tranexamic acid has been researched along with Hematochezia in 98 studies
Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.
Hematochezia: The passage of bright red blood from the rectum. The blood may or may not be mixed with formed stool in the form of blood, blood clots, bloody stool or diarrhea.
Excerpt | Relevance | Reference |
---|---|---|
"Tranexamic acid (TXA) is an antifibrinolytic agent used to control bleeding in different circumstances." | 6.94 | A randomized controlled trial of the effects of local tranexamic acid on mortality, rebleeding, and recurrent endoscopy need in patients with upper gastrointestinal hemorrhage. ( Doğan, NÖ; Karadaş, A; Pekdemir, M; Pinar, SG; Yaka, E; Yeşil, O; Yilmaz, S, 2020) |
"The current therapeutic strategy for disseminated intravascular coagulation (DIC) is limited to control of the underlying disease, and methods for the effective management of DIC have not been established." | 5.34 | Successful combined use of tranexamic acid and unfractionated heparin for life-threatening bleeding associated with intravascular coagulation in a patient with chronic myelogenous leukemia in blast crisis. ( Asada, N; Asakura, H; Koseki, M; Matsue, K; Takeuchi, M; Uryu, H, 2007) |
"Colonic angiodysplasias are a common source of gastrointestinal bleeding in patients with end-stage renal disease (ESRD)." | 5.30 | Successful treatment of bleeding from colonic angiodysplasias with tranexamic acid in a hemodialysis patient. ( Lavre, J; Sabovic, M; Vujkovac, B, 1998) |
"Tranexamic acid appears to be a reasonable adjunct for the emergency medicine clinician to consider in the management of many hemorrhagic conditions and angiotensin converting enzyme inhibitor-induced angioedema." | 5.22 | Tranexamic acid - A narrative review for the emergency medicine clinician. ( Santiago, R; Wang, K, 2022) |
"We studied the effects of tranexamic acid (an antifibrinolytic agent) and cimetidine on acute upper-gastrointestinal-tract bleeding in a double-blind randomized placebo-controlled trial in 775 patients with hematemesis or melena or both." | 5.05 | Cimetidine and tranexamic acid in the treatment of acute upper-gastrointestinal-tract bleeding. ( Atkinson, M; Barer, D; Coggon, D; Dronfield, M; Ellis, S; French, S; Henry, D; Langman, M; Ogilvie, A, 1983) |
"The effect or oral tranexamic acid on massive upper gastrointestinal hemorrhage was evaluated in a randomized double-blind study." | 5.05 | Local inhibition of the fibrinolytic system in patients with massive upper gastrointestinal hemorrhage. ( Bergqvist, D; Dahlgren, S; Hessman, Y, 1980) |
"To report a case of toxic epidermal necrolysis (TEN) induced by orally administered tranexamic acid in a patient with liver cirrhosis and acute rectal bleeding." | 3.79 | Tranexamic acid-induced toxic epidermal necrolysis. ( Aguado Gil, L; Idoate Gastearena, MA; Marques Martin, L; Pretel Irazabal, M, 2013) |
" prevented formation of ulcers induced by serotonin, indomethacin, acetylsalicylic acid or stress (acute ulcer models), its effect being greater against gastric ulcers induced by serotonin." | 3.67 | Anti-ulcer effect of 3-[p-(trans-4-aminomethylcyclohexylcarbonyl) phenyl] propionic acid hydrochloride (TEI-5103). ( Hoshina, K; Naruchi, T; Takeshita, T; Yamazaki, N, 1985) |
"Tranexamic acid (TXA) is a common haemorrhage control agent in both emergency department (ED) settings and intra-operatively." | 3.01 | Tranexamic acid in emergency medicine. An overview of reviews. ( Dhingra, P; Lang, E; Yeung, M, 2023) |
"Tranexamic acid (TXA) is an antifibrinolytic agent used to control bleeding in different circumstances." | 2.94 | A randomized controlled trial of the effects of local tranexamic acid on mortality, rebleeding, and recurrent endoscopy need in patients with upper gastrointestinal hemorrhage. ( Doğan, NÖ; Karadaş, A; Pekdemir, M; Pinar, SG; Yaka, E; Yeşil, O; Yilmaz, S, 2020) |
"Venous thromboembolic events (deep vein thrombosis or pulmonary embolism) were higher in tranexamic acid group than in the placebo group (48 [0·8%] of 5952 vs 26 [0·4%] of 5977; RR 1·85; 95% CI 1·15 to 2·98)." | 2.94 | Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial. ( , 2020) |
"Tranexamic acid is an antifibrinolytic that has been shown to reduce blood loss in a variety of clinical conditions." | 2.87 | Tranexamic Acid for Lower GI Hemorrhage: A Randomized Placebo-Controlled Clinical Trial. ( Bendinelli, C; Carroll, R; Draganic, BD; Murray, D; Pockney, PG; Smith, SR, 2018) |
