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tranexamic acid and Hemorrhage, Uterine

tranexamic acid has been researched along with Hemorrhage, Uterine in 33 studies

Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.

Research Excerpts

ExcerptRelevanceReference
"Although intravascular thrombi and infarct-type necrosis have been reported in leiomyomas following tranexamic acid therapy, intratumoral vasculopathy resembling acute atherosis has not been reported to date in patients without exposure to gonadotropin receptor agonist."7.85Intratumoral Vasculopathy in Leiomyoma Treated With Tranexamic Acid. ( Krigman, HR; Kudose, S, 2017)
"This study investigated the efficacy of GnRH agonists concomitantly with transient aromatase inhibitor and tranexamic acid to treat women with uterine arteriovenous malformations (AVMs) associated with abnormal uterine bleeding (AUB) to preserve fertility and determine reproductive outcome."3.91Resolution of Uterine Arteriovenous Malformation and Maintenance of Reproduction in 20 Women Treated with a GnRH Agonist Concomitantly with an Aromatase Inhibitor and Tranexamic Acid. ( Abu-Rafea, B; Machado, M; Oraif, A; Vilos, AG; Vilos, GA, 2019)
"Although intravascular thrombi and infarct-type necrosis have been reported in leiomyomas following tranexamic acid therapy, intratumoral vasculopathy resembling acute atherosis has not been reported to date in patients without exposure to gonadotropin receptor agonist."3.85Intratumoral Vasculopathy in Leiomyoma Treated With Tranexamic Acid. ( Krigman, HR; Kudose, S, 2017)
" A rapid recourse to prostaglandins (sulprostone in France) may reverse uterine atony."3.83Major obstetric hemorrhage. ( Le Gouez, A; Mercier, FJ, 2016)
" We present a case of postmenopausal bleeding, because of chronic DIC, which resulted from aortic aneurysm and was managed with replacement blood products and tranexamic acid."3.72Postmenopausal bleeding due to chronic DIC. ( Bollapragada, SS; Garg, M; McFarlane, T, 2004)
"Tranexamic acid is a synthetic lysine derivative with antifibrinolytic activity used in other surgical disciplines to reduce blood loss during surgery."2.94Intraoperative tranexamic acid to decrease blood loss during myomectomy: a randomized, double-blind, placebo-controlled trial. ( Maasen, MS; Marfori, CQ; Moawad, G; Opoku-Anane, J; Robinson, JK; Vargas, MV, 2020)
"Uterine fibroids are the commonest tumour of the female genital tract; about one third are symptomatic and require management."2.90Adjunctive use of tranexamic acid to tourniquet in reducing haemorrhage during abdominal myomectomy - A randomized controlled trial. ( Abdul, IF; Adesina, KT; Amadu, MB; Olarinoye, AO; Omokanye, LO, 2019)
"Tranexamic acid was more effective than placebo in short-term treatment of irregular uterine bleeding/spotting associated with DMPA use."2.74The effect of tranexamic acid for treatment irregular uterine bleeding secondary to DMPA use. ( Senthong, AJ; Taneepanichskul, S, 2009)
"Women with advanced cancer of the cervix often need palliation for distressing symptoms, such as vaginal bleeding."2.61Palliative interventions for controlling vaginal bleeding in advanced cervical cancer. ( Eke, AC; Eleje, GU; Eleje, LI; Igberase, GO; Igwegbe, AO, 2019)
"The most common form of BDs is von Willebrand Disease, reflecting 13% of adolescents with AUB."2.58Abnormal Uterine Bleeding including coagulopathies and other menstrual disorders. ( Deligeoroglou, E; Karountzos, V, 2018)
"Abnormal uterine bleeding is one of the most common reasons for outpatient gynecologic visits."2.58Abnormal Uterine Bleeding: Treatment Options. ( Oberman, E; Rodriguez-Triana, V, 2018)
" The effectiveness of treatment methods and the optimal dosage of misoprostol are research priorities."2.53Preventing deaths due to haemorrhage. ( Hofmeyr, GJ; Qureshi, Z, 2016)
"Women with advanced cancer of the cervix often need palliation for distressing symptoms, such as vaginal bleeding."2.52Palliative interventions for controlling vaginal bleeding in advanced cervical cancer. ( Eke, AC; Eleje, GU; Eleje, LI; Igberase, GO; Igwegbe, AO, 2015)
"Dysfunctional uterine bleeding is defined as heavy menstrual uterine bleeding not due to any recognisable cause and is therefore a diagnosis of exclusion."2.42Dysfunctional uterine bleeding. ( Farrell, E, 2004)
"Abnormal uterine bleeding is a common gynaecological problem that traditionally has been treated with hysterectomy."2.41Alternatives to hysterectomy for the treatment of excessive uterine bleeding. ( Liu, J; Robins, JC, 2000)
"Uterine leiomyomas (fibroids) are the most common solid and symptomatic neoplasm in women."1.62Management of Symptomatic Uterine Leiomyomas: ACOG Practice Bulletin, Number 228. ( , 2021)
"Cervical cancer is the commonest cancer affecting women in Malawi, which has the highest rate of this disease in the world."1.42A review of patients with advanced cervical cancer presenting to palliative care services at Queen Elizabeth Central Hospital in Blantyre, Malawi. ( Bates, MJ; Mijoya, A, 2015)
"Severe vaginal bleeding can be the result of cervical arteriovenous malformation, and GnRH agonist may be used for treatment."1.32A life-threatening event: uterine cervical arteriovenous malformation. ( Amit, A; Deutsch, M; Kerner, H; Lowenstein, L; Solt, I, 2004)

