Compounds > tranexamic acid
Page last updated: 2024-11-05

tranexamic acid and Arthritis

tranexamic acid has been researched along with Arthritis in 11 studies

Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.

Arthritis: Acute or chronic inflammation of JOINTS.

Research Excerpts

ExcerptRelevanceReference
"Multiple doses of dexamethasone and tranexamic acid can inhibit postoperative inflammation and reduce fibrinolysis and perioperative blood loss in total knee arthroplasty."9.69Tourniquets can further reduce perioperative blood loss in patients on dexamethasone and tranexamic acid during cemented total knee arthritis: a single-center, double-blind, randomized controlled trial. ( Huang, Q; Jiang, W; Liu, M; Pei, F; Wang, X; Xie, J; Xu, H; Zhou, R; Zhou, Z, 2023)
" The purpose of this study was to assess the safety of tranexamic acid (TXA) utilization with respect to the incidence of deep venous thrombosis (DVT) in hemophiliacs undergoing total knee arthroplasty (TKA)."9.69Tranexamic acid is safe with respect to the risk of deep venous thrombosis in patients with hemophilic arthritis undergoing total knee arthroplasty without chemoprophylaxis: A prospective study. ( Guo, JJ; Yu, Z; Zhang, Q; Zhao, L, 2023)
"Multiple doses of dexamethasone and tranexamic acid can inhibit postoperative inflammation and reduce fibrinolysis and perioperative blood loss in total knee arthroplasty."5.69Tourniquets can further reduce perioperative blood loss in patients on dexamethasone and tranexamic acid during cemented total knee arthritis: a single-center, double-blind, randomized controlled trial. ( Huang, Q; Jiang, W; Liu, M; Pei, F; Wang, X; Xie, J; Xu, H; Zhou, R; Zhou, Z, 2023)
" The purpose of this study was to assess the safety of tranexamic acid (TXA) utilization with respect to the incidence of deep venous thrombosis (DVT) in hemophiliacs undergoing total knee arthroplasty (TKA)."5.69Tranexamic acid is safe with respect to the risk of deep venous thrombosis in patients with hemophilic arthritis undergoing total knee arthroplasty without chemoprophylaxis: A prospective study. ( Guo, JJ; Yu, Z; Zhang, Q; Zhao, L, 2023)
"Knee arthritis is the primary cause of disability in middle-aged and older adults."3.30Value of Tranexamic Acid and Progressive Nursing in Accelerating Postoperative Rehabilitation After Total Knee Arthroplasty. ( Li, L; Liu, G; Pan, H; Wang, F; Wang, J; Zheng, S, 2023)
" In Group A, 1 g of tranexamic acid dissolved in 250 ml of normal saline was intravenously infused before deflation of the tourniquet; another intravenous administration of the same drug of the same dosage was given 3 hours later."2.73[Clinical comparative studies on effect of tranexamic acid on blood loss associated with total knee arthroplasty]. ( Gao, Z; Yu, J; Zhang, F, 2007)
"Ninety-two hemophilia A patients who underwent total knee arthroplasty in our center were included."1.72Hidden blood loss of total knee arthroplasty in hemophilia arthritis: an analysis of influencing factors. ( Lv, SJ; Shen, SN; Tong, PJ; Wu, DX, 2022)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (9.09)18.2507
2000's2 (18.18)29.6817
2010's3 (27.27)24.3611
2020's5 (45.45)2.80

Authors

AuthorsStudies
Shen, SN1
Wu, DX1
Lv, SJ1
Tong, PJ1
Li, L1
Pan, H1
Liu, G1
Wang, F2
Zheng, S1
Wang, J1
Jiang, W1
Wang, X1
Xu, H1
Liu, M1
Xie, J1
Huang, Q1
Zhou, R1
Zhou, Z1
Pei, F1
Zhang, Q1
Zhao, L1
Yu, Z1
Guo, JJ1
Yoon, JY1
Park, JH1
Kim, YS1
Shin, SJ1
Yoo, JC1
Oh, JH1
Yuan, X1
Li, B1
Wang, Q1
Zhang, X1
Zhao, KC1
Zhao, MM1
Zhao, DX1
Lošťák, J1
Gallo, J1
Špička, J1
Langová, K1
Orpen, NM1
Little, C1
Walker, G1
Crawfurd, EJ1
Zhang, F1
Gao, Z1
Yu, J1
Ronday, HK1
Te Koppele, JM1
Greenwald, RA1
Moak, SA1
De Roos, JA1
Dijkmans, BA1
Breedveld, FC1
Verheijen, JH1