"Studies were analyzed as high-dose IV tranexamic acid versus all other dosing strategies for tranexamic acid using fixed-effects models." | 2.82 | Tranexamic Acid in Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis. ( Antonelli, M; Dionne, JC; Hunt, BJ; Oczkowski, SJW; Raasveld, SJ; Vlaar, APJ; Wijnberge, M, 2022) |
"Tranexamic acid has been shown to reduce the need for blood transfusion in surgical patients and to reduce mortality in bleeding trauma patients, with no apparent increase in thromboembolic events." | 2.79 | HALT-IT--tranexamic acid for the treatment of gastrointestinal bleeding: study protocol for a randomised controlled trial. ( Coats, T; Edwards, P; Gilmore, I; Jairath, V; Ker, K; Manno, D; Roberts, I; Shakur, H; Stanworth, S; Veitch, A, 2014) |
" In 16 episodes of bleeding TXA was used (in a dosage of 20 mg intravenously, followed for the next 4 weeks by 10 mg/kg/48 h orally), whereas in 20 other cases of bleeding, TXA was not used." | 2.71 | Tranexamic acid is beneficial as adjunctive therapy in treating major upper gastrointestinal bleeding in dialysis patients. ( Lavre, J; Sabovic, M; Vujkovac, B, 2003) |
"Treatment with tranexamic acid was associated with a 20-30% reduction in the rate of rebleeding, a 30-40% reduction (95% confidence interval 10% to 60%) in mortality." | 2.66 | Effects of fibrinolytic inhibitors on mortality from upper gastrointestinal haemorrhage. ( Henry, DA; O'Connell, DL, 1989) |
" Therefore, thromboembolic risk and tranexamic acid dosage should be carefully evaluated." | 2.53 | [Tranexamic acid for upper gastrointestinal bleeding]. ( Fenger-Eriksen, C; Jessing, TD, 2016) |
"The current therapeutic strategy for disseminated intravascular coagulation (DIC) is limited to control of the underlying disease, and methods for the effective management of DIC have not been established." | 1.34 | Successful combined use of tranexamic acid and unfractionated heparin for life-threatening bleeding associated with intravascular coagulation in a patient with chronic myelogenous leukemia in blast crisis. ( Asada, N; Asakura, H; Koseki, M; Matsue, K; Takeuchi, M; Uryu, H, 2007) |
"A patient with von Willebrand's disease had recurrent gastrointestinal bleeding from angiodysplasia, with inadequate response to von Willebrand factor substitution, medical and endoscopic treatment, and resection of affected bowel." | 1.31 | Recurrent severe bleeding from gastrointestinal angiodysplasia in a patient with von Willebrand's disease, controlled with recombinant factor VIIa. ( Meijer, K; Peters, FT; van der Meer, J, 2001) |
"Colonic angiodysplasias are a common source of gastrointestinal bleeding in patients with end-stage renal disease (ESRD)." | 1.30 | Successful treatment of bleeding from colonic angiodysplasias with tranexamic acid in a hemodialysis patient. ( Lavre, J; Sabovic, M; Vujkovac, B, 1998) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 21 (21.43) | 18.7374 |
1990's | 7 (7.14) | 18.2507 |
2000's | 12 (12.24) | 29.6817 |
2010's | 27 (27.55) | 24.3611 |
2020's | 31 (31.63) | 2.80 |
Authors | Studies |
---|---|
Roberts, I | 8 |
Shakur-Still, H | 3 |
Afolabi, A | 2 |
Akere, A | 1 |
Arribas, M | 3 |
Austin, E | 1 |
Bal, K | 1 |
Bazeer, N | 1 |
Beaumont, D | 2 |
Brenner, A | 2 |
Carrington, L | 1 |
Chaudhri, R | 2 |
Coats, T | 4 |
Gilmore, I | 4 |
Halligan, K | 1 |
Hussain, I | 1 |
Jairath, V | 4 |
Javaid, K | 2 |
Kayani, A | 2 |
Lisman, T | 1 |
Mansukhani, R | 2 |
Miners, A | 1 |
Mutti, M | 2 |
Nadeem, MA | 2 |
Pollok, R | 1 |
Prowse, D | 1 |
Simmons, J | 1 |
Stanworth, S | 3 |
Veitch, A | 4 |
Williams, J | 1 |
Dionne, JC | 1 |
Oczkowski, SJW | 1 |
Hunt, BJ | 1 |
Antonelli, M | 1 |
Wijnberge, M | 1 |
Raasveld, SJ | 1 |
Vlaar, APJ | 1 |
Fong, MW | 1 |
Morningstar-Kywi, N | 1 |
O'Connell, C | 1 |
Qureshi, U | 1 |
Han, EE | 1 |
Wang, K | 1 |
Santiago, R | 1 |
Tran, QK | 1 |
Tang, K | 1 |
Pourmand, A | 1 |
Tsai, HW | 2 |
Lee, PL | 4 |
Kang, YN | 5 |
Grocott, MPW | 2 |
Murphy, M | 2 |
Sayers, R | 2 |
Toh, CH | 2 |
Dhingra, P | 1 |
Yeung, M | 1 |
Lang, E | 1 |
Ker, K | 3 |
Fujimori, S | 1 |
Ochoco, GETD | 1 |
Enriquez, CAG | 1 |
Urgel, RJL | 1 |
Catibog, JS | 1 |
Karadaş, A | 1 |
Doğan, NÖ | 1 |
Pinar, SG | 1 |
Yeşil, O | 1 |
Pekdemir, M | 1 |
Yilmaz, S | 1 |
Yaka, E | 1 |
Stanworth, SJ | 2 |
Twum-Barimah, E | 1 |
Abdelgadir, I | 1 |
Gordon, M | 1 |
Akobeng, AK | 1 |
Perner, A | 1 |
Møller, MH | 1 |
Dorgalaleh, A | 1 |
Baghaipour, MR | 1 |
