tranexamic acid has been researched along with Brain Injuries in 32 studies
Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To summarize current literature evaluating tranexamic acid in the management of intracranial bleeding associated with traumatic and nontraumatic brain injuries and implications for clinical practice." | 9.69 | Therapeutic review: The role of tranexamic acid in management of traumatic brain injury, nontraumatic intracranial hemorrhage, and aneurysmal subarachnoid hemorrhage. ( Crowley, KL; Groth, CM; Sigmon, J, 2023) |
| "To summarize current literature evaluating tranexamic acid in the management of intracranial bleeding associated with traumatic and nontraumatic brain injuries and implications for clinical practice." | 5.69 | Therapeutic review: The role of tranexamic acid in management of traumatic brain injury, nontraumatic intracranial hemorrhage, and aneurysmal subarachnoid hemorrhage. ( Crowley, KL; Groth, CM; Sigmon, J, 2023) |
| "Analysis of these reviews yielded meanfuling observations: (1) The effectiveness of most ordinary treatments in TBI is inconclusive except that corticosteroids are likely to be ineffective or harmful, and tranexamic acid, nimodipine and progesterone show a promising effect in bleeding trauma, traumatic subarachnoid hemorrhage, TBI or severe TBI." | 4.88 | Is management of acute traumatic brain injury effective? A literature review of published Cochrane Systematic Reviews. ( Gao, GY; Jiang, JY; Lei, J, 2012) |
| "Several studies have demonstrated the clinical utility of tranexamic acid (TXA) for use in trauma patients presenting with significant hemorrhage." | 4.31 | EFFECTS OF TRANEXAMIC ACID ON NEUROPATHOLOGY, ELECTROENCEPHALOGRAPHY, AND CEREBRAL FIBRIN DEPOSITION IN A RAT MODEL OF POLYTRAUMA WITH CONCOMITANT PENETRATING TRAUMATIC BRAIN INJURY. ( Bailey, ZS; Cao, Y; Cardiff, K; Gilsdorf, J; Houchins, M; Lu, XC; Scultetus, A; Shear, D; Wang, P; Yang, X, 2023) |
| "Tranexamic acid (TXA) has shown to be beneficial in selected patients with hemorrhagic shock." | 4.12 | The effect of prehospital tranexamic acid on outcome in polytrauma patients with associated severe brain injury. ( Jochems, D; Leenen, LPH; van Wessem, KJP, 2022) |
| "A reduction in mortality with the early use of tranexamic acid has been demonstrated in severely injured patients who are bleeding." | 3.85 | Effectiveness of early administration of tranexamic acid in patients with severe trauma. ( Hagiwara, A; Kushimoto, S; Matsui, H; Murata, K; Otomo, Y; Shiraishi, A, 2017) |
| " Risks of adverse events (all moderate, low, or very low certainty) were similar between placebo and TXA." | 2.72 | Efficacy and safety of tranexamic acid in acute traumatic brain injury: a systematic review and meta-analysis of randomized-controlled trials. ( Alhazzani, W; Belley-Cote, EP; Fernando, SM; Lawati, KA; Maqbali, SA; Morgenstern, J; Owen, JJ; Petrosoniak, A; Quinlan, D; Rimawi, HA; Rochwerg, B; Sharif, S; Sharma, SV; Zeller, M, 2021) |
