tranexamic acid and Atrial Fibrillation studies

Atrial Fibrillation: Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.

Research Excerpts

Excerpt	Relevance	Reference
" He was anticoagulated with dabigatran due to past atrial fibrillation."	7.80	Dabigatran anticoagulation and Stanford type A aortic dissection: lethal coincidence: Case report with literature review. ( Bettex, D; Bosshart, M; Brand, B; Schlicker, A; Spahn, DR; Stein, P, 2014)
"2020 has seen the birth of several relevant studies in emergency medicine of which the following is a selection : 1) conservative treatment for primary spontaneous pneumothorax may be offered ; 2) tranexamic acid does not provide benefit in gastrointestinal bleeding ; 3) the Canadian Syncope Risk Score is validated for the risk stratification of syncopal patients ; 4) early administration of tranexamic acid does not have a significant effect on the neurological prognosis of patients with moderate to severe trauma brain injury ; 5) the notion of frailty seems to be predictive of mortality in the event of intra-hospital cardiac arrest in elderly patients ; 6) a pharmacological cardioversion strategy followed by electrical cardioversion is as effective as initial electrical cardioversion for atrial fibrillation in the emergency room."	5.12	[Emergency medicine : update 2020]. ( Chevallier, JL; Darioli, V; Fehlmann, CA; Garcin, S; Gartner, B; Rojas Lazo, R, 2021)
" He was anticoagulated with dabigatran due to past atrial fibrillation."	3.80	Dabigatran anticoagulation and Stanford type A aortic dissection: lethal coincidence: Case report with literature review. ( Bettex, D; Bosshart, M; Brand, B; Schlicker, A; Spahn, DR; Stein, P, 2014)
" Reducing injection pain of local anesthetics, reducing irradiation by using alternative diagnostic tools in appendicitis suspicion, and identification of trauma patients who benefit from tranexamic acid administration are other illustrations of the efforts to improve efficacy, safety and comfort in the management of emergency patients."	3.78	[Emergency medicine: updates 2011]. ( Carron, PN; Dami, F; Grosgurin, O; Marti, C; Rutschmann, O; Rutz, P, 2012)

Research

Studies (7)

Authors

Clinical Trials (2)

Trial Overview

Trial Outcomes

Number of Patients Required Blood Transfusion

Total Hemoglobin Loss

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (14.29)	29.6817
2010's	3 (42.86)	24.3611
2020's	3 (42.86)	2.80

Authors	Studies
Tang, S	1
Zhou, Z	1
Yang, J	1
Kang, P	1
Shen, B	1
Pei, F	1
Shi, X	1
Barzilai, M	1
Kirgner, I	1
Steimatzky, A	1
Salzer Gotler, D	1
Belnick, Y	1
Shacham-Abulafia, A	1
Avivi, I	1
Raanani, P	1
Yahalom, V	1
Nakav, S	1
Varon, D	1
Yussim, E	1
Bachar, GN	1
Spectre, G	1
Chevallier, JL	1
Rojas Lazo, R	1
Gartner, B	1
Garcin, S	1
Fehlmann, CA	1
Darioli, V	1
Stein, P	1
Bosshart, M	1
Brand, B	1
Schlicker, A	1
Spahn, DR	1
Bettex, D	1
Madrid, C	1
Sanz, M	1
Marti, C	1
Grosgurin, O	1
Dami, F	1
Rutz, P	1
Carron, PN	1
Rutschmann, O	1
Seo, JG	1
Moon, YW	1
Park, SH	1
Kim, SM	1
Ko, KR	1

Trial	Enrollment	Study Type	Start Date	Status
Efficacy of Local Hemostatic Management in Implant Surgery in Anticoagulated Patients on Warfarin: a Randomized Clinical Study[NCT04846114]	71 participants (Actual)	Interventional	2016-03-31	Completed
Efficacy of Low-dose Intra-articular Tranexamic Acid in Total Knee Replacement; A Prospective Triple-blinded Randomized Controlled Trial.[NCT01850394]	152 participants (Actual)	Interventional	2010-01-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Intervention	participants (Number)
Control Group	10
TXA-250 Group	6
TXA-500 Group	0

Total hemoglobin loos measured by difference between hemoglobin preoperatively and the fourth postoperative day (NCT01850394)
Timeframe: 5 days after surgery

