Page last updated: 2024-11-05

tranexamic acid and Hemorrhage, Oral

tranexamic acid has been researched along with Hemorrhage, Oral in 44 studies

Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.

Research Excerpts

ExcerptRelevanceReference
"Tranexamic acid was the only agent that demonstrated a significantly lower risk of developing postoperative bleeding events (OR 0."3.01The effect of different hemostatic agents following dental extraction in patients under oral antithrombotic therapy: a network meta-analysis. ( Arunjaroensuk, S; Jiaranuchart, S; Mahardawi, B; Pimkhaokham, A; Somboonsavatdee, A; Tompkins, KA, 2023)
"Sixteen patients with haemophilia who required dental scaling participated in this pilot study."2.71Effectiveness in controlling haemorrhage after dental scaling in people with haemophilia by using tranexamic acid mouthwash. ( Boyle, CA; Fiske, J; Lee, AP; Savidge, GF, 2005)
" It was concluded that patients on oral anticoagulants can undergo oral surgery within the therapeutic range without reducing the dosage of anticoagulants, provided that local antifibrinolytic treatment with tranexamic acid solution is instituted."2.67Prevention of postsurgical bleeding in oral surgery using tranexamic acid without dose modification of oral anticoagulants. ( Alander, U; Blombäck, M; Hall, G; Ramström, G; Sindet-Pedersen, S, 1993)
"Dental extraction in hemophiliacs is associated with a high risk of bleeding."1.33Management options for dental extraction in hemophiliacs: a study of 55 extractions (2000-2002). ( Berthier, AM; De Mello, G; Frachon, X; Garnier, J; Hourdin-Eude, S; Lejeune, S; Mézière, X; Pommereuil, M; Quéro, J, 2005)
"Tranexamic acid, 1 g q."1.28Dental surgery in patients with severe factor XI deficiency without plasma replacement. ( Berliner, S; Brenner, B; Horowitz, I; Martinowitz, U; Seligsohn, U, 1992)

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-199013 (29.55)18.7374
1990's6 (13.64)18.2507
2000's16 (36.36)29.6817
2010's7 (15.91)24.3611
2020's2 (4.55)2.80

Authors

AuthorsStudies
Mahardawi, B1
Jiaranuchart, S1
Arunjaroensuk, S1
Tompkins, KA1
Somboonsavatdee, A1
Pimkhaokham, A1
Queiroz, SIML1
Silvestre, VD1
Soares, RM1
Campos, GBP1
Germano, AR1
da Silva, JSP1
Zirk, M1
Zinser, M1
Buller, J1
Bilinsky, V1
Dreiseidler, T1
Zöller, JE1
Kreppel, M1
Engelen, ET2
Schutgens, RE2
Mauser-Bunschoten, EP2
van Es, RJ2
van Galen, KP2
Adams, L1
Creamer, D1
Broekema, FI1
van Minnen, B1
Jansma, J1
Bos, RR1
Rath, A1
Nakamura, L1
van der Werf-Grohmann, N1
Zieger, B1
Perdigão, JP1
de Almeida, PC1
Rocha, TD1
Mota, MR1
Soares, EC1
Alves, AP1
Sousa, FB1
Piot, B1
Sigaud-Fiks, M1
Huet, P1
Fressinaud, E1
Trossaërt, M1
Mercier, J1
Garcia-Darennes, F1
Darennes, J1
Freidel, M1
Breton, P1
Keiani Motlagh, K1
Loeb, I1
Legrand, W1
Daelemans, P1
Van Reck, J1
Dodson, TB1
Carter, G2
Goss, A2
Lloyd, J2
Tocchetti, R1
Zellin, G1
Rasmusson, L1
Pålsson, J1
Kahnberg, KE1
Frachon, X1
Pommereuil, M1
Berthier, AM1
Lejeune, S1
Hourdin-Eude, S1
Quéro, J1
Mézière, X1
De Mello, G1
Garnier, J1
Lee, AP1
Boyle, CA1
Savidge, GF1
Fiske, J1
Morimoto, Y1
Yoshioka, A1
Sugimoto, M1
Imai, Y1
Kirita, T1
Tjønnfjord, GE1
Mason, WE1
Sacco, R2
Sacco, M1
Carpenedo, M2
Moia, M1
Rada, RE1
Jensen, SS1
Skottun, T1
Tauris, P1
Hansen, PW1
Jørgensen, JR1
Ramström, G4
Sindet-Pedersen, S6
Hall, G1
Blombäck, M4
Alander, U1
Borea, G1
Montebugnoli, L1
Capuzzi, P1
Magelli, C1
Davies, R1
Panula, K1
Oikarinen, K1
Federici, AB1
Stabile, F1
Zingaro, E1
Mannucci, PM1
Stubbs, M1
Gortzak, RA1
Huijgens, PC1
Nilsson, IM1
Berliner, S1
Horowitz, I1
Martinowitz, U1
Brenner, B1
Seligsohn, U1
Baudo, F1
deCataldo, F1
Landonio, G1
Muti, G1
Ingerslev, J3
Egberg, N1
Johnsson, H1
Ljungberg, B1
Schulman, S1
Stenbjerg, S2
Pignanelli, M1
Rota, L1
Pignanelli, C1
Vinckier, F2
Vermylen, J2
Peterson, J1
Evans, BE1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Efficacy of Local Hemostatic Management in Implant Surgery in Anticoagulated Patients on Warfarin: a Randomized Clinical Study[NCT04846114]71 participants (Actual)Interventional2016-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

