiple Trauma; Resuscitation | 2014 |
Reversal of dabigatran anticoagulation ex vivo: Porcine study comparing prothrombin complex concentrates and idarucizumab.
Topics: Administration, Oral; Animals; Antibodies, Monoclonal, Humanized; Antifibrinolytic Agents; Antithrom | 2015 |
Patients with multiple traumatic amputations: An analysis of operation enduring freedom joint theatre trauma registry data.
Topics: Adult; Afghan Campaign 2001-; Amputation, Traumatic; Antifibrinolytic Agents; Blast Injuries; Blood | 2017 |
Tranexamic Acid Attenuates The Loss of Lung Barrier Function in a Rat Model of Polytrauma And Hemorrhage With Resuscitation.
Topics: Acute Lung Injury; Animals; Disease Models, Animal; Hemorrhage; Lung; Male; Multiple Trauma; Rats; R | 2017 |
The pre-hospital administration of tranexamic acid to patients with multiple injuries and its effects on rotational thrombelastometry: a prospective observational study in pre-hospital emergency medicine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antifibrinolytic Agents; Blood Coagulation; Dose-Respons | 2016 |
Tranexamic acid--a recipe for saving lives in traumatic bleeding.
Topics: Antifibrinolytic Agents; Hemorrhage; Humans; Multiple Trauma; Randomized Controlled Trials as Topic; | 2011 |
[Coagulation management of trauma patients with unstabile circulation : establishment of a hemoglobin-oriented standard operating procedure].
Topics: Aged; Algorithms; Anticoagulants; Blood Coagulation Tests; Critical Care; Crystalloid Solutions; Dea | 2012 |
Tranexamic acid in the treatment of anaphylactic shock.
Topics: Adult; Anaphylaxis; Fluid Therapy; Humans; Male; Multiple Trauma; Tranexamic Acid | 1991 |