tranexamic acid has been researched along with Acute Brain Injuries in 32 studies
Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To summarize current literature evaluating tranexamic acid in the management of intracranial bleeding associated with traumatic and nontraumatic brain injuries and implications for clinical practice." | 9.69 | Therapeutic review: The role of tranexamic acid in management of traumatic brain injury, nontraumatic intracranial hemorrhage, and aneurysmal subarachnoid hemorrhage. ( Crowley, KL; Groth, CM; Sigmon, J, 2023) |
| "To summarize current literature evaluating tranexamic acid in the management of intracranial bleeding associated with traumatic and nontraumatic brain injuries and implications for clinical practice." | 5.69 | Therapeutic review: The role of tranexamic acid in management of traumatic brain injury, nontraumatic intracranial hemorrhage, and aneurysmal subarachnoid hemorrhage. ( Crowley, KL; Groth, CM; Sigmon, J, 2023) |
| "Analysis of these reviews yielded meanfuling observations: (1) The effectiveness of most ordinary treatments in TBI is inconclusive except that corticosteroids are likely to be ineffective or harmful, and tranexamic acid, nimodipine and progesterone show a promising effect in bleeding trauma, traumatic subarachnoid hemorrhage, TBI or severe TBI." | 4.88 | Is management of acute traumatic brain injury effective? A literature review of published Cochrane Systematic Reviews. ( Gao, GY; Jiang, JY; Lei, J, 2012) |
| "Several studies have demonstrated the clinical utility of tranexamic acid (TXA) for use in trauma patients presenting with significant hemorrhage." | 4.31 | EFFECTS OF TRANEXAMIC ACID ON NEUROPATHOLOGY, ELECTROENCEPHALOGRAPHY, AND CEREBRAL FIBRIN DEPOSITION IN A RAT MODEL OF POLYTRAUMA WITH CONCOMITANT PENETRATING TRAUMATIC BRAIN INJURY. ( Bailey, ZS; Cao, Y; Cardiff, K; Gilsdorf, J; Houchins, M; Lu, XC; Scultetus, A; Shear, D; Wang, P; Yang, X, 2023) |
| "Tranexamic acid (TXA) has shown to be beneficial in selected patients with hemorrhagic shock." | 4.12 | The effect of prehospital tranexamic acid on outcome in polytrauma patients with associated severe brain injury. ( Jochems, D; Leenen, LPH; van Wessem, KJP, 2022) |
| "A reduction in mortality with the early use of tranexamic acid has been demonstrated in severely injured patients who are bleeding." | 3.85 | Effectiveness of early administration of tranexamic acid in patients with severe trauma. ( Hagiwara, A; Kushimoto, S; Matsui, H; Murata, K; Otomo, Y; Shiraishi, A, 2017) |
| " Risks of adverse events (all moderate, low, or very low certainty) were similar between placebo and TXA." | 2.72 | Efficacy and safety of tranexamic acid in acute traumatic brain injury: a systematic review and meta-analysis of randomized-controlled trials. ( Alhazzani, W; Belley-Cote, EP; Fernando, SM; Lawati, KA; Maqbali, SA; Morgenstern, J; Owen, JJ; Petrosoniak, A; Quinlan, D; Rimawi, HA; Rochwerg, B; Sharif, S; Sharma, SV; Zeller, M, 2021) |
