tranexamic acid and Burns studies

Burns: Injuries to tissues caused by contact with heat, steam, chemicals (BURNS, CHEMICAL), electricity (BURNS, ELECTRIC), or the like.

Research Excerpts

Excerpt	Relevance	Reference
"We describe, for the first time, the use of topical tranexamic acid as an adjunct to traditional methods in the control of bleeding in burns surgery."	7.78	Use of tranexamic acid to reduce bleeding in burns surgery. ( Brooks, P; Chapman, TW; Tang, YM, 2012)
"This study was carried out to evaluate role of intravenous tranexamic acid (TXA) in reducing blood loss during tangential excision of burns."	5.51	Effect of single dose intravenous tranexamic acid on blood loss in tangential excision of burn wounds - A double blind randomised controlled trial. ( K S, A; Kumar, P; Sharma, RK; Subair, M, 2022)
"We describe, for the first time, the use of topical tranexamic acid as an adjunct to traditional methods in the control of bleeding in burns surgery."	3.78	Use of tranexamic acid to reduce bleeding in burns surgery. ( Brooks, P; Chapman, TW; Tang, YM, 2012)
"Tranexamic acid (TXA) is an anti-fibrinolytic that has been shown to reduce surgical blood losses; however, its use in burn surgery is not well established."	3.01	Tranexamic acid in burn surgery: A systematic review and meta-analysis. ( Boctor, MJ; Fijany, AJ; Gandhi, RR; Givechian, KB; Olsson, SE; Pekarev, M; Zago, I, 2023)
"Tranexamic acid has also emerged as a promising agent in aesthetic surgery and burn care, due to its favorable safety profile and role in reducing blood loss, achieving an improved surgical field, and reducing edema and ecchymosis."	2.58	Antifibrinolytic Agents in Plastic Surgery: Current Practices and Future Directions. ( Brown, S; Taub, PJ; Yao, A, 2018)

Research

Studies (10)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Number of Breasts With Development of Hematoma

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	7 (70.00)	24.3611
2020's	3 (30.00)	2.80

Authors	Studies
K S, A	1
Kumar, P	1
Subair, M	1
Sharma, RK	1
Tapking, C	1
Hundeshagen, G	1
Kirchner, M	1
Fischer, S	1
Kneser, U	1
Bliesener, B	1
Fijany, AJ	1
Givechian, KB	1
Zago, I	1
Olsson, SE	1
Boctor, MJ	1
Gandhi, RR	1
Pekarev, M	1
Brown, S	1
Yao, A	1
Taub, PJ	1
Carter, DW	1
Prudovsky, I	1
Kacer, D	1
Soul, T	1
Kumpel, C	1
Pyburn, K	1
Palmeri, M	1
Kramer, R	1
Rappold, J	1
Walsh, K	1
Nikkhah, D	1
Dheansa, B	1
Domínguez, A	1
Alsina, E	1
Landín, L	1
García-Miguel, JF	1
Casado, C	1
Gilsanz, F	1
Kopp, R	1
Bruells, C	1
Troccola, A	1
Maruccia, M	1
Zampieri, AE	1
Dessy, LA	1
Tang, YM	1
Chapman, TW	1
Brooks, P	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Efficacy of Tranexamic Acid in Debridement Surgery of Burns on the Volume of Bleeding in Transfusion Requirements at Centro Medico de Occidente'[NCT05855590]	Phase 3	20 participants (Anticipated)	Interventional	2022-01-01	Recruiting
Use of TRanEXamic Acid in Reduction Mammoplasty (TREX-ARM): a Double-blinded Randomized Controlled Trial[NCT04947514]	Phase 4	98 participants (Actual)	Interventional	2021-10-29	Completed
The Effect of Tranexamic Acid (TXA) on Blood Loss and Transfusion Rates in Burn Wound Surgery - A Randomized, Double-Blinded Placebo-Controlled Trial[NCT02753816]		25 participants (Actual)	Interventional	2016-04-30	Terminated (stopped due to Study enrollment and goals unable to be reached.)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

The number of breasts with clinically significant hematoma (collection of blood under the skin) requiring either conservative management or operative washout was determined. (NCT04947514)
Timeframe: Up to 30 days

Number of Participants Requiring a Blood Transfusion

Intervention	breasts (Number)
Treatment Side (Right or Left)	2
Placebo Side (Right or Left)	1

