tranexamic acid and Arthritis, Rheumatoid studies

Arthritis, Rheumatoid: A chronic systemic disease, primarily of the joints, marked by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Etiology is unknown, but autoimmune mechanisms have been implicated.

Research Excerpts

Excerpt	Relevance	Reference
"We aimed to determine the efficacy and safety of multiple doses of intravenous tranexamic acid (IV-TXA) on perioperative blood loss in patients with rheumatoid arthritis (RA) who had undergone primary unilateral total knee arthroplasty (TKA)."	9.41	Multiple intravenous tranexamic acid doses in total knee arthroplasty in patients with rheumatoid arthritis: a randomized controlled study. ( Gao, CX; Gao, XJ; Kang, BX; Ma, YH; Sun, ST; Xiao, LB; Xie, J; Xu, H; Xu, XR; Zhai, WT; Zhang, J; Zhao, C; Zhong, S, 2021)
"This clinical trial is designed to evaluate the effect of multiple-dose tranexamic acid (TXA) on perioperative blood loss in patients with rheumatoid arthritis (RA)."	9.34	Multiple-dose tranexamic acid for perioperative blood loss in total knee arthroplasty in patients with rheumatoid arthritis：a single-blinded, randomised, parallel-controlled study protocol in China. ( Gao, CX; Kang, BX; Ma, YH; Sun, ST; Xiao, LB; Xie, J; Xu, H; Zhai, WT; Zhang, J; Zhong, S, 2020)
"In a double-blind controlled study on 45 rheumatoid arthritis patients, no effect of tranexamic acid (Cyklocapron, 4."	9.05	Lack of effect of tranexamic acid on rheumatoid arthritis. ( Arfelt, E; Brandslund, I; Hindersson, P; Jensen, A; Lund, HI; Nielsen, EF; Rasmussen, GG; Siersted, HC; Teisner, B; Urfe, P, 1984)
"We aimed to determine the efficacy and safety of multiple doses of intravenous tranexamic acid (IV-TXA) on perioperative blood loss in patients with rheumatoid arthritis (RA) who had undergone primary unilateral total knee arthroplasty (TKA)."	5.41	Multiple intravenous tranexamic acid doses in total knee arthroplasty in patients with rheumatoid arthritis: a randomized controlled study. ( Gao, CX; Gao, XJ; Kang, BX; Ma, YH; Sun, ST; Xiao, LB; Xie, J; Xu, H; Xu, XR; Zhai, WT; Zhang, J; Zhao, C; Zhong, S, 2021)
"This clinical trial is designed to evaluate the effect of multiple-dose tranexamic acid (TXA) on perioperative blood loss in patients with rheumatoid arthritis (RA)."	5.34	Multiple-dose tranexamic acid for perioperative blood loss in total knee arthroplasty in patients with rheumatoid arthritis：a single-blinded, randomised, parallel-controlled study protocol in China. ( Gao, CX; Kang, BX; Ma, YH; Sun, ST; Xiao, LB; Xie, J; Xu, H; Zhai, WT; Zhang, J; Zhong, S, 2020)
"In a double-blind controlled study on 45 rheumatoid arthritis patients, no effect of tranexamic acid (Cyklocapron, 4."	5.05	Lack of effect of tranexamic acid on rheumatoid arthritis. ( Arfelt, E; Brandslund, I; Hindersson, P; Jensen, A; Lund, HI; Nielsen, EF; Rasmussen, GG; Siersted, HC; Teisner, B; Urfe, P, 1984)
"Only one patient in IV group exhibited deep venous thrombosis."	2.87	Tranexamic acid in primary total knee arthroplasty without tourniquet: a randomized, controlled trial of oral versus intravenous versus topical administration. ( Cao, C; Li, DH; Li, LL; Meng, WK; Pei, FX; Wang, D; Wang, HY; Zeng, WN; Zhou, ZK, 2018)
" In Group A, 1 g of tranexamic acid dissolved in 250 ml of normal saline was intravenously infused before deflation of the tourniquet; another intravenous administration of the same drug of the same dosage was given 3 hours later."	2.73	[Clinical comparative studies on effect of tranexamic acid on blood loss associated with total knee arthroplasty]. ( Gao, Z; Yu, J; Zhang, F, 2007)

Research

Studies (15)

Authors

Clinical Trials (7)

Trial Overview

Trial Outcomes

Number of Participants Experiencing Deep Vein Thrombosis

Timeframe	Studies, this research(%)	All Research%
pre-1990	1 (6.67)	18.7374
1990's	1 (6.67)	18.2507
2000's	2 (13.33)	29.6817
2010's	2 (13.33)	24.3611
2020's	9 (60.00)	2.80

Authors	Studies
Li, J	2
Li, Y	1
Huang, Y	1
Zhang, H	1
Ye, P	1
Deng, P	1
Chen, J	1
Qi, X	1
Zeng, J	1
Feng, W	2
Zeng, Y	1
Cao, G	1
Zhang, S	1
Wang, Y	1
Xu, H	3
Quan, S	1
Cai, L	1
Yao, J	1
Tan, H	1
Pei, F	2
Ghaffari, S	1
Fateh, S	1
Faramarzi, F	1
Rafiei, A	1
Razavipour, M	1
Zafari, P	1
Morse, KW	2
Heinz, NK	2
Abolade, JM	2
Wright-Chisem, JI	2
Russell, LA	2
Zhang, M	2
Mirza, SZ	2
Orange, DE	2
Figgie, MP	2
Sculco, PK	2
Goodman, SM	2
Lei, Y	1
Liu, J	1
Liang, X	1
Hu, N	1
Huang, W	1
Kang, BX	2
Gao, CX	2
Zhong, S	2
Zhang, J	2
Xie, J	2
Sun, ST	2
Ma, YH	2
Zhai, WT	2
Xiao, LB	2
Li, S	1
Lu, Q	1
Ma, H	1
Liu, P	1
Xu, XR	1
Zhao, C	1
Gao, XJ	1
Wang, D	1
Wang, HY	1
Cao, C	1
Li, LL	1
Meng, WK	1
Pei, FX	1
Li, DH	1
Zhou, ZK	1
Zeng, WN	1
Sepah, YJ	1
Umer, M	1
Ahmad, T	1
Nasim, F	1
Chaudhry, MU	1
Umar, M	1
Zhang, F	1
Gao, Z	1
Yu, J	1
Rasmussen, GG	1
Brandslund, I	1
Urfe, P	1
Teisner, B	1
Siersted, HC	1
Hindersson, P	1
Lund, HI	1
Nielsen, EF	1
Arfelt, E	1
Jensen, A	1
Ronday, HK	1
Te Koppele, JM	1
Greenwald, RA	1
Moak, SA	1
De Roos, JA	1
Dijkmans, BA	1
Breedveld, FC	1
Verheijen, JH	1
Tanaka, N	1
Sakahashi, H	1
Sato, E	1
Hirose, K	1
Ishima, T	1
Ishii, S	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
Comparative Study of the Efficiency of Oral Tranexamic Tcid vs. Oral Tminocaproic Acid to Reduce Blood Loss and Transfusion After Total Knee Replacement. A Prospective, Randomized, Double Blinded Controlled Clinical Trial.[NCT03365999]	Phase 2	92 participants (Actual)	Interventional	2017-10-15	Completed
Intravenous Tranexamic Acid to Reduce Blood Loss in Reverse Total Shoulder Arthroplasty[NCT02043132]	Phase 2/Phase 3	116 participants (Actual)	Interventional	2013-09-30	Completed
Comparison of Combined Topical Tranexamic Acid With Floseal® With Intravenous Tranexamic Acid on Blood Loss in Total Knee Arthroplasty[NCT03328832]	Phase 4	70 participants (Actual)	Interventional	2017-09-12	Completed
Evaluating the Use of Tranexamic Acid (TXA) in Total Joint Arthroplasty[NCT03825939]	Phase 4	52 participants (Actual)	Interventional	2015-04-21	Terminated (stopped due to Lack of patient enrollment due to only one surgeon that was enrolling.)
Randomized Placebo Controlled Study Using Tranexamic Acid in Revision Total Hip Arthroplasty[NCT00375440]		0 participants (Actual)	Interventional	2005-02-28	Withdrawn (stopped due to Study halted prematurely as investigator left the institution.)
The Blood Saving Effect and Wound-related Complications of Tranexamic Acid in Mininally Invasive Total Knee Arthroplasty With Rivaroxaban as Thromboprophylaxis[NCT02458729]	Phase 4	294 participants (Actual)	Interventional	2012-08-31	Completed
Blood-saving Effect of Kaolin-based Hemostatic Gauze Combined With Intravenous Tranexamic Acid in Total Knee Arthroplasty[NCT05504577]	Phase 4	120 participants (Anticipated)	Interventional	2022-03-16	Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"The occurrence of the following systemic and surgical site complications within 6 weeks of surgery will be recorded. Data will be obtained from EMR and from patient at standard of care 2 week and 6 week follow-up appointment.~Deep venous thrombosis" (NCT02043132)
Timeframe: up to 6-weeks post-operatively

Number of Participants Experiencing Hematoma as a Surgical Site Complication

Intervention	Participants (Count of Participants)
Tranexamic Acid	0
Normal Saline	0

"The occurrence of the following systemic and surgical site complications within 6 weeks of surgery will be recorded. Data will be obtained from EMR and from patient at standard of care 2 week and 6 week follow-up appointment.~Hematoma" (NCT02043132)
Timeframe: up to 6-weeks post-operatively

Number of Participants Experiencing Infection as a Surgical Site Complication

Intervention	Participants (Count of Participants)
Tranexamic Acid	0
Normal Saline	0

"The occurrence of the following systemic and surgical site complications within 6 weeks of surgery will be recorded. Data will be obtained from EMR and from patient at standard of care 2 week and 6 week follow-up appointment.~Infection" (NCT02043132)
Timeframe: up to 6-weeks post-operatively

Number of Participants Experiencing Myocardial Infarction

Intervention	Participants (Count of Participants)
Tranexamic Acid	0
Normal Saline	0

"The occurrence of the following systemic and surgical site complications within 6 weeks of surgery will be recorded. Data will be obtained from EMR and from patient at standard of care 2 week and 6 week follow-up appointment.~Myocardial infarction" (NCT02043132)
Timeframe: up to 6-weeks post-operatively

Number of Participants Experiencing Pulmonary Embolism

Intervention	Participants (Count of Participants)
Tranexamic Acid	0
Normal Saline	1

"The occurrence of the following systemic and surgical site complications within 6 weeks of surgery will be recorded. Data will be obtained from EMR and from patient at standard of care 2 week and 6 week follow-up appointment.~Pulmonary Embolism" (NCT02043132)
Timeframe: up to 6-weeks post-operatively

Total Blood Loss

Intervention	Participants (Count of Participants)
Tranexamic Acid	0
Normal Saline	0

Total Blood Loss as calculated according to method as described by Good et al. Total Blood Loss (mL) = 1000 X Hb(loss)/Hb(initial) (NCT02043132)
Timeframe: Preoperative through Postoperative Days 1 and 2

Total Drain Output

Intervention	Total Blood Loss (mL) (Mean)
Tranexamic Acid	1122.4
Normal Saline	1472

Total Drain Output as measured postoperatively 0-48 hours (NCT02043132)
Timeframe: 0-48 hours postoperatively

Total Hemoglobin Loss

Intervention	mL (Mean)
Tranexamic Acid	221
Normal Saline	372

Total hemoglobin loss estimated using the formula for total blood volume described by Nadler et al Hb(loss) = blood volume (L) x [Hb(initial)(g/L) - Hb(final)(g/L)] + Hb(transfused) (NCT02043132)
Timeframe: Preoperative through Postoperative Days 1 and 2

Blood Transfusion Rate

Intervention	g (Mean)
Tranexamic Acid	154.6
Normal Saline	200.1

We will record the event of blood transfusion, and calculate the incidence of transfusion (NCT03328832)
Timeframe: From the operation to the postoperative day 3 or 4

Incidence of Thrombosis Events

Intervention	Participants (Count of Participants)
Combined Topical TXA and Floseal	1
Topical TXA Alone	0

The composite of any venous thromoembolism events, ischemic heart attacks, cerebrovascular accidents (NCT03328832)
Timeframe: within 30 days of the operation

Total Blood Loss After Operation

Intervention	Participants (Count of Participants)
Combined Topical TXA and Floseal	0
Topical TXA Alone	0

Total blood loss was calculated according to Nadler et al., which used maximum postoperative reduction of the Hb level adjust for weight and height of the patient. The formula is as follows, Total blood loss = (Total blood volume x [change in Hb level / preoperative Hb level])x1000+volume transfused (NCT03328832)
Timeframe: From the operation to the postoperative day 3 or 4

Intervention	Days (Mean)
Intravenous Tranexamic Acid	3
Intravenous Placebo	3
Intravenous Tranexamic Acid Followed by Intravenous Placebo	3

Article	Year
Effectiveness of preemptive antifibrinolysis with tranexamic acid in rheumatoid arthritis patients undergoing total knee arthroplasty: a study protocol for a randomized controlled trial. BMC musculoskeletal disorders, 2020, Jul-15, Volume: 21, Issue:1 Topics: Administration, Intravenous; Antifibrinolytic Agents; Arthritis, Rheumatoid; Arthroplasty, Replaceme	2020
Multiple-dose tranexamic acid for perioperative blood loss in total knee arthroplasty in patients with rheumatoid arthritis：a single-blinded, randomised, parallel-controlled study protocol in China. BMJ open, 2020, 08-20, Volume: 10, Issue:8 Topics: Administration, Intravenous; Aged; Antifibrinolytic Agents; Arthritis, Rheumatoid; Arthroplasty, Rep	2020
Multiple intravenous tranexamic acid doses in total knee arthroplasty in patients with rheumatoid arthritis: a randomized controlled study. BMC musculoskeletal disorders, 2021, May-07, Volume: 22, Issue:1 Topics: Administration, Intravenous; Aged; Antifibrinolytic Agents; Arthritis, Rheumatoid; Arthroplasty, Rep	2021
Tranexamic acid in primary total knee arthroplasty without tourniquet: a randomized, controlled trial of oral versus intravenous versus topical administration. Scientific reports, 2018, 09-11, Volume: 8, Issue:1 Topics: Administration, Intravenous; Administration, Oral; Aged; Antifibrinolytic Agents; Arthritis, Rheumat	2018
[Clinical comparative studies on effect of tranexamic acid on blood loss associated with total knee arthroplasty]. Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery, 2007, Volume: 21, Issue:12 Topics: Aged; Antifibrinolytic Agents; Arthritis; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Bl	2007
Lack of effect of tranexamic acid on rheumatoid arthritis. Scandinavian journal of rheumatology, 1984, Volume: 13, Issue:4 Topics: Adult; Antigen-Antibody Complex; Arthritis, Rheumatoid; Clinical Trials as Topic; Complement Activat	1984
Tranexamic acid, an inhibitor of plasminogen activation, reduces urinary collagen cross-link excretion in both experimental and rheumatoid arthritis. British journal of rheumatology, 1998, Volume: 37, Issue:1 Topics: Amino Acids; Animals; Antifibrinolytic Agents; Arthritis; Arthritis, Rheumatoid; Biomarkers; Collage	1998

Article	Year
Predictors and complications of blood transfusion in rheumatoid arthritis patients undergoing total joint arthroplasty. Clinical rheumatology, 2023, Volume: 42, Issue:1 Topics: Antifibrinolytic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement, Hip; Blood Loss, Surgical	2023
The efficacy and safety of tranexamic acid in rheumatoid arthritis patients undergoing simultaneous bilateral total knee arthroplasty: a multicenter retrospective study. BMC musculoskeletal disorders, 2023, May-15, Volume: 24, Issue:1 Topics: Administration, Intravenous; Antifibrinolytic Agents; Arthritis, Rheumatoid; Arthroplasty, Replaceme	2023
The effect of tranexamic acid on synovium of patients undergoing arthroplasty and anterior cruciate ligament reconstruction surgery. Naunyn-Schmiedeberg's archives of pharmacology, 2023, Volume: 396, Issue:12 Topics: Adult; Anterior Cruciate Ligament Reconstruction; Arthritis, Rheumatoid; Arthroplasty; Cells, Cultur	2023
Tranexamic Acid Does Not Reduce the Risk of Transfusion in Rheumatoid Arthritis Patients Undergoing Total Joint Arthroplasty. The Journal of arthroplasty, 2020, Volume: 35, Issue:9 Topics: Antifibrinolytic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement, Hip; Arthroplasty, Replac	2020
Letter to the Editor on "Tranexamic Acid Does Not Reduce the Risk of Transfusion in Rheumatoid Arthritis Patients Undergoing Total Joint Arthroplasty". The Journal of arthroplasty, 2020, Volume: 35, Issue:12 Topics: Antifibrinolytic Agents; Arthritis, Rheumatoid; Arthroplasty; Blood Transfusion; Humans; Tranexamic	2020
Response to Letter to the Editor on: Tranexamic Acid Does Not Reduce the Risk of Transfusion in Rheumatoid Arthritis Patients Undergoing Total Joint Arthroplasty. The Journal of arthroplasty, 2020, Volume: 35, Issue:12 Topics: Antifibrinolytic Agents; Arthritis, Rheumatoid; Arthroplasty; Blood Transfusion; Humans; Tranexamic	2020
Use of tranexamic acid is a cost effective method in preventing blood loss during and after total knee replacement. Journal of orthopaedic surgery and research, 2011, May-21, Volume: 6 Topics: Antifibrinolytic Agents; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgica	2011
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001
Timing of the administration of tranexamic acid for maximum reduction in blood loss in arthroplasty of the knee. The Journal of bone and joint surgery. British volume, 2001, Volume: 83, Issue:5 Topics: Aged; Arthritis, Rheumatoid; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Drug Administrat	2001

tranexamic acid and Arthritis, Rheumatoid