tranexamic acid has been researched along with Exsanguinating Hemorrhage in 8 studies
Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Tranexamic acid (TXA) has been widely used in orthopedic surgery, but its efficacy in adolescent scoliosis (AS) surgery remains unclear in the literature." | 9.41 | Tranexamic acid can reduce blood loss in adolescent scoliosis surgery: a systematic review and meta-analysis. ( Chen, K; Gao, Q; Masood, U; Song, Y; Wang, L; Yang, H; Zeng, Z, 2023) |
| "To investigate the mechanism of action of tranexamic acid (TXA) in bleeding trauma patients, we examined the timing of its effect on mortality." | 9.19 | Mechanism of action of tranexamic acid in bleeding trauma patients: an exploratory analysis of data from the CRASH-2 trial. ( Manno, D; Prieto-Merino, D; Roberts, I, 2014) |
| "Tranexamic acid (TXA) has been widely used in orthopedic surgery, but its efficacy in adolescent scoliosis (AS) surgery remains unclear in the literature." | 5.41 | Tranexamic acid can reduce blood loss in adolescent scoliosis surgery: a systematic review and meta-analysis. ( Chen, K; Gao, Q; Masood, U; Song, Y; Wang, L; Yang, H; Zeng, Z, 2023) |
| "To investigate the mechanism of action of tranexamic acid (TXA) in bleeding trauma patients, we examined the timing of its effect on mortality." | 5.19 | Mechanism of action of tranexamic acid in bleeding trauma patients: an exploratory analysis of data from the CRASH-2 trial. ( Manno, D; Prieto-Merino, D; Roberts, I, 2014) |
| "Tranexamic acid (TXA) has demonstrated efficacy in reducing blood loss, reduction in hemoglobin, and blood transfusion requirements in primary total hip arthroplasty (THA)." | 2.87 | Oral vs Intravenous vs Topical Tranexamic Acid in Primary Hip Arthroplasty: A Prospective, Randomized, Double-Blind, Controlled Study. ( Luo, ZY; Pei, FX; Wang, D; Wang, HY; Zhou, K; Zhou, ZK, 2018) |
| "No deep venous thrombosis or other severe complications had occurred." | 2.84 | Intra-articular Application is More Effective Than Intravenous Application of Tranexamic Acid in Total Knee Arthroplasty: A Prospective Randomized Controlled Trial. ( Wang, J; Wang, Q; Zhang, X, 2017) |
| "Mean 25% of the present 2017 Joint Trauma System Clinical Practice Guideline dosing of TXA can be lost to hemorrhage if a blood volume is transfused within an hour of initiating therapy." | 1.48 | The effects of hemorrhage on the pharmacokinetics of tranexamic acid in a swine model. ( Barron, MR; Derickson, MJ; Kuckelman, JP; Loughren, MJ; Marko, ST; Martin, MJ; McClellan, JM; Phillips, CJ, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (75.00) | 24.3611 |
| 2020's | 2 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Xiao, C | 1 |
| Gao, Z | 1 |
| Yu, W | 1 |
| Yao, K | 1 |
| Cao, Y | 1 |
| Long, N | 1 |
| Zhang, S | 1 |
| Jiang, Y | 1 |
| Chen, K | 1 |
| Wang, L | 1 |
| Gao, Q | 1 |
| Masood, U | 1 |
| Zeng, Z | 1 |
| Yang, H | 1 |
| Song, Y | 1 |
| Wang, J | 1 |
| Wang, Q | 2 |
| Zhang, X | 1 |
| Luo, ZY | 1 |
| Wang, HY | 1 |
| Wang, D | 1 |
| Zhou, K | 1 |
| Pei, FX | 1 |
| Zhou, ZK | 1 |
| Derickson, MJ | 1 |
| McClellan, JM | 1 |
| Marko, ST | 1 |
| Kuckelman, JP | 1 |
| Phillips, CJ | 1 |
| Barron, MR | 1 |
| Martin, MJ | 1 |
| Loughren, MJ | 1 |
| Smith, I | 1 |
| Rapchuk, I | 1 |
| MacDonald, C | 1 |
| Thomson, B | 1 |
| Pearse, B | 1 |
| Roberts, I | 2 |
| Prieto-Merino, D | 1 |
| Manno, D | 1 |
| Shakur, H | 1 |
| Piot, P | 1 |
| Horton, R | 1 |
| Krug, E | 1 |
