Page last updated: 2024-11-05

tranexamic acid and Absence Seizure

tranexamic acid has been researched along with Absence Seizure in 74 studies

Tranexamic Acid: Antifibrinolytic hemostatic used in severe hemorrhage.

Research Excerpts

ExcerptRelevanceReference
"Tranexamic acid (TXA) reduces surgical bleeding and reduces death from bleeding after trauma and childbirth."9.12Effect of tranexamic acid on thrombotic events and seizures in bleeding patients: a systematic review and meta-analysis. ( Murao, S; Nakata, H; Roberts, I; Yamakawa, K, 2021)
"This study aimed to evaluate the efficacy and safety of using high-dose intravenous tranexamic acid (TXA) to reduce blood loss in idiopathic scoliosis surgery."9.12The efficacy and safety of high-dose tranexamic acid in adolescent idiopathic scoliosis: a meta-analysis. ( Chen, JC; Lin, L; Na, XQ; Qu, QC; Ruan, TY; Shrestha, IK; Si, YY; Tan, M; Tao, JP, 2021)
"The aim of this meta-analysis was to assess whether tranexamic acid (TXA) therapy for adult cardiac surgery is associated with an increase in the risk of seizures, and we performed a meta-analysis of randomized controlled trials (RCTs) and non-randomized observational studies."8.95Seizures associated with tranexamic acid for cardiac surgery: a meta-analysis of randomized and non-randomized studies. ( Ando, T; Takagi, H; Umemoto, T, 2017)
"To investigate the incidence rate of tranexamic acid (TXA)-associated seizures."8.93Tranexamic acid-associated seizures: A meta-analysis. ( Lin, Z; Xiaoyi, Z, 2016)
" The most commonly used antifibrinolytic drug, tranexamic acid, is associated with an increased incidence of postoperative seizures."8.93Tranexamic acid-associated seizures: Causes and treatment. ( Avramescu, S; Lecker, I; Mazer, CD; Orser, BA; Wang, DS; Whissell, PD, 2016)
"This study described the outcomes of patients receiving topical, nebulized, endobronchial, or systemic tranexamic acid (TXA) for bleeding events while on extracorporeal membrane oxygenation (ECMO)."8.31Tranexamic Acid for Bleeding Management in Adult Patients on Extracorporeal Membrane Oxygenation. ( Jakowenko, ND; Kalvelage, EL; Macielak, RJ; Nabzdyk, CGS; Nei, SD; Seelhammer, TG; Wieruszewski, PM, 2023)
"To evaluate the effects of administering tranexamic acid (TXA) after cardiopulmonary bypass, instead of after anesthesia induction, on postoperative seizures and blood transfusion requirements."8.12Tranexamic acid after cardiopulmonary bypass does not increase risk of postoperative seizures: a retrospective study. ( Chen, C; Du, L; Liu, J, 2022)
"In cardiac surgery, use of the antifibrinolytic agent tranexamic acid (TXA) and acute perioperative stroke are both associated with convulsive seizures."8.02Associations of preoperative stroke and tranexamic acid administration with convulsive seizures in valvular open-heart surgery. ( Deutsch, MA; Gummert, JF; Hulde, N; Koster, A; von Dossow, V; Zittermann, A, 2021)
"High-dose tranexamic acid (TXA) can cause seizures in patients who have undergone pulmonary endarterectomy (PTE)."7.96Deprescribing practices for anticonvulsants after benign seizures secondary to high-dose tranexamic acid in a single, large UK cardiothoracic centre. ( Barrow, L; Jenkins, D; Ng, CY; Tan, Z; Valchanov, K, 2020)
"The incidence of postoperative nonischemic seizures associated with the use of tranexamic acid (TXA) and the possibility of prevention with a low-dose regimen of TXA were evaluated."7.85Low-Dose Versus High-Dose Tranexamic Acid Reduces the Risk of Nonischemic Seizures After Cardiac Surgery With Cardiopulmonary Bypass. ( Ayoub, C; Chamberland, MÈ; Cogan, J; Couture, P; Denault, A; Deschamps, A; Desjardins, G; Laliberté, É; Lebon, JS; Rochon, A, 2017)
"Tranexamic acid (TXA) is an antifibrinolytic that is widely used to reduce surgical bleeding."7.83Intravenous tranexamic acid for intracerebral meningioma resections: A randomized, parallel-group, non-inferiority trial. ( Li, S; Liu, M; Peng, Y; Sessler, DI; Wu, Y; Yan, X; Yang, J; Zeng, M; Zhang, L; Zhou, D, 2024)
