tranexamic acid has been researched along with Fibroid in 20 studies
Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although intravascular thrombi and infarct-type necrosis have been reported in leiomyomas following tranexamic acid therapy, intratumoral vasculopathy resembling acute atherosis has not been reported to date in patients without exposure to gonadotropin receptor agonist." | 7.85 | Intratumoral Vasculopathy in Leiomyoma Treated With Tranexamic Acid. ( Krigman, HR; Kudose, S, 2017) |
| "To evaluate the efficacy and safety of oral, modified-release tranexamic acid in women with heavy menstrual bleeding and fibroids." | 7.79 | Efficacy and safety of oral tranexamic acid in women with heavy menstrual bleeding and fibroids. ( Adomako, TL; Baker, J; Eder, S; Gersten, J; Mabey, RG, 2013) |
| "Infarct-type necrosis was observed in the leiomyomas of 38 patients, 22 of whom had tranexamic acid (15%) whereas the remaining 16 had no drug exposure (4." | 7.74 | Tranexamic acid-associated necrosis and intralesional thrombosis of uterine leiomyomas: a clinicopathologic study of 147 cases emphasizing the importance of drug-induced necrosis and early infarcts in leiomyomas. ( Chan, QK; Cheung, AN; Cheung, CL; Ip, PP; Lam, KW; Pun, TC; Yeung, MC, 2007) |
| "The objective of this study was to investigate the effects of tranexamic acid on uterine vascular resistance in women with dysfunctional uterine bleeding and in women with menorrhagia associated with fibroids." | 7.70 | Uterine artery blood flow parameters in women with dysfunctional uterine bleeding and uterine fibroids: the effects of tranexamic acid. ( Hardiman, P; Lakhani, KP; Marsh, MS; Purcell, W, 1998) |
| "To evaluate the efficacy of tranexamic acid (TA) in decreasing blood loss during and after open myomectomy for patients with 3 or more uterine fibroids." | 5.22 | Efficacy of Tranexamic Acid on Myomectomy-Associated Blood Loss in Patients With Multiple Myomas: A Randomized Controlled Clinical Trial. ( Ahmed, MR; Dardeer, HH; Farhan, RE; Shaaban, MM, 2016) |
| "Although intravascular thrombi and infarct-type necrosis have been reported in leiomyomas following tranexamic acid therapy, intratumoral vasculopathy resembling acute atherosis has not been reported to date in patients without exposure to gonadotropin receptor agonist." | 3.85 | Intratumoral Vasculopathy in Leiomyoma Treated With Tranexamic Acid. ( Krigman, HR; Kudose, S, 2017) |
| "To evaluate the efficacy and safety of oral, modified-release tranexamic acid in women with heavy menstrual bleeding and fibroids." | 3.79 | Efficacy and safety of oral tranexamic acid in women with heavy menstrual bleeding and fibroids. ( Adomako, TL; Baker, J; Eder, S; Gersten, J; Mabey, RG, 2013) |
| "Infarct-type necrosis was observed in the leiomyomas of 38 patients, 22 of whom had tranexamic acid (15%) whereas the remaining 16 had no drug exposure (4." | 3.74 | Tranexamic acid-associated necrosis and intralesional thrombosis of uterine leiomyomas: a clinicopathologic study of 147 cases emphasizing the importance of drug-induced necrosis and early infarcts in leiomyomas. ( Chan, QK; Cheung, AN; Cheung, CL; Ip, PP; Lam, KW; Pun, TC; Yeung, MC, 2007) |
