tranexamic acid has been researched along with Acute Brain Injuries in 32 studies
Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.
Excerpt | Relevance | Reference |
---|---|---|
"To summarize current literature evaluating tranexamic acid in the management of intracranial bleeding associated with traumatic and nontraumatic brain injuries and implications for clinical practice." | 9.69 | Therapeutic review: The role of tranexamic acid in management of traumatic brain injury, nontraumatic intracranial hemorrhage, and aneurysmal subarachnoid hemorrhage. ( Crowley, KL; Groth, CM; Sigmon, J, 2023) |
"To summarize current literature evaluating tranexamic acid in the management of intracranial bleeding associated with traumatic and nontraumatic brain injuries and implications for clinical practice." | 5.69 | Therapeutic review: The role of tranexamic acid in management of traumatic brain injury, nontraumatic intracranial hemorrhage, and aneurysmal subarachnoid hemorrhage. ( Crowley, KL; Groth, CM; Sigmon, J, 2023) |
"Analysis of these reviews yielded meanfuling observations: (1) The effectiveness of most ordinary treatments in TBI is inconclusive except that corticosteroids are likely to be ineffective or harmful, and tranexamic acid, nimodipine and progesterone show a promising effect in bleeding trauma, traumatic subarachnoid hemorrhage, TBI or severe TBI." | 4.88 | Is management of acute traumatic brain injury effective? A literature review of published Cochrane Systematic Reviews. ( Gao, GY; Jiang, JY; Lei, J, 2012) |
"Several studies have demonstrated the clinical utility of tranexamic acid (TXA) for use in trauma patients presenting with significant hemorrhage." | 4.31 | EFFECTS OF TRANEXAMIC ACID ON NEUROPATHOLOGY, ELECTROENCEPHALOGRAPHY, AND CEREBRAL FIBRIN DEPOSITION IN A RAT MODEL OF POLYTRAUMA WITH CONCOMITANT PENETRATING TRAUMATIC BRAIN INJURY. ( Bailey, ZS; Cao, Y; Cardiff, K; Gilsdorf, J; Houchins, M; Lu, XC; Scultetus, A; Shear, D; Wang, P; Yang, X, 2023) |
"Tranexamic acid (TXA) has shown to be beneficial in selected patients with hemorrhagic shock." | 4.12 | The effect of prehospital tranexamic acid on outcome in polytrauma patients with associated severe brain injury. ( Jochems, D; Leenen, LPH; van Wessem, KJP, 2022) |
"A reduction in mortality with the early use of tranexamic acid has been demonstrated in severely injured patients who are bleeding." | 3.85 | Effectiveness of early administration of tranexamic acid in patients with severe trauma. ( Hagiwara, A; Kushimoto, S; Matsui, H; Murata, K; Otomo, Y; Shiraishi, A, 2017) |
" Risks of adverse events (all moderate, low, or very low certainty) were similar between placebo and TXA." | 2.72 | Efficacy and safety of tranexamic acid in acute traumatic brain injury: a systematic review and meta-analysis of randomized-controlled trials. ( Alhazzani, W; Belley-Cote, EP; Fernando, SM; Lawati, KA; Maqbali, SA; Morgenstern, J; Owen, JJ; Petrosoniak, A; Quinlan, D; Rimawi, HA; Rochwerg, B; Sharif, S; Sharma, SV; Zeller, M, 2021) |
"Fibrinogen depletes early after severe trauma; therefore, it seems to be reasonable to maintain plasma fibrinogen as early as possible." | 2.50 | Tranexamic acid, fibrinogen concentrate, and prothrombin complex concentrate: data to support prehospital use? ( Maegele, M; Schlimp, CJ; Schöchl, H, 2014) |
"Mice were then subjected to controlled hemorrhagic shock for 1 h to a goal MAP of 25 mmHg." | 1.72 | MULTIMODAL TREATMENT APPROACHES TO COMBINED TRAUMATIC BRAIN INJURY AND HEMORRHAGIC SHOCK ALTER POSTINJURY INFLAMMATORY RESPONSE. ( Baucom, MR; England, LG; Goodman, MD; Pritts, TA; Schuster, RM; Wallen, TE, 2022) |
