Compounds > tranexamic acid
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tranexamic acid and Gastric Ulcer

tranexamic acid has been researched along with Gastric Ulcer in 29 studies

Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.

Research Excerpts

ExcerptRelevanceReference
"We introduced a double-blind controlled clinical study to compare intravenous human epidermal growth factor (hEGF) to cetraxate hydrochloride (CH), an antiulcer drug, for their healing effect on gastric ulcers."9.07Gastric ulcer treatment with intravenous human epidermal growth factor: a double-blind controlled clinical study. ( Itoh, M; Matsuo, Y, 1994)
"Forty-nine Chinese patients, ages 65 years or over, with endoscopically and pathologically diagnosed benign gastric ulcer, completed a randomized double-blind double dummy trial in treatment with either cetraxate 200 mg four times daily or ranitidine 150 mg two times daily for 12 weeks or less if the gastric ulcer had completely healed."9.06Healing of gastric ulcer in the elderly: a double-blind study of cetraxate versus ranitidine. ( Lee, YC; Ng, NS; Tam, HC; Wong, HY, 1989)
"We investigated the effect of the anti-ulcer drug cetraxate on the development of the gastric ulcer induced by the submucosal injection of endothelin-1 in the rat gastric body, and its effects on gastric mucosal hemodynamics and tissue oxygenation by Laser doppler flowmetry and tissue spectrophotometry."7.68Endothelin-1-induced gastric ulcer is attenuated by cetraxate. ( Fukutomi, H; Goto, K; Kashimura, H; Lazaratos, S; Miyauchi, T; Nakahara, A; Osuga, T, 1993)
"Ligneous conjunctivitis is a rare severe conjunctivitis characterised by fibrin-rich, 'woody', pseudomembranes on the tarsal conjunctiva complicated by congenital hypoplasminogenaemia."5.40Tranexamic acid-induced ligneous conjunctivitis with renal failure showed reversible hypoplasminogenaemia. ( Izumi, N; Potts, LB; Song, Y; Yoshida, A, 2014)
" pylori) infection is known to affect the gastric microcirculation, and cetraxate is reported to accelerate gastric ulcer healing, possibly by augmenting gastric mucosal blood flow (MBF)."5.09Influence of Helicobacter pylori infection and cetraxate on gastric mucosal blood flow during healing of endoscopic mucosal resection-induced ulcers. ( Adachi, K; Fujishiro, H; Ishihara, S; Kawamura, A; Kazumori, H; Kinoshita, Y; Moriyama, N; Okuyama, T; Sato, H; Suetsugu, H; Watanabe, M, 2001)
"We introduced a double-blind controlled clinical study to compare intravenous human epidermal growth factor (hEGF) to cetraxate hydrochloride (CH), an antiulcer drug, for their healing effect on gastric ulcers."5.07Gastric ulcer treatment with intravenous human epidermal growth factor: a double-blind controlled clinical study. ( Itoh, M; Matsuo, Y, 1994)
"Forty-nine Chinese patients, ages 65 years or over, with endoscopically and pathologically diagnosed benign gastric ulcer, completed a randomized double-blind double dummy trial in treatment with either cetraxate 200 mg four times daily or ranitidine 150 mg two times daily for 12 weeks or less if the gastric ulcer had completely healed."5.06Healing of gastric ulcer in the elderly: a double-blind study of cetraxate versus ranitidine. ( Lee, YC; Ng, NS; Tam, HC; Wong, HY, 1989)
"We studied the effects of tranexamic acid (an antifibrinolytic agent) and cimetidine on acute upper-gastrointestinal-tract bleeding in a double-blind randomized placebo-controlled trial in 775 patients with hematemesis or melena or both."5.05Cimetidine and tranexamic acid in the treatment of acute upper-gastrointestinal-tract bleeding. ( Atkinson, M; Barer, D; Coggon, D; Dronfield, M; Ellis, S; French, S; Henry, D; Langman, M; Ogilvie, A, 1983)
"We investigated the effect of the anti-ulcer drug cetraxate on the development of the gastric ulcer induced by the submucosal injection of endothelin-1 in the rat gastric body, and its effects on gastric mucosal hemodynamics and tissue oxygenation by Laser doppler flowmetry and tissue spectrophotometry."3.68Endothelin-1-induced gastric ulcer is attenuated by cetraxate. ( Fukutomi, H; Goto, K; Kashimura, H; Lazaratos, S; Miyauchi, T; Nakahara, A; Osuga, T, 1993)
" The several trans-GMCHA arylamide derivatives showed more potent inhibitory effects on the stress- and HCl-ethanol-induced gastric ulcers than cetraxate in rats."3.68Syntheses and inhibitory effects on gastric lesions of trans-guanidinomethylcyclohexane carboxylic acid arylamides. ( Ikeda, T; Kakegawa, H; Matsumoto, H; Miyataka, H; Momoi, Y; Satoh, T; Ueda, H, 1993)
"The effect of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate (MN-1695) on various experimental gastric ulcers and gastric secretion in experimental animals was compared with that of cimetidine and cetraxate."3.67Effect of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate (MN-1695) on gastric ulcers and gastric secretion in experimental animals. ( Aratani, S; Enomoto, H; Kimura, K; Mimura, K; Nomura, A; Ueda, F, 1984)
" prevented formation of ulcers induced by serotonin, indomethacin, acetylsalicylic acid or stress (acute ulcer models), its effect being greater against gastric ulcers induced by serotonin."3.67Anti-ulcer effect of 3-[p-(trans-4-aminomethylcyclohexylcarbonyl) phenyl] propionic acid hydrochloride (TEI-5103). ( Hoshina, K; Naruchi, T; Takeshita, T; Yamazaki, N, 1985)
" To determine whether or not the anti-ulcer action of cetraxate hydrochloride was due to the unchanged drug, PHPA, or tranexamic acid, studies with aspirin and water-immersion -induced gastric ulcers in rats were performed."3.67[Pharmacokinetic and pharmacological studies on cetraxate, an anti-ulcer agent]. ( Naito, S; Tanaka, H, 1985)
"Ligneous conjunctivitis is a rare severe conjunctivitis characterised by fibrin-rich, 'woody', pseudomembranes on the tarsal conjunctiva complicated by congenital hypoplasminogenaemia."1.40Tranexamic acid-induced ligneous conjunctivitis with renal failure showed reversible hypoplasminogenaemia. ( Izumi, N; Potts, LB; Song, Y; Yoshida, A, 2014)
"Practice is variable, even in areas with established evidence based on randomized controlled studies, such as dosage and way of administration and duration of PPI treatment, injection treatment used as monotherapy and the volume used, including ulcers with clots for treatment, and the use of scheduled second-look endoscopy."1.34Clinical practice and evidence in endoscopic treatment of bleeding peptic gastroduodenal ulcer. ( Adamsen, S; Bendix, J; Kallehave, F; Moesgaard, F; Nilsson, T; Wille-Jørgensen, P, 2007)
"Cetraxate treatment increased NO synthase activity throughout the experiment in rats with or without stress treatment."1.29Prevention of water immersion stress-induced gastric lesions through the enhancement of nitric oxide synthase activity in rats. ( Goto, H; Hayakawa, T; Sugiyama, S; Tachi, K, 1996)