| "Fibrinogen depletes early after severe trauma; therefore, it seems to be reasonable to maintain plasma fibrinogen as early as possible." | 2.50 | Tranexamic acid, fibrinogen concentrate, and prothrombin complex concentrate: data to support prehospital use? ( Maegele, M; Schlimp, CJ; Schöchl, H, 2014) |
| "Mice were then subjected to controlled hemorrhagic shock for 1 h to a goal MAP of 25 mmHg." | 1.72 | MULTIMODAL TREATMENT APPROACHES TO COMBINED TRAUMATIC BRAIN INJURY AND HEMORRHAGIC SHOCK ALTER POSTINJURY INFLAMMATORY RESPONSE. ( Baucom, MR; England, LG; Goodman, MD; Pritts, TA; Schuster, RM; Wallen, TE, 2022) |
| "Persistent intracerebral hemorrhage (ICH) is a major cause of death and disability after traumatic brain injury (TBI) for which no medical treatment is available." | 1.42 | Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice. ( Abdeen, S; Abramovitch, R; Abu Fanne, R; Basheer, M; Cines, DB; Higazi, AA; Higazi, M; Hijazi, N; Maraga, E; Yarovoi, S, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (3.13) | 29.6817 |
| 2010's | 14 (43.75) | 24.3611 |
| 2020's | 17 (53.13) | 2.80 |
| Authors | Studies |
|---|---|
| van Wessem, KJP | 1 |
| Jochems, D | 1 |
| Leenen, LPH | 1 |
| Wallen, TE | 1 |
| Baucom, MR | 1 |
| England, LG | 1 |
| Schuster, RM | 1 |
| Pritts, TA | 1 |
| Goodman, MD | 1 |
| Bailey, ZS | 1 |
| Yang, X | 1 |
| Cardiff, K | 1 |
| Wang, P | 1 |
| Houchins, M | 1 |
| Lu, XC | 1 |
| Cao, Y | 1 |
| Gilsdorf, J | 1 |
| Scultetus, A | 1 |
| Shear, D | 1 |
| Sigmon, J | 1 |
| Crowley, KL | 1 |
| Groth, CM | 1 |
| Tanaka, T | 1 |
| Suehiro, E | 1 |
| Matsuno, A | 1 |
| Cap, AP | 1 |
| Taccone, FS | 1 |
| Citerio, G | 2 |
| Stocchetti, N | 1 |
| Blanchard, PG | 1 |
| Paré, D | 1 |
| Truchot, J | 1 |
| Mercier, E | 1 |
| Solla, DJF | 1 |
| Rubiano, AM | 1 |
| Teixeira, MJ | 1 |
| de Andrade, AF | 1 |
| Paiva, WS | 1 |
| Reynard, C | 1 |
| Berg, PVD | 1 |
| Body, R | 1 |
| Kolias, AG | 1 |
| Horner, D | 1 |
| Menon, DK | 1 |
| Wilson, M | 1 |
| Hutchinson, PJ | 1 |
| Bourn, S | 1 |
| Dodds, N | 1 |
| Schober, P | 1 |
| Mascha, EJ | 1 |
| Loer, SA | 1 |
| Schwarte, LA | 1 |
| Bossers, SM | 1 |
| Goursaud, S | 1 |
| Gaberel, T | 1 |
| Kawada, T | 1 |
| Lawati, KA | 1 |
| Sharif, S | 1 |
| Maqbali, SA | 1 |
| Rimawi, HA | 1 |
| Petrosoniak, A | 1 |
| Belley-Cote, EP | 1 |
| Sharma, SV | 1 |
| Morgenstern, J | 1 |
| Fernando, SM | 1 |
| Owen, JJ | 1 |
| Zeller, M | 1 |
| Quinlan, D | 1 |
| Alhazzani, W | 1 |
| Rochwerg, B | 1 |
| Maas, AIR | 1 |
| Steyerberg, EW | 1 |
| Brenner, A | 1 |
| Belli, A | 1 |
| Chaudhri, R | 1 |
| Coats, T | 1 |
| Frimley, L | 1 |
| Jamaluddin, SF | 1 |
| Jooma, R | 1 |
| Mansukhani, R | 1 |
| Sandercock, P | 1 |
| Shakur-Still, H | 1 |
| Shokunbi, T | 1 |
| Roberts, I | 2 |
| Ghawnni, A | 1 |
| Coates, A | 1 |
| Owen, J | 1 |
| Schöchl, H | 1 |
| Schlimp, CJ | 1 |
| Maegele, M | 1 |
| Valle, EJ | 1 |
| Allen, CJ | 1 |
| Van Haren, RM | 1 |
| Jouria, JM | 1 |
| Li, H | 1 |
| Livingstone, AS | 1 |
| Namias, N | 1 |
| Schulman, CI | 1 |
| Proctor, KG | 1 |
| Piper, BJ | 1 |
| Zehtabchi, S | 2 |
| Abdel Baki, SG | 2 |
| Falzon, L | 2 |