| "Fibrinogen depletes early after severe trauma; therefore, it seems to be reasonable to maintain plasma fibrinogen as early as possible." | 2.50 | Tranexamic acid, fibrinogen concentrate, and prothrombin complex concentrate: data to support prehospital use? ( Maegele, M; Schlimp, CJ; Schöchl, H, 2014) |
| "Mice were then subjected to controlled hemorrhagic shock for 1 h to a goal MAP of 25 mmHg." | 1.72 | MULTIMODAL TREATMENT APPROACHES TO COMBINED TRAUMATIC BRAIN INJURY AND HEMORRHAGIC SHOCK ALTER POSTINJURY INFLAMMATORY RESPONSE. ( Baucom, MR; England, LG; Goodman, MD; Pritts, TA; Schuster, RM; Wallen, TE, 2022) |
| "Persistent intracerebral hemorrhage (ICH) is a major cause of death and disability after traumatic brain injury (TBI) for which no medical treatment is available." | 1.42 | Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice. ( Abdeen, S; Abramovitch, R; Abu Fanne, R; Basheer, M; Cines, DB; Higazi, AA; Higazi, M; Hijazi, N; Maraga, E; Yarovoi, S, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (3.13) | 29.6817 |
| 2010's | 14 (43.75) | 24.3611 |
| 2020's | 17 (53.13) | 2.80 |
| Authors | Studies |
|---|---|
| van Wessem, KJP | 1 |
| Jochems, D | 1 |
| Leenen, LPH | 1 |
| Wallen, TE | 1 |
| Baucom, MR | 1 |
| England, LG | 1 |
| Schuster, RM | 1 |
| Pritts, TA | 1 |
| Goodman, MD | 1 |
| Bailey, ZS | 1 |
| Yang, X | 1 |
| Cardiff, K | 1 |
| Wang, P | 1 |
| Houchins, M | 1 |
| Lu, XC | 1 |
| Cao, Y | 1 |
| Gilsdorf, J | 1 |
| Scultetus, A | 1 |
| Shear, D | 1 |
| Sigmon, J | 1 |
| Crowley, KL | 1 |
| Groth, CM | 1 |
| Tanaka, T | 1 |
| Suehiro, E | 1 |
| Matsuno, A | 1 |
| Cap, AP | 1 |
| Taccone, FS | 1 |
| Citerio, G | 2 |
| Stocchetti, N | 1 |
| Blanchard, PG | 1 |
| Paré, D | 1 |
| Truchot, J | 1 |
| Mercier, E | 1 |
| Solla, DJF | 1 |
| Rubiano, AM | 1 |
| Teixeira, MJ | 1 |
| de Andrade, AF | 1 |
| Paiva, WS | 1 |
| Reynard, C | 1 |
| Berg, PVD | 1 |
| Body, R | 1 |
| Kolias, AG | 1 |
| Horner, D | 1 |
| Menon, DK | 1 |
| Wilson, M | 1 |
| Hutchinson, PJ | 1 |
| Bourn, S | 1 |
| Dodds, N | 1 |
| Schober, P | 1 |
| Mascha, EJ | 1 |
| Loer, SA | 1 |
| Schwarte, LA | 1 |
| Bossers, SM | 1 |
| Goursaud, S | 1 |
| Gaberel, T | 1 |
| Kawada, T | 1 |
| Lawati, KA | 1 |
| Sharif, S | 1 |
| Maqbali, SA | 1 |
| Rimawi, HA | 1 |
| Petrosoniak, A | 1 |
| Belley-Cote, EP | 1 |
| Sharma, SV | 1 |
| Morgenstern, J | 1 |
| Fernando, SM | 1 |
| Owen, JJ | 1 |
| Zeller, M | 1 |
| Quinlan, D | 1 |
| Alhazzani, W | 1 |
| Rochwerg, B | 1 |
| Maas, AIR | 1 |
| Steyerberg, EW | 1 |
| Brenner, A | 1 |
| Belli, A | 1 |
| Chaudhri, R | 1 |
| Coats, T | 1 |
| Frimley, L | 1 |
| Jamaluddin, SF | 1 |
| Jooma, R | 1 |
| Mansukhani, R | 1 |
| Sandercock, P | 1 |
| Shakur-Still, H | 1 |
| Shokunbi, T | 1 |
| Roberts, I | 2 |
| Ghawnni, A | 1 |
| Coates, A | 1 |
| Owen, J | 1 |
| Schöchl, H | 1 |
| Schlimp, CJ | 1 |
| Maegele, M | 1 |
| Valle, EJ | 1 |
| Allen, CJ | 1 |
| Van Haren, RM | 1 |
| Jouria, JM | 1 |
| Li, H | 1 |
| Livingstone, AS | 1 |
| Namias, N | 1 |
| Schulman, CI | 1 |
| Proctor, KG | 1 |
| Piper, BJ | 1 |
| Zehtabchi, S | 2 |
| Abdel Baki, SG | 2 |
| Falzon, L | 2 |
| Nishijima, DK | 2 |
| Hijazi, N | 1 |
| Abu Fanne, R | 1 |
| Abramovitch, R | 1 |
| Yarovoi, S | 1 |
| Higazi, M | 1 |
| Abdeen, S | 1 |
| Basheer, M | 1 |
| Maraga, E | 1 |
| Cines, DB | 1 |
| Higazi, AA | 1 |
| Shiraishi, A | 1 |
| Kushimoto, S | 1 |
| Otomo, Y | 1 |
| Matsui, H | 1 |
| Hagiwara, A | 1 |
| Murata, K | 1 |
| Roos, YB | 1 |
| Lei, J | 1 |
| Gao, GY | 1 |
| Jiang, JY | 1 |
| Dewan, Y | 1 |
| Komolafe, EO | 1 |
| Mejía-Mantilla, JH | 1 |
| Perel, P | 1 |
| Shakur, H | 1 |
| Boling, B | 1 |
| Moore, K | 1 |
| Liu-DeRyke, X | 1 |
| Rhoney, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Tranexamic Acid for the Treatment of Significant Traumatic Brain Injury: an International Randomised, Double Blind Placebo Controlled Trial[NCT01402882] | Phase 3 | 12,737 participants (Actual) | Interventional | 2012-07-31 | Completed | ||
| TRACE STUDY: A Randomized Controlled Trial Using Tranexamic Acid in the Treatment of Subdural Hematoma[NCT05713630] | Phase 3 | 130 participants (Anticipated) | Interventional | 2024-03-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for tranexamic acid and Brain Injuries
| Article | Year |
|---|---|
Efficacy and safety of tranexamic acid in acute traumatic brain injury: a systematic review and meta-analysis of randomized-controlled trials.
Topics: Adolescent; Adult; Brain Injuries; Brain Injuries, Traumatic; Humans; Randomized Controlled Trials a | 2021 |
Tranexamic acid, fibrinogen concentrate, and prothrombin complex concentrate: data to support prehospital use?
Topics: Antifibrinolytic Agents; Blood Coagulation; Blood Coagulation Factors; Blood Transfusion; Brain Inju | 2014 |
Tranexamic acid for traumatic brain injury: a systematic review and meta-analysis.
Topics: Antifibrinolytic Agents; Brain Injuries; Humans; Intracranial Hemorrhages; Randomized Controlled Tri | 2014 |
Is management of acute traumatic brain injury effective? A literature review of published Cochrane Systematic Reviews.
Topics: Brain Injuries; Hemorrhage; Humans; Systematic Reviews as Topic; Tranexamic Acid | 2012 |
Tranexamic acid (TXA) use in trauma.
Topics: Antifibrinolytic Agents; Blood Coagulation Disorders; Brain Injuries; Cause of Death; Emergency Serv | 2012 |
Hemostatic therapy for the treatment of intracranial hemorrhage.
Topics: Aminocaproates; Antifibrinolytic Agents; Brain Injuries; Clinical Trials as Topic; Factor VIIa; Hemo | 2008 |
6 trials available for tranexamic acid and Brain Injuries
| Article | Year |
|---|---|
Therapeutic review: The role of tranexamic acid in management of traumatic brain injury, nontraumatic intracranial hemorrhage, and aneurysmal subarachnoid hemorrhage.
Topics: Brain Injuries; Brain Injuries, Traumatic; Craniocerebral Trauma; Humans; Intracranial Hemorrhages; | 2023 |
Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial.
