tranexamic acid and Brain Diseases

tranexamic acid has been researched along with Brain Diseases in 2 studies

Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.

Brain Diseases: Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.

Research

Studies (2)

Authors

Clinical Trials (1)

Trial Overview

Trial Outcomes

Disability Rating Scale (DRS) at 6 Months

The DRS is designed to classify patients based on their degree of function after brain injury. The DRS consists of 8 items that fall into 4 categories: (a) arousability, awareness and responsivity, (b) cognitive ability for self-care activities, (c) dependence on others, and (d) psychosocial adaptability. The score ranges from 0 (no disability) to 30 (death). (NCT01990768)
Timeframe: 6 months post-injury

Disability Rating Scale (DRS) at Discharge

The DRS is designed to classify patients based on their degree of function after brain injury. The DRS consists of 8 items that fall into 4 categories: (a) arousability, awareness and responsivity, (b) cognitive ability for self-care activities, (c) dependence on others, and (d) psychosocial adaptability. The score ranges from 0 (no disability) to 30 (death). (NCT01990768)
Timeframe: At the end of the hospital stay (average of 9 days post injury)

Hospital-free Days

Hospital-free days count any day from hospital admission through day 28 that the patient is alive and out of the hospital. (NCT01990768)
Timeframe: From hospital admission through day 28

Intensive Care Unit (ICU)-Free Days

ICU-free days count any day from hospital admission through day 28 that the patient is alive and not in the ICU. Subjects who die prior to discharge (even if after 28 days) are assigned a value of 0. (NCT01990768)
Timeframe: From hospital admission through day 28

Number of Participants Who Died Within 28 Days

The counts of patients who died on or before day 28 are reported. (NCT01990768)
Timeframe: 28 days after hospital arrival

Number of Participants With Any Thromboembolic Event

Diagnosis of one or more of the following: cerebral ischemic event, myocardial infarction (MI), deep vein thrombosis (DVT), pulmonary embolism (PE), or any other thromboembolic event (NCT01990768)
Timeframe: From hospital admission through 28 days or the end of the hospital stay if sooner (average of 9 days)

Number of Participants With Cerebral Ischemic Event

Diagnosis of cerebral ischemic event (NCT01990768)
Timeframe: From hospital admission through 28 days or the end of the hospital stay if sooner (average of 9 days)

Number of Participants With Deep Vein Thrombosis (DVT)

Diagnosis of DVT (NCT01990768)
Timeframe: From hospital admission through 28 days or the end of the hospital stay if sooner (average of 9 days)

Number of Participants With Intracranial Hemorrhage (ICH) Progression

All clinically indicated head computed tomography (CT) scans obtained during the initial hospitalization or within the first 28 days were assessed for ICH. Parenchymal (IPH), subdural (SDH) and epidural (EDH) hemorrhage volumes were measured and quantified using volumetric software and verified by manual calculations based on the previously validated ABC/2 technique. The sum of the IPH, SDH, and EDH volumes were compared across scans. A relative increase of 33% (and at least a 1 ml increase) on any subsequent scan compared to the initial scan was defined as a progression. (NCT01990768)
Timeframe: From hospital admission through 28 days or the end of the hospital stay if sooner (average of 13 days among patients with multiple scans)

Number of Participants With Myocardial Infarction (MI)

Diagnosis of an acute myocardial infarction (NCT01990768)
Timeframe: From hospital admission through 28 days or the end of the hospital stay if sooner (average of 9 days)

Number of Participants With One or More Neurosurgical Interventions

Neurosurgical interventions include craniotomy, craniectomy, and placement of a neuromonitoring or drainage device. Counts are of subjects with one or more neurosurgical interventions. (NCT01990768)
Timeframe: From hospital admission through 28 days or the end of the hospital stay if sooner (average of 9 days)

Number of Participants With Pulmonary Embolus (PE)

Diagnosis of PE (NCT01990768)
Timeframe: From hospital admission through 28 days or the end of the hospital stay if sooner (average of 9 days)

Number of Participants With Seizure

Seizures may cause involuntary changes in body movement or function, sensation, awareness, or behavior. Seizures are often associated with a sudden and involuntary contraction of a group of muscles and loss of consciousness. Seizures or episodes of seizure-like activity were reported by medics in the field following the start of study drug infusion through hand-off to the trauma center and by trauma center staff through discharge. Reported events were included if providers gave anti-seizure medication and/or the event was confirmed by EEG. (NCT01990768)
Timeframe: From start of study drug infusion through 28 days or the end of the hospital stay if sooner (average of 9 days)

Number of Participants With Unfavorable Outcome on Dichotomized Glasgow Outcome Scale Extended (GOS-E) at Discharge

GOS-E subdivides the categories of severe and moderate disability and good recovery using a scale of 1 to 8 where 1 = death, 2 = vegetative state, 3 = lower severe disability, 4 = upper severe disability, 5 = lower moderate disability, 6 = upper moderate disability, 7 = lower good recovery, and 8 = upper good recovery. Structured telephone interviews have been developed and validated for the GOS-E and these questions were incorporated into the follow-up survey. GOS-E was dichotomized into unfavorable (1 to 4) and favorable (5 to 8) outcomes. The number of subjects with unfavorable outcome is reported. (NCT01990768)
Timeframe: At the end of the hospital stay (average of 9 days post injury)

Ventilator-free Days

Ventilator-free days count any day from hospital admission through day 28 that the patient is alive and does not require mechanical ventilatory support. Subjects who die prior to discharge (even if after 28 days) are assigned a value of 0. (NCT01990768)
Timeframe: From hospital admission through day 28

Trials

1 trial available for tranexamic acid and Brain Diseases

Other Studies

1 other study available for tranexamic acid and Brain Diseases