Research

Studies (33)

TimeframeStudies, this research(%)All Research%
pre-19905 (15.15)18.7374
1990's1 (3.03)18.2507
2000's9 (27.27)29.6817
2010's16 (48.48)24.3611
2020's2 (6.06)2.80

Authors

AuthorsStudies
Abdul, IF1
Amadu, MB1
Adesina, KT1
Olarinoye, AO1
Omokanye, LO1
Opoku-Anane, J1
Vargas, MV1
Marfori, CQ1
Moawad, G1
Maasen, MS1
Robinson, JK1
Deligeoroglou, E1
Karountzos, V1
Oberman, E1
Rodriguez-Triana, V1
Vilos, AG1
Oraif, A1
Machado, M1
Abu-Rafea, B1
Vilos, GA1
Eleje, GU2
Eke, AC2
Igberase, GO2
Igwegbe, AO2
Eleje, LI2
Bistervels, IM1
Scheres, LJJ1
Hamulyák, EN1
Middeldorp, S1
Friedlander, E1
Kaneshiro, B1
Bates, MJ1
Mijoya, A1
Hofmeyr, GJ1
Qureshi, Z1
Le Gouez, A1
Mercier, FJ1
Kudose, S1
Krigman, HR1
Wiseman, DM1
Meidler, R1
Lyahovetsky, Y1
Kurman, E1
Horn, S1
Nur, I1
Sekhavat, L1
Tabatabaii, A1
Dalili, M1
Farajkhoda, T1
Tafti, AD1
Senthong, AJ1
Taneepanichskul, S1
Boama, V1
Haynes, S1
Movafegh, A1
Eslamian, L1
Dorabadi, A1
Martín-Salces, M1
Jiménez-Yuste, V1
Álvarez-Román, MT1
Rivas-Pollmar, I1
Rodríguez de la Rúa, A1
Sajdak, S1
Moszynski, R1
Opala, T1
Huang, Z1
Fang, A1
Dai, Z1
Bollapragada, SS1
Garg, M1
McFarlane, T1
Lowenstein, L1
Solt, I1
Deutsch, M1
Kerner, H1
Amit, A1
Farrell, E1
Fernandez, H1
Gervaise, A1
Lundvall, F1
Nielsen, NC1
Agnelli, G1
Gresele, P1
De Cunto, M1
Gallai, V1
Nenci, GG1
Valsecchi, A2
Robins, JC1
Liu, J1
Nilsson, IM1
Cappelletti, M1
Sapire, KE1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Effect of Intravenous Tranexamic Acid Plus Intramyometrial Desmopressin on Blood Loss During Laparoscopic Myomectomy: Randomized, Double-blind, Placebo-controlled Trial[NCT05517590]100 participants (Anticipated)Interventional2022-09-01Recruiting
Comparative Study For Role Of Different Prophylactic Doses Of Intravenous Tranexamic Acid In Reducing Blood Loss At Caesarean Section: A Randomised Controlled Trial[NCT02739815]Phase 4200 participants (Actual)Interventional2016-04-30Completed
Tranexamic Acid Versus Novel Uterine Cooling Technique in Reducing Blood Loss and Incidence of Postpartum Hemorrhage at Caesarean Section[NCT02780245]Phase 4100 participants (Actual)Interventional2016-06-30Completed
A Novel Technique Of Uterine Cooling During Repeated Cesarean Section For Reducing Blood Loss[NCT03793153]99 participants (Actual)Interventional2018-12-19Completed
Efficacy in Controlling Bleeding Post-coronary Bypass Surgery Using Combination of Local Application of Tranexamic Acid and Intravenous Tranexamic Compared to Intravenous Tranexamic Acid Alone. A Randomized Controlled Trial[NCT01600599]40 participants (Actual)Interventional2011-01-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

11 reviews available for tranexamic acid and Hemorrhage, Uterine

ArticleYear
Abnormal Uterine Bleeding including coagulopathies and other menstrual disorders.
    Best practice & research. Clinical obstetrics & gynaecology, 2018, Volume: 48

    Topics: Adolescent; Antifibrinolytic Agents; Contraceptives, Oral, Combined; Female; Humans; Menorrhagia; Me

2018
Abnormal Uterine Bleeding: Treatment Options.
    Clinical obstetrics and gynecology, 2018, Volume: 61, Issue:1

    Topics: Antifibrinolytic Agents; Contraceptives, Oral; Female; Gynecologic Surgical Procedures; Gynecologica

2018
Palliative interventions for controlling vaginal bleeding in advanced cervical cancer.
    The Cochrane database of systematic reviews, 2019, 03-19, Volume: 3

    Topics: Antifibrinolytic Agents; Female; Humans; Palliative Care; Tampons, Surgical; Tranexamic Acid; Uterin

2019
Sex matters: Practice 5P's when treating young women with venous thromboembolism.
    Journal of thrombosis and haemostasis : JTH, 2019, Volume: 17, Issue:9

    Topics: Adult; Anticoagulants; Contraceptives, Oral, Combined; Disease Susceptibility; Female; Heparin, Low-

2019
Palliative interventions for controlling vaginal bleeding in advanced cervical cancer.
    The Cochrane database of systematic reviews, 2015, May-01, Issue:5

    Topics: Antifibrinolytic Agents; Female; Humans; Palliative Care; Tampons, Surgical; Tranexamic Acid; Uterin

2015
Therapeutic Options for Unscheduled Bleeding Associated with Long-Acting Reversible Contraception.
    Obstetrics and gynecology clinics of North America, 2015, Volume: 42, Issue:4

    Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antifibrinolytic Agents; Contraception; Doxycycline;

2015
Preventing deaths due to haemorrhage.
    Best practice & research. Clinical obstetrics & gynaecology, 2016, Volume: 36

    Topics: Abruptio Placentae; Antifibrinolytic Agents; Blood Transfusion; Cesarean Section; Crystalloid Soluti

2016
Dysfunctional uterine bleeding.
    Australian family physician, 2004, Volume: 33, Issue:11

    Topics: Antifibrinolytic Agents; Diagnosis, Differential; Female; Gynecologic Surgical Procedures; Humans; I

2004
[Dysfunctionnal uterin bleedings].
    Journal de gynecologie, obstetrique et biologie de la reproduction, 2007, Volume: 36, Issue:6

    Topics: Endometrium; Female; Humans; Hysteroscopy; Levonorgestrel; Pregnancy; Premenopause; Tranexamic Acid;

2007
Alternatives to hysterectomy for the treatment of excessive uterine bleeding.
    International journal of clinical practice, 2000, Volume: 54, Issue:4

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antifibrinolytic Agents; Catheter Ablation; Contraceptives,

2000
Local fibrinolysis as a mechanism for haemorrhage.
    Thrombosis et diathesis haemorrhagica, 1975, Dec-15, Volume: 34, Issue:3

    Topics: Aminocaproates; Endometrium; Epistaxis; Female; Fibrinolysis; Gastric Juice; Gastrointestinal Hemorr

1975

Trials

7 trials available for tranexamic acid and Hemorrhage, Uterine

ArticleYear
Adjunctive use of tranexamic acid to tourniquet in reducing haemorrhage during abdominal myomectomy - A randomized controlled trial.
    European journal of obstetrics, gynecology, and reproductive biology, 2019, Volume: 242

    Topics: Adult; Antifibrinolytic Agents; Blood Loss, Surgical; Double-Blind Method; Female; Humans; Leiomyoma

2019
Intraoperative tranexamic acid to decrease blood loss during myomectomy: a randomized, double-blind, placebo-controlled trial.
    American journal of obstetrics and gynecology, 2020, Volume: 223, Issue:3

    Topics: Adult; Antifibrinolytic Agents; Blood Loss, Surgical; Double-Blind Method; Female; Humans; Injection

2020
Efficacy of tranexamic acid in reducing blood loss after cesarean section.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2009, Volume: 22, Issue:1

    Topics: Adult; Antifibrinolytic Agents; Cesarean Section; Female; Humans; Monitoring, Physiologic; Placebos;

2009
Efficacy of tranexamic acid in reducing blood loss after cesarean section.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2009, Volume: 22, Issue:1

    Topics: Adult; Antifibrinolytic Agents; Cesarean Section; Female; Humans; Monitoring, Physiologic; Placebos;

2009
Efficacy of tranexamic acid in reducing blood loss after cesarean section.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2009, Volume: 22, Issue:1

    Topics: Adult; Antifibrinolytic Agents; Cesarean Section; Female; Humans; Monitoring, Physiologic; Placebos;

2009
Efficacy of tranexamic acid in reducing blood loss after cesarean section.
    The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians, 2009, Volume: 22, Issue:1

    Topics: Adult; Antifibrinolytic Agents; Cesarean Section; Female; Humans; Monitoring, Physiologic; Placebos;

2009
The effect of tranexamic acid for treatment irregular uterine bleeding secondary to DMPA use.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 2009, Volume: 92, Issue:4

    Topics: Adult; Antifibrinolytic Agents; Contraceptive Agents, Female; Double-Blind Method; Endometrium; Fema

2009
Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2011, Volume: 115, Issue:3

    Topics: Adult; Antifibrinolytic Agents; Blood Loss, Surgical; Cesarean Section; Double-Blind Method; Female;

2011
Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2011, Volume: 115, Issue:3

    Topics: Adult; Antifibrinolytic Agents; Blood Loss, Surgical; Cesarean Section; Double-Blind Method; Female;

2011
Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2011, Volume: 115, Issue:3

    Topics: Adult; Antifibrinolytic Agents; Blood Loss, Surgical; Cesarean Section; Double-Blind Method; Female;

2011
Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2011, Volume: 115, Issue:3

    Topics: Adult; Antifibrinolytic Agents; Blood Loss, Surgical; Cesarean Section; Double-Blind Method; Female;

2011
Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2011, Volume: 115, Issue:3

    Topics: Adult; Antifibrinolytic Agents; Blood Loss, Surgical; Cesarean Section; Double-Blind Method; Female;

2011
Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2011, Volume: 115, Issue:3

    Topics: Adult; Antifibrinolytic Agents; Blood Loss, Surgical; Cesarean Section; Double-Blind Method; Female;

2011
Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2011, Volume: 115, Issue:3

    Topics: Adult; Antifibrinolytic Agents; Blood Loss, Surgical; Cesarean Section; Double-Blind Method; Female;

2011
Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2011, Volume: 115, Issue:3

    Topics: Adult; Antifibrinolytic Agents; Blood Loss, Surgical; Cesarean Section; Double-Blind Method; Female;

2011
Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2011, Volume: 115, Issue:3

    Topics: Adult; Antifibrinolytic Agents; Blood Loss, Surgical; Cesarean Section; Double-Blind Method; Female;

2011
The hemostatic effect of tranexamic acid in conisatio colli uteri.
    Acta obstetricia et gynecologica Scandinavica, 1984, Volume: 63, Issue:1

    Topics: Adult; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Dilatation and Curettage; Double-Blind

1984
A study of bleeding patterns with two injectable contraceptives given postpartum and the effect of two non-hormonal treatments.
    Advances in contraception : the official journal of the Society for the Advancement of Contraception, 1991, Volume: 7, Issue:4

    Topics: Contraceptive Agents, Female; Double-Blind Method; Female; Humans; Injections; Medroxyprogesterone;

1991

Other Studies

15 other studies available for tranexamic acid and Hemorrhage, Uterine

ArticleYear
Management of Symptomatic Uterine Leiomyomas: ACOG Practice Bulletin, Number 228.
    Obstetrics and gynecology, 2021, Jun-01, Volume: 137, Issue:6

    Topics: Antifibrinolytic Agents; Contraceptive Agents, Hormonal; Endometrial Ablation Techniques; Ethinyl Es

2021
Resolution of Uterine Arteriovenous Malformation and Maintenance of Reproduction in 20 Women Treated with a GnRH Agonist Concomitantly with an Aromatase Inhibitor and Tranexamic Acid.
    Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC, 2019, Volume: 41, Issue:6

    Topics: Abortion, Spontaneous; Adult; Antifibrinolytic Agents; Aromatase Inhibitors; Arteriovenous Fistula;

2019
A review of patients with advanced cervical cancer presenting to palliative care services at Queen Elizabeth Central Hospital in Blantyre, Malawi.
    Malawi medical journal : the journal of Medical Association of Malawi, 2015, Volume: 27, Issue:3

    Topics: Adult; Age Distribution; Anti-HIV Agents; Antifibrinolytic Agents; Female; HIV Infections; Humans; M

2015
Major obstetric hemorrhage.
    Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine, 2016, Volume: 23, Issue:4

    Topics: Blood Component Transfusion; Combined Modality Therapy; Dinoprostone; Factor VIIa; Female; Fibrinoge

2016
Intratumoral Vasculopathy in Leiomyoma Treated With Tranexamic Acid.
    International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 2017, Volume: 36, Issue:4

    Topics: Female; Humans; Hysterectomy; Leiomyoma; Menorrhagia; Middle Aged; Necrosis; Telangiectasia, Heredit

2017
Evaluation of a fibrin preparation containing tranexamic acid (Adhexil) in a rabbit uterine horn model of adhesions with and without bleeding and in a model with two surgical loci.
    Fertility and sterility, 2010, Mar-01, Volume: 93, Issue:4

    Topics: Animals; Disease Models, Animal; Drug Combinations; Drug Evaluation, Preclinical; Female; Fibrin; He

2010
Conservative management of a haemorrhagic adnexal cyst in a patient with Type 3 von Willebrand Disease.
    European journal of obstetrics, gynecology, and reproductive biology, 2011, Volume: 159, Issue:1

    Topics: Abdominal Pain; Adult; Antifibrinolytic Agents; Blood Component Transfusion; Coagulants; Factor VIII

2011
Management of delivery with FVIII/VWF concentrates in a pregnant woman with type 3 von Willebrand disease and alloantibodies.
    Thrombosis and haemostasis, 2012, Volume: 108, Issue:4

    Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Cesarean Section; Factor VIII; Female; Humans; In

2012
Bleeding from endometrial and vaginal malignant tumors treated with activated recombinant factor VII.
    European journal of gynaecological oncology, 2002, Volume: 23, Issue:4

    Topics: Adenocarcinoma; Administration, Intravaginal; Adult; Aged; Endometrial Neoplasms; Ethamsylate; Facto

2002
Decreasing bleeding effect of transamin on the induced abortion.
    Zhonghua fu chan ke za zhi, 2002, Volume: 37, Issue:7

    Topics: Abortion, Induced; Female; Humans; Pregnancy; Tranexamic Acid; Uterine Hemorrhage

2002
Postmenopausal bleeding due to chronic DIC.
    European journal of obstetrics, gynecology, and reproductive biology, 2004, Jan-15, Volume: 112, Issue:1

    Topics: Aged; Aortic Aneurysm; Blood Transfusion; Chronic Disease; Disseminated Intravascular Coagulation; F

2004
A life-threatening event: uterine cervical arteriovenous malformation.
    Obstetrics and gynecology, 2004, Volume: 103, Issue:5 Pt 2

    Topics: Adult; Antifibrinolytic Agents; Arteriovenous Malformations; Brachytherapy; Cervix Uteri; Embolizati

2004
Tranexamic acid, intrauterine contraceptive devices and fatal cerebral arterial thrombosis. Case report.
    British journal of obstetrics and gynaecology, 1982, Volume: 89, Issue:8

    Topics: Adult; Carotid Artery Thrombosis; Carotid Artery, Internal; Cyclohexanecarboxylic Acids; Female; Hum

1982
[Further notes on the topical use of tranexamic acid in the treatment of gynecological hemorrhage].
    Minerva ginecologica, 1980, Volume: 32, Issue:9

    Topics: Adolescent; Adult; Aged; Cyclohexanecarboxylic Acids; Female; Hemorrhage; Humans; Metrorrhagia; Midd

1980
[Possibilities of the use of an inhibitor of hemolysis (AMCHA), by rectal and vaginal administration, for gynecological hemorrhages].
    Minerva ginecologica, 1975, Volume: 27, Issue:4

    Topics: Adolescent; Adult; Aged; Blood Coagulation Disorders; Child; Cyclohexanecarboxylic Acids; Female; He

1975