tranexamic acid has been researched along with Craniocerebral Trauma in 10 studies
Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.
Craniocerebral Trauma: Traumatic injuries involving the cranium and intracranial structures (i.e., BRAIN; CRANIAL NERVES; MENINGES; and other structures). Injuries may be classified by whether or not the skull is penetrated (i.e., penetrating vs. nonpenetrating) or whether there is an associated hemorrhage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To summarize current literature evaluating tranexamic acid in the management of intracranial bleeding associated with traumatic and nontraumatic brain injuries and implications for clinical practice." | 9.69 | Therapeutic review: The role of tranexamic acid in management of traumatic brain injury, nontraumatic intracranial hemorrhage, and aneurysmal subarachnoid hemorrhage. ( Crowley, KL; Groth, CM; Sigmon, J, 2023) |
| " The CRASH-2 trial aimed to determine the effect of the early administration of tranexamic acid on death and transfusion requirement in bleeding trauma patients." | 9.17 | The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. ( Balogun, E; Barnetson, L; Cairns, J; Coats, T; Cook, L; Guerriero, C; Hunt, B; Kawahara, T; Perel, P; Prieto-Merino, D; Ramos, M; Roberts, I; Shakur, H, 2013) |
| "We describe, for the first time, the use of topical tranexamic acid as an adjunct to traditional methods in the control of bleeding in burns surgery." | 7.78 | Use of tranexamic acid to reduce bleeding in burns surgery. ( Brooks, P; Chapman, TW; Tang, YM, 2012) |
| "To summarize current literature evaluating tranexamic acid in the management of intracranial bleeding associated with traumatic and nontraumatic brain injuries and implications for clinical practice." | 5.69 | Therapeutic review: The role of tranexamic acid in management of traumatic brain injury, nontraumatic intracranial hemorrhage, and aneurysmal subarachnoid hemorrhage. ( Crowley, KL; Groth, CM; Sigmon, J, 2023) |
| " The CRASH-2 trial aimed to determine the effect of the early administration of tranexamic acid on death and transfusion requirement in bleeding trauma patients." | 5.17 | The CRASH-2 trial: a randomised controlled trial and economic evaluation of the effects of tranexamic acid on death, vascular occlusive events and transfusion requirement in bleeding trauma patients. ( Balogun, E; Barnetson, L; Cairns, J; Coats, T; Cook, L; Guerriero, C; Hunt, B; Kawahara, T; Perel, P; Prieto-Merino, D; Ramos, M; Roberts, I; Shakur, H, 2013) |
| "We describe, for the first time, the use of topical tranexamic acid as an adjunct to traditional methods in the control of bleeding in burns surgery." | 3.78 | Use of tranexamic acid to reduce bleeding in burns surgery. ( Brooks, P; Chapman, TW; Tang, YM, 2012) |
| " Reducing injection pain of local anesthetics, reducing irradiation by using alternative diagnostic tools in appendicitis suspicion, and identification of trauma patients who benefit from tranexamic acid administration are other illustrations of the efforts to improve efficacy, safety and comfort in the management of emergency patients." | 3.78 | [Emergency medicine: updates 2011]. ( Carron, PN; Dami, F; Grosgurin, O; Marti, C; Rutschmann, O; Rutz, P, 2012) |
| "Tranexamic acid (TXA) has been shown to decrease mortality and blood product requirements in severely injured patients." | 1.51 | Tranexamic acid administration following head trauma in a combat setting: Does tranexamic acid result in improved neurologic outcomes? ( Bingham, J; Eckert, M; Kuckelman, J; Lammers, D; Martin, M; Morte, D, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 4 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sigmon, J | 1 |
| Crowley, KL | 1 |
| Groth, CM | 1 |
| Chew, SJHL | 1 |
| Ooi, JZ | 1 |
| Coats, TJ | 1 |
| Lecky, FE | 1 |
| Morales-Cané, I | 1 |
| Valverde-León, MDR | 1 |
| Rodríguez-Borrego, MA | 1 |
| López Soto, PJ | 1 |
| Morte, D | 1 |
| Lammers, D | 1 |
| Bingham, J | 1 |
| Kuckelman, J | 1 |
| Eckert, M | 1 |
| Martin, M | 1 |
| Roberts, I | 1 |
| Shakur, H | 1 |
| Coats, T | 1 |
| Hunt, B | 1 |
| Balogun, E | 1 |
| Barnetson, L | 1 |
| Cook, L | 1 |
| Kawahara, T | 1 |
| Perel, P | 1 |
| Prieto-Merino, D | 1 |
| Ramos, M | 1 |
| Cairns, J | 1 |
| Guerriero, C | 1 |
| Majima, N | 1 |
| Nishihara, I | 1 |
| Yamaguchi, K | 1 |
| Kawakami, M | 1 |
| Amissah-Arthur, KN | 1 |
| Groppe, M | 1 |
| Scotcher, S | 1 |
| Tang, YM | 1 |
| Chapman, TW | 1 |
| Brooks, P | 1 |
| Marti, C | 1 |
| Grosgurin, O | 1 |
| Dami, F | 1 |
| Rutz, P | 1 |
| Carron, PN | 1 |
| Rutschmann, O | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Tranexamic Acid for Blood Loss Minimization in Endoscopic Pituitary Surgery: A Double-Blind Randomized Controlled Trial[NCT04863339] | Phase 2 | 0 participants (Actual) | Interventional | 2022-03-31 | Withdrawn (stopped due to Challenges in recruitment) | ||
| Randomized Study on the Topical Application of Tranexamic Acid to Wound Bed for Hemostasis in the Setting Granulating Wounds Following Mohs Micrographic Surgery[NCT04541303] | Early Phase 1 | 62 participants (Anticipated) | Interventional | 2020-10-08 | Recruiting | ||
| The Immunomodulatory Effect of Antrifibrinolytic (Tranexamic Acid) in Total Knee Arthroplasty[NCT03795649] | 80 participants (Anticipated) | Interventional | 2018-12-18 | Recruiting | |||
| A Large Randomised Placebo Controlled Trial Among Trauma Patients With, or at Risk of, Significant Haemorrhage, of the Effects of Antifibrinolytic Treatment on Death and Transfusion Requirement[NCT00375258] | Phase 3 | 20,211 participants (Actual) | Interventional | 2005-05-31 | Completed | ||
| Tranexamic Acid to Prevent Bleeding After Endoscopic Resection of Large Colorectal Polyps: A Pilot Project[NCT04559880] | Phase 4 | 25 participants (Actual) | Interventional | 2020-09-10 | Active, not recruiting | ||
| The Effect of Tranexamic Acid (TXA) on Blood Loss and Transfusion Rates in Burn Wound Surgery - A Randomized, Double-Blinded Placebo-Controlled Trial[NCT02753816] | 25 participants (Actual) | Interventional | 2016-04-30 | Terminated (stopped due to Study enrollment and goals unable to be reached.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
To determine the impact of perioperative administration of Tranexamic Acid on transfusion rates in major burn surgeries. (NCT02753816)
Timeframe: First burn surgery to hospital discharge
| Intervention | Patients with 1 or more transfusions (Number) |
|---|---|
| Tranexamic Acid | 2 |
| Placebo | 3 |
To determine the impact of Tranexamic Acid on total hospital length of stay by comparing the hospital admission date and the hospital discharge date. This determination will take into account current burn size and location, procedures performed and their effect on wound healing and skin graft survival. (NCT02753816)
Timeframe: Hospital admission to hospital discharge
| Intervention | Days (Median) |
|---|---|
| Tranexamic Acid | 23 |
| Placebo | 9 |
To determine the impact of perioperative administration of Tranexamic Acid on blood loss in major burn surgeries. (NCT02753816)
Timeframe: Intraoperative, average 122 minutes
| Intervention | mL (Median) |
|---|---|
| Tranexamic Acid | 100 |
| Placebo | 325 |
2 trials available for tranexamic acid and Craniocerebral Trauma
8 other studies available for tranexamic acid and Craniocerebral Trauma
| Article | Year |
|---|---|
"Tranexamic acid administration following head trauma in a combat setting: Does tranexamic acid result in improved neurologic outcomes?"
Topics: Antifibrinolytic Agents; Craniocerebral Trauma; Humans; Tranexamic Acid | 2020 |
The CRASH3 study: prehospital TXA for every injured patient?
Topics: Adult; Aged; Aged, 80 and over; Antifibrinolytic Agents; Craniocerebral Trauma; Emergency Medical Se | 2020 |
Tranexamic acid for head injuries: on the CRASH-3 trial.
Topics: Antifibrinolytic Agents; Clinical Trials as Topic; Craniocerebral Trauma; Hemorrhage; Humans; Tranex | 2021 |
Tranexamic acid administration following head trauma in a combat setting: Does tranexamic acid result in improved neurologic outcomes?
Topics: Abbreviated Injury Scale; Adult; Afghan Campaign 2001-; Antifibrinolytic Agents; Blood Transfusion; | 2019 |
[Usefulness of tranexamic acid in patients with severe head injury].
Topics: Acute Disease; Antifibrinolytic Agents; Craniocerebral Trauma; Female; Humans; Male; Middle Aged; Re | 2013 |
Orbital subperiosteal hematoma after thrombolysis and anticoagulation for acute myocardial infarction.
Topics: Accidental Falls; Acute Disease; Adult; Anticoagulants; Antifibrinolytic Agents; Craniocerebral Trau | 2009 |
Use of tranexamic acid to reduce bleeding in burns surgery.
Topics: Bandages; Blood Loss, Surgical; Burns; Craniocerebral Trauma; Humans; Male; Middle Aged; Neck Injuri | 2012 |
[Emergency medicine: updates 2011].
Topics: Acute Disease; Ambulatory Care; Anisoles; Antifibrinolytic Agents; Appendicitis; Atrial Fibrillation | 2012 |