Tabibian, S | 1 |
Ghazizadeh, F | 1 |
Dabbagh, A | 1 |
Bahoush, G | 1 |
Jazebi, M | 1 |
Bahraini, M | 1 |
Fazeli, A | 1 |
Baghaipour, N | 1 |
Yousefi, F | 1 |
Roberts, LN | 1 |
Miyamoto, Y | 1 |
Ohbe, H | 1 |
Ishimaru, M | 1 |
Matsui, H | 1 |
Fushimi, K | 1 |
Yasunaga, H | 1 |
Gilbert, BW | 1 |
Rech, MA | 1 |
Yang, KS | 1 |
Hou, SK | 1 |
Chang, CC | 2 |
Horton, LC | 1 |
Feuerstein, JD | 1 |
Erasu, V | 1 |
Novak, A | 1 |
Kamal, F | 1 |
Khan, MA | 1 |
Lee-Smith, W | 1 |
Sharma, S | 1 |
Imam, Z | 1 |
Jowhar, D | 1 |
Petryna, E | 1 |
Marella, HK | 1 |
Aksionav, P | 1 |
Iqbal, U | 1 |
Tombazzi, C | 1 |
Howden, CW | 1 |
Suk, FM | 1 |
Al-Samkari, H | 1 |
Ho, YW | 1 |
Chang, CY | 1 |
Huang, HK | 1 |
Chen, YL | 1 |
Wu, MY | 1 |
Polsky, Z | 1 |
Damji, O | 1 |
Bond, C | 1 |
Ma, C | 1 |
Lin, YC | 1 |
Chen, CY | 1 |
Murata, M | 1 |
Bamba, S | 1 |
Takahashi, K | 1 |
Imaeda, H | 1 |
Nishida, A | 1 |
Inatomi, O | 1 |
Tsujikawa, T | 1 |
Kushima, R | 1 |
Sugimoto, M | 1 |
Andoh, A | 1 |
Stollings, JL | 1 |
Landsperger, JS | 1 |
Semler, MW | 1 |
Rice, TW | 1 |
Grooteman, KV | 1 |
van Geenen, EJM | 1 |
Drenth, JPH | 1 |
Smith, SR | 1 |
Murray, D | 1 |
Pockney, PG | 1 |
Bendinelli, C | 1 |
Draganic, BD | 1 |
Carroll, R | 1 |
Sepulveda, A | 1 |
Soriano, H | 1 |
Espino, A | 1 |
Heidet, M | 1 |
Amathieu, R | 1 |
Audureau, E | 1 |
Augusto, O | 1 |
Nicolazo de Barmon, V | 1 |
Rialland, A | 1 |
Schmitz, D | 1 |
Pierrang, F | 1 |
Marty, J | 1 |
Chollet-Xémard, C | 1 |
Thirion, O | 1 |
Jacob, L | 1 |
Altawil, Z | 1 |
Gendron, BJ | 1 |
Schechter-Perkins, EM | 1 |
Cotzias, E | 1 |
Rehman, SF | 1 |
Arsalani Zadeh, R | 1 |
Smith, D | 1 |
Ahmad, SM | 1 |
Cuzick, J | 1 |
Hawkey, C | 1 |
Pretel Irazabal, M | 1 |
Marques Martin, L | 1 |
Aguado Gil, L | 1 |
Idoate Gastearena, MA | 1 |
Otrock, ZK | 1 |
Degheili, JA | 1 |
Sibai, H | 1 |
Salem, ZM | 1 |
Cho, SH | 1 |
Kim, SW | 1 |
Kim, WC | 1 |
Chul-Hyun, L | 1 |
Go, BS | 1 |
Manno, D | 3 |
Fischer, Q | 1 |
Huisse, MG | 1 |
Voiriot, G | 1 |
Caron, C | 1 |
Lepage, L | 1 |
Dilly, MP | 1 |
Nataf, P | 1 |
Ajzenberg, N | 1 |
Kirsch, M | 1 |
Edwards, P | 2 |
Shakur, H | 2 |
Bennett, C | 1 |
Klingenberg, SL | 3 |
Langholz, E | 2 |
Gluud, LL | 4 |
Bilkhu, A | 1 |
Saha, A | 1 |
Ilsley, DW | 1 |
Atikah, N | 1 |
Singh, G | 1 |
Maulahela, H | 1 |
Cahyanur, R | 1 |
Flores, S | 1 |
Avilés, C | 1 |
Rada, G | 1 |
Tutchenko, MI | 1 |
Rudyk, DV | 1 |
Iskra, NI | 1 |
Trofimenko, SP | 1 |
Shchur, IV | 1 |
Jessing, TD | 1 |
Fenger-Eriksen, C | 1 |
Hu, D | 1 |
Miliam, PB | 1 |
Carron, M | 1 |
Globokar, P | 1 |
Sicard, BA | 1 |
Hansen, LF | 1 |
Wewer, V | 1 |
Pedersen, SA | 1 |
Matzen, P | 1 |
Paerregaard, A | 1 |
Kovacs, TO | 1 |
Jensen, DM | 1 |
Almadi, M | 1 |
Ghali, PM | 1 |
Constantin, A | 1 |
Galipeau, J | 1 |
Szilagyi, A | 1 |
Yadav, SP | 1 |
Sachdeva, A | 1 |
Bhat, S | 1 |
Katewa, S | 1 |
Sabovic, M | 2 |
Lavre, J | 2 |
Vujkovac, B | 2 |
Amarapurkar, DN | 1 |
Patel, ND | 1 |
Stovicek, J | 1 |
Keil, R | 1 |
Pálová, S | 1 |
Lochmannová, J | 1 |
Koseki, M | 1 |
Asada, N | 1 |
Uryu, H | 1 |
Takeuchi, M | 1 |
Asakura, H | 1 |
Matsue, K | 1 |
Langholz, SE | 1 |
Barer, D | 2 |
Ogilvie, A | 1 |
Henry, D | 1 |
Dronfield, M | 1 |
Coggon, D | 1 |
French, S | 1 |
Ellis, S | 1 |
Atkinson, M | 1 |
Langman, M | 1 |
Chalmers, TC | 1 |
Low, J | 1 |
Dodds, AJ | 2 |
Biggs, JC | 2 |
Hollanders, D | 1 |
Thomson, JM | 1 |
Schofield, PF | 1 |
Poller, L | 1 |
Bergqvist, D | 1 |
Dahlgren, S | 1 |
Hessman, Y | 1 |
Patchett, SE | 1 |
O'Donoghue, DP | 1 |
de Pont, AC | 1 |
Zandstra, DF | 1 |
Katsaros, D | 1 |
Grundfest-Broniatowski, S | 1 |
McCormick, PA | 1 |
Ooi, H | 1 |
Crosbie, O | 1 |
Baerlocher, GM | 1 |
Leoncini-Franscini, L | 1 |
Wuillemin, WA | 1 |
Furlan, M | 1 |
Meijer, K | 1 |
Peters, FT | 1 |
van der Meer, J | 1 |
Hawkey, GM | 1 |
Cole, AT | 1 |
McIntyre, AS | 1 |
Long, RG | 1 |
Hawkey, CJ | 1 |
Burak, KW | 1 |
Lee, SS | 1 |
Beck, PL | 1 |
MacLean, JE | 1 |
Cohen, E | 1 |
Weinstein, M | 1 |
Nilsson, IM | 2 |
Bergentz, SE | 1 |
Hedner, U | 1 |
Kullenberg, K | 1 |
Ostberg, HO | 1 |
Ulfberg, J | 1 |
Wennerholm, M | 1 |
Zellner, K | 1 |
Engqvist, A | 1 |
Broström, O | 1 |
von Feilitzen, F | 1 |
Halldin, M | 1 |
Nyström, B | 1 |
Ost, A | 1 |
Reichard, H | 1 |
Sandqvist, S | 1 |
Törngren, S | 1 |
Wedlund, JE | 1 |
Hugh, TB | 1 |
Prentice, CR | 1 |
Henry, DA | 1 |
O'Connell, DL | 1 |
Langman, MJ | 1 |
von Holstein, CC | 2 |
Eriksson, SB | 2 |
Källén, R | 2 |
Berstad, A | 1 |
Almodovar, K | 1 |
Berstad, K | 1 |