Clinical Trials (4)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluating the Use of Tranexamic Acid (TXA) in Total Joint Arthroplasty[NCT03825939]Phase 452 participants (Actual)Interventional2015-04-21Terminated (stopped due to Lack of patient enrollment due to only one surgeon that was enrolling.)
The Use of Tranexamic Acid to Reduce Blood Loss in Acetabular Surgery[NCT02684851]Phase 387 participants (Actual)Interventional2012-10-31Completed
Peri-articular Tranexamic Acid Injection in Total Knee Arthroplasty: A Randomized Controlled Trial[NCT02829346]Phase 260 participants (Actual)Interventional2012-10-31Completed
Intravenous Tranexamic Acid to Reduce Blood Loss in Reverse Total Shoulder Arthroplasty[NCT02043132]Phase 2/Phase 3116 participants (Actual)Interventional2013-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Length of Hospital Stay

Measured in Days (NCT03825939)
Timeframe: At Hospital Discharge

InterventionDays (Mean)
Intravenous Tranexamic Acid3
Intravenous Placebo3
Intravenous Tranexamic Acid Followed by Intravenous Placebo3

Allogenic Blood Transfusion Rates

Number of participant received allogenic blood transfusions. (NCT02684851)
Timeframe: post-operative

InterventionParticipants (Count of Participants)
Tranexamic21
Placebo13

Estimate Blood Loss

To measure average estimate perioperative blood loss (NCT02684851)
Timeframe: perioperative

InterventionmL (Mean)
Tranexamic727.6
Placebo560.1

Number of Participants With a Thromboembolic Event

Do patients undergoing acetabular ORIF who receive tranexamic acid have a higher risk for thromboembolic events than patients who receive placebo? (NCT02684851)
Timeframe: 30 days

InterventionParticipants (Count of Participants)
Tranexamic1
Placebo0

Units of Packed Red Blood Cells Transfused

Average units packed red blood cells transfused among participants (NCT02684851)
Timeframe: perioperative

InterventionUnits of packed red blood cells (Mean)
Tranexamic2.65
Placebo2.36

Number of Participants Experiencing Deep Vein Thrombosis

"The occurrence of the following systemic and surgical site complications within 6 weeks of surgery will be recorded. Data will be obtained from EMR and from patient at standard of care 2 week and 6 week follow-up appointment.~Deep venous thrombosis" (NCT02043132)
Timeframe: up to 6-weeks post-operatively

InterventionParticipants (Count of Participants)
Tranexamic Acid0
Normal Saline0

Number of Participants Experiencing Hematoma as a Surgical Site Complication

"The occurrence of the following systemic and surgical site complications within 6 weeks of surgery will be recorded. Data will be obtained from EMR and from patient at standard of care 2 week and 6 week follow-up appointment.~Hematoma" (NCT02043132)
Timeframe: up to 6-weeks post-operatively

InterventionParticipants (Count of Participants)
Tranexamic Acid0
Normal Saline0

Number of Participants Experiencing Infection as a Surgical Site Complication

"The occurrence of the following systemic and surgical site complications within 6 weeks of surgery will be recorded. Data will be obtained from EMR and from patient at standard of care 2 week and 6 week follow-up appointment.~Infection" (NCT02043132)
Timeframe: up to 6-weeks post-operatively

InterventionParticipants (Count of Participants)
Tranexamic Acid0
Normal Saline0

Number of Participants Experiencing Myocardial Infarction

"The occurrence of the following systemic and surgical site complications within 6 weeks of surgery will be recorded. Data will be obtained from EMR and from patient at standard of care 2 week and 6 week follow-up appointment.~Myocardial infarction" (NCT02043132)
Timeframe: up to 6-weeks post-operatively

InterventionParticipants (Count of Participants)
Tranexamic Acid0
Normal Saline1

Number of Participants Experiencing Pulmonary Embolism

"The occurrence of the following systemic and surgical site complications within 6 weeks of surgery will be recorded. Data will be obtained from EMR and from patient at standard of care 2 week and 6 week follow-up appointment.~Pulmonary Embolism" (NCT02043132)
Timeframe: up to 6-weeks post-operatively