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-199013 (44.83)18.7374
1990's10 (34.48)18.2507
2000's4 (13.79)29.6817
2010's2 (6.90)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Song, Y1
Izumi, N1
Potts, LB1
Yoshida, A1
Bagnenko, SF1
Verbitskiĭ, VG1
Higuchi, K1
Watanabe, T1
Tanigawa, T1
Shiba, M1
Tominaga, K1
Fujiwara, Y1
Oshitani, N1
Arakawa, T1
Adamsen, S2
Bendix, J1
Kallehave, F1
Moesgaard, F1
Nilsson, T1
Wille-Jørgensen, P1
de Muckadell, OB1
Barer, D1
Ogilvie, A1
Henry, D1
Dronfield, M1
Coggon, D1
French, S1
Ellis, S1
Atkinson, M1
Langman, M2
Ueda, F1
Aratani, S1
Mimura, K1
Kimura, K1
Nomura, A1
Enomoto, H1
Stenberg, B1
Karlsson, L1
Alpsten, M1
Risberg, B1
Itoh, M1
Matsuo, Y1
Katschinski, B1
Logan, R1
Davies, J1
Faulkner, G1
Pearson, J1
Ishizuka, Y1
Kamisaki, T1
Matsuda, M1
Shimazaki, I1
Kawashima, M1
Yaginuma, H1
Terashima, K1
Sato, M1
Lazaratos, S1
Kashimura, H1
Nakahara, A1
Fukutomi, H1
Osuga, T1
Miyauchi, T1
Goto, K1
Ueda, H2
Ikeda, T2
Kakegawa, H2
Miyataka, H2
Matsumoto, H2
Satoh, T2
Momoi, Y1
Tachi, K1
Goto, H2
Hayakawa, T1
Sugiyama, S2
Adachi, K1
Suetsugu, H1
Moriyama, N1
Kazumori, H1
Kawamura, A1
Fujishiro, H1
Sato, H1
Okuyama, T1
Ishihara, S1
Watanabe, M1
Kinoshita, Y1
Nilsson, IM1
Bergentz, SE1
Hedner, U1
Kullenberg, K1
Suzuki, Y1
Ito, M1
Sudo, Y1
Ito, S1
Murakami, T1
Kambara, T1
Kishi, S1
Hashizume, T1
Aibara, S1
Hirokawa, K1
Nishida, A2
Ogawa, H1
Kasahara, A1
Miyata, K1
Kamato, T1
Honda, K1
Kuroiwa, M1
Tsukamoto, Y1
Nakazawa, S1
Ozawa, T1
Onoda, Y1
Takido, M1
Magaribuchi, T1
Tamaki, H1
Tam, HC1
Lee, YC1
Wong, HY1
Ng, NS1
Langman, MJ1
Maeda, T1
Hoshina, K1
Yamazaki, N1
Takeshita, T1
Naruchi, T1
Wilairatana, S1
Kladchareon, N1
Kositsurunkakul, S1
Israsena, S1
Tanaka, H1
Naito, S1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Comparison of High Dose Infusion and Low Dose Bolus Intravenous Omeprazole for Treatment of Bleeding Ulcer With Adherent Clot[NCT02536989]Phase 440 participants (Actual)Interventional2009-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