"Persistent intracerebral hemorrhage (ICH) is a major cause of death and disability after traumatic brain injury (TBI) for which no medical treatment is available." | 1.42 | Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice. ( Abdeen, S; Abramovitch, R; Abu Fanne, R; Basheer, M; Cines, DB; Higazi, AA; Higazi, M; Hijazi, N; Maraga, E; Yarovoi, S, 2015) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 1 (3.13) | 29.6817 |
2010's | 14 (43.75) | 24.3611 |
2020's | 17 (53.13) | 2.80 |
Authors | Studies |
---|---|
van Wessem, KJP | 1 |
Jochems, D | 1 |
Leenen, LPH | 1 |
Wallen, TE | 1 |
Baucom, MR | 1 |
England, LG | 1 |
Schuster, RM | 1 |
Pritts, TA | 1 |
Goodman, MD | 1 |
Bailey, ZS | 1 |
Yang, X | 1 |
Cardiff, K | 1 |
Wang, P | 1 |
Houchins, M | 1 |
Lu, XC | 1 |
Cao, Y | 1 |
Gilsdorf, J | 1 |
Scultetus, A | 1 |
Shear, D | 1 |
Sigmon, J | 1 |
Crowley, KL | 1 |
Groth, CM | 1 |
Tanaka, T | 1 |
Suehiro, E | 1 |
Matsuno, A | 1 |
Cap, AP | 1 |
Taccone, FS | 1 |
Citerio, G | 2 |
Stocchetti, N | 1 |
Blanchard, PG | 1 |
Paré, D | 1 |
Truchot, J | 1 |
Mercier, E | 1 |
Solla, DJF | 1 |
Rubiano, AM | 1 |
Teixeira, MJ | 1 |
de Andrade, AF | 1 |
Paiva, WS | 1 |
Reynard, C | 1 |
Berg, PVD | 1 |
Body, R | 1 |
Kolias, AG | 1 |
Horner, D | 1 |
Menon, DK | 1 |
Wilson, M | 1 |
Hutchinson, PJ | 1 |
Bourn, S | 1 |
Dodds, N | 1 |
Schober, P | 1 |
Mascha, EJ | 1 |
Loer, SA | 1 |
Schwarte, LA | 1 |
Bossers, SM | 1 |
Goursaud, S | 1 |
Gaberel, T | 1 |
Kawada, T | 1 |
Lawati, KA | 1 |
Sharif, S | 1 |
Maqbali, SA | 1 |
Rimawi, HA | 1 |
Petrosoniak, A | 1 |
Belley-Cote, EP | 1 |
Sharma, SV | 1 |
Morgenstern, J | 1 |
Fernando, SM | 1 |
Owen, JJ | 1 |
Zeller, M | 1 |
Quinlan, D | 1 |
Alhazzani, W | 1 |
Rochwerg, B | 1 |
Maas, AIR | 1 |
Steyerberg, EW | 1 |
Brenner, A | 1 |
Belli, A | 1 |
Chaudhri, R | 1 |
Coats, T | 1 |
Frimley, L | 1 |
Jamaluddin, SF | 1 |
Jooma, R | 1 |
Mansukhani, R | 1 |
Sandercock, P | 1 |
Shakur-Still, H | 1 |
Shokunbi, T | 1 |
Roberts, I | 2 |
Ghawnni, A | 1 |
Coates, A | 1 |
Owen, J | 1 |
Schöchl, H | 1 |
Schlimp, CJ | 1 |
Maegele, M | 1 |
Valle, EJ | 1 |
Allen, CJ | 1 |
Van Haren, RM | 1 |
Jouria, JM | 1 |
Li, H | 1 |
Livingstone, AS | 1 |
Namias, N | 1 |
Schulman, CI | 1 |
Proctor, KG | 1 |
Piper, BJ | 1 |
Zehtabchi, S | 2 |
Abdel Baki, SG | 2 |
Falzon, L | 2 |
Nishijima, DK | 2 |
Hijazi, N | 1 |
Abu Fanne, R | 1 |
Abramovitch, R | 1 |
Yarovoi, S | 1 |
Higazi, M | 1 |
Abdeen, S | 1 |
Basheer, M | 1 |
Maraga, E | 1 |
Cines, DB | 1 |
Higazi, AA | 1 |
Shiraishi, A | 1 |
Kushimoto, S | 1 |
Otomo, Y | 1 |
Matsui, H | 1 |
Hagiwara, A | 1 |
Murata, K | 1 |
Roos, YB | 1 |
Lei, J | 1 |
Gao, GY | 1 |
Jiang, JY | 1 |
Dewan, Y | 1 |
Komolafe, EO | 1 |
Mejía-Mantilla, JH | 1 |
Perel, P | 1 |
Shakur, H | 1 |
Boling, B | 1 |
Moore, K | 1 |
Liu-DeRyke, X | 1 |
Rhoney, D | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Tranexamic Acid for the Treatment of Significant Traumatic Brain Injury: an International Randomised, Double Blind Placebo Controlled Trial[NCT01402882] | Phase 3 | 12,737 participants (Actual) | Interventional | 2012-07-31 | Completed | ||
TRACE STUDY: A Randomized Controlled Trial Using Tranexamic Acid in the Treatment of Subdural Hematoma[NCT05713630] | Phase 3 | 130 participants (Anticipated) | Interventional | 2024-03-31 | Not yet recruiting | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
6 reviews available for tranexamic acid and Acute Brain Injuries
Article | Year |
---|---|
Efficacy and safety of tranexamic acid in acute traumatic brain injury: a systematic review and meta-analysis of randomized-controlled trials.
Topics: Adolescent; Adult; Brain Injuries; Brain Injuries, Traumatic; Humans; Randomized Controlled Trials a | 2021 |
Tranexamic acid, fibrinogen concentrate, and prothrombin complex concentrate: data to support prehospital use?
Topics: Antifibrinolytic Agents; Blood Coagulation; Blood Coagulation Factors; Blood Transfusion; Brain Inju | 2014 |
Tranexamic acid for traumatic brain injury: a systematic review and meta-analysis.