Knee Function Scores

Intervention	g/dL (Mean)
Control Group	2.9
TXA-250 Group	2.2
TXA-500 Group	2.2

"Knee function score was measured with 2 methods, and were evaluated preoperatively and then postoperatively at 3-month, 6-month, and 1-year period.~Knee Society Knee Score using for rating knee function measurement and subdivided into two parts; knee score and function score 1.1. Knee score : calculated from pain, presence of deformity, total range of flexion, alignment, and stability. Total score is 100 (0-100), more score means better.~1.2. Function score : calculated from patient's ability to walk and climb stairs. The score ranges from 0-100, more score means better.~Western Ontario and McMaster Universities Arthritis Index or WOMAC score : a widely used, standardized questionnaires for evaluating the condition of patients with knee osteoarthritis, including pain (score = 0-20), stiffness (0-8), and functional limitation (0-68). Total score ranges from 0-68, lower score means better." (NCT01850394)
Timeframe: 1 year after surgery

Number of Patients Having Postoperative Complications

Intervention	units on a scale (Mean)
	Knee Society Knee score at 1 year	WOMAC score at 1 year
Control Group	148.9	15.5
TXA-250 Group	151.2	15.1
TXA-500 Group	150.9	14.5

"Postoperative complications were measured as an incidence of the following complications;~wound hematoma~surgical site infection~systemic infection~deep vein thrombosis~pulmonary embolism~knee stiffness requiring manipulation~medical complication such as myocardial infarction, congestive hear failure" (NCT01850394)
Timeframe: postoperative 1-year period

Perioperative Blood Loss

Intervention	participants (Number)
	Re-clamp incidence	Re-dressing incidence	Venous thromboembolic complication	Congestive heart failure
Control Group	6	3	4	0
TXA-250 Group	1	0	1	1
TXA-500 Group	0	0	2	0

"Drainage blood loss measured by accumulating total drainage volume postoperatively~Calculated total blood loss measured by using specific formula and difference between hematocrit preoperatively and the fourth postoperative day" (NCT01850394)
Timeframe: 5 days after surgery

Intervention	ml (Median)
	Drainage blood loss	Calculated total blood loss
Control Group	546.9	329.2
TXA-250 Group	475.0	239.7
TXA-500 Group	430.2	217.2

Article	Year
[Emergency medicine : update 2020]. Revue medicale suisse, 2021, Jan-13, Volume: 17, Issue:720-1 Topics: Aged; Atrial Fibrillation; Brain Injuries, Traumatic; Canada; Electric Countershock; Emergency Medic	2021
What influence do anticoagulants have on oral implant therapy? A systematic review. Clinical oral implants research, 2009, Volume: 20 Suppl 4 Topics: Administration, Oral; Administration, Topical; Anticoagulants; Atrial Fibrillation; Contraindication	2009

Article	Year
Effects of tranexamic acid on vascular occlusive events and perioperative resuscitation in patients with atrial fibrillation undergoing total joint arthroplasty. Chinese medical journal, 2022, 10-05, Volume: 135, Issue:19 Topics: Antifibrinolytic Agents; Arthroplasty; Arthroplasty, Replacement, Hip; Atrial Fibrillation; Blood Lo	2022
Prothrombin Complex Concentrate before Urgent Surgery in Patients Treated with Rivaroxaban and Apixaban. Acta haematologica, 2020, Volume: 143, Issue:3 Topics: Academic Medical Centers; Aged; Aged, 80 and over; Atrial Fibrillation; Blood Coagulation Factors; B	2020
Dabigatran anticoagulation and Stanford type A aortic dissection: lethal coincidence: Case report with literature review. Acta anaesthesiologica Scandinavica, 2014, Volume: 58, Issue:5 Topics: Aged; Anticoagulants; Aortic Aneurysm, Thoracic; Aortic Dissection; Aortic Valve Insufficiency; Atri	2014
[Emergency medicine: updates 2011]. Revue medicale suisse, 2012, Jan-11, Volume: 8, Issue:323 Topics: Acute Disease; Ambulatory Care; Anisoles; Antifibrinolytic Agents; Appendicitis; Atrial Fibrillation	2012

tranexamic acid and Atrial Fibrillation