The number of participants requiring blood transfusion was based on the postoperative decline in hematocrit level (NCT04947514)
Timeframe: Up to 30 days

Number of Participants With Deep Vein Thrombosis/Venous Thromboembolism

Intervention	Participants (Count of Participants)
Treatment Side (Right or Left)	0
Placebo Side (Right or Left)	0

Incidence of clinically significant deep vein thrombosis or pulmonary embolism detected on imaging (ultrasound or CT scan) (NCT04947514)
Timeframe: Up to 30 days

Blood Transfusion Rates, Defined Nominally (Binary) as Having at Least One Transfusion

Intervention	Participants (Count of Participants)
Treatment Side (Right or Left)	0
Placebo Side (Right or Left)	0

To determine the impact of perioperative administration of Tranexamic Acid on transfusion rates in major burn surgeries. (NCT02753816)
Timeframe: First burn surgery to hospital discharge

Effect of Tranexamic Acid on the Total Length of Hospital Admission for a Large (350 cm2) Burn Injury

Intervention	Patients with 1 or more transfusions (Number)
Tranexamic Acid	2
Placebo	3

To determine the impact of Tranexamic Acid on total hospital length of stay by comparing the hospital admission date and the hospital discharge date. This determination will take into account current burn size and location, procedures performed and their effect on wound healing and skin graft survival. (NCT02753816)
Timeframe: Hospital admission to hospital discharge

Intraoperative Blood Loss in mL

Intervention	Days (Median)
Tranexamic Acid	23
Placebo	9

To determine the impact of perioperative administration of Tranexamic Acid on blood loss in major burn surgeries. (NCT02753816)
Timeframe: Intraoperative, average 122 minutes

Article	Year
Tranexamic acid in burn surgery: A systematic review and meta-analysis. Burns : journal of the International Society for Burn Injuries, 2023, Volume: 49, Issue:6 Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Burns; Humans; Tranexamic Acid; Venous Thromboembolis	2023
Antifibrinolytic Agents in Plastic Surgery: Current Practices and Future Directions. Plastic and reconstructive surgery, 2018, Volume: 141, Issue:6 Topics: Aminocaproic Acid; Antifibrinolytic Agents; Burns; Clinical Trials as Topic; Cohort Studies; Forecas	2018

Article	Year
Tranexamic acid reduced blood transfusions in acute burn surgery: A retrospective case-controlled trial. Burns : journal of the International Society for Burn Injuries, 2022, Volume: 48, Issue:3 Topics: Adult; Aged; Antifibrinolytic Agents; Blood Loss, Surgical; Blood Transfusion; Burns; Case-Control S	2022
Tranexamic acid suppresses the release of mitochondrial DAMPs and reduces lung inflammation in a murine burn model. The journal of trauma and acute care surgery, 2019, Volume: 86, Issue:4 Topics: Administration, Topical; Alarmins; Animals; Burns; Disease Models, Animal; DNA, Mitochondrial; Male;	2019
What is the evidence for tranexamic acid in burns? Burns : journal of the International Society for Burn Injuries, 2014, Volume: 40, Issue:5 Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Burns; Hemorrhage; Humans; Tranexamic Acid	2014
Transfusion requirements in burn patients undergoing primary wound excision: effect of tranexamic acid. Minerva anestesiologica, 2017, Volume: 83, Issue:4 Topics: Adult; Aged; Antifibrinolytic Agents; Blood Transfusion; Burns; Erythrocyte Transfusion; Female; Hum	2017
Management of coagulopathy in the severely burned patient: a place for antifibrinolytic therapy? Minerva anestesiologica, 2017, Volume: 83, Issue:4 Topics: Antifibrinolytic Agents; Blood Coagulation Disorders; Blood Transfusion; Burns; Humans; Tranexamic A	2017
Management of second-degree burn induced by dry ice in a Christmas disease patient. Burns : journal of the International Society for Burn Injuries, 2010, Volume: 36, Issue:6 Topics: Administration, Oral; Adult; Antifibrinolytic Agents; Bandages; Burns; Dry Ice; Factor IX; Hemophili	2010
Use of tranexamic acid to reduce bleeding in burns surgery. Journal of plastic, reconstructive & aesthetic surgery : JPRAS, 2012, Volume: 65, Issue:5 Topics: Bandages; Blood Loss, Surgical; Burns; Craniocerebral Trauma; Humans; Male; Middle Aged; Neck Injuri	2012

tranexamic acid and Burns