Anderson, W | 1 |
Hirschowitz, BI | 1 |
Isacson, S | 1 |
Hoshina, K | 1 |
Yamazaki, N | 1 |
Takeshita, T | 1 |
Naruchi, T | 1 |
Navab, F | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Tranexamic Acid for the Treatment of Gastrointestinal Haemorrhage: an International Randomised, Double Blind Placebo Controlled Trial[NCT01658124] | Phase 3 | 12,009 participants (Actual) | Interventional | 2013-07-31 | Completed | ||
Precise Application of Topical Tranexamic Acid to Enhance Endoscopic Hemostasis for Peptic Ulcer Bleeding: A Randomized Controlled Study[NCT05248321] | 60 participants (Actual) | Interventional | 2022-03-24 | Completed | |||
Tranexamic Acid to Prevent Bleeding After Endoscopic Resection of Large Colorectal Polyps: A Pilot Project[NCT04559880] | Phase 4 | 25 participants (Actual) | Interventional | 2020-09-10 | Active, not recruiting | ||
Efficacy and Safety of Early Administration of Tranexamic Acid in Cirrhotic Patients Presenting With Acute Upper Gastrointestinal Bleeding: a Multicenter, Randomized, Double Blind, Placebo-controlled Trial (Modified by amendment1)[NCT03023189] | Phase 4 | 500 participants (Anticipated) | Interventional | 2017-04-03 | Recruiting | ||
Pilot RCT: Use of Tranexamic Acid (TXA) in Post Mastectomy Patients for Seroma and Hematoma Prevention[NCT03738527] | Phase 4 | 100 participants (Anticipated) | Interventional | 2019-10-07 | Recruiting | ||
The Role of Tranexamic Acid for the Treatment of Gastrointestinal Bleeding: A Randomized Double-blind Controlled Trial[NCT03540368] | 336 participants (Anticipated) | Interventional | 2018-07-04 | Suspended (stopped due to increased number of patients death) | |||
Local Administration of Tranexamic Acid in Upper Gastrointestinal Hemorrhage: A Double-Blind, Randomized, Placebo-Controlled Trial[NCT02903017] | Phase 4 | 114 participants (Actual) | Interventional | 2016-09-30 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
23 reviews available for tranexamic acid and Hematochezia
Article | Year |
---|---|
Tranexamic Acid in Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis.
Topics: Antifibrinolytic Agents; Gastrointestinal Hemorrhage; Humans; Length of Stay; Secondary Prevention; | 2022 |
Tranexamic acid - A narrative review for the emergency medicine clinician.
Topics: Angioedema; Antifibrinolytic Agents; Emergency Medicine; Gastrointestinal Hemorrhage; Humans; Tranex | 2022 |
Tranexamic acid and Gastrointestinal bleed: Effect of the HALT-IT trial on current meta-analysis.
Topics: Antifibrinolytic Agents; Clinical Trials as Topic; Gastrointestinal Hemorrhage; Humans; Tranexamic A | 2022 |
Tranexamic acid in emergency medicine. An overview of reviews.
Topics: Antifibrinolytic Agents; Emergency Medicine; Gastrointestinal Hemorrhage; Humans; Subarachnoid Hemor | 2023 |
Tranexamic acid for gastrointestinal bleeding: can a reduction in the risk of death be discounted? A systematic review and meta-analysis of individual patient data from 64 724 bleeding patients.
Topics: Antifibrinolytic Agents; Female; Gastrointestinal Hemorrhage; Humans; Pregnancy; Tranexamic Acid; Va | 2023 |
Tranexamic acid may be a useful pharmacotherapy for endoscopically resistant small bowel angiodysplasia.
Topics: Angiodysplasia; Colonic Diseases; Gastrointestinal Hemorrhage; Humans; Telangiectasia, Hereditary He | 2023 |
Systematic review with meta-analysis: the efficacy of tranexamic acid in upper gastrointestinal bleeding.
Topics: Antifibrinolytic Agents; Blood Transfusion; Controlled Clinical Trials as Topic; Female; Gastrointes | 2020 |
Tranexamic acid for gastrointestinal bleeding: A systematic review with meta-analysis of randomized clinical trials.
Topics: Antifibrinolytic Agents; Gastrointestinal Hemorrhage; Humans; Randomized Controlled Trials as Topic; | 2021 |
Efficacy and safety of tranexamic acid in acute upper gastrointestinal bleeding: meta-analysis of randomised controlled trials.
Topics: Blood Transfusion; Gastrointestinal Hemorrhage; Humans; Tranexamic Acid | 2020 |
Hereditary hemorrhagic telangiectasia: systemic therapies, guidelines, and an evolving standard of care.
Topics: Anemia; Angiogenesis Inhibitors; Anticoagulants; Antifibrinolytic Agents; Clinical Trials as Topic; | 2021 |
How effective is tranexamic acid for acute gastrointestinal bleeding?
Topics: Acute Disease; Antifibrinolytic Agents; Gastrointestinal Hemorrhage; Humans; Injections, Intravenous | 2014 |
Tranexamic acid for upper gastrointestinal bleeding.