| "The objective of this study was to investigate the effects of tranexamic acid on uterine vascular resistance in women with dysfunctional uterine bleeding and in women with menorrhagia associated with fibroids." | 3.70 | Uterine artery blood flow parameters in women with dysfunctional uterine bleeding and uterine fibroids: the effects of tranexamic acid. ( Hardiman, P; Lakhani, KP; Marsh, MS; Purcell, W, 1998) |
| "However, uterine fibroids are highly vascular tumors and, consequently, extremely susceptible to problems from myomectomy-related hemorrhage." | 3.30 | Oxytocin versus a combination of tranexamic acid and ethamsylate in reducing intraoperative bleeding during abdominal myomectomy: a randomized clinical trial. ( Abd-ElGawad, M; Abdel-Hakam, F; Abdelaziz, DFM; Abdelhamed, SA; Abdelmonem, H; Abdou, AM; Afiffi, IK; Bosilah, AH; Eldesouky, E; Elhalim, AEMA; Ellaban, M; Elrashedy, AA; Elsayed, HGA; Elsror, AGA; Farag, E; Kamel, MA; Marai, AAE; Marie, H; Mohammed, A; Shaaban, A, 2023) |
| "Uterine fibroids are the commonest tumour of the female genital tract; about one third are symptomatic and require management." | 2.90 | Adjunctive use of tranexamic acid to tourniquet in reducing haemorrhage during abdominal myomectomy - A randomized controlled trial. ( Abdul, IF; Adesina, KT; Amadu, MB; Olarinoye, AO; Omokanye, LO, 2019) |
| "Tranexamic acid does not seem to be a useful adjunct in myomectomy if given according to the described protocol in this study." | 2.73 | Intravenous tranexamic acid use in myomectomy: a prospective randomized double-blind placebo controlled study. ( Caglar, GS; Haberal, A; Kayikcioglu, F; Tasci, Y, 2008) |
| "The surgical removal of fibroids can be associated with excessive blood loss requiring transfusion." | 2.61 | The Effectiveness of Tranexamic Acid at Reducing Blood Loss and Transfusion Requirement for Women Undergoing Myomectomy: A Systematic Review and Meta-analysis. ( Boutet, M; Chen, I; Fergusson, D; Fusca, L; Perelman, I, 2019) |
| "Uterine leiomyomas, or fibroids, are the most common benign tumor in reproductive aged women." | 2.53 | Role of Medical Management for Uterine Leiomyomas. ( Centini, G; Kashani, BN; Morelli, SS; Petraglia, F; Weiss, G, 2016) |
| "Uterine leiomyomas (fibroids) are the most common solid and symptomatic neoplasm in women." | 1.62 | Management of Symptomatic Uterine Leiomyomas: ACOG Practice Bulletin, Number 228. ( , 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.00) | 18.7374 |
| 1990's | 1 (5.00) | 18.2507 |
| 2000's | 5 (25.00) | 29.6817 |
| 2010's | 11 (55.00) | 24.3611 |
| 2020's | 2 (10.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abdou, AM | 1 |
| Eldesouky, E | 1 |
| Farag, E | 1 |
| Mohammed, A | 1 |
| Abdelaziz, DFM | 1 |
| Shaaban, A | 1 |
| Ellaban, M | 1 |
| Elhalim, AEMA | 1 |
| Elsror, AGA | 1 |
| Marai, AAE | 1 |
| Abdel-Hakam, F | 1 |
| Abd-ElGawad, M | 1 |
| Elrashedy, AA | 1 |
| Abdelmonem, H | 1 |
| Kamel, MA | 1 |
| Afiffi, IK | 1 |
| Elsayed, HGA | 1 |
| Abdelhamed, SA | 1 |
| Bosilah, AH | 1 |
| Marie, H | 1 |
| Abdul, IF | 1 |
| Amadu, MB | 1 |
| Adesina, KT | 1 |
| Olarinoye, AO | 1 |
| Omokanye, LO | 1 |
| Tarabrin, OA | 1 |
| Tyutrin, II | 1 |
| Gavrichenkov, DG | 1 |
| Shcherbakov, SS | 1 |
| Mazurenko, AI | 1 |
| Turenko, AV | 1 |
| Ito, T | 1 |
| Mattingly, PJ | 1 |
| Jan, AG | 1 |
| Biscette, SM | 1 |
| Kim, JHJ | 1 |
| Fusca, L | 1 |
| Perelman, I | 1 |
| Fergusson, D | 1 |
