Page last updated: 2024-11-05

tranexamic acid and Ecchymosis

tranexamic acid has been researched along with Ecchymosis in 16 studies

Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.

Ecchymosis: Extravasation of blood into the skin, resulting in a nonelevated, rounded or irregular, blue or purplish patch, larger than a petechia.

Research Excerpts

ExcerptRelevanceReference
"Dexamethasone and tranexamic acid are used to decrease post-rhinoplasty periorbital edema and ecchymosis."9.27Comparison of the Effect of Dexamethasone and Tranexamic Acid, Separately or in Combination on Post-Rhinoplasty Edema and Ecchymosis. ( Bijani, A; Ghanepur, H; Ghassemi, A; Khakzad, M; Mehdizadeh, M; Mehrbakhsh, Z; Mir, M; Moghadamnia, A; Nekoohesh, L, 2018)
"The aim of this study was to investigate the efficacy of tranexamic acid (TA) and methylprednisolone on periorbital edema, ecchymosis, and intraoperative bleeding in patients who underwent open septorhinoplasty (oSRP)."9.20The efficacy of tranexamic acid and corticosteroid on edema and ecchymosis in septorhinoplasty. ( Akyiğit, A; Düzer, S; Orhan, İ; Polat, C; Sakallioğlu, Ö; Soylu, E, 2015)
"To systematically examine the role of tranexamic acid in reducing intraoperative blood loss and postoperative edema and ecchymosis among patients undergoing primary elective rhinoplasty."9.01Role of Tranexamic Acid in Reducing Intraoperative Blood Loss and Postoperative Edema and Ecchymosis in Primary Elective Rhinoplasty: A Systematic Review and Meta-analysis. ( Bezuhly, M; McGuire, C; Nurmsoo, S; Samargandi, OA, 2019)
"To investigate the results of tranexamic acid use to reduce intraoperative bleeding, postoperative eyelid edema, and periorbital ecchymosis in rhinoplasty."8.98Preoperative Tranexamic Acid for Treatment of Bleeding, Edema, and Ecchymosis in Patients Undergoing Rhinoplasty: A Systematic Review and Meta-analysis. ( de Aguiar Menezes, MV; de Souza Dantas, R; de Vasconcellos, SJA; do Nascimento-Júnior, EM; Martins-Filho, PRS; Tavares Mendes, ML, 2018)
"Tranexamic acid (TXA) has gained increasing recognition in plastic surgery as a dependable adjunct capable of minimizing blood loss, ecchymosis, and edema."8.02Local Infiltration of Tranexamic Acid (TXA) in Liposuction: A Single-Surgeon Outcomes Analysis and Considerations for Minimizing Postoperative Donor Site Ecchymosis. ( Banuelos, J; Molinar, VE; Tran, NV; Weissler, JM, 2021)
"The aim of the present study is to examine the effect of local administration of tranexamic acid (TXA) through lateral osteotomy line on postoperative periorbital edema and ecchymosis."8.02The Effects of Intraoperative Local Tranexamic Acid on Periorbital Edema and Ecchymosis in Septorhinoplasty. ( Bezgin, SÜ; Çakabay, T; Çelebi, Ş; İpek, HD, 2021)
"Previous studies have shown that systemic tranexamic acid reduces bleeding during soft tissue surgeries and reduces postoperative ecchymosis and edema experienced by surgical patients."8.02Effect of Tranexamic Acid Administration on Postoperative Ecchymosis and Edema in Excision of Lipomas. ( Choi, YJ; Kim, WS; Lee, GY; Lee, HJ; Park, HJ, 2021)
"Dexamethasone and tranexamic acid are used to decrease post-rhinoplasty periorbital edema and ecchymosis."5.27Comparison of the Effect of Dexamethasone and Tranexamic Acid, Separately or in Combination on Post-Rhinoplasty Edema and Ecchymosis. ( Bijani, A; Ghanepur, H; Ghassemi, A; Khakzad, M; Mehdizadeh, M; Mehrbakhsh, Z; Mir, M; Moghadamnia, A; Nekoohesh, L, 2018)