| Mersch, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Oral Tranexamic Acid vs. Oral Aminocaproic Acid to Reduce Blood Loss, Transfusion Index and Complications After Total Hip Replacement. A Prospective, Randomized, Double Blind Clinical Trial[NCT04187014] | Phase 2 | 90 participants (Actual) | Interventional | 2020-02-06 | Completed | ||
| Extended Postoperative Tranexamic Acid Use in Primary Total Knee Arthroplasty: A Prospective, Randomized Controlled Trial[NCT05099276] | Phase 4 | 46 participants (Actual) | Interventional | 2021-12-07 | Active, not recruiting | ||
| A Large Randomised Placebo Controlled Trial Among Trauma Patients With, or at Risk of, Significant Haemorrhage, of the Effects of Antifibrinolytic Treatment on Death and Transfusion Requirement[NCT00375258] | Phase 3 | 20,211 participants (Actual) | Interventional | 2005-05-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for tranexamic acid and Exsanguinating Hemorrhage
| Article | Year |
|---|---|
Tranexamic acid can reduce blood loss in adolescent scoliosis surgery: a systematic review and meta-analysis.
Topics: Adolescent; Blood Loss, Surgical; Exsanguination; Humans; Orthopedic Procedures; Scoliosis; Tranexam | 2023 |
4 trials available for tranexamic acid and Exsanguinating Hemorrhage
| Article | Year |
|---|---|
Medullary cavity application of tranexamic acid to reduce blood loss in tibial intramedullary nailing procedures-a randomized controlled trial.
Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Exsanguination; Fracture Fixation, Intramedullary; Hu | 2023 |
Intra-articular Application is More Effective Than Intravenous Application of Tranexamic Acid in Total Knee Arthroplasty: A Prospective Randomized Controlled Trial.
Topics: Administration, Intravenous; Adult; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; | 2017 |
Oral vs Intravenous vs Topical Tranexamic Acid in Primary Hip Arthroplasty: A Prospective, Randomized, Double-Blind, Controlled Study.
Topics: Administration, Intravenous; Administration, Oral; Administration, Topical; Aged; Antifibrinolytic A | 2018 |
Oral vs Intravenous vs Topical Tranexamic Acid in Primary Hip Arthroplasty: A Prospective, Randomized, Double-Blind, Controlled Study.
Topics: Administration, Intravenous; Administration, Oral; Administration, Topical; Aged; Antifibrinolytic A | 2018 |
Oral vs Intravenous vs Topical Tranexamic Acid in Primary Hip Arthroplasty: A Prospective, Randomized, Double-Blind, Controlled Study.
Topics: Administration, Intravenous; Administration, Oral; Administration, Topical; Aged; Antifibrinolytic A | 2018 |
Oral vs Intravenous vs Topical Tranexamic Acid in Primary Hip Arthroplasty: A Prospective, Randomized, Double-Blind, Controlled Study.
Topics: Administration, Intravenous; Administration, Oral; Administration, Topical; Aged; Antifibrinolytic A | 2018 |
Mechanism of action of tranexamic acid in bleeding trauma patients: an exploratory analysis of data from the CRASH-2 trial.
Topics: Antifibrinolytic Agents; Cause of Death; Exsanguination; Female; Hemorrhage; Humans; Male; Mortality | 2014 |
3 other studies available for tranexamic acid and Exsanguinating Hemorrhage
| Article | Year |
|---|---|
The effects of hemorrhage on the pharmacokinetics of tranexamic acid in a swine model.
Topics: Animals; Antifibrinolytic Agents; Disease Models, Animal; Exsanguination; Hypovolemia; Infusions, In | 2018 |
Management of exsanguination during laser lead extraction.
Topics: Anticoagulants; Antifibrinolytic Agents; Cardiopulmonary Bypass; Crystalloid Solutions; Defibrillato | 2014 |
A promise to save 100,000 trauma patients.
Topics: Antifibrinolytic Agents; Exsanguination; Humans; Tranexamic Acid; Wounds and Injuries | 2012 |