Topics: Antifibrinolytic Agents; Brain Injuries; Humans; Multiple Trauma; Neuroprotective Agents; Protective | 2020 |
Compliance of tranexamic acid administration to trauma patients at a level-one trauma centre.
Topics: Antifibrinolytic Agents; Brain Injuries; Dose-Response Relationship, Drug; Follow-Up Studies; Humans | 2018 |
Do all trauma patients benefit from tranexamic acid?
Topics: Adult; Antifibrinolytic Agents; Brain Injuries; Dose-Response Relationship, Drug; Double-Blind Metho | 2014 |
Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study).
Topics: Adult; Antifibrinolytic Agents; Brain Injuries; Case-Control Studies; Female; Glasgow Coma Scale; Hu | 2011 |
CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial.
Topics: Adult; Antifibrinolytic Agents; Brain Injuries; Clinical Protocols; Cost-Benefit Analysis; Data Coll | 2012 |
20 other studies available for tranexamic acid and Brain Injuries
| Article | Year |
|---|---|
The effect of prehospital tranexamic acid on outcome in polytrauma patients with associated severe brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Female; Humans; Male; Middle Age | 2022 |
MULTIMODAL TREATMENT APPROACHES TO COMBINED TRAUMATIC BRAIN INJURY AND HEMORRHAGIC SHOCK ALTER POSTINJURY INFLAMMATORY RESPONSE.
Topics: Animals; Biomarkers; Brain Injuries; Brain Injuries, Traumatic; Chemokine CCL3; Combined Modality Th | 2022 |
EFFECTS OF TRANEXAMIC ACID ON NEUROPATHOLOGY, ELECTROENCEPHALOGRAPHY, AND CEREBRAL FIBRIN DEPOSITION IN A RAT MODEL OF POLYTRAUMA WITH CONCOMITANT PENETRATING TRAUMATIC BRAIN INJURY.
Topics: Animals; Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Electroencephalography; | 2023 |
[Initial Management of Traumatic Brain Injury].
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Japan; Tranexamic Acid | 2023 |
CRASH-3: a win for patients with traumatic brain injury.
Topics: Brain Injuries; Brain Injuries, Traumatic; Humans; Morbidity; Tranexamic Acid | 2019 |
Is tranexamic acid going to CRASH the management of traumatic brain injury?
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula | 2020 |
Does tranexamic acid reduce traumatic brain injury-related death?
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid | 2020 |
Tranexamic acid for traumatic brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula | 2020 |
Tranexamic acid for traumatic brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula | 2020 |
Tranexamic acid for traumatic brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula | 2020 |
Tranexamic acid for traumatic brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula | 2020 |
Tranexamic acid for traumatic brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula | 2020 |
Tranexamic acid for traumatic brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula | 2020 |
The efficacy of tranexamic acid for brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Humans; Tranexamic Acid | 2021 |
Tranexamic acid in traumatic brain injury: systematic review and meta-analysis trumps a large clinical trial?
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid | 2021 |
Tranexamic acid in brain injury: the devil in the detail.
Topics: Antifibrinolytic Agents; Brain Injuries; Humans; Tranexamic Acid | 2015 |
Tranexamic acid in brain injury: devil in the detail.
Topics: Antifibrinolytic Agents; Brain Injuries; Humans; Tranexamic Acid | 2015 |
Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice.
Topics: Animals; Antifibrinolytic Agents; Brain; Brain Injuries; Cerebral Hemorrhage; Fibrin; Fibrinolysis; | 2015 |
Effectiveness of early administration of tranexamic acid in patients with severe trauma.
Topics: Adult; Aged; Antifibrinolytic Agents; Blood Transfusion; Brain Injuries; Female; Hemorrhage; Humans; | 2017 |
Tranexamic acid for traumatic brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Female; Humans; Intracranial Hemorrhages; Male; Tranexamic | 2011 |