"The aim of this randomized double-blind study was to evaluate the efficacy of Tranexamic acid (TXA) on intraoperative bleeding, postoperative eyelid edema, and postoperative periorbital ecchymosis in rhinoplasty."5.24Efficacy of tranexamic acid on side effects of rhinoplasty: A randomized double-blind study. ( Chavoshzadeh, MA; Ghavimi, MA; Ghoreishizadeh, A; Taheri Talesh, K; Zarandi, A, 2017)
"The aim of this study was to investigate the efficacy of tranexamic acid (TA) and methylprednisolone on periorbital edema, ecchymosis, and intraoperative bleeding in patients who underwent open septorhinoplasty (oSRP)."5.20The efficacy of tranexamic acid and corticosteroid on edema and ecchymosis in septorhinoplasty. ( Akyiğit, A; Düzer, S; Orhan, İ; Polat, C; Sakallioğlu, Ö; Soylu, E, 2015)
"To systematically examine the role of tranexamic acid in reducing intraoperative blood loss and postoperative edema and ecchymosis among patients undergoing primary elective rhinoplasty."5.01Role of Tranexamic Acid in Reducing Intraoperative Blood Loss and Postoperative Edema and Ecchymosis in Primary Elective Rhinoplasty: A Systematic Review and Meta-analysis. ( Bezuhly, M; McGuire, C; Nurmsoo, S; Samargandi, OA, 2019)
"To investigate the results of tranexamic acid use to reduce intraoperative bleeding, postoperative eyelid edema, and periorbital ecchymosis in rhinoplasty."4.98Preoperative Tranexamic Acid for Treatment of Bleeding, Edema, and Ecchymosis in Patients Undergoing Rhinoplasty: A Systematic Review and Meta-analysis. ( de Aguiar Menezes, MV; de Souza Dantas, R; de Vasconcellos, SJA; do Nascimento-Júnior, EM; Martins-Filho, PRS; Tavares Mendes, ML, 2018)
"Tranexamic acid (TXA) has gained increasing recognition in plastic surgery as a dependable adjunct capable of minimizing blood loss, ecchymosis, and edema."4.02Local Infiltration of Tranexamic Acid (TXA) in Liposuction: A Single-Surgeon Outcomes Analysis and Considerations for Minimizing Postoperative Donor Site Ecchymosis. ( Banuelos, J; Molinar, VE; Tran, NV; Weissler, JM, 2021)
"The aim of the present study is to examine the effect of local administration of tranexamic acid (TXA) through lateral osteotomy line on postoperative periorbital edema and ecchymosis."4.02The Effects of Intraoperative Local Tranexamic Acid on Periorbital Edema and Ecchymosis in Septorhinoplasty. ( Bezgin, SÜ; Çakabay, T; Çelebi, Ş; İpek, HD, 2021)
"Previous studies have shown that systemic tranexamic acid reduces bleeding during soft tissue surgeries and reduces postoperative ecchymosis and edema experienced by surgical patients."4.02Effect of Tranexamic Acid Administration on Postoperative Ecchymosis and Edema in Excision of Lipomas. ( Choi, YJ; Kim, WS; Lee, GY; Lee, HJ; Park, HJ, 2021)
"Edema and ecchymosis were the two most investigated outcomes."2.82Complications Associated with Rhinoplasty: An Umbrella Review of Meta-analyses. ( Chen, S; Sun, K; Wu, B; Xu, X, 2022)
"Tranexamic acid (TXA) is an antifibrinolytic, and it was used to reduce the perioperative bleeding."2.61Role of tranexamic acid in nasal surgery: A systemic review and meta-analysis of randomized control trial. ( Li, F; Lu, HS; Ping, WD; Sun, HF; Zhao, QM, 2019)
"Tranexamic acid (TXA) has been widely used as an antifibrinolytic in dentoalveolar surgery and only recently has its effects been explored in facial procedures."1.62The Use of Tranexamic Acid in Facial Cosmetic Surgery Procedures: A Technical Note. ( Christensen, BJ; Fathimani, K; Perenack, J, 2021)

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's8 (50.00)24.3611
2020's8 (50.00)2.80