Topics: Administration, Oral; Aluminum Hydroxide; Anti-Ulcer Agents; Antifibrinolytic Agents; Cimetidine; Dr | 2014 |
Tranexamic acid for upper gastrointestinal bleeding.
Topics: Administration, Oral; Aluminum Hydroxide; Anti-Ulcer Agents; Antifibrinolytic Agents; Cimetidine; Dr | 2014 |
Tranexamic acid for upper gastrointestinal bleeding.
Topics: Administration, Oral; Aluminum Hydroxide; Anti-Ulcer Agents; Antifibrinolytic Agents; Cimetidine; Dr | 2014 |
Tranexamic acid for upper gastrointestinal bleeding.
Topics: Administration, Oral; Aluminum Hydroxide; Anti-Ulcer Agents; Antifibrinolytic Agents; Cimetidine; Dr | 2014 |
Tranexamic acid for upper gastrointestinal bleeding.
Topics: Administration, Oral; Aluminum Hydroxide; Anti-Ulcer Agents; Antifibrinolytic Agents; Cimetidine; Dr | 2014 |
Tranexamic acid for upper gastrointestinal bleeding.
Topics: Administration, Oral; Aluminum Hydroxide; Anti-Ulcer Agents; Antifibrinolytic Agents; Cimetidine; Dr | 2014 |
Tranexamic acid for upper gastrointestinal bleeding.
Topics: Administration, Oral; Aluminum Hydroxide; Anti-Ulcer Agents; Antifibrinolytic Agents; Cimetidine; Dr | 2014 |
Tranexamic acid for upper gastrointestinal bleeding.
Topics: Administration, Oral; Aluminum Hydroxide; Anti-Ulcer Agents; Antifibrinolytic Agents; Cimetidine; Dr | 2014 |
Tranexamic acid for upper gastrointestinal bleeding.
Topics: Administration, Oral; Aluminum Hydroxide; Anti-Ulcer Agents; Antifibrinolytic Agents; Cimetidine; Dr | 2014 |
Extending evidence for the use of tranexamic acid from traumatic haemorrhage to other patients with major bleeding: do we need more than one haemorrhage protocol? The case of gastrointestinal bleeding.
Topics: Adult; Clinical Trials as Topic; Female; Gastrointestinal Hemorrhage; Humans; Male; Tranexamic Acid; | 2015 |
Is tranexamic acid effective for acute upper gastrointestinal bleeding?
Topics: Acute Disease; Antifibrinolytic Agents; Gastrointestinal Hemorrhage; Humans; Randomized Controlled T | 2015 |
[Tranexamic acid for upper gastrointestinal bleeding].
Topics: Antifibrinolytic Agents; Gastrointestinal Hemorrhage; Humans; Risk Factors; Thromboembolism; Tranexa | 2016 |
The short-term medical management of non-variceal upper gastrointestinal bleeding.
Topics: Animals; Gastrointestinal Hemorrhage; Histamine H2 Antagonists; Hormone Antagonists; Humans; Octreot | 2008 |
Recurrent obscure gastrointestinal bleeding: dilemmas and success with pharmacological therapies. Case series and review.
Topics: Aged; Aged, 80 and over; Angiodysplasia; Angiogenesis Inhibitors; Angiography; Animals; Antifibrinol | 2009 |
Tranexamic acid for upper gastrointestinal bleeding.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Administration, Oral; Aluminum Hydroxide; Anti-Ulcer Agents | 2012 |
Systematic review: tranexamic acid for upper gastrointestinal bleeding.
Topics: Antifibrinolytic Agents; Endoscopy, Gastrointestinal; Gastrointestinal Hemorrhage; Humans; Randomize | 2008 |
Portal hypertensive gastropathy and gastric antral vascular ectasia (GAVE) syndrome.
Topics: Adrenergic beta-Antagonists; Antifibrinolytic Agents; Diagnosis, Differential; Esophageal and Gastri | 2001 |
Local fibrinolysis as a mechanism for haemorrhage.
Topics: Aminocaproates; Endometrium; Epistaxis; Female; Fibrinolysis; Gastric Juice; Gastrointestinal Hemorr | 1975 |
Indications for antifibrinolytic therapy.
Topics: Aminocaproates; Antifibrinolytic Agents; Aprotinin; Blood Coagulation Disorders; Disseminated Intrav | 1975 |
Tranexamic acid in acute upper gastrointestinal bleeding.
Topics: Blood Transfusion; Cyclohexanecarboxylic Acids; Gastrointestinal Hemorrhage; Humans; Tranexamic Acid | 1987 |
20 trials available for tranexamic acid and Hematochezia
Article | Year |
---|---|
A high-dose 24-hour tranexamic acid infusion for the treatment of significant gastrointestinal bleeding: HALT-IT RCT.
Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Cost-Benefit Analysis; Gastrointestinal Hemorrhag | 2021 |
A randomized controlled trial of the effects of local tranexamic acid on mortality, rebleeding, and recurrent endoscopy need in patients with upper gastrointestinal hemorrhage.
Topics: Antifibrinolytic Agents; Double-Blind Method; Endoscopy; Gastrointestinal Hemorrhage; Humans; Tranex | 2020 |
Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial.
Topics: Acute Disease; Adult; Aged; Antifibrinolytic Agents; Case-Control Studies; Double-Blind Method; Fema | 2020 |
Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial.
Topics: Acute Disease; Adult; Aged; Antifibrinolytic Agents; Case-Control Studies; Double-Blind Method; Fema | 2020 |
Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial.
Topics: Acute Disease; Adult; Aged; Antifibrinolytic Agents; Case-Control Studies; Double-Blind Method; Fema | 2020 |
Effects of a high-dose 24-h infusion of tranexamic acid on death and thromboembolic events in patients with acute gastrointestinal bleeding (HALT-IT): an international randomised, double-blind, placebo-controlled trial.
Topics: Acute Disease; Adult; Aged; Antifibrinolytic Agents; Case-Control Studies; Double-Blind Method; Fema | 2020 |
An alternative perspective to just halting tranexamic acid utilization in gastrointestinal bleeding.