4 reviews available for tranexamic acid and Hemorrhage, Oral

ArticleYear
The effect of different hemostatic agents following dental extraction in patients under oral antithrombotic therapy: a network meta-analysis.
    Scientific reports, 2023, 08-02, Volume: 13, Issue:1

    Topics: Chitosan; Collagen; Cyanoacrylates; Fibrinolytic Agents; Hemostatics; Humans; Network Meta-Analysis;

2023
Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or dental extractions.
    The Cochrane database of systematic reviews, 2018, 07-02, Volume: 7

    Topics: Anticoagulants; Antifibrinolytic Agents; Humans; Middle Aged; Minor Surgical Procedures; Oral Hemorr

2018
Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease undergoing minor oral surgery or dental extractions.
    The Cochrane database of systematic reviews, 2015, Dec-24, Issue:12

    Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Factor IX; Factor VIII; Hemophilia

2015
Local fibrinolysis as a mechanism for haemorrhage.
    Thrombosis et diathesis haemorrhagica, 1975, Dec-15, Volume: 34, Issue:3

    Topics: Aminocaproates; Endometrium; Epistaxis; Female; Fibrinolysis; Gastric Juice; Gastrointestinal Hemorr

1975

Trials

12 trials available for tranexamic acid and Hemorrhage, Oral

ArticleYear
Tranexamic acid as a local hemostasis method after dental extraction in patients on warfarin: a randomized controlled clinical study.
    Clinical oral investigations, 2018, Volume: 22, Issue:6

    Topics: Anticoagulants; Antifibrinolytic Agents; Female; Hemostatics; Humans; Male; Middle Aged; Oral Hemorr

2018
Postoperative bleeding after dental extraction in liver pretransplant patients.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2012, Volume: 70, Issue:3

    Topics: Adult; Antifibrinolytic Agents; Cross-Sectional Studies; Dental Care for Chronically Ill; Female; He

2012
[Dental extraction in patients with bleeding disorders. Proposal of a protocol based on the type of anesthesia used].
    Revue de stomatologie et de chirurgie maxillo-faciale, 2003, Volume: 104, Issue:2

    Topics: Adolescent; Adult; Aged; Anesthesia, Dental; Anesthesia, General; Anesthesia, Local; Anticoagulants;

2003
[Prevention of postoperative bleeding in patients taking oral anticoagulants. Effects of tranexamic acid].
    Revue de stomatologie et de chirurgie maxillo-faciale, 2003, Volume: 104, Issue:2

    Topics: Acenocoumarol; Administration, Oral; Adult; Aged; Aged, 80 and over; Anticoagulants; Antifibrinolyti

2003
Tranexamic acid mouthwash versus autologous fibrin glue in patients taking warfarin undergoing dental extractions: a randomized prospective clinical study.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2003, Volume: 61, Issue:12

    Topics: Adult; Aged; Anticoagulants; Blood Loss, Surgical; Dental Care for Chronically Ill; Drug Interaction

2003
Tranexamic acid mouthwash--a prospective randomized study of a 2-day regimen vs 5-day regimen to prevent postoperative bleeding in anticoagulated patients requiring dental extractions.
    International journal of oral and maxillofacial surgery, 2003, Volume: 32, Issue:5

    Topics: Administration, Topical; Adult; Aged; Anticoagulants; Antifibrinolytic Agents; Dental Care for Chron

2003
Evaluation of hemorrhage depressors on blood loss during orthognathic surgery: a retrospective study.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2004, Volume: 62, Issue:6

    Topics: Adolescent; Adult; Anesthesia, Dental; Blood Loss, Surgical; Combined Modality Therapy; Deamino Argi

2004
Effectiveness in controlling haemorrhage after dental scaling in people with haemophilia by using tranexamic acid mouthwash.
    British dental journal, 2005, Jan-08, Volume: 198, Issue:1

    Topics: Adolescent; Adult; Aged; Cross-Over Studies; Dental Care for Chronically Ill; Dental Scaling; Double