| Boutet, M | 1 |
| Chen, I | 1 |
| Eder, S | 1 |
| Baker, J | 1 |
| Gersten, J | 1 |
| Mabey, RG | 1 |
| Adomako, TL | 1 |
| Abu Saadeh, F | 1 |
| Galvin, D | 1 |
| Alsharbaty, MJ | 1 |
| Gleeson, N | 1 |
| Conforti, A | 1 |
| Mollo, A | 1 |
| Alviggi, C | 1 |
| Tsimpanakos, I | 1 |
| Strina, I | 1 |
| Magos, A | 1 |
| De Placido, G | 1 |
| Bradley, LD | 1 |
| Gueye, NA | 1 |
| Shaaban, MM | 1 |
| Ahmed, MR | 1 |
| Farhan, RE | 1 |
| Dardeer, HH | 1 |
| Kashani, BN | 1 |
| Centini, G | 1 |
| Morelli, SS | 1 |
| Weiss, G | 1 |
| Petraglia, F | 1 |
| Kudose, S | 1 |
| Krigman, HR | 1 |
| Roman, H | 1 |
| Loisel, C | 1 |
| Puscasiu, L | 1 |
| Sentilhes, L | 1 |
| Marpeau, L | 1 |
| Iacobellis, G | 2 |
| Sarris, I | 1 |
| Arafa, A | 1 |
| Konaris, L | 1 |
| Kadir, RA | 1 |
| Caglar, GS | 1 |
| Tasci, Y | 1 |
| Kayikcioglu, F | 1 |
| Haberal, A | 1 |
| Ip, PP | 1 |
| Lam, KW | 1 |
| Cheung, CL | 1 |
| Yeung, MC | 1 |
| Pun, TC | 1 |
| Chan, QK | 1 |
| Cheung, AN | 1 |
| Lakhani, KP | 1 |
| Marsh, MS | 1 |
| Purcell, W | 1 |
| Hardiman, P | 1 |
| Valsecchi, A | 1 |
| Cappelletti, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Use of Peri-Operative Intravenous Estrogen for the Mitigation of Ischemia Reperfusion Injury in the Setting of Renal Transplantation[NCT03663543] | Phase 1/Phase 2 | 30 participants (Anticipated) | Interventional | 2016-08-26 | Active, not recruiting | ||
| Efficacy and Safety of Rapamycin (Sirolimus) in the Treatment of Symptomatic Uterine Fibroids and Leiomyomatosis[NCT03500367] | Phase 4 | 25 participants (Anticipated) | Interventional | 2018-01-01 | Recruiting | ||
| Early Versus Late Post Caesarean Section Oral Anticoagulation Initiation and Risk of Maternal Complications in Patients With Mechanical Heart Valve Prosthesis[NCT04855110] | 114 participants (Anticipated) | Interventional | 2021-04-19 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 reviews available for tranexamic acid and Fibroid
| Article | Year |
|---|---|
Alternatives to excisional therapy: a clinical review of our current options to conservatively manage symptomatic leiomyomas.
Topics: Antifibrinolytic Agents; Aromatase Inhibitors; Female; Gonadotropin-Releasing Hormone; Humans; Leiom | 2018 |
The Effectiveness of Tranexamic Acid at Reducing Blood Loss and Transfusion Requirement for Women Undergoing Myomectomy: A Systematic Review and Meta-analysis.
Topics: Adult; Antifibrinolytic Agents; Blood Loss, Surgical; Blood Transfusion; Female; Humans; Leiomyoma; | 2019 |
Techniques to reduce blood loss during open myomectomy: a qualitative review of literature.
Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Female; Gonadotropin-Releasing Hormone; Hemostasis, S | 2015 |
The medical management of abnormal uterine bleeding in reproductive-aged women.
Topics: Adult; Anti-Inflammatory Agents, Non-Steroidal; Anticoagulants; Antifibrinolytic Agents; Blood Coagu | 2016 |
Role of Medical Management for Uterine Leiomyomas.
Topics: Antifibrinolytic Agents; Aromatase Inhibitors; Cabergoline; Cholecalciferol; Contraceptive Agents, F | 2016 |
4 trials available for tranexamic acid and Fibroid
| Article | Year |
|---|---|
Oxytocin versus a combination of tranexamic acid and ethamsylate in reducing intraoperative bleeding during abdominal myomectomy: a randomized clinical trial.