Topics: Antifibrinolytic Agents; Brain Injuries; Humans; Intracranial Hemorrhages; Randomized Controlled Tri | 2014 |
Is management of acute traumatic brain injury effective? A literature review of published Cochrane Systematic Reviews.
Topics: Brain Injuries; Hemorrhage; Humans; Systematic Reviews as Topic; Tranexamic Acid | 2012 |
Tranexamic acid (TXA) use in trauma.
Topics: Antifibrinolytic Agents; Blood Coagulation Disorders; Brain Injuries; Cause of Death; Emergency Serv | 2012 |
Hemostatic therapy for the treatment of intracranial hemorrhage.
Topics: Aminocaproates; Antifibrinolytic Agents; Brain Injuries; Clinical Trials as Topic; Factor VIIa; Hemo | 2008 |
6 trials available for tranexamic acid and Acute Brain Injuries
Article | Year |
---|---|
Therapeutic review: The role of tranexamic acid in management of traumatic brain injury, nontraumatic intracranial hemorrhage, and aneurysmal subarachnoid hemorrhage.
Topics: Brain Injuries; Brain Injuries, Traumatic; Craniocerebral Trauma; Humans; Intracranial Hemorrhages; | 2023 |
Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial.
Topics: Antifibrinolytic Agents; Brain Injuries; Humans; Multiple Trauma; Neuroprotective Agents; Protective | 2020 |
Compliance of tranexamic acid administration to trauma patients at a level-one trauma centre.
Topics: Antifibrinolytic Agents; Brain Injuries; Dose-Response Relationship, Drug; Follow-Up Studies; Humans | 2018 |
Do all trauma patients benefit from tranexamic acid?
Topics: Adult; Antifibrinolytic Agents; Brain Injuries; Dose-Response Relationship, Drug; Double-Blind Metho | 2014 |
Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study).
Topics: Adult; Antifibrinolytic Agents; Brain Injuries; Case-Control Studies; Female; Glasgow Coma Scale; Hu | 2011 |
CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial.
Topics: Adult; Antifibrinolytic Agents; Brain Injuries; Clinical Protocols; Cost-Benefit Analysis; Data Coll | 2012 |
20 other studies available for tranexamic acid and Acute Brain Injuries
Article | Year |
---|---|
The effect of prehospital tranexamic acid on outcome in polytrauma patients with associated severe brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Female; Humans; Male; Middle Age | 2022 |
MULTIMODAL TREATMENT APPROACHES TO COMBINED TRAUMATIC BRAIN INJURY AND HEMORRHAGIC SHOCK ALTER POSTINJURY INFLAMMATORY RESPONSE.
Topics: Animals; Biomarkers; Brain Injuries; Brain Injuries, Traumatic; Chemokine CCL3; Combined Modality Th | 2022 |
EFFECTS OF TRANEXAMIC ACID ON NEUROPATHOLOGY, ELECTROENCEPHALOGRAPHY, AND CEREBRAL FIBRIN DEPOSITION IN A RAT MODEL OF POLYTRAUMA WITH CONCOMITANT PENETRATING TRAUMATIC BRAIN INJURY.
Topics: Animals; Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Electroencephalography; | 2023 |
[Initial Management of Traumatic Brain Injury].
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Japan; Tranexamic Acid | 2023 |
CRASH-3: a win for patients with traumatic brain injury.
Topics: Brain Injuries; Brain Injuries, Traumatic; Humans; Morbidity; Tranexamic Acid | 2019 |
Is tranexamic acid going to CRASH the management of traumatic brain injury?
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula | 2020 |
Does tranexamic acid reduce traumatic brain injury-related death?
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid | 2020 |
Tranexamic acid for traumatic brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula | 2020 |
Tranexamic acid for traumatic brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula | 2020 |
Tranexamic acid for traumatic brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula | 2020 |
Tranexamic acid for traumatic brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula | 2020 |
Tranexamic acid for traumatic brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula | 2020 |
Tranexamic acid for traumatic brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula | 2020 |
The efficacy of tranexamic acid for brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Humans; Tranexamic Acid | 2021 |
Tranexamic acid in traumatic brain injury: systematic review and meta-analysis trumps a large clinical trial?
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid | 2021 |
Tranexamic acid in brain injury: the devil in the detail.
Topics: Antifibrinolytic Agents; Brain Injuries; Humans; Tranexamic Acid | 2015 |
Tranexamic acid in brain injury: devil in the detail.
Topics: Antifibrinolytic Agents; Brain Injuries; Humans; Tranexamic Acid | 2015 |
Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice.
Topics: Animals; Antifibrinolytic Agents; Brain; Brain Injuries; Cerebral Hemorrhage; Fibrin; Fibrinolysis; | 2015 |
Effectiveness of early administration of tranexamic acid in patients with severe trauma.
Topics: Adult; Aged; Antifibrinolytic Agents; Blood Transfusion; Brain Injuries; Female; Hemorrhage; Humans; | 2017 |
Tranexamic acid for traumatic brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Female; Humans; Intracranial Hemorrhages; Male; Tranexamic | 2011 |