Page last updated: 2024-11-05

tranexamic acid and Hemorrhage, Peptic Ulcer

tranexamic acid has been researched along with Hemorrhage, Peptic Ulcer in 17 studies

Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.

Research Excerpts

ExcerptRelevanceReference
"We studied the effects of tranexamic acid (an antifibrinolytic agent) and cimetidine on acute upper-gastrointestinal-tract bleeding in a double-blind randomized placebo-controlled trial in 775 patients with hematemesis or melena or both."5.05Cimetidine and tranexamic acid in the treatment of acute upper-gastrointestinal-tract bleeding. ( Atkinson, M; Barer, D; Coggon, D; Dronfield, M; Ellis, S; French, S; Henry, D; Langman, M; Ogilvie, A, 1983)
"Practice is variable, even in areas with established evidence based on randomized controlled studies, such as dosage and way of administration and duration of PPI treatment, injection treatment used as monotherapy and the volume used, including ulcers with clots for treatment, and the use of scheduled second-look endoscopy."1.34Clinical practice and evidence in endoscopic treatment of bleeding peptic gastroduodenal ulcer. ( Adamsen, S; Bendix, J; Kallehave, F; Moesgaard, F; Nilsson, T; Wille-Jørgensen, P, 2007)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19909 (52.94)18.7374
1990's2 (11.76)18.2507
2000's4 (23.53)29.6817
2010's2 (11.76)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kovacs, TO1
Jensen, DM1
Greenspoon, J1
Barkun, A1
Bagnenko, SF1
Verbitskiĭ, VG1
Breckan, RK1
Wessel-Berg, AM1
Jorde, R1
Adamsen, S2
Bendix, J1
Kallehave, F1
Moesgaard, F1
Nilsson, T1
Wille-Jørgensen, P1
de Muckadell, OB1
Barer, D1
Ogilvie, A1
Henry, D1
Dronfield, M1
Coggon, D1
French, S1
Ellis, S1
Atkinson, M1
Langman, M2
Stenberg, B1
Karlsson, L1
Alpsten, M1
Risberg, B1
Katschinski, B1
Logan, R1
Davies, J1
Faulkner, G1
Pearson, J1
Biggs, JC1
Hugh, TB1
Dodds, AJ1
Stallemo, A1
Bang, C1
Børkje, B1
Hausken, T1
Pedersen, R1
Odegaard, S1
Berstad, A1
Petite, JP1
Bejanin, H1
Langman, MJ2
von Holstein, CC1
Eriksson, SB1
Källén, R1
Navab, F1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of High Dose Infusion and Low Dose Bolus Intravenous Omeprazole for Treatment of Bleeding Ulcer With Adherent Clot[NCT02536989]Phase 440 participants (Actual)Interventional2009-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

5 reviews available for tranexamic acid and Hemorrhage, Peptic Ulcer

ArticleYear
The short-term medical management of non-variceal upper gastrointestinal bleeding.
    Drugs, 2008, Volume: 68, Issue:15

    Topics: Animals; Gastrointestinal Hemorrhage; Histamine H2 Antagonists; Hormone Antagonists; Humans; Octreot

2008
The pharmacological therapy of non-variceal upper gastrointestinal bleeding.
    Gastroenterology clinics of North America, 2010, Volume: 39, Issue:3

    Topics: Acute Disease; Gastric Acid; Histamine H2 Antagonists; Humans; Peptic Ulcer Hemorrhage; Proton Pump

2010
[Treatment of bleeding gastroduodenal ulcer].
    Ugeskrift for laeger, 2007, Apr-23, Volume: 169, Issue:17

    Topics: Antacids; Antifibrinolytic Agents; Duodenal Ulcer; Duodenoscopy; Embolization, Therapeutic; Epinephr

2007
[Endoscopic hemostasis in hemorrhagic peptic ulcer. A review and pilot study of local thrombin injection combined with systemic fibrinolysis inhibition (with tranexamic acid)].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 1990, Feb-10, Volume: 110, Issue:4

    Topics: Cyclohexanecarboxylic Acids; Female; Gastroscopy; Hemostatic Techniques; Humans; Male; Peptic Ulcer