InterventionParticipants (Count of Participants)
Tranexamic Acid0
Normal Saline0

Total Blood Loss

Total Blood Loss as calculated according to method as described by Good et al. Total Blood Loss (mL) = 1000 X Hb(loss)/Hb(initial) (NCT02043132)
Timeframe: Preoperative through Postoperative Days 1 and 2

InterventionTotal Blood Loss (mL) (Mean)
Tranexamic Acid1122.4
Normal Saline1472

Total Drain Output

Total Drain Output as measured postoperatively 0-48 hours (NCT02043132)
Timeframe: 0-48 hours postoperatively

InterventionmL (Mean)
Tranexamic Acid221
Normal Saline372

Total Hemoglobin Loss

Total hemoglobin loss estimated using the formula for total blood volume described by Nadler et al Hb(loss) = blood volume (L) x [Hb(initial)(g/L) - Hb(final)(g/L)] + Hb(transfused) (NCT02043132)
Timeframe: Preoperative through Postoperative Days 1 and 2

Interventiong (Mean)
Tranexamic Acid154.6
Normal Saline200.1

Reviews

1 review available for tranexamic acid and Arthritis

ArticleYear
The efficacy of oral versus intravenous tranexamic acid in reducing blood loss after primary total knee and hip arthroplasty: A meta-analysis.
    Medicine, 2018, Volume: 97, Issue:36

    Topics: Administration, Intravenous; Administration, Oral; Antifibrinolytic Agents; Arthritis; Arthroplasty,

2018

Trials

7 trials available for tranexamic acid and Arthritis

ArticleYear
Value of Tranexamic Acid and Progressive Nursing in Accelerating Postoperative Rehabilitation After Total Knee Arthroplasty.
    Alternative therapies in health and medicine, 2023, Volume: 29, Issue:1

    Topics: Activities of Daily Living; Aged; Antifibrinolytic Agents; Arthritis; Arthroplasty, Replacement, Kne

2023
Tourniquets can further reduce perioperative blood loss in patients on dexamethasone and tranexamic acid during cemented total knee arthritis: a single-center, double-blind, randomized controlled trial.
    Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology, 2023, Apr-29, Volume: 24, Issue:1

    Topics: Albumins; Antifibrinolytic Agents; Arthritis; Blood Loss, Surgical; Dexamethasone; Humans; Inflammat

2023
Tranexamic acid is safe with respect to the risk of deep venous thrombosis in patients with hemophilic arthritis undergoing total knee arthroplasty without chemoprophylaxis: A prospective study.
    The Knee, 2023, Volume: 44

    Topics: Administration, Intravenous; Adult; Anticoagulants; Antifibrinolytic Agents; Arthritis; Arthroplasty

2023
Effect of tranexamic acid on blood loss after reverse total shoulder arthroplasty according to the administration method: a prospective, multicenter, randomized, controlled study.
    Journal of shoulder and elbow surgery, 2020, Volume: 29, Issue:6

    Topics: Administration, Intravenous; Administration, Topical; Aged; Antifibrinolytic Agents; Arthritis; Arth

2020
Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients.
    The Knee, 2006, Volume: 13, Issue:2

    Topics: Aged; Antifibrinolytic Agents; Arthritis; Arthroplasty, Replacement, Knee; Double-Blind Method; Fema

2006
Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients.
    The Knee, 2006, Volume: 13, Issue:2

    Topics: Aged; Antifibrinolytic Agents; Arthritis; Arthroplasty, Replacement, Knee; Double-Blind Method; Fema

2006
Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients.
    The Knee, 2006, Volume: 13, Issue:2

    Topics: Aged; Antifibrinolytic Agents; Arthritis; Arthroplasty, Replacement, Knee; Double-Blind Method; Fema

2006
Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients.
    The Knee, 2006, Volume: 13, Issue:2

    Topics: Aged; Antifibrinolytic Agents; Arthritis; Arthroplasty, Replacement, Knee; Double-Blind Method; Fema

2006
Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients.
    The Knee, 2006, Volume: 13, Issue:2

    Topics: Aged; Antifibrinolytic Agents; Arthritis; Arthroplasty, Replacement, Knee; Double-Blind Method; Fema