1 review available for tranexamic acid and Gastric Ulcer

ArticleYear
[Treatment of bleeding gastroduodenal ulcer].
    Ugeskrift for laeger, 2007, Apr-23, Volume: 169, Issue:17

    Topics: Antacids; Antifibrinolytic Agents; Duodenal Ulcer; Duodenoscopy; Embolization, Therapeutic; Epinephr

2007

Trials

8 trials available for tranexamic acid and Gastric Ulcer

ArticleYear
[Antifibrinolitic therapy for the treatment of massive ulcerative gastro-intestinal bleedings].
    Khirurgiia, 2011, Issue:4

    Topics: Aged; Antifibrinolytic Agents; Dose-Response Relationship, Drug; Duodenal Ulcer; Endoscopy, Gastroin

2011
Cimetidine and tranexamic acid in the treatment of acute upper-gastrointestinal-tract bleeding.
    The New England journal of medicine, 1983, Jun-30, Volume: 308, Issue:26

    Topics: Acute Disease; Aged; Cimetidine; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Double-Blind

1983
Gastric ulcer treatment with intravenous human epidermal growth factor: a double-blind controlled clinical study.
    Journal of gastroenterology and hepatology, 1994, Volume: 9 Suppl 1

    Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Ulcer Agents; Double-Blind Me

1994
Prognostic factors in upper gastrointestinal bleeding.
    Digestive diseases and sciences, 1994, Volume: 39, Issue:4

    Topics: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal; Cimetidine; Duodenal Ulcer; Female

1994
Influence of Helicobacter pylori infection and cetraxate on gastric mucosal blood flow during healing of endoscopic mucosal resection-induced ulcers.
    Journal of gastroenterology and hepatology, 2001, Volume: 16, Issue:11

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Aged; Aged, 80 and over; Anti-Ulcer Agents; Female; Gastric