2005
Oral surgery in patients on oral anticoagulant therapy: a randomized comparison of different INR targets.
    Journal of thrombosis and haemostasis : JTH, 2006, Volume: 4, Issue:3

    Topics: Administration, Oral; Aged; Anticoagulants; Blood Coagulation; Cardiovascular Diseases; Cellulose, O

2006
Prevention of postsurgical bleeding in oral surgery using tranexamic acid without dose modification of oral anticoagulants.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1993, Volume: 51, Issue:11

    Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Anticoagulants; Cardiovascular Diseases; Denta

1993
Tranexamic acid as a mouthwash in anticoagulant-treated patients undergoing oral surgery. An alternative method to discontinuing anticoagulant therapy.
    Oral surgery, oral medicine, and oral pathology, 1993, Volume: 75, Issue:1

    Topics: Anticoagulants; Blood Loss, Surgical; Dental Care for Disabled; Double-Blind Method; Female; Heart V

1993
Optimising local therapy during oral surgery in patients with von Willebrand disease: effective results from a retrospective analysis of 63 cases.
    Haemophilia : the official journal of the World Federation of Hemophilia, 2000, Volume: 6, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Child, Preschool; Deamino Arginine Vasopressin; D

2000

Other Studies

28 other studies available for tranexamic acid and Hemorrhage, Oral

ArticleYear
Supportive topical tranexamic acid application for hemostasis in oral bleeding events - Retrospective cohort study of 542 patients.
    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2018, Volume: 46, Issue:6

    Topics: Administration, Oral; Administration, Topical; Adult; Aged; Aged, 80 and over; Anticoagulants; Blood

2018
Controlling oral hemorrhages in Steven-Johnson syndrome/toxic epidermal necrolysis.
    Journal of the American Academy of Dermatology, 2020, Volume: 82, Issue:1

    Topics: Administration, Topical; Antifibrinolytic Agents; Hospitals, University; Humans; Mouth Mucosa; Oral

2020
Risk of bleeding after dentoalveolar surgery in patients taking anticoagulants.
    The British journal of oral & maxillofacial surgery, 2014, Volume: 52, Issue:3

    Topics: Adult; Aged; Aged, 80 and over; Anticoagulants; Antifibrinolytic Agents; Apicoectomy; Dental Implant

2014
Acute "Tumour-like" Tongue Haematoma: The Challenge to Diagnose Haemophilia A.
    Klinische Padiatrie, 2015, Volume: 227, Issue:6-7

    Topics: Child, Preschool; Diagnosis, Differential; Drug Therapy, Combination; Hemophilia A; Humans; Male; Or

2015
[Protocol for adapting treatment with vitamin K antagonists before dental extraction].
    Revue de stomatologie et de chirurgie maxillo-faciale, 2003, Volume: 104, Issue:2

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anticoagulants; Antifibrinolytic Agents; Blood Loss, Sur

2003
Strategies for managing anticoagulated patients requiring dental extractions: an exercise in evidence-based clinical practice.
    Journal of the Massachusetts Dental Society, 2002,Winter, Volume: 50, Issue:4

    Topics: Anticoagulants; Antifibrinolytic Agents; Dental Care for Chronically Ill; Evidence-Based Medicine; H

2002
Management options for dental extraction in hemophiliacs: a study of 55 extractions (2000-2002).
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 2005, Volume: 99, Issue:3

    Topics: Adolescent; Adult; Aged; Child; Clinical Protocols; Deamino Arginine Vasopressin; Dental Care for Ch

2005
Haemostatic management of intraoral bleeding in patients with von Willebrand disease.
    Oral diseases, 2005, Volume: 11, Issue:4

    Topics: Adolescent; Adult; Child; Deamino Arginine Vasopressin; Dental Care for Chronically Ill; Factor VIII

2005
[Anticoagulation therapy and oral surgery].
    Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke, 2005, Nov-03, Volume: 125, Issue:21

    Topics: Anticoagulants; Aspirin; Fibrinolytic Agents; Humans; Oral Hemorrhage; Risk Factors; Tooth Extractio

2005
Anticoagulants: another option.
    The Journal of the Michigan Dental Association, 2005, Volume: 87, Issue:11

    Topics: Anticoagulants; Antifibrinolytic Agents; Dental Care; Humans; Oral Hemorrhage; Therapeutic Irrigatio

2005
Management of the dental patient on anticoagulant medication.
    Dentistry today, 2006, Volume: 25, Issue:8

    Topics: Anticoagulants; Bleeding Time; Blood Coagulation Disorders; Blood Loss, Surgical; Dental Care for Ch

2006
[Congenital factor VII deficiency].
    Ugeskrift for laeger, 1980, Sep-01, Volume: 142, Issue:36

    Topics: Aged; Factor VII; Factor VII Deficiency; Female; Humans; Male; Middle Aged; Oral Hemorrhage; Tooth E

1980
Re: Devani et al. Dental extractions in patients on warfarin: is alteration of anticoagulant regime necessary?
    The British journal of oral & maxillofacial surgery, 1998, Volume: 36, Issue:6

    Topics: Anticoagulants; Antifibrinolytic Agents; Drug Administration Schedule; Hemostatic Techniques; Humans

1998
Severe hemorrhage after implant surgery.
    Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics, 1999, Volume: 87, Issue:1

    Topics: Adult; Airway Obstruction; Antifibrinolytic Agents; Dental Implantation, Endosseous; Hematoma; Human

1999
A protocol for the dental management of von Willebrand's disease, haemophilia A and haemophilia B.
    Australian dental journal, 2001, Volume: 46, Issue:1

    Topics: Adolescent; Adult; Aged; Antifibrinolytic Agents; Clinical Protocols; Deamino Arginine Vasopressin;

2001
[A patient with thrombocytopenia: what do I do?].
    Nederlands tijdschrift voor tandheelkunde, 1999, Volume: 106, Issue:12

    Topics: Adult; Antifibrinolytic Agents; Humans; Male; Methylprednisolone; Oral Hemorrhage; Postoperative Car

1999
Dental surgery in patients with severe factor XI deficiency without plasma replacement.
    Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, 1992, Volume: 3, Issue:4

    Topics: Adult; Aged; Factor XI Deficiency; Female; Humans; Male; Middle Aged; Oral Hemorrhage; Surgery, Oral

1992
Management of oral bleeding in haemophilic patients.
    Lancet (London, England), 1988, Nov-05, Volume: 2, Issue:8619

    Topics: Aprotinin; Cyclohexanecarboxylic Acids; Drug Combinations; Factor XIII; Fibrin Tissue Adhesive; Fibr

1988
Management of oral bleeding in haemophilic patients.
    Lancet (London, England), 1989, Feb-11, Volume: 1, Issue:8633

    Topics: Aprotinin; Drug Combinations; Drug Therapy, Combination; Factor XIII; Fibrin Tissue Adhesive; Fibrin

1989
Oral surgery in patients with hereditary bleeding disorders. A survey of treatment in the Stockholm area (1974-1985).
    International journal of oral and maxillofacial surgery, 1989, Volume: 18, Issue:6

    Topics: Blood Coagulation Disorders; Blood Coagulation Factors; Clinical Protocols; Dental Care for Disabled

1989
Management of oral bleeding in haemophilic patients.
    Lancet (London, England), 1988, Sep-03, Volume: 2, Issue:8610

    Topics: Cyclohexanecarboxylic Acids; Hemophilia A; Hemostasis; Humans; Mouthwashes; Oral Hemorrhage; Tranexa

1988
Effect of local antifibrinolytic treatment with tranexamic acid in hemophiliacs undergoing oral surgery.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1986, Volume: 44, Issue:9

    Topics: Administration, Oral; Administration, Topical; Cyclohexanecarboxylic Acids; Dental Care for Disabled

1986
Control of gingival hemorrhage in hemophilic patients by inhibition of fibrinolysis with tranexamic acid.
    Journal of periodontal research, 1988, Volume: 23, Issue:1

    Topics: Administration, Oral; Adolescent; Adult; Child; Child, Preschool; Cyclohexanecarboxylic Acids; Fibri

1988
[Extractions in hemophilic patients. Control of hemostasis with DDAVP].
    Dental Cadmos, 1988, Oct-15, Volume: 56, Issue:15

    Topics: Adolescent; Adult; Child; Deamino Arginine Vasopressin; Dental Care for Disabled; Hemophilia A; Hemo

1988
Dental extractions in hemophilia: reflections on 10 years' experience.
    Oral surgery, oral medicine, and oral pathology, 1985, Volume: 59, Issue:1

    Topics: Aminocaproic Acid; Bandages; Cellulose, Oxidized; Dental Care for Disabled; Factor IX; Factor VIII;

1985
Tranexamic acid to reduce hemorrhage in hemophiliacs.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1988, Volume: 46, Issue:3

    Topics: Cyclohexanecarboxylic Acids; Hemophilia A; Humans; Oral Hemorrhage; Tranexamic Acid

1988
Oral surgery in hemophiliacs.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 1987, Volume: 45, Issue:3

    Topics: Cyclohexanecarboxylic Acids; Hemophilia A; Humans; Mouth; Oral Hemorrhage; Tranexamic Acid

1987
Blood loss following dental extractions in anticoagulated rabbits: effects of tranexamic acid and socket packing.
    Oral surgery, oral medicine, and oral pathology, 1985, Volume: 59, Issue:1

    Topics: Administration, Oral; Administration, Topical; Animals; Bandages; Cellulose, Oxidized; Chromium Radi

1985