| Nishijima, DK | 2 |
| Hijazi, N | 1 |
| Abu Fanne, R | 1 |
| Abramovitch, R | 1 |
| Yarovoi, S | 1 |
| Higazi, M | 1 |
| Abdeen, S | 1 |
| Basheer, M | 1 |
| Maraga, E | 1 |
| Cines, DB | 1 |
| Higazi, AA | 1 |
| Shiraishi, A | 1 |
| Kushimoto, S | 1 |
| Otomo, Y | 1 |
| Matsui, H | 1 |
| Hagiwara, A | 1 |
| Murata, K | 1 |
| Roos, YB | 1 |
| Lei, J | 1 |
| Gao, GY | 1 |
| Jiang, JY | 1 |
| Dewan, Y | 1 |
| Komolafe, EO | 1 |
| Mejía-Mantilla, JH | 1 |
| Perel, P | 1 |
| Shakur, H | 1 |
| Boling, B | 1 |
| Moore, K | 1 |
| Liu-DeRyke, X | 1 |
| Rhoney, D | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Tranexamic Acid for the Treatment of Significant Traumatic Brain Injury: an International Randomised, Double Blind Placebo Controlled Trial[NCT01402882] | Phase 3 | 12,737 participants (Actual) | Interventional | 2012-07-31 | Completed | ||
| TRACE STUDY: A Randomized Controlled Trial Using Tranexamic Acid in the Treatment of Subdural Hematoma[NCT05713630] | Phase 3 | 130 participants (Anticipated) | Interventional | 2024-03-31 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for tranexamic acid and Acute Brain Injuries
| Article | Year |
|---|---|
Efficacy and safety of tranexamic acid in acute traumatic brain injury: a systematic review and meta-analysis of randomized-controlled trials.
Topics: Adolescent; Adult; Brain Injuries; Brain Injuries, Traumatic; Humans; Randomized Controlled Trials a | 2021 |
Tranexamic acid, fibrinogen concentrate, and prothrombin complex concentrate: data to support prehospital use?
Topics: Antifibrinolytic Agents; Blood Coagulation; Blood Coagulation Factors; Blood Transfusion; Brain Inju | 2014 |
Tranexamic acid for traumatic brain injury: a systematic review and meta-analysis.
Topics: Antifibrinolytic Agents; Brain Injuries; Humans; Intracranial Hemorrhages; Randomized Controlled Tri | 2014 |
Is management of acute traumatic brain injury effective? A literature review of published Cochrane Systematic Reviews.
Topics: Brain Injuries; Hemorrhage; Humans; Systematic Reviews as Topic; Tranexamic Acid | 2012 |
Tranexamic acid (TXA) use in trauma.
Topics: Antifibrinolytic Agents; Blood Coagulation Disorders; Brain Injuries; Cause of Death; Emergency Serv | 2012 |
Hemostatic therapy for the treatment of intracranial hemorrhage.
Topics: Aminocaproates; Antifibrinolytic Agents; Brain Injuries; Clinical Trials as Topic; Factor VIIa; Hemo | 2008 |
6 trials available for tranexamic acid and Acute Brain Injuries
| Article | Year |
|---|---|
Therapeutic review: The role of tranexamic acid in management of traumatic brain injury, nontraumatic intracranial hemorrhage, and aneurysmal subarachnoid hemorrhage.
Topics: Brain Injuries; Brain Injuries, Traumatic; Craniocerebral Trauma; Humans; Intracranial Hemorrhages; | 2023 |
Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial.
Topics: Antifibrinolytic Agents; Brain Injuries; Humans; Multiple Trauma; Neuroprotective Agents; Protective | 2020 |
Compliance of tranexamic acid administration to trauma patients at a level-one trauma centre.