2006
Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients.
    The Knee, 2006, Volume: 13, Issue:2

    Topics: Aged; Antifibrinolytic Agents; Arthritis; Arthroplasty, Replacement, Knee; Double-Blind Method; Fema

2006
Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients.
    The Knee, 2006, Volume: 13, Issue:2

    Topics: Aged; Antifibrinolytic Agents; Arthritis; Arthroplasty, Replacement, Knee; Double-Blind Method; Fema

2006
Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients.
    The Knee, 2006, Volume: 13, Issue:2

    Topics: Aged; Antifibrinolytic Agents; Arthritis; Arthroplasty, Replacement, Knee; Double-Blind Method; Fema

2006
Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients.
    The Knee, 2006, Volume: 13, Issue:2

    Topics: Aged; Antifibrinolytic Agents; Arthritis; Arthroplasty, Replacement, Knee; Double-Blind Method; Fema

2006
Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients.
    The Knee, 2006, Volume: 13, Issue:2

    Topics: Aged; Antifibrinolytic Agents; Arthritis; Arthroplasty, Replacement, Knee; Double-Blind Method; Fema

2006
Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients.
    The Knee, 2006, Volume: 13, Issue:2

    Topics: Aged; Antifibrinolytic Agents; Arthritis; Arthroplasty, Replacement, Knee; Double-Blind Method; Fema

2006
Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients.
    The Knee, 2006, Volume: 13, Issue:2

    Topics: Aged; Antifibrinolytic Agents; Arthritis; Arthroplasty, Replacement, Knee; Double-Blind Method; Fema

2006
Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients.
    The Knee, 2006, Volume: 13, Issue:2

    Topics: Aged; Antifibrinolytic Agents; Arthritis; Arthroplasty, Replacement, Knee; Double-Blind Method; Fema

2006
Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients.
    The Knee, 2006, Volume: 13, Issue:2

    Topics: Aged; Antifibrinolytic Agents; Arthritis; Arthroplasty, Replacement, Knee; Double-Blind Method; Fema

2006
Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients.
    The Knee, 2006, Volume: 13, Issue:2

    Topics: Aged; Antifibrinolytic Agents; Arthritis; Arthroplasty, Replacement, Knee; Double-Blind Method; Fema

2006
Tranexamic acid reduces early post-operative blood loss after total knee arthroplasty: a prospective randomised controlled trial of 29 patients.
    The Knee, 2006, Volume: 13, Issue:2

    Topics: Aged; Antifibrinolytic Agents; Arthritis; Arthroplasty, Replacement, Knee; Double-Blind Method; Fema

2006
[Clinical comparative studies on effect of tranexamic acid on blood loss associated with total knee arthroplasty].
    Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2007, Volume: 21, Issue:12

    Topics: Aged; Antifibrinolytic Agents; Arthritis; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Bl

2007
Tranexamic acid, an inhibitor of plasminogen activation, reduces urinary collagen cross-link excretion in both experimental and rheumatoid arthritis.
    British journal of rheumatology, 1998, Volume: 37, Issue:1

    Topics: Amino Acids; Animals; Antifibrinolytic Agents; Arthritis; Arthritis, Rheumatoid; Biomarkers; Collage

1998

Other Studies

3 other studies available for tranexamic acid and Arthritis

ArticleYear
Hidden blood loss of total knee arthroplasty in hemophilia arthritis: an analysis of influencing factors.
    BMC musculoskeletal disorders, 2022, Jun-17, Volume: 23, Issue:1

    Topics: Aged; Antifibrinolytic Agents; Arthritis; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Blo

2022
Comparison of 3 Routes of Administration of Tranexamic Acid on Primary Unilateral Total Knee Arthroplasty: A Prospective, Randomized, Controlled Study.
    The Journal of arthroplasty, 2017, Volume: 32, Issue:9

    Topics: Administration, Intravenous; Administration, Oral; Administration, Topical; Aged; Antifibrinolytic A

2017
[Intra-Articular Application of Tranexamic Acid Significantly Reduces Blood Loss and Transfusion Requirement in Primary Total Knee Arthroplasty].
    Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca, 2016, Volume: 83, Issue:4

    Topics: Administration, Topical; Aged; Antifibrinolytic Agents; Arthritis; Arthroplasty, Replacement, Knee;

2016