2001
Healing of gastric ulcer in the elderly: a double-blind study of cetraxate versus ranitidine.
    Journal of clinical gastroenterology, 1989, Volume: 11, Issue:2

    Topics: Aged; Aged, 80 and over; Anti-Ulcer Agents; China; Clinical Trials as Topic; Cyclohexanecarboxylic A

1989
Drug treatment for haematemesis and melaena.
    Postgraduate medical journal, 1986, Volume: 62 Suppl 2

    Topics: Clinical Trials as Topic; Duodenal Ulcer; Hematemesis; Histamine H2 Antagonists; Humans; Laser Thera

1986
Cetraxate and antacid in the treatment of gastric ulcer. A controlled clinical trial.
    Journal of the Medical Association of Thailand = Chotmaihet thangphaet, 1985, Volume: 68, Issue:7

    Topics: Adult; Aged; Antacids; Anti-Ulcer Agents; Clinical Trials as Topic; Cyclohexanecarboxylic Acids; Fem

1985

Other Studies

20 other studies available for tranexamic acid and Gastric Ulcer

ArticleYear
Tranexamic acid-induced ligneous conjunctivitis with renal failure showed reversible hypoplasminogenaemia.
    BMJ case reports, 2014, May-19, Volume: 2014

    Topics: Administration, Oral; Aged; Conjunctivitis; Dose-Response Relationship, Drug; Drug Administration Sc

2014
Are gastroprotective drugs useful for gastric ulcer healing: re-evaluation using current ICH E9 guidelines.
    Inflammopharmacology, 2007, Volume: 15, Issue:1

    Topics: Anti-Ulcer Agents; Gastric Mucosa; Guidelines as Topic; Humans; Randomized Controlled Trials as Topi

2007
Clinical practice and evidence in endoscopic treatment of bleeding peptic gastroduodenal ulcer.
    Scandinavian journal of gastroenterology, 2007, Volume: 42, Issue:3

    Topics: Anesthetics; Antifibrinolytic Agents; Denmark; Drug Prescriptions; Duodenal Ulcer; Epinephrine; Evid

2007
Effect of 2,4-diamino-6-(2,5-dichlorophenyl)-s-triazine maleate (MN-1695) on gastric ulcers and gastric secretion in experimental animals.
    Arzneimittel-Forschung, 1984, Volume: 34, Issue:4

    Topics: Acetates; Acetic Acid; Animals; Anti-Ulcer Agents; Cimetidine; Female; Gastric Acid; Gastric Mucosa;

1984
Reduction of gastric haemorrhage by fibrinolysis inhibition - an experimental study in rats.
    Thrombosis and haemostasis, 1983, Apr-28, Volume: 49, Issue:2

    Topics: Animals; Cyclohexanecarboxylic Acids; Fibrinolysis; Male; Peptic Ulcer Hemorrhage; Rats; Rats, Inbre

1983
Anti-ulcer effect of 1,6-dihydro-2-[2-(2-methylpropoxy) anilino]-6-oxo-5-pyrimidinecarboxylic acid on experimental gastric ulcers in rats.
    Arzneimittel-Forschung, 1994, Volume: 44, Issue:4

    Topics: Acetates; Animals; Anti-Ulcer Agents; Aspirin; Cimetidine; Ethanol; Hydrochloric Acid; Male; p-Metho

1994
Endothelin-1-induced gastric ulcer is attenuated by cetraxate.
    Life sciences, 1993, Volume: 53, Issue:7

    Topics: Animals; Anti-Ulcer Agents; Endothelins; Gastric Mucosa; Hemodynamics; Male; Rats; Rats, Wistar; Sto

1993
Syntheses and inhibitory effects on gastric lesions of 4-guanidinomethylbenzoic acid arylamides.
    Chemical & pharmaceutical bulletin, 1993, Volume: 41, Issue:8

    Topics: Animals; Anti-Ulcer Agents; Benzamides; Guanidines; Male; Mice; Mice, Inbred ICR; Rats; Rats, Spragu

1993
Syntheses and inhibitory effects on gastric lesions of trans-guanidinomethylcyclohexane carboxylic acid arylamides.
    Chemical & pharmaceutical bulletin, 1993, Volume: 41, Issue:3

    Topics: Animals; Anti-Ulcer Agents; Benzoates; Carbanilides; Cimetidine; Cyclohexanecarboxylic Acids; Gastri

1993
Prevention of water immersion stress-induced gastric lesions through the enhancement of nitric oxide synthase activity in rats.
    Alimentary pharmacology & therapeutics, 1996, Volume: 10, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Gastric Mucosa; Immersion; Male; Nitric Oxide Synthase; omega-N-Methylar

1996
Gastric fibrinolysis.
    Thrombosis et diathesis haemorrhagica, 1975, Nov-15, Volume: 34, Issue:2

    Topics: Aged; Aminocaproates; Blood Coagulation; Female; Fibrin Fibrinogen Degradation Products; Fibrinolysi

1975
Studies on the mechanism of action of cetraxate [4'-(2-carboxyethyl)phenyl trans-4-aminomethyl cyclohexanecarboxylate hydrochloride], a new anti-ulcer agent.
    Japanese journal of pharmacology, 1979, Volume: 29, Issue:6

    Topics: Acetates; Animals; Anti-Ulcer Agents; Aspirin; Connective Tissue; Cyclohexanecarboxylic Acids; Femal

1979
Therapeutic effect of cetraxate on gastric ulcers (Phase I).
    Gastroenterologia Japonica, 1979, Volume: 14, Issue:3

    Topics: Cyclohexanecarboxylic Acids; Humans; Stomach Ulcer; Tranexamic Acid

1979
Protective effect of cetraxate, a new antiulcer drug, against serotonin-induced ulcer.
    Archives internationales de pharmacodynamie et de therapie, 1979, Volume: 240, Issue:2

    Topics: Animals; Anti-Ulcer Agents; Aorta; Cyclohexanecarboxylic Acids; Gastric Emptying; Gastric Mucosa; Ga

1979
Studies on the mechanism for the gastric mucosal protection by famotidine in rats.
    Japanese journal of pharmacology, 1991, Volume: 55, Issue:2

    Topics: Animals; Anti-Ulcer Agents; Cimetidine; Famotidine; Gastric Mucosa; Male; Pirenzepine; Rats; Rats, I

1991
The role of mucosal prostaglandin levels in healing of water immersion-induced gastric ulcers in rats.
    Scandinavian journal of gastroenterology, 1990, Volume: 25, Issue:1

    Topics: Animals; Anti-Ulcer Agents; Gastric Mucosa; Immersion; Male; Prostaglandins; Rats; Rats, Inbred Stra

1990
Effects of 12-sulfodehydroabietic acid monosodium salt (TA-2711), a new anti-ulcer agent, on gastric mucosal lesions induced by necrotizing agents and gastric mucosal defensive factors in rats.
    Japanese journal of pharmacology, 1990, Volume: 52, Issue:4

    Topics: Abietanes; Animals; Anti-Ulcer Agents; Dinoprostone; Diterpenes; Gastric Acid; Gastric Mucosa; Male;

1990
[A study on pathogenesis of gastric ulcer in patient with liver cirrhosis: with special reference to the gastric mucosal blood flow].
    Fukuoka igaku zasshi = Hukuoka acta medica, 1988, Volume: 79, Issue:8

    Topics: Adult; Anti-Ulcer Agents; Gastric Mucosa; Humans; Liver Cirrhosis; Middle Aged; Regional Blood Flow;

1988
Anti-ulcer effect of 3-[p-(trans-4-aminomethylcyclohexylcarbonyl) phenyl] propionic acid hydrochloride (TEI-5103).
    Arzneimittel-Forschung, 1985, Volume: 35, Issue:2

    Topics: Acetates; Acetic Acid; Aminopyrine; Animals; Anti-Ulcer Agents; Aspirin; Bethanechol Compounds; Cime

1985
[Pharmacokinetic and pharmacological studies on cetraxate, an anti-ulcer agent].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1985, Volume: 85, Issue:5

    Topics: Animals; Anti-Ulcer Agents; Chromatography, High Pressure Liquid; Cyclohexanecarboxylic Acids; Hydro

1985