Page last updated: 2024-11-05

tranexamic acid and Anesthesia

tranexamic acid has been researched along with Anesthesia in 19 studies

Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.

Anesthesia: A state characterized by loss of feeling or sensation. This depression of nerve function is usually the result of pharmacologic action and is induced to allow performance of surgery or other painful procedures.

Research Excerpts

ExcerptRelevanceReference
"Convulsive seizures (CS) occur in ∼1% of the patients after cardiac surgery with cardiopulmonary bypass."5.39Moderate dosage of tranexamic acid during cardiac surgery with cardiopulmonary bypass and convulsive seizures: incidence and clinical outcome. ( Börgermann, J; Gillis-Januszewski, T; Koster, A; Lueth, JU; Schirmer, U; Zittermann, A, 2013)
"Postoperative seizures occurred significantly more frequently in TXA patients (7."5.37Seizures after open heart surgery: comparison of ε-aminocaproic acid and tranexamic acid. ( Breuer, T; Gertler, R; Knorr, J; Lange, R; Macguill, M; Martin, K; Tassani, P; Wiesner, G, 2011)
" A standard blood management protocol that consisted of hypotensive anesthesia, local and systemic administration of tranexamic acid (TXA) and intraoperative cell salvage was applied to all patients."3.96Does tourniquet use decrease blood loss following primary total knee arthroplasty in Jehovah's Witness patients? ( Çıtak, M; Gehrke, T; Köse, Ö; Levent, A; Linke, P, 2020)
"Correction of craniosynostosis may require extensive surgical interventions with related intra and postoperative complications especially hemorrhage."2.53Surgical treatment of craniosynostosis in infants: open vs closed repair. ( Erb, TO; Meier, PM, 2016)
"The management of trauma patients has matured significantly since a systematic approach to trauma care was introduced nearly a half century ago."2.48Review article: update in trauma anesthesiology: perioperative resuscitation management. ( Tobin, JM; Varon, AJ, 2012)
"For the TXA+ group, 0."1.46Low Risk of Thromboembolic Events After Routine Administration of Tranexamic Acid in Hip and Knee Arthroplasty. ( Husted, H; Kallemose, T; Madsen, RV; Nielsen, CS; Troelsen, A, 2017)
"Convulsive seizures (CS) occur in ∼1% of the patients after cardiac surgery with cardiopulmonary bypass."1.39Moderate dosage of tranexamic acid during cardiac surgery with cardiopulmonary bypass and convulsive seizures: incidence and clinical outcome. ( Börgermann, J; Gillis-Januszewski, T; Koster, A; Lueth, JU; Schirmer, U; Zittermann, A, 2013)
"Blood conservation; the area of greatest clinical variability was seen in dosing regimes for Tranexamic acid."1.37Blood conservation and pain control in scoliosis corrective surgery: an online survey of UK practice. ( Bird, S; McGill, N, 2011)
"Postoperative seizures occurred significantly more frequently in TXA patients (7."1.37Seizures after open heart surgery: comparison of ε-aminocaproic acid and tranexamic acid. ( Breuer, T; Gertler, R; Knorr, J; Lange, R; Macguill, M; Martin, K; Tassani, P; Wiesner, G, 2011)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.26)18.7374
1990's0 (0.00)18.2507
2000's2 (10.53)29.6817
2010's13 (68.42)24.3611
2020's3 (15.79)2.80

Authors

AuthorsStudies
Godec, S1
Gradisek, MJ1
Mirkovic, T1
Gradisek, P1
Taunton, MJ1
Levent, A1
Köse, Ö1
Linke, P1
Gehrke, T1
Çıtak, M1
Neely, D1
Elnour, S1
Chiem, J1
Ivanova, I1
Jimenez, N1
Hoffmann, C1
Goudard, Y1
Falzone, E1
Leclerc, T1
Planchet, M1
Cazes, N1
Pons, F1
Lenoir, B1
Debien, B1
Chamaraux-Tran, TN1
Levy, F1
Zappaterra, M1
Goetz, J1
Goichot, B1
Steib, A1
Rasouli, MR1
Gomes, LS1
Parsley, B1
Barsoum, W1
Bezwada, H1
Cashman, J1
Garcia, J1
Hamilton, W1
Hume, E1
Malhotra, R1
Memtsoudis, S1
Ong, A1
Orozco, F1
Padgett, D1
Reina, R1
Teloken, M1
Thienpont, E1
Waters, JH1
Erb, TO1
Meier, PM1
Madsen, RV1
Nielsen, CS1
Kallemose, T1
Husted, H1
Troelsen, A1
Harkness, M1
Palmer, JB1
Watson, D1
Walsh, TS1
Raghunathan, K1
Connelly, NR1
Kanter, GJ1
Bird, S1
McGill, N1
Martin, K1
Knorr, J1
Breuer, T1
Gertler, R1
Macguill, M1
Lange, R1
Tassani, P1
Wiesner, G1
Tobin, JM1
Varon, AJ1
Sharma, V1
Fan, J1
Jerath, A1
Pang, KS1
Bojko, B1
Pawliszyn, J1
Karski, JM1
Yau, T1
McCluskey, S1
Wąsowicz, M1
Koster, A1
Börgermann, J1
Zittermann, A1
Lueth, JU1
Gillis-Januszewski, T1
Schirmer, U1
Casati, V1
Benussi, S1
Sandrelli, L1
Grasso, MA1
Spagnolo, S1
D'Angelo, A1
Sabato, AF1
Foti, A1
De Cosmo, G1
Bondoli, A1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Prospective Randomized Study Comparing Topical Versus Intravenous Tranexamic Acid in Anterior Total Hip Arthroplasty[NCT03359525]Phase 4114 participants (Anticipated)Interventional2017-07-01Recruiting
Outcome Impact of Different Tranexamic Acid Regimen in Cardiac Surgery With Cardiopulmonary Bypass (the OPTIMAL Study)[NCT03782350]Phase 43,079 participants (Actual)Interventional2018-12-26Completed
The Comparative Efficacy of Peri-articular and Intraarticular Tranexamic Acid in Total Knee Arthroplasty: A Prospective, Double-Blind Randomized, Controlled Trial[NCT03074994]Phase 2108 participants (Anticipated)Interventional2016-10-31Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

3 reviews available for tranexamic acid and Anesthesia

ArticleYear
[Management of penetrating abdominal trauma: what we need to know?].
    Annales francaises d'anesthesie et de reanimation, 2013, Volume: 32, Issue:2

    Topics: Abdominal Injuries; Anesthesia; Antifibrinolytic Agents; Emergency Medical Services; France; Humans;

2013
Surgical treatment of craniosynostosis in infants: open vs closed repair.
    Current opinion in anaesthesiology, 2016, Volume: 29, Issue:3

    Topics: Anesthesia; Antifibrinolytic Agents; Craniosynostoses; Craniotomy; Hemodynamic Monitoring; Humans; I

2016
Review article: update in trauma anesthesiology: perioperative resuscitation management.
    Anesthesia and analgesia, 2012, Volume: 115, Issue:6

    Topics: Anesthesia; Anesthesiology; Antifibrinolytic Agents; Blood Transfusion; Factor VIIa; Humans; Hypoten

2012

Trials

1 trial available for tranexamic acid and Anesthesia

ArticleYear
Intraoperative moderate acute normovolemic hemodilution associated with a comprehensive blood-sparing protocol in off-pump coronary surgery.
    Anesthesia and analgesia, 2004, Volume: 98, Issue:5

    Topics: Aged; Anesthesia; Antifibrinolytic Agents; Blood Cell Count; Blood Transfusion; Blood Volume; Cardia

2004

Other Studies

15 other studies available for tranexamic acid and Anesthesia

ArticleYear
Ventriculolumbar perfusion and inhalational anesthesia with sevoflurane in an accidental intrathecal injection of tranexamic acid: unreported treatment options.
    Regional anesthesia and pain medicine, 2022, Volume: 47, Issue:1

    Topics: Anesthesia; Anesthetics, Inhalation; Cardiotoxicity; Humans; Injections, Spinal; Perfusion; Sevoflur

2022
What's New in Adult Reconstructive Knee Surgery.
    The Journal of bone and joint surgery. American volume, 2020, 01-15, Volume: 102, Issue:2

    Topics: Analgesics, Opioid; Anesthesia; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss

2020
Does tourniquet use decrease blood loss following primary total knee arthroplasty in Jehovah's Witness patients?
    Joint diseases and related surgery, 2020, Volume: 31, Issue:3

    Topics: Aged; Anesthesia; Antifibrinolytic Agents; Arthroplasty, Replacement, Knee; Blood Loss, Surgical; Fe

2020
Anaesthesia for abnormally invasive placenta: cell salvage and tranexamic acid.
    International journal of obstetric anesthesia, 2017, Volume: 32

    Topics: Anesthesia; Anesthesiology; Antifibrinolytic Agents; Female; Humans; Placenta; Placenta Accreta; Pre

2017
Reply to Clark, Natasha; Morris, Stephen; Sargant, Nicholas, regarding their comment "Comment on Case Report 'Anaphylactic reaction to tranexamic acid in an adolescent undergoing posterior spinal fusion' by Chiem J, Ivanova I, Jimenez N et al. Paediatric
    Paediatric anaesthesia, 2018, Volume: 28, Issue:3

    Topics: Adolescent; Anaphylaxis; Anesthesia; Antifibrinolytic Agents; Child; Humans; Spinal Fusion; Tranexam

2018
Cardiac surgery and C1-inhibitor deficiency.
    Journal of cardiothoracic and vascular anesthesia, 2014, Volume: 28, Issue:6

    Topics: Aged, 80 and over; Amines; Analgesics; Anesthesia; Angioedemas, Hereditary; Antifibrinolytic Agents;

2014
Blood conservation.
    Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2014, Volume: 32 Suppl 1

    Topics: Anesthesia; Antifibrinolytic Agents; Arthritis, Infectious; Arthroplasty, Replacement; Blood Loss, S

2014
Low Risk of Thromboembolic Events After Routine Administration of Tranexamic Acid in Hip and Knee Arthroplasty.
    The Journal of arthroplasty, 2017, Volume: 32, Issue:4

    Topics: Administration, Intravenous; Aged; Aged, 80 and over; Anesthesia; Antifibrinolytic Agents; Arthropla

2017
A questionnaire-based survey of perioperative blood conservation practice for revision hip arthroplasty in Scotland.
    Transfusion medicine (Oxford, England), 2008, Volume: 18, Issue:5

    Topics: Anesthesia; Anesthesiology; Antifibrinolytic Agents; Arthroplasty, Replacement, Hip; Blood Loss, Sur

2008
ε-Aminocaproic acid and clinical value in cardiac anesthesia.
    Journal of cardiothoracic and vascular anesthesia, 2011, Volume: 25, Issue:1

    Topics: Algorithms; Aminocaproic Acid; Anesthesia; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical;

2011
Blood conservation and pain control in scoliosis corrective surgery: an online survey of UK practice.
    Paediatric anaesthesia, 2011, Volume: 21, Issue:1

    Topics: Adolescent; Analgesia, Epidural; Analgesics, Opioid; Anesthesia; Anticoagulants; Antifibrinolytic Ag

2011
Seizures after open heart surgery: comparison of ε-aminocaproic acid and tranexamic acid.
    Journal of cardiothoracic and vascular anesthesia, 2011, Volume: 25, Issue:1

    Topics: Aged; Aminocaproic Acid; Anesthesia; Antifibrinolytic Agents; Blood Loss, Surgical; Cardiac Surgical

2011
Pharmacokinetics of tranexamic acid in patients undergoing cardiac surgery with use of cardiopulmonary bypass.
    Anaesthesia, 2012, Volume: 67, Issue:11

    Topics: Aged; Algorithms; Anesthesia; Antifibrinolytic Agents; Cardiac Surgical Procedures; Cardiopulmonary

2012
Moderate dosage of tranexamic acid during cardiac surgery with cardiopulmonary bypass and convulsive seizures: incidence and clinical outcome.
    British journal of anaesthesia, 2013, Volume: 110, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia; Antifibrinolytic Agents; Cardiac Surgical Pr

2013
[Coagulative changes in gynecologic surgery. Clinical and therapeutic evaluation].
    Recenti progressi in medicina, 1980, Volume: 68, Issue:4

    Topics: Adult; Aged; Anesthesia; Aprotinin; Blood Coagulation Disorders; Disseminated Intravascular Coagulat

1980