Topics: Antifibrinolytic Agents; Gastrointestinal Hemorrhage; Humans; Tranexamic Acid; Treatment Outcome | 2021 |
Tranexamic acid should be avoided for acute gastrointestinal bleeds.
Topics: Antifibrinolytic Agents; Double-Blind Method; Gastrointestinal Hemorrhage; Humans; Thromboembolism; | 2021 |
Tranexamic Acid for Lower GI Hemorrhage: A Randomized Placebo-Controlled Clinical Trial.
Topics: Adult; Aged; Aged, 80 and over; Antifibrinolytic Agents; Digestive System Diseases; Double-Blind Met | 2018 |
Efficacy and tolerance of early administration of tranexamic acid in patients with cirrhosis presenting with acute upper gastrointestinal bleeding: a study protocol for a multicentre, randomised, double-blind, placebo-controlled trial (the EXARHOSE study)
Topics: Administration, Intravenous; Adult; Antifibrinolytic Agents; Double-Blind Method; France; Gastrointe | 2018 |
Tranexamic acid for acute gastrointestinal bleeding (the HALT-IT trial): statistical analysis plan for an international, randomised, double-blind, placebo-controlled trial.
Topics: Antifibrinolytic Agents; Data Interpretation, Statistical; Double-Blind Method; Gastrointestinal Hem | 2019 |
HALT-IT--tranexamic acid for the treatment of gastrointestinal bleeding: study protocol for a randomised controlled trial.
Topics: Antifibrinolytic Agents; Blood Transfusion; Clinical Protocols; Double-Blind Method; Drug Administra | 2014 |
Tranexamic acid is beneficial as adjunctive therapy in treating major upper gastrointestinal bleeding in dialysis patients.
Topics: Aged; Antifibrinolytic Agents; Combined Modality Therapy; Female; Gastrointestinal Hemorrhage; Hemos | 2003 |
Cimetidine and tranexamic acid in the treatment of acute upper-gastrointestinal-tract bleeding.
Topics: Acute Disease; Aged; Cimetidine; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Double-Blind | 1983 |
Tranexamic acid therapy in ulcerative colitis.
Topics: Adult; Aged; Colitis, Ulcerative; Cyclohexanecarboxylic Acids; Female; Gastrointestinal Hemorrhage; | 1982 |
Fibrinolysis and gastrointestinal haemorrhage.
Topics: Clinical Trials as Topic; Fibrinolysis; Gastric Mucosa; Gastrointestinal Hemorrhage; Humans; Tranexa | 1980 |
Local inhibition of the fibrinolytic system in patients with massive upper gastrointestinal hemorrhage.
Topics: Administration, Oral; Adult; Aged; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Double-Bli | 1980 |
Drug treatments in upper gastrointestinal bleeding: value of endoscopic findings as surrogate end points.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Anti-Ulcer Agents; Antifibrinolytic Agents; Blood Transfusi | 2001 |
Tranexamic acid in massive haemorrhage from the upper gastrointestinal tract: a double-blind study.
Topics: Aged; Alcohol Drinking; Blood Transfusion; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Do | 1979 |
Tranexamic acid and upper gastrointestinal haemorrhage--a double-blind trial.
Topics: Adolescent; Adult; Aged; Blood Coagulation Tests; Blood Transfusion; Clinical Trials as Topic; Cyclo | 1976 |
Effects of fibrinolytic inhibitors on mortality from upper gastrointestinal haemorrhage.
Topics: Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Double-Blind Method; Gastrointestinal Hemorrh | 1989 |
Tranexamic acid as an aid to reducing blood transfusion requirements in gastric and duodenal bleeding.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Blood Transfusion; Clinical Trials as Topic; Cyclohexane | 1987 |
Tranexamic acid in gastric and duodenal bleeding.
Topics: Adult; Aged; Aged, 80 and over; Blood Transfusion; Cyclohexanecarboxylic Acids; Double-Blind Method; | 1987 |
55 other studies available for tranexamic acid and Hematochezia
Article | Year |
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Tranexamic Acid in the Treatment of Refractory Gastrointestinal Arteriovenous Malformation Bleeding in Left Ventricular Assist Device Patients.
Topics: Arteriovenous Malformations; Gastrointestinal Hemorrhage; Heart Failure; Heart Ventricles; Heart-Ass | 2022 |
Is it the time to rethink how to use tranexamic acids in managing gastrointestinal bleeding?
Topics: Antifibrinolytic Agents; Gastrointestinal Hemorrhage; Humans; Tranexamic Acid | 2022 |
Tranexamic acid for safer surgery: does the evidence support preventative use? Response to Br J Anaesth 2023; 130: e23-e24.
Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Gastrointestinal Hemorrhage; Humans; Tranexamic Acid | 2023 |
Tranexamic acid for safer surgery: does the evidence support preventative use? Response to Br J Anaesth 2023; 130: e23-e24.
Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Gastrointestinal Hemorrhage; Humans; Tranexamic Acid | 2023 |
Tranexamic acid for safer surgery: does the evidence support preventative use? Response to Br J Anaesth 2023; 130: e23-e24.
Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Gastrointestinal Hemorrhage; Humans; Tranexamic Acid | 2023 |
Tranexamic acid for safer surgery: does the evidence support preventative use? Response to Br J Anaesth 2023; 130: e23-e24.
Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Gastrointestinal Hemorrhage; Humans; Tranexamic Acid | 2023 |
Multimodality imaging approach in a patient with Klippel-Trenaunay syndrome.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Antifibrinolytic Agents; Endoscopy, Digestive System | 2019 |
Use of tranexamic acid in gastrointestinal bleeding and patients with haematological malignancies.
Topics: Antifibrinolytic Agents; Gastrointestinal Hemorrhage; Hematologic Neoplasms; Humans; Tranexamic Acid | 2020 |
Tranexamic acid for severe gastrointestinal bleeding.
Topics: Antifibrinolytic Agents; Double-Blind Method; Gastrointestinal Hemorrhage; Humans; Thromboembolism; | 2020 |
Gastrointestinal bleeding in a newborn infant with congenital factor X deficiency and COVID-19-A common clinical feature between a rare disorder and a new, common infection.
Topics: Betacoronavirus; Cesarean Section; Clinical Laboratory Techniques; Consanguinity; Coronavirus Infect | 2020 |
Tranexamic acid in acute gastrointestinal bleeding - A cautionary tale.
Topics: Acute Disease; Antifibrinolytic Agents; Gastrointestinal Hemorrhage; Humans; Tranexamic Acid | 2020 |
Effect of tranexamic acid in patients with colonic diverticular bleeding: A nationwide inpatient database study.
Topics: Blood Transfusion; Databases, Factual; Diverticulum, Colon; Female; Gastrointestinal Hemorrhage; Hos | 2021 |
In adults with severe acute GI bleeding, tranexamic acid did not reduce death due to bleeding at 5 days.
Topics: Adult; Antifibrinolytic Agents; Double-Blind Method; Gastrointestinal Hemorrhage; Humans; Thromboemb | 2020 |
No role for tranexamic acid in the treatment of acute gastrointestinal bleeding.
Topics: Gastrointestinal Hemorrhage; Humans; Tranexamic Acid | 2021 |
Letter: does tranexamic acid reduce the need for surgery in patients with upper gastrointestinal bleeding?
Topics: Gastrointestinal Hemorrhage; Humans; Tranexamic Acid | 2020 |
Is Tranexamic Acid for Upper Gastrointestinal Bleeding Under Debate?
Topics: Acute Disease; Antifibrinolytic Agents; Gastrointestinal Hemorrhage; Humans; Tranexamic Acid | 2021 |
Tranexamic acid for acute gastrointestinal bleeding: updated after the HALT-IT trial.
Topics: Acute Disease; Antifibrinolytic Agents; Gastrointestinal Hemorrhage; Humans; Tranexamic Acid | 2021 |
Does tranexamic acid reduce 5-day death due to bleeding in acute gastrointestinal bleed?
Topics: Acute Disease; Antifibrinolytic Agents; Gastrointestinal Hemorrhage; Humans; Tranexamic Acid | 2021 |
Letter: is there no conclusive evidence for the effect of tranexamic acid on mortality in gastrointestinal bleeding?
Topics: Antifibrinolytic Agents; Gastrointestinal Hemorrhage; Humans; Tranexamic Acid | 2021 |
Application of novel magnified single balloon enteroscopy for a patient with Cronkhite-Canada syndrome.
Topics: Aged; Antifibrinolytic Agents; Biopsy; Colonoscopy; Female; Gastrointestinal Hemorrhage; Glucocortic | 2017 |
Tranexamic acid for refractory gastrointestinal bleeds: A cohort study.
Topics: Aged; Antifibrinolytic Agents; Cohort Studies; Female; Gastrointestinal Hemorrhage; Humans; Male; Mi | 2018 |
Tranexamic acid in treatment-resistant chronic transfusion-dependent gastrointestinal angiodysplasia bleeding.
Topics: Aged; Angiodysplasia; Antifibrinolytic Agents; Erythrocyte Transfusion; Female; Gastrointestinal Hem | 2017 |
Gastrointestinal tract involvement in Klippel-Trénaunay syndrome.
Topics: Antifibrinolytic Agents; Child; Colon; Colonoscopy; Female; Gastrointestinal Hemorrhage; Humans; Kli | 2018 |
Topical use of tranexamic acid for the management of post-procedural rectal bleeding.
Topics: Administration, Topical; Antifibrinolytic Agents; Biopsy, Needle; Emergency Service, Hospital; Gastr | 2019 |
Conservative management of diffuse cavernous haemangioma of the sigmoid and rectum.
Topics: Administration, Oral; Antifibrinolytic Agents; Colonoscopy; Conservative Treatment; Gastrointestinal | 2020 |
Tranexamic acid-induced toxic epidermal necrolysis.
Topics: Aged; Antifibrinolytic Agents; Gastrointestinal Hemorrhage; Humans; Liver Cirrhosis; Male; Stevens-J | 2013 |
Recurrent jejunal bleeding due to angiodysplasia in a Bernard-Soulier patient.
Topics: Aged; Angiodysplasia; Antifibrinolytic Agents; Bernard-Soulier Syndrome; Blood Vessels; Female; Gast | 2013 |
Hemorrhagic bullous colitis in a patient with multiple myeloma.
Topics: Aged; Amyloidosis; Antifibrinolytic Agents; Blister; Bone Density Conservation Agents; Colitis, Isch | 2013 |
Von Willebrand factor, a versatile player in gastrointestinal bleeding in left ventricular assist device recipients?
Topics: Aged; Combined Modality Therapy; Deamino Arginine Vasopressin; Embolization, Therapeutic; Erythrocyt | 2015 |
Topical use of tranexamic acid to control parastomal bleeding.
Topics: Administration, Topical; Antifibrinolytic Agents; Bandages; Esophageal and Gastric Varices; Gastroin | 2015 |
Tranexamic acid in the management of upper gastrointestinal bleeding: an evidence-based case report.
Topics: Disease Management; Evidence-Based Medicine; Female; Gastrointestinal Hemorrhage; Humans; Middle Age | 2015 |
[MODERN VIEW ON INTENSIVE THERAPY OF GASTRO-INTESTINAL HEMORRHAGE].
Topics: Adolescent; Adult; Aged; Antifibrinolytic Agents; Female; Gastrointestinal Agents; Gastrointestinal | 2015 |
Emergency medicine questions: Can tranexamic acid be used to treat upper gastrointestinal bleeds?
Topics: Antifibrinolytic Agents; Emergency Medicine; Gastrointestinal Hemorrhage; Humans; Tranexamic Acid | 2016 |
[Should we use tranexamic acid in upper gastrointestinal bleeding?].
Topics: Antifibrinolytic Agents; Gastrointestinal Hemorrhage; Humans; Tranexamic Acid | 2016 |
Acute gastrointestinal haemorrhage on board a cruise ship in the Antarctic Peninsula.
Topics: Adult; Antarctic Regions; Antifibrinolytic Agents; Gastrointestinal Hemorrhage; Humans; Male; Maurit | 2016 |
Severe blue rubber bleb nevus syndrome in a neonate.
Topics: Antifibrinolytic Agents; Arteriovenous Malformations; Drug Therapy, Combination; Electrocoagulation; | 2009 |
Successful control of massive gastrointestinal bleeding following umbilical cord blood transplantation (UCBT) by use of recombinant activated factor VII (rFVIIa) and octreotide infusion.
Topics: beta-Thalassemia; Bone Marrow Transplantation; Cord Blood Stem Cell Transplantation; Delayed Graft F | 2010 |
Gastric antral vascular ectasia (GAVE) syndrome.
Topics: Aged; Anemia, Iron-Deficiency; Chronic Disease; Disease Progression; Female; Gastric Antral Vascular | 2004 |
Intestinal lymphangiectasia: a rare cause of gastrointestinal bleeding?
Topics: Adult; Antifibrinolytic Agents; Dietary Fats; Female; Gastrointestinal Hemorrhage; Gastroscopy; Huma | 2007 |
Successful combined use of tranexamic acid and unfractionated heparin for life-threatening bleeding associated with intravascular coagulation in a patient with chronic myelogenous leukemia in blast crisis.
Topics: Acute Disease; Adult; alpha-2-Antiplasmin; Antifibrinolytic Agents; Antineoplastic Agents; Antithrom | 2007 |
Cimetidine and tranexamic acid for upper-gastrointestinal-tract bleeding.
Topics: Cimetidine; Cyclohexanecarboxylic Acids; Gastrointestinal Hemorrhage; Humans; Tranexamic Acid | 1983 |
Fibrinolytic activity of gastroduodenal secretions--a possible role in upper gastrointestinal haemorrhage.
Topics: Aminocaproates; Chymotrypsin; Duodenum; Electrophoresis, Polyacrylamide Gel; Fibrinolysis; Gastric J | 1980 |
Pharmacological manipulation of gastric juice: thrombelastographic assessment and implications for treatment of gastrointestinal haemorrhage.
Topics: Aprotinin; Blood Coagulation; Fibrinolysis; Gastric Acid; Gastric Juice; Gastrointestinal Hemorrhage | 1995 |
[Antifibrinolytic therapy].
Topics: Gastrointestinal Hemorrhage; Humans; Randomized Controlled Trials as Topic; Tranexamic Acid | 1995 |
Successful treatment of bleeding from colonic angiodysplasias with tranexamic acid in a hemodialysis patient.
Topics: Angiodysplasia; Antifibrinolytic Agents; Colonic Diseases; Gastrointestinal Hemorrhage; Humans; Kidn | 1998 |
Successful management of visceral Klippel-Trenaunay-Weber syndrome with the antifibrinolytic agent tranexamic acid (cyclocapron): a case report.
Topics: Adult; Antifibrinolytic Agents; Blood Coagulation Tests; Colon, Sigmoid; Disseminated Intravascular | 1998 |
Tranexamic acid for severe bleeding gastric antral vascular ectasia in cirrhosis.
Topics: Aged; Antifibrinolytic Agents; Female; Gastrointestinal Hemorrhage; Humans; Liver Cirrhosis; Stomach | 1998 |
[Patient with recurrent gastrointestinal hemorrhage in acquired von Willebrand disease].
Topics: Autoantibodies; Female; Gastrointestinal Hemorrhage; Humans; Middle Aged; Recurrence; Tranexamic Aci | 1999 |
Recurrent severe bleeding from gastrointestinal angiodysplasia in a patient with von Willebrand's disease, controlled with recombinant factor VIIa.
Topics: Angiodysplasia; Blood Transfusion; Combined Modality Therapy; Deamino Arginine Vasopressin; Estrogen | 2001 |
Primary intestinal and thoracic lymphangiectasia: a response to antiplasmin therapy.
Topics: Adolescent; alpha-2-Antiplasmin; Antifibrinolytic Agents; Female; Gastrointestinal Hemorrhage; Human | 2002 |
Gastric fibrinolysis.
Topics: Aged; Aminocaproates; Blood Coagulation; Female; Fibrin Fibrinogen Degradation Products; Fibrinolysi | 1975 |
Fibrinolytic inhibitors for acute gastric haemorrhage.
Topics: Cyclohexanecarboxylic Acids; Fibrinolysis; Gastrointestinal Hemorrhage; Humans; Tranexamic Acid | 1977 |
Acute gastrointestinal haemorrhage. Experience with early panendoscopy and tranexamic acid in a rural hospital.
Topics: Acute Disease; Adult; Aged; Cyclohexanecarboxylic Acids; Endoscopy; Gastrointestinal Hemorrhage; Hem | 1977 |
Drug treatment for acute upper gastrointestinal bleeding.
Topics: Acute Disease; Gastrointestinal Hemorrhage; Humans; Research Design; Tranexamic Acid | 1992 |
Upper gastrointestinal bleeding: the trials of trials.
Topics: Clinical Trials as Topic; Gastrointestinal Hemorrhage; Histamine H2 Antagonists; Humans; Peptic Ulce | 1985 |
Effect of tranexamic acid on gastric bleeding in rats.
Topics: Animals; Cyclohexanecarboxylic Acids; Fibrinolysis; Gastrointestinal Hemorrhage; Infusions, Intraven | 1988 |
Anti-ulcer effect of 3-[p-(trans-4-aminomethylcyclohexylcarbonyl) phenyl] propionic acid hydrochloride (TEI-5103).
Topics: Acetates; Acetic Acid; Aminopyrine; Animals; Anti-Ulcer Agents; Aspirin; Bethanechol Compounds; Cime | 1985 |
Advances in treatment of acute upper gastrointestinal hemorrhage.
Topics: Angiography; Antacids; Barium Sulfate; Cimetidine; Combined Modality Therapy; Embolization, Therapeu | 1985 |