Page last updated: 2024-11-05

tranexamic acid and Acute Kidney Injury

tranexamic acid has been researched along with Acute Kidney Injury in 13 studies

Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.

Acute Kidney Injury: Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.

Research Excerpts

ExcerptRelevanceReference
"To conduct a systematic review of tranexamic acid (TXA) and the risk of renal failure from urinary clots in adult patients with hematuria."9.22Systematic review of hematuria and acute renal failure with tranexamic acid. ( Boctor, M; Fralick, J; Fralick, M; Lee, SG; Sholzberg, M; Wallis, CJD, 2022)
"We conducted a secondary analysis of the MAssive Transfusion in Children (MATIC), a prospectively collected database of children with life-threatening hemorrhage (LTH), and evaluated for risk of adverse events with either antifibrinolytic treatment, epsilon aminocaproic acid (EACA) or tranexamic acid (TXA)."8.31Epsilon aminocaproic acid is associated with acute kidney injury after life-threatening hemorrhage in children. ( Josephson, CD; Kolodziej, JH; Leeper, CM; Leonard, JC; Spinella, PC; Zenati, MS, 2023)
"To conduct a systematic review of tranexamic acid (TXA) and the risk of renal failure from urinary clots in adult patients with hematuria."5.22Systematic review of hematuria and acute renal failure with tranexamic acid. ( Boctor, M; Fralick, J; Fralick, M; Lee, SG; Sholzberg, M; Wallis, CJD, 2022)
"We conducted a secondary analysis of the MAssive Transfusion in Children (MATIC), a prospectively collected database of children with life-threatening hemorrhage (LTH), and evaluated for risk of adverse events with either antifibrinolytic treatment, epsilon aminocaproic acid (EACA) or tranexamic acid (TXA)."4.31Epsilon aminocaproic acid is associated with acute kidney injury after life-threatening hemorrhage in children. ( Josephson, CD; Kolodziej, JH; Leeper, CM; Leonard, JC; Spinella, PC; Zenati, MS, 2023)
"The present study aimed to examine the association between tranexamic acid use and adverse effects (seizures, thromboembolism, and renal dysfunction) in a pediatric trauma population using a national inpatient database in Japan."3.88Safety of Tranexamic Acid During Pediatric Trauma: A Nationwide Database Study. ( Maeda, T; Matsui, H; Michihata, N; Miyata, S; Ohnishi, Y; Sasabuchi, Y; Yasunaga, H, 2018)
"Aprotinin treatment was associated with an increased use of plasma and platelet transfusion and an increased risk for postoperative dialysis, but not with other adverse outcomes, including short-term mortality."1.35Use of aprotinin in cardiac surgery: effectiveness and safety in a population-based study. ( Hjortdal, VE; Jakobsen, CJ; Johnsen, SP; Søndergaard, F, 2009)
"Fibrinolysis was inhibited by intravenous injection of AMCA and thrombin was infused into the jugular vein, giving rise to heavy intravascular fibrin deposition in the kidneys."1.25Protection against the impairment of renal function after intravascular coagulation in the rat kidney by increased ingestion of sodium chloride. ( Gerdin, B; Rammer, L, 1975)

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19902 (15.38)18.7374
1990's4 (30.77)18.2507
2000's3 (23.08)29.6817
2010's2 (15.38)24.3611
2020's2 (15.38)2.80

Authors

AuthorsStudies
Lee, SG1
Fralick, J1
Wallis, CJD1
Boctor, M1
Sholzberg, M1
Fralick, M1
Kolodziej, JH1
Leeper, CM1
Leonard, JC1
Josephson, CD1
Zenati, MS1
Spinella, PC1
Maeda, T1
Michihata, N1
Sasabuchi, Y1
Matsui, H1
Ohnishi, Y1
Miyata, S1
Yasunaga, H1
Halawi, MJ1
Plourde, JM1
Cote, MP1
Lindvall, G1
Sartipy, U1
Ivert, T1
van der Linden, J1
Jakobsen, CJ1
Søndergaard, F1
Hjortdal, VE1
Johnsen, SP1
Levin, MD1
Betjes, MG1
V d Kwast, TH1
Wenberg, BL1
Leebeek, FW1
Fernández Lucas, M1
Liaño, F1
Navarro, JF1
Sastre, JL1
Quereda, C1
Ortuño, J1
Koo, JR1
Lee, YK1
Kim, YS1
Cho, WY1
Kim, HK1
Won, NH1
Rammer, L1
Gerdin, B1
Albronda, T1
Gökemeyer, JD1
van Haeflen, TW1
Foster, GR1
Carmichael, DJ1
Kermode, A1
Hulme, B1
Gabriel, JR1
Cattell, V1
Eriksson, M1
Saldeen, T1

Reviews

1 review available for tranexamic acid and Acute Kidney Injury

ArticleYear
Systematic review of hematuria and acute renal failure with tranexamic acid.
    European journal of haematology, 2022, Volume: 108, Issue:6

    Topics: Acute Kidney Injury; Adult; Antifibrinolytic Agents; Female; Hematuria; Humans; Male; Tranexamic Aci

2022

Other Studies

12 other studies available for tranexamic acid and Acute Kidney Injury

ArticleYear
Epsilon aminocaproic acid is associated with acute kidney injury after life-threatening hemorrhage in children.
    Transfusion, 2023, Volume: 63 Suppl 3

    Topics: Acute Kidney Injury; Adolescent; Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; C

2023
Safety of Tranexamic Acid During Pediatric Trauma: A Nationwide Database Study.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2018, Volume: 19, Issue:12

    Topics: Acute Kidney Injury; Antifibrinolytic Agents; Case-Control Studies; Child; Child, Preschool; Databas

2018
Routine Postoperative Laboratory Tests Are Not Necessary After Primary Total Hip Arthroplasty.
    The Journal of arthroplasty, 2019, Volume: 34, Issue:3

    Topics: Acute Kidney Injury; Aged; Anemia; Arthroplasty, Replacement, Hip; Blood Chemical Analysis; Blood Lo

2019
Aprotinin is not associated with postoperative renal impairment after primary coronary surgery.
    The Annals of thoracic surgery, 2008, Volume: 86, Issue:1

    Topics: Acute Kidney Injury; Aged; Aprotinin; Blood Loss, Surgical; Blood Transfusion; Case-Control Studies;

2008
Use of aprotinin in cardiac surgery: effectiveness and safety in a population-based study.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2009, Volume: 36, Issue:5

    Topics: Acute Kidney Injury; Aged; Aged, 80 and over; Aprotinin; Blood Component Transfusion; Cardiac Surgic

2009
Acute renal cortex necrosis caused by arterial thrombosis during treatment for acute promyelocytic leukemia.
    Haematologica, 2003, Volume: 88, Issue:6

    Topics: Acute Kidney Injury; Adult; Antifibrinolytic Agents; Antineoplastic Agents; Female; Humans; Kidney C

2003
Acute renal failure secondary to antifibrinolytic therapy.
    Nephron, 1995, Volume: 69, Issue:4

    Topics: Acute Kidney Injury; Aged; Humans; Male; Myelodysplastic Syndromes; Thrombocytopenia; Tranexamic Aci

1995
Acute renal cortical necrosis caused by an antifibrinolytic drug (tranexamic acid).
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1999, Volume: 14, Issue:3

    Topics: Acute Disease; Acute Kidney Injury; Adult; Antifibrinolytic Agents; Humans; Kidney Cortex Necrosis;

1999
Protection against the impairment of renal function after intravascular coagulation in the rat kidney by increased ingestion of sodium chloride.
    Nephron, 1975, Volume: 14, Issue:6

    Topics: Acute Kidney Injury; Animals; Diet; Disseminated Intravascular Coagulation; Female; Fibrin; Fibrinol

1975
Transient acute renal failure due to tranexaminic acid therapy for diffuse intravascular coagulation.
    The Netherlands journal of medicine, 1991, Volume: 39, Issue:1-2

    Topics: Acute Kidney Injury; Aged; Disseminated Intravascular Coagulation; Humans; Male; Tranexamic Acid

1991
Extensive crescent formation with antifibrinolytic therapy in a case of diffuse endocapillary glomerulonephritis.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 1990, Volume: 5, Issue:2

    Topics: Acute Disease; Acute Kidney Injury; Cyclohexanecarboxylic Acids; Female; Glomerulonephritis; Humans;

1990
Effects of an inhibitor of angiotensin converting enzyme (Captopril) on pulmonary and renal insufficiency due to intravascular coagulation in the rat.
    International journal of microcirculation, clinical and experimental, 1989, Volume: 8, Issue:3

    Topics: Acute Kidney Injury; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Disseminated Intr

1989