"To investigate the incidence of postoperative generalized seizures in patients undergoing aortic valve replacement (AVR) under extracorporeal circulation, who received either high-dose tranexamic acid (TXA) or epsilon aminocaproic acid (EACA) as an antifibrinolytic agent."7.77High-dose tranexamic acid is related to increased risk of generalized seizures after aortic valve replacement. ( Beyersdorf, F; Keyl, C; Lehane, C; Stampf, S; Trenk, D; Uhl, R; Wiesenack, C, 2011)
"A 68-year-old man was admitted and received tranexamic acid for persistent hemoptysis."7.77Generalized convulsion resulted in hyperammonemia during treatment with tranexamic acid for hemoptysis. ( Chen, HC; Chen, SC; Huang, MS; Wang, CS; Yang, CJ, 2011)
"Usually, TXA-associated seizures persist for a few minutes with no progression into status epilepticus."6.82Tranexamic acid-associated fatal status epilepticus in a paediatric non-cardiac surgery: A case report and literature review. ( Aboul-Fotouh, S; Habib, MZ; Hassan, BEE; Magdy, SM, 2022)
"Tranexamic acid (TXA) has been used extensively to minimize blood loss in cardiac surgery and more recently in orthopedic surgery."5.56Tranexamic acid administration during total joint arthroplasty surgery is not associated with an increased risk of perioperative seizures: a national database analysis. ( Fiasconaro, M; Kirksey, MA; Liu, J; Memtsoudis, SG; Poeran, J; Wilson, LA, 2020)
" Therefore, the dosage of TA should be decreased judiciously in patients with chronic kidney disease especially on hemodialysis to prevent postoperative seizures."5.46[Two Cases of Convulsive Seizures after Cardiac Surgery Suspiciously Caused by Tranexamic Acid Administration in Patients on Chronic Hemodialysis]. ( Aoi, R; Kawashima, E; Kitagawa, H; Maehira, M; Soga, M; Takahashi, K; Yuasa, M, 2017)
"Convulsive seizures are a serious postoperative complication after cardiac surgery."5.40The association between tranexamic acid and convulsive seizures after cardiac surgery: a multivariate analysis in 11 529 patients. ( Carroll, J; Djaiani, G; Garrido-Olivares, L; Jerath, A; Katznelson, R; Rao, V; Sharma, V; Wasowicz, M, 2014)
"Convulsive seizures (CS) occur in ∼1% of the patients after cardiac surgery with cardiopulmonary bypass."5.39Moderate dosage of tranexamic acid during cardiac surgery with cardiopulmonary bypass and convulsive seizures: incidence and clinical outcome. ( Börgermann, J; Gillis-Januszewski, T; Koster, A; Lueth, JU; Schirmer, U; Zittermann, A, 2013)
"Compared to the non-seizure group, seizure patients had an increased rate of postoperative neurological complications, defined as delirium and/or stroke (3."5.38Seizures following cardiac surgery: the impact of tranexamic acid and other risk factors. ( Ariano, RE; Grocott, HP; Jacobsohn, E; Leake, J; Manji, JS; Manji, RA; Menkis, AH, 2012)
"Postoperative seizures occurred significantly more frequently in TXA patients (7."5.37Seizures after open heart surgery: comparison of ε-aminocaproic acid and tranexamic acid. ( Breuer, T; Gertler, R; Knorr, J; Lange, R; Macguill, M; Martin, K; Tassani, P; Wiesner, G, 2011)
"All patients with seizures did not have permanent neurological abnormalities."5.36High-dose tranexamic Acid is associated with nonischemic clinical seizures in cardiac surgical patients. ( Burt, C; Chu, M; Falter, F; Granton, J; Murkin, JM; Young, B, 2010)
"The exact mechanism of TxA-induced seizures is thought to be via inhibition of gamma-aminobutyric acid receptors in neurons."5.36Tranexamic Acid in cardiac surgery and postoperative seizures: a case report series. ( Almeida, A; Bell, D; Marasco, S; Rowland, M, 2010)
"However, tAMCA has been shown to cause epileptic seizures."5.31Epileptic seizures following cortical application of fibrin sealants containing tranexamic acid in rats. ( Hopf, R; Redl, H; Schlag, MG; Zifko, U, 2002)
"Tranexamic acid may cause severe complications when used in the central nervous system."5.31Convulsive seizures following subdural application of fibrin sealant containing tranexamic acid in a rat model. ( Hopf, R; Redl, H; Schlag, MG, 2000)
"An initial retrospective study suggested that tranexamic acid (TXA) administration increased the incidence of seizures in paediatric patients undergoing cardiac surgery."5.30Safety and efficacy of tranexamic acid in paediatric cardiac surgery: study protocol for a double-blind randomised controlled trial. ( