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tranexamic acid and Acute Brain Injuries

tranexamic acid has been researched along with Acute Brain Injuries in 32 studies

Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.

Research Excerpts

ExcerptRelevanceReference
"To summarize current literature evaluating tranexamic acid in the management of intracranial bleeding associated with traumatic and nontraumatic brain injuries and implications for clinical practice."9.69Therapeutic review: The role of tranexamic acid in management of traumatic brain injury, nontraumatic intracranial hemorrhage, and aneurysmal subarachnoid hemorrhage. ( Crowley, KL; Groth, CM; Sigmon, J, 2023)
"To summarize current literature evaluating tranexamic acid in the management of intracranial bleeding associated with traumatic and nontraumatic brain injuries and implications for clinical practice."5.69Therapeutic review: The role of tranexamic acid in management of traumatic brain injury, nontraumatic intracranial hemorrhage, and aneurysmal subarachnoid hemorrhage. ( Crowley, KL; Groth, CM; Sigmon, J, 2023)
"Analysis of these reviews yielded meanfuling observations: (1) The effectiveness of most ordinary treatments in TBI is inconclusive except that corticosteroids are likely to be ineffective or harmful, and tranexamic acid, nimodipine and progesterone show a promising effect in bleeding trauma, traumatic subarachnoid hemorrhage, TBI or severe TBI."4.88Is management of acute traumatic brain injury effective? A literature review of published Cochrane Systematic Reviews. ( Gao, GY; Jiang, JY; Lei, J, 2012)
"Several studies have demonstrated the clinical utility of tranexamic acid (TXA) for use in trauma patients presenting with significant hemorrhage."4.31EFFECTS OF TRANEXAMIC ACID ON NEUROPATHOLOGY, ELECTROENCEPHALOGRAPHY, AND CEREBRAL FIBRIN DEPOSITION IN A RAT MODEL OF POLYTRAUMA WITH CONCOMITANT PENETRATING TRAUMATIC BRAIN INJURY. ( Bailey, ZS; Cao, Y; Cardiff, K; Gilsdorf, J; Houchins, M; Lu, XC; Scultetus, A; Shear, D; Wang, P; Yang, X, 2023)
"Tranexamic acid (TXA) has shown to be beneficial in selected patients with hemorrhagic shock."4.12The effect of prehospital tranexamic acid on outcome in polytrauma patients with associated severe brain injury. ( Jochems, D; Leenen, LPH; van Wessem, KJP, 2022)
"A reduction in mortality with the early use of tranexamic acid has been demonstrated in severely injured patients who are bleeding."3.85Effectiveness of early administration of tranexamic acid in patients with severe trauma. ( Hagiwara, A; Kushimoto, S; Matsui, H; Murata, K; Otomo, Y; Shiraishi, A, 2017)
" Risks of adverse events (all moderate, low, or very low certainty) were similar between placebo and TXA."2.72Efficacy and safety of tranexamic acid in acute traumatic brain injury: a systematic review and meta-analysis of randomized-controlled trials. ( Alhazzani, W; Belley-Cote, EP; Fernando, SM; Lawati, KA; Maqbali, SA; Morgenstern, J; Owen, JJ; Petrosoniak, A; Quinlan, D; Rimawi, HA; Rochwerg, B; Sharif, S; Sharma, SV; Zeller, M, 2021)
"Fibrinogen depletes early after severe trauma; therefore, it seems to be reasonable to maintain plasma fibrinogen as early as possible."2.50Tranexamic acid, fibrinogen concentrate, and prothrombin complex concentrate: data to support prehospital use? ( Maegele, M; Schlimp, CJ; Schöchl, H, 2014)
"Mice were then subjected to controlled hemorrhagic shock for 1 h to a goal MAP of 25 mmHg."1.72MULTIMODAL TREATMENT APPROACHES TO COMBINED TRAUMATIC BRAIN INJURY AND HEMORRHAGIC SHOCK ALTER POSTINJURY INFLAMMATORY RESPONSE. ( Baucom, MR; England, LG; Goodman, MD; Pritts, TA; Schuster, RM; Wallen, TE, 2022)
"Persistent intracerebral hemorrhage (ICH) is a major cause of death and disability after traumatic brain injury (TBI) for which no medical treatment is available."1.42Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice. ( Abdeen, S; Abramovitch, R; Abu Fanne, R; Basheer, M; Cines, DB; Higazi, AA; Higazi, M; Hijazi, N; Maraga, E; Yarovoi, S, 2015)

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (3.13)29.6817
2010's14 (43.75)24.3611
2020's17 (53.13)2.80

Authors

AuthorsStudies
van Wessem, KJP1
Jochems, D1
Leenen, LPH1
Wallen, TE1
Baucom, MR1
England, LG1
Schuster, RM1
Pritts, TA1
Goodman, MD1
Bailey, ZS1
Yang, X1
Cardiff, K1
Wang, P1
Houchins, M1
Lu, XC1
Cao, Y1
Gilsdorf, J1
Scultetus, A1
Shear, D1
Sigmon, J1
Crowley, KL1
Groth, CM1
Tanaka, T1
Suehiro, E1
Matsuno, A1
Cap, AP1
Taccone, FS1
Citerio, G2
Stocchetti, N1
Blanchard, PG1
Paré, D1
Truchot, J1
Mercier, E1
Solla, DJF1
Rubiano, AM1
Teixeira, MJ1
de Andrade, AF1
Paiva, WS1
Reynard, C1
Berg, PVD1
Body, R1
Kolias, AG1
Horner, D1
Menon, DK1
Wilson, M1
Hutchinson, PJ1
Bourn, S1
Dodds, N1
Schober, P1
Mascha, EJ1
Loer, SA1
Schwarte, LA1
Bossers, SM1
Goursaud, S1
Gaberel, T1
Kawada, T1
Lawati, KA1
Sharif, S1
Maqbali, SA1
Rimawi, HA1
Petrosoniak, A1
Belley-Cote, EP1
Sharma, SV1
Morgenstern, J1
Fernando, SM1
Owen, JJ1
Zeller, M1
Quinlan, D1
Alhazzani, W1
Rochwerg, B1
Maas, AIR1
Steyerberg, EW1
Brenner, A1
Belli, A1
Chaudhri, R1
Coats, T1
Frimley, L1
Jamaluddin, SF1
Jooma, R1
Mansukhani, R1
Sandercock, P1
Shakur-Still, H1
Shokunbi, T1
Roberts, I2
Ghawnni, A1
Coates, A1
Owen, J1
Schöchl, H1
Schlimp, CJ1
Maegele, M1
Valle, EJ1
Allen, CJ1
Van Haren, RM1
Jouria, JM1
Li, H1
Livingstone, AS1
Namias, N1
Schulman, CI1
Proctor, KG1
Piper, BJ1
Zehtabchi, S2
Abdel Baki, SG2
Falzon, L2
Nishijima, DK2
Hijazi, N1
Abu Fanne, R1
Abramovitch, R1
Yarovoi, S1
Higazi, M1
Abdeen, S1
Basheer, M1
Maraga, E1
Cines, DB1
Higazi, AA1
Shiraishi, A1
Kushimoto, S1
Otomo, Y1
Matsui, H1
Hagiwara, A1
Murata, K1
Roos, YB1
Lei, J1
Gao, GY1
Jiang, JY1
Dewan, Y1
Komolafe, EO1
Mejía-Mantilla, JH1
Perel, P1
Shakur, H1
Boling, B1
Moore, K1
Liu-DeRyke, X1
Rhoney, D1

Clinical Trials (2)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Tranexamic Acid for the Treatment of Significant Traumatic Brain Injury: an International Randomised, Double Blind Placebo Controlled Trial[NCT01402882]Phase 312,737 participants (Actual)Interventional2012-07-31Completed
TRACE STUDY: A Randomized Controlled Trial Using Tranexamic Acid in the Treatment of Subdural Hematoma[NCT05713630]Phase 3130 participants (Anticipated)Interventional2024-03-31Not yet recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

6 reviews available for tranexamic acid and Acute Brain Injuries

ArticleYear
Efficacy and safety of tranexamic acid in acute traumatic brain injury: a systematic review and meta-analysis of randomized-controlled trials.
    Intensive care medicine, 2021, Volume: 47, Issue:1

    Topics: Adolescent; Adult; Brain Injuries; Brain Injuries, Traumatic; Humans; Randomized Controlled Trials a

2021
Tranexamic acid, fibrinogen concentrate, and prothrombin complex concentrate: data to support prehospital use?
    Shock (Augusta, Ga.), 2014, Volume: 41 Suppl 1

    Topics: Antifibrinolytic Agents; Blood Coagulation; Blood Coagulation Factors; Blood Transfusion; Brain Inju

2014
Tranexamic acid for traumatic brain injury: a systematic review and meta-analysis.
    The American journal of emergency medicine, 2014, Volume: 32, Issue:12

    Topics: Antifibrinolytic Agents; Brain Injuries; Humans; Intracranial Hemorrhages; Randomized Controlled Tri

2014
Is management of acute traumatic brain injury effective? A literature review of published Cochrane Systematic Reviews.
    Chinese journal of traumatology = Zhonghua chuang shang za zhi, 2012, Volume: 15, Issue:1

    Topics: Brain Injuries; Hemorrhage; Humans; Systematic Reviews as Topic; Tranexamic Acid

2012
Tranexamic acid (TXA) use in trauma.
    Journal of emergency nursing, 2012, Volume: 38, Issue:5

    Topics: Antifibrinolytic Agents; Blood Coagulation Disorders; Brain Injuries; Cause of Death; Emergency Serv

2012
Hemostatic therapy for the treatment of intracranial hemorrhage.
    Pharmacotherapy, 2008, Volume: 28, Issue:4

    Topics: Aminocaproates; Antifibrinolytic Agents; Brain Injuries; Clinical Trials as Topic; Factor VIIa; Hemo

2008

Trials

6 trials available for tranexamic acid and Acute Brain Injuries

ArticleYear
Therapeutic review: The role of tranexamic acid in management of traumatic brain injury, nontraumatic intracranial hemorrhage, and aneurysmal subarachnoid hemorrhage.
    American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2023, 09-07, Volume: 80, Issue:18

    Topics: Brain Injuries; Brain Injuries, Traumatic; Craniocerebral Trauma; Humans; Intracranial Hemorrhages;

2023
Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial.
    Critical care (London, England), 2020, 11-11, Volume: 24, Issue:1

    Topics: Antifibrinolytic Agents; Brain Injuries; Humans; Multiple Trauma; Neuroprotective Agents; Protective

2020
Compliance of tranexamic acid administration to trauma patients at a level-one trauma centre.
    CJEM, 2018, Volume: 20, Issue:2

    Topics: Antifibrinolytic Agents; Brain Injuries; Dose-Response Relationship, Drug; Follow-Up Studies; Humans

2018
Do all trauma patients benefit from tranexamic acid?
    The journal of trauma and acute care surgery, 2014, Volume: 76, Issue:6

    Topics: Adult; Antifibrinolytic Agents; Brain Injuries; Dose-Response Relationship, Drug; Double-Blind Metho

2014
Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study).
    BMJ (Clinical research ed.), 2011, Jul-01, Volume: 343

    Topics: Adult; Antifibrinolytic Agents; Brain Injuries; Case-Control Studies; Female; Glasgow Coma Scale; Hu

2011
CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial.
    Trials, 2012, Jun-21, Volume: 13

    Topics: Adult; Antifibrinolytic Agents; Brain Injuries; Clinical Protocols; Cost-Benefit Analysis; Data Coll

2012

Other Studies

20 other studies available for tranexamic acid and Acute Brain Injuries

ArticleYear
The effect of prehospital tranexamic acid on outcome in polytrauma patients with associated severe brain injury.
    European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2022, Volume: 48, Issue:3

    Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Female; Humans; Male; Middle Age

2022
MULTIMODAL TREATMENT APPROACHES TO COMBINED TRAUMATIC BRAIN INJURY AND HEMORRHAGIC SHOCK ALTER POSTINJURY INFLAMMATORY RESPONSE.
    Shock (Augusta, Ga.), 2022, 12-01, Volume: 58, Issue:6

    Topics: Animals; Biomarkers; Brain Injuries; Brain Injuries, Traumatic; Chemokine CCL3; Combined Modality Th

2022
EFFECTS OF TRANEXAMIC ACID ON NEUROPATHOLOGY, ELECTROENCEPHALOGRAPHY, AND CEREBRAL FIBRIN DEPOSITION IN A RAT MODEL OF POLYTRAUMA WITH CONCOMITANT PENETRATING TRAUMATIC BRAIN INJURY.
    Shock (Augusta, Ga.), 2023, 08-01, Volume: 60, Issue:2

    Topics: Animals; Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Electroencephalography;

2023
[Initial Management of Traumatic Brain Injury].
    No shinkei geka. Neurological surgery, 2023, Volume: 51, Issue:6

    Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Japan; Tranexamic Acid

2023
CRASH-3: a win for patients with traumatic brain injury.
    Lancet (London, England), 2019, 11-09, Volume: 394, Issue:10210

    Topics: Brain Injuries; Brain Injuries, Traumatic; Humans; Morbidity; Tranexamic Acid

2019
Is tranexamic acid going to CRASH the management of traumatic brain injury?
    Intensive care medicine, 2020, Volume: 46, Issue:6

    Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula

2020
Does tranexamic acid reduce traumatic brain injury-related death?
    CJEM, 2020, Volume: 22, Issue:3

    Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid

2020
Tranexamic acid for traumatic brain injury.
    Lancet (London, England), 2020, 07-18, Volume: 396, Issue:10245

    Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula

2020
Tranexamic acid for traumatic brain injury.
    Lancet (London, England), 2020, 07-18, Volume: 396, Issue:10245

    Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula

2020
Tranexamic acid for traumatic brain injury.
    Lancet (London, England), 2020, 07-18, Volume: 396, Issue:10245

    Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula

2020
Tranexamic acid for traumatic brain injury.
    Lancet (London, England), 2020, 07-18, Volume: 396, Issue:10245

    Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula

2020
Tranexamic acid for traumatic brain injury.
    Lancet (London, England), 2020, 07-18, Volume: 396, Issue:10245

    Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula

2020
Tranexamic acid for traumatic brain injury.
    Lancet (London, England), 2020, 07-18, Volume: 396, Issue:10245

    Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula

2020
The efficacy of tranexamic acid for brain injury.
    The American journal of emergency medicine, 2021, Volume: 45

    Topics: Antifibrinolytic Agents; Brain Injuries; Humans; Tranexamic Acid

2021
Tranexamic acid in traumatic brain injury: systematic review and meta-analysis trumps a large clinical trial?
    Intensive care medicine, 2021, Volume: 47, Issue:1

    Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid

2021
Tranexamic acid in brain injury: the devil in the detail.
    The American journal of emergency medicine, 2015, Volume: 33, Issue:3

    Topics: Antifibrinolytic Agents; Brain Injuries; Humans; Tranexamic Acid

2015
Tranexamic acid in brain injury: devil in the detail.
    The American journal of emergency medicine, 2015, Volume: 33, Issue:3

    Topics: Antifibrinolytic Agents; Brain Injuries; Humans; Tranexamic Acid

2015
Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice.
    Blood, 2015, Apr-16, Volume: 125, Issue:16

    Topics: Animals; Antifibrinolytic Agents; Brain; Brain Injuries; Cerebral Hemorrhage; Fibrin; Fibrinolysis;

2015
Effectiveness of early administration of tranexamic acid in patients with severe trauma.
    The British journal of surgery, 2017, Volume: 104, Issue:6

    Topics: Adult; Aged; Antifibrinolytic Agents; Blood Transfusion; Brain Injuries; Female; Hemorrhage; Humans;

2017
Tranexamic acid for traumatic brain injury.
    BMJ (Clinical research ed.), 2011, Jul-01, Volume: 343

    Topics: Antifibrinolytic Agents; Brain Injuries; Female; Humans; Intracranial Hemorrhages; Male; Tranexamic

2011