Topics: Antifibrinolytic Agents; Brain Injuries; Dose-Response Relationship, Drug; Follow-Up Studies; Humans | 2018 |
Do all trauma patients benefit from tranexamic acid?
Topics: Adult; Antifibrinolytic Agents; Brain Injuries; Dose-Response Relationship, Drug; Double-Blind Metho | 2014 |
Effect of tranexamic acid in traumatic brain injury: a nested randomised, placebo controlled trial (CRASH-2 Intracranial Bleeding Study).
Topics: Adult; Antifibrinolytic Agents; Brain Injuries; Case-Control Studies; Female; Glasgow Coma Scale; Hu | 2011 |
CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial.
Topics: Adult; Antifibrinolytic Agents; Brain Injuries; Clinical Protocols; Cost-Benefit Analysis; Data Coll | 2012 |
20 other studies available for tranexamic acid and Acute Brain Injuries
| Article | Year |
|---|---|
The effect of prehospital tranexamic acid on outcome in polytrauma patients with associated severe brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Female; Humans; Male; Middle Age | 2022 |
MULTIMODAL TREATMENT APPROACHES TO COMBINED TRAUMATIC BRAIN INJURY AND HEMORRHAGIC SHOCK ALTER POSTINJURY INFLAMMATORY RESPONSE.
Topics: Animals; Biomarkers; Brain Injuries; Brain Injuries, Traumatic; Chemokine CCL3; Combined Modality Th | 2022 |
EFFECTS OF TRANEXAMIC ACID ON NEUROPATHOLOGY, ELECTROENCEPHALOGRAPHY, AND CEREBRAL FIBRIN DEPOSITION IN A RAT MODEL OF POLYTRAUMA WITH CONCOMITANT PENETRATING TRAUMATIC BRAIN INJURY.
Topics: Animals; Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Electroencephalography; | 2023 |
[Initial Management of Traumatic Brain Injury].
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Japan; Tranexamic Acid | 2023 |
CRASH-3: a win for patients with traumatic brain injury.
Topics: Brain Injuries; Brain Injuries, Traumatic; Humans; Morbidity; Tranexamic Acid | 2019 |
Is tranexamic acid going to CRASH the management of traumatic brain injury?
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula | 2020 |
Does tranexamic acid reduce traumatic brain injury-related death?
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid | 2020 |
Tranexamic acid for traumatic brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula | 2020 |
Tranexamic acid for traumatic brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula | 2020 |
Tranexamic acid for traumatic brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula | 2020 |
Tranexamic acid for traumatic brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula | 2020 |
Tranexamic acid for traumatic brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula | 2020 |
Tranexamic acid for traumatic brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid; Vascula | 2020 |
The efficacy of tranexamic acid for brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Humans; Tranexamic Acid | 2021 |
Tranexamic acid in traumatic brain injury: systematic review and meta-analysis trumps a large clinical trial?
Topics: Antifibrinolytic Agents; Brain Injuries; Brain Injuries, Traumatic; Humans; Tranexamic Acid | 2021 |
Tranexamic acid in brain injury: the devil in the detail.
Topics: Antifibrinolytic Agents; Brain Injuries; Humans; Tranexamic Acid | 2015 |
Tranexamic acid in brain injury: devil in the detail.
Topics: Antifibrinolytic Agents; Brain Injuries; Humans; Tranexamic Acid | 2015 |
Endogenous plasminogen activators mediate progressive intracerebral hemorrhage after traumatic brain injury in mice.
Topics: Animals; Antifibrinolytic Agents; Brain; Brain Injuries; Cerebral Hemorrhage; Fibrin; Fibrinolysis; | 2015 |
Effectiveness of early administration of tranexamic acid in patients with severe trauma.
Topics: Adult; Aged; Antifibrinolytic Agents; Blood Transfusion; Brain Injuries; Female; Hemorrhage; Humans; | 2017 |
Tranexamic acid for traumatic brain injury.
Topics: Antifibrinolytic Agents; Brain Injuries; Female; Humans; Intracranial Hemorrhages; Male; Tranexamic | 2011 |