Topics: Blood Loss, Surgical; Ethamsylate; Female; Humans; Leiomyoma; Oxytocin; Saline Solution; Tranexamic | 2023 |
Adjunctive use of tranexamic acid to tourniquet in reducing haemorrhage during abdominal myomectomy - A randomized controlled trial.
Topics: Adult; Antifibrinolytic Agents; Blood Loss, Surgical; Double-Blind Method; Female; Humans; Leiomyoma | 2019 |
Efficacy of Tranexamic Acid on Myomectomy-Associated Blood Loss in Patients With Multiple Myomas: A Randomized Controlled Clinical Trial.
Topics: Adult; Antifibrinolytic Agents; Blood Loss, Surgical; Female; Humans; Leiomyoma; Prospective Studies | 2016 |
Intravenous tranexamic acid use in myomectomy: a prospective randomized double-blind placebo controlled study.
Topics: Adult; Antifibrinolytic Agents; Blood Loss, Surgical; Blood Transfusion; Double-Blind Method; Female | 2008 |
11 other studies available for tranexamic acid and Fibroid
| Article | Year |
|---|---|
Management of Symptomatic Uterine Leiomyomas: ACOG Practice Bulletin, Number 228.
Topics: Antifibrinolytic Agents; Contraceptive Agents, Hormonal; Endometrial Ablation Techniques; Ethinyl Es | 2021 |
DIAGNOSTICS AND CORRECTION OF THROMBOHEMORRHAGIC DISORDERS IN PATIENTS WITH GIANT UTERINE MYOMA AT THE PERIOPERATIVE STAGE OF TREATMENT.
Topics: Antifibrinolytic Agents; Drug Administration Schedule; Female; Humans; Leiomyoma; Middle Aged; Perio | 2016 |
Efficacy and safety of oral tranexamic acid in women with heavy menstrual bleeding and fibroids.
Topics: Administration, Oral; Adult; Antifibrinolytic Agents; Female; Humans; Leiomyoma; Menorrhagia; Middle | 2013 |
Paravaginal aggressive angiomyxoma.
Topics: Adult; Antifibrinolytic Agents; Blood Transfusion; Female; Humans; Laparotomy; Leiomyoma; Myxoma; Pl | 2015 |
Intratumoral Vasculopathy in Leiomyoma Treated With Tranexamic Acid.
Topics: Female; Humans; Hysterectomy; Leiomyoma; Menorrhagia; Middle Aged; Necrosis; Telangiectasia, Heredit | 2017 |
[Management of menometrorrhagia in women with and without pregnancy intention: hierarchy of therapies].
Topics: Adolescent; Anti-Inflammatory Agents, Non-Steroidal; Contraceptives, Oral, Hormonal; Embolization, T | 2008 |
Combined treatment with tranexamic acid and oral contraceptive pill causes coronary ulcerated plaque and acute myocardial infarction.
Topics: Adult; Chest Pain; Contraceptives, Oral; Coronary Angiography; Coronary Vessels; Drug Therapy, Combi | 2004 |
Topical use of tranexamic acid to control perioperative local bleeding in gynaecology patients with clotting disorders: two cases.
Topics: Administration, Oral; Administration, Topical; Aged; Antifibrinolytic Agents; Blood Coagulation Diso | 2007 |
Tranexamic acid-associated necrosis and intralesional thrombosis of uterine leiomyomas: a clinicopathologic study of 147 cases emphasizing the importance of drug-induced necrosis and early infarcts in leiomyomas.
Topics: Adult; Aged; Aged, 80 and over; Antifibrinolytic Agents; Female; Humans; Infarction; Leiomyoma; Meno | 2007 |
Uterine artery blood flow parameters in women with dysfunctional uterine bleeding and uterine fibroids: the effects of tranexamic acid.
Topics: Adult; Antifibrinolytic Agents; Female; Humans; Leiomyoma; Menorrhagia; Tranexamic Acid; Uterine Neo | 1998 |
[Possibilities of the use of an inhibitor of hemolysis (AMCHA), by rectal and vaginal administration, for gynecological hemorrhages].
Topics: Adolescent; Adult; Aged; Blood Coagulation Disorders; Child; Cyclohexanecarboxylic Acids; Female; He | 1975 |