Authors

AuthorsStudies
Laikhter, E1
Comer, CD1
Shiah, E1
Manstein, SM1
Bain, PA1
Lin, SJ1
Wu, B1
Chen, S1
Sun, K1
Xu, X1
Wang, S1
Yang, J1
Lin, L1
Wang, HY1
Wang, L1
Luo, ZY1
Wang, D1
Tang, X1
Zhou, ZK1
Pei, FX1
Weissler, JM1
Banuelos, J1
Molinar, VE1
Tran, NV1
İpek, HD1
Bezgin, SÜ1
Çakabay, T1
Çelebi, Ş1
Choi, YJ1
Park, HJ1
Lee, HJ1
Lee, GY1
Kim, WS1
Hunstad, J1
Alsubaie, S1
Fathimani, K1
Perenack, J1
Christensen, BJ1
Ghavimi, MA1
Taheri Talesh, K1
Ghoreishizadeh, A1
Chavoshzadeh, MA1
Zarandi, A1
Mehdizadeh, M1
Ghassemi, A1
Khakzad, M1
Mir, M1
Nekoohesh, L1
Moghadamnia, A1
Bijani, A1
Mehrbakhsh, Z1
Ghanepur, H1
Berkowitz, RL1
de Vasconcellos, SJA1
do Nascimento-Júnior, EM1
de Aguiar Menezes, MV1
Tavares Mendes, ML1
de Souza Dantas, R1
Martins-Filho, PRS1
McGuire, C1
Nurmsoo, S1
Samargandi, OA1
Bezuhly, M1
Ping, WD1
Zhao, QM1
Sun, HF1
Lu, HS1
Li, F1
Sakallioğlu, Ö1
Polat, C1
Soylu, E1
Düzer, S1
Orhan, İ1
Akyiğit, A1

Clinical Trials (5)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Extended Postoperative Tranexamic Acid Use in Primary Total Knee Arthroplasty: A Prospective, Randomized Controlled Trial[NCT05099276]Phase 446 participants (Actual)Interventional2021-12-07Active, not recruiting
Tranexamic Acid in Rhinoplasty: Perioperative Bleeding, Edema and Ecchymosis[NCT05774717]Phase 160 participants (Anticipated)Interventional2023-04-01Recruiting
Tranexamic Acid for Blood Loss Minimization in Endoscopic Pituitary Surgery: A Double-Blind Randomized Controlled Trial[NCT04863339]Phase 20 participants (Actual)Interventional2022-03-31Withdrawn (stopped due to Challenges in recruitment)
Effect of Tranexamic Acid on Postoperative Bleeding Following Sinus and Nasal Surgery[NCT04754230]Phase 440 participants (Actual)Interventional2021-06-17Completed
The Effect of Local Tranexamic Acid on Post-operative Edema and Ecchymosis in Eyelid Surgery[NCT04951128]Phase 450 participants (Anticipated)Interventional2021-08-01Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Bleeding VAS - POD1

Patient-reported Visual Analog Scale - Bleeding Score Day 1. Score range: 0 (no bleeding) to 10 (uncontrolled bleeding). (NCT04754230)
Timeframe: Postoperative Day 1 (assessed within first 24 hours following surgery)

Interventionscore on a scale (Mean)
Normal Saline5.03
1,000mg IV Tranexamic Acid4.82

Bleeding VAS - POD2

Patient-reported Visual Analog Scale - Bleeding Score Day 2. Score range: 0 (no bleeding) to 10 (uncontrolled bleeding). (NCT04754230)
Timeframe: Postoperative Day 2

Interventionscore on a scale (Mean)
Normal Saline4.47
1,000mg IV Tranexamic Acid3.89

Bleeding VAS - POD3

Patient-reported Visual Analog Scale - Bleeding Score Day 3. Score range: 0 (no bleeding) to 10 (uncontrolled bleeding). (NCT04754230)
Timeframe: Postoperative Day 3

Interventionscore on a scale (Mean)
Normal Saline2.93
1,000mg IV Tranexamic Acid2.29

Bleeding VAS - POD4

Patient-reported Visual Analog Scale - Bleeding Score Day 4. Score range: 0 (no bleeding) to 10 (uncontrolled bleeding). (NCT04754230)
Timeframe: Postoperative Day 4

Interventionscore on a scale (Mean)
Normal Saline2.12
1,000mg IV Tranexamic Acid1.44

Bleeding VAS - POD5

Patient-reported Visual Analog Scale - Bleeding Score Day 5. Score range: 0 (no bleeding) to 10 (uncontrolled bleeding). (NCT04754230)
Timeframe: Postoperative Day 5

Interventionscore on a scale (Mean)
Normal Saline1.32
1,000mg IV Tranexamic Acid1.15

Bleeding VAS - POD6

Patient-reported Visual Analog Scale - Bleeding Score Day 6. Score range: 0 (no bleeding) to 10 (uncontrolled bleeding). (NCT04754230)
Timeframe: Postoperative Day 6

Interventionscore on a scale (Mean)
Normal Saline1.36
1,000mg IV Tranexamic Acid0.76

Bleeding VAS - POD7

Patient-reported Visual Analog Scale - Bleeding Score Day 7. Score range: 0 (no bleeding) to 10 (uncontrolled bleeding). (NCT04754230)
Timeframe: Postoperative Day 7

Interventionscore on a scale (Mean)
Normal Saline0.97
1,000mg IV Tranexamic Acid0.72

Frequency of Participant Follow-up

Number of patients in each arm requiring evaluation by the resident service for bleeding concerns expressed by the recovery nurse (in PACU), had any follow-up visit or phone call outside of regularly scheduled follow-up (NCT04754230)
Timeframe: Day of surgery through 1 week

,
InterventionParticipants (Count of Participants)
PACUFollow-up visitFollow-up phone call
1,000mg IV Tranexamic Acid012
Normal Saline002

Guaze Saturation VAS Though POD7

Patient-reported Visual Analog Scale - Guaze Saturation Score through Postoperative Day 7. Score range: 0 (not at all) to 10 (dripping blood). (NCT04754230)
Timeframe: Postoperative Day 2 through Postoperative Day 7

,
Interventionscore on a scale (Mean)
Postoperative day 2Postoperative day 3Postoperative day 4Postoperative day 5Postoperative day 6Postoperative day 7
1,000mg IV Tranexamic Acid4.562.090.760.400.290.28
Normal Saline5.163.031.741.110.990.80

Reviews

6 reviews available for tranexamic acid and Ecchymosis

ArticleYear
A Systematic Review and Meta-Analysis Evaluating the Impact of Tranexamic Acid Administration in Aesthetic Plastic Surgery.
    Aesthetic surgery journal, 2022, 04-12, Volume: 42, Issue:5

    Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Ecchymosis; Female; Hematoma; Humans; Surgery, Plasti

2022
Complications Associated with Rhinoplasty: An Umbrella Review of Meta-analyses.
    Aesthetic plastic surgery, 2022, Volume: 46, Issue:2

    Topics: Ecchymosis; Edema; Humans; Osteotomy; Rhinoplasty; Tranexamic Acid; Treatment Outcome

2022
Local Application of Tranexamic Acid in Plastic Surgery Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
    Aesthetic plastic surgery, 2023, Volume: 47, Issue:4

    Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Ecchymosis; Humans; Randomized Controlled Trials as T

2023
Preoperative Tranexamic Acid for Treatment of Bleeding, Edema, and Ecchymosis in Patients Undergoing Rhinoplasty: A Systematic Review and Meta-analysis.
    JAMA otolaryngology-- head & neck surgery, 2018, 09-01, Volume: 144, Issue:9

    Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Drug Administration Schedule; Ecchymosis; Edema; Eyel

2018
Role of Tranexamic Acid in Reducing Intraoperative Blood Loss and Postoperative Edema and Ecchymosis in Primary Elective Rhinoplasty: A Systematic Review and Meta-analysis.
    JAMA facial plastic surgery, 2019, May-01, Volume: 21, Issue:3

    Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Ecchymosis; Edema; Humans; Postoperative Complication

2019
Role of tranexamic acid in nasal surgery: A systemic review and meta-analysis of randomized control trial.
    Medicine, 2019, Volume: 98, Issue:16

    Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Ecchymosis; Edema; Eyelid Diseases; Humans; Nasal Sur

2019
Role of tranexamic acid in nasal surgery: A systemic review and meta-analysis of randomized control trial.
    Medicine, 2019, Volume: 98, Issue:16

    Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Ecchymosis; Edema; Eyelid Diseases; Humans; Nasal Sur

2019
Role of tranexamic acid in nasal surgery: A systemic review and meta-analysis of randomized control trial.
    Medicine, 2019, Volume: 98, Issue:16

    Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Ecchymosis; Edema; Eyelid Diseases; Humans; Nasal Sur

2019
Role of tranexamic acid in nasal surgery: A systemic review and meta-analysis of randomized control trial.
    Medicine, 2019, Volume: 98, Issue:16

    Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Ecchymosis; Edema; Eyelid Diseases; Humans; Nasal Sur

2019

Trials

4 trials available for tranexamic acid and Ecchymosis

ArticleYear
Intravenous and subsequent long-term oral tranexamic acid in enhanced-recovery primary total knee arthroplasty without the application of a tourniquet: a randomized placebo-controlled trial.
    BMC musculoskeletal disorders, 2019, Oct-25, Volume: 20, Issue:1

    Topics: Administration, Intravenous; Aged; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood L

2019
Efficacy of tranexamic acid on side effects of rhinoplasty: A randomized double-blind study.
    Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, 2017, Volume: 45, Issue:6

    Topics: Adult; Antifibrinolytic Agents; Blood Loss, Surgical; Double-Blind Method; Ecchymosis; Edema; Female

2017
Comparison of the Effect of Dexamethasone and Tranexamic Acid, Separately or in Combination on Post-Rhinoplasty Edema and Ecchymosis.
    Aesthetic plastic surgery, 2018, Volume: 42, Issue:1

    Topics: Adolescent; Adult; Analysis of Variance; Dexamethasone; Double-Blind Method; Drug Therapy, Combinati

2018
The efficacy of tranexamic acid and corticosteroid on edema and ecchymosis in septorhinoplasty.
    Annals of plastic surgery, 2015, Volume: 74, Issue:4

    Topics: Adult; Anti-Inflammatory Agents; Antifibrinolytic Agents; Blood Loss, Surgical; Drug Administration

2015

Other Studies

6 other studies available for tranexamic acid and Ecchymosis

ArticleYear
Local Infiltration of Tranexamic Acid (TXA) in Liposuction: A Single-Surgeon Outcomes Analysis and Considerations for Minimizing Postoperative Donor Site Ecchymosis.
    Aesthetic surgery journal, 2021, 06-14, Volume: 41, Issue:7

    Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Ecchymosis; Humans; Lipectomy; Postoperative Hemorrha

2021
The Effects of Intraoperative Local Tranexamic Acid on Periorbital Edema and Ecchymosis in Septorhinoplasty.
    The Journal of craniofacial surgery, 2021, Sep-01, Volume: 32, Issue:6

    Topics: Ecchymosis; Edema; Humans; Postoperative Complications; Rhinoplasty; Tranexamic Acid

2021
Effect of Tranexamic Acid Administration on Postoperative Ecchymosis and Edema in Excision of Lipomas.
    Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2021, 03-01, Volume: 47, Issue:3

    Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antifibrinolytic Agents; Dermatologic Surgical

2021
Commentary on: Local Infiltration of Tranexamic Acid (TXA) in Liposuction: A Single-Surgeon Outcomes Analysis and Considerations for Minimizing Postoperative Donor Site Ecchymosis.
    Aesthetic surgery journal, 2021, 06-14, Volume: 41, Issue:7

    Topics: Blood Loss, Surgical; Ecchymosis; Humans; Lipectomy; Surgeons; Tranexamic Acid

2021
The Use of Tranexamic Acid in Facial Cosmetic Surgery Procedures: A Technical Note.
    Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 2021, Volume: 79, Issue:11

    Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Ecchymosis; Humans; Surgery, Plastic; Tranexamic Acid

2021
Commentary on: "Comparison of the Effect of Dexamethasone and Tranexamic Acid, Separately or in Combination on Post-rhinoplasty and Edema and Ecchymosis".
    Aesthetic plastic surgery, 2018, Volume: 42, Issue:1

    Topics: Dexamethasone; Ecchymosis; Edema; Humans; Osteotomy; Postoperative Complications; Rhinoplasty; Trane

2018