1990
[Hemorrhagic gastroduodenal ulcer: contribution of new medical treatments].
    Annales de chirurgie, 1989, Volume: 43, Issue:1

    Topics: Antacids; Cimetidine; Duodenoscopy; Electrocoagulation; Gastroscopy; Humans; Injections; Lasers; Lig

1989

Trials

7 trials available for tranexamic acid and Hemorrhage, Peptic Ulcer

ArticleYear
[Antifibrinolitic therapy for the treatment of massive ulcerative gastro-intestinal bleedings].
    Khirurgiia, 2011, Issue:4

    Topics: Aged; Antifibrinolytic Agents; Dose-Response Relationship, Drug; Duodenal Ulcer; Endoscopy, Gastroin

2011
Non-endoscopic first-line treatment of bleeding peptic ulcer with ranitidine and tranexamic acid.
    Scandinavian journal of gastroenterology, 2003, Volume: 38, Issue:9

    Topics: Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Antifibrinolytic Agents; Drug Therapy, Combinatio

2003
Cimetidine and tranexamic acid in the treatment of acute upper-gastrointestinal-tract bleeding.
    The New England journal of medicine, 1983, Jun-30, Volume: 308, Issue:26

    Topics: Acute Disease; Aged; Cimetidine; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Double-Blind

1983
Prognostic factors in upper gastrointestinal bleeding.
    Digestive diseases and sciences, 1994, Volume: 39, Issue:4

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cimetidine; Duodenal Ulcer; Female

1994
Tranexamic acid and upper gastrointestinal haemorrhage--a double-blind trial.
    Gut, 1976, Volume: 17, Issue:9

    Topics: Adolescent; Adult; Aged; Blood Coagulation Tests; Blood Transfusion; Clinical Trials as Topic; Cyclo

1976
Drug treatment for haematemesis and melaena.
    Postgraduate medical journal, 1986, Volume: 62 Suppl 2

    Topics: Clinical Trials as Topic; Duodenal Ulcer; Hematemesis; Histamine H2 Antagonists; Humans; Laser Thera

1986
Tranexamic acid as an aid to reducing blood transfusion requirements in gastric and duodenal bleeding.
    British medical journal (Clinical research ed.), 1987, Jan-03, Volume: 294, Issue:6563

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Transfusion; Clinical Trials as Topic; Cyclohexane

1987

Other Studies

5 other studies available for tranexamic acid and Hemorrhage, Peptic Ulcer

ArticleYear
Clinical practice and evidence in endoscopic treatment of bleeding peptic gastroduodenal ulcer.
    Scandinavian journal of gastroenterology, 2007, Volume: 42, Issue:3

    Topics: Anesthetics; Antifibrinolytic Agents; Denmark; Drug Prescriptions; Duodenal Ulcer; Epinephrine; Evid

2007
Does drug therapy prevent recurrent bleeding from peptic ulcers?
    Drug and therapeutics bulletin, 1984, Nov-19, Volume: 22, Issue:23

    Topics: Histamine H2 Antagonists; Humans; Peptic Ulcer Hemorrhage; Recurrence; Tranexamic Acid

1984
Reduction of gastric haemorrhage by fibrinolysis inhibition - an experimental study in rats.
    Thrombosis and haemostasis, 1983, Apr-28, Volume: 49, Issue:2

    Topics: Animals; Cyclohexanecarboxylic Acids; Fibrinolysis; Male; Peptic Ulcer Hemorrhage; Rats; Rats, Inbre

1983
Upper gastrointestinal bleeding: the trials of trials.
    Gut, 1985, Volume: 26, Issue:3

    Topics: Clinical Trials as Topic; Gastrointestinal Hemorrhage; Histamine H2 Antagonists; Humans; Peptic Ulce

1985
Advances in treatment of acute upper gastrointestinal hemorrhage.
    Southern medical journal, 1985, Volume: 78, Issue:7

    Topics: Angiography; Antacids; Barium Sulfate; Cimetidine; Combined Modality Therapy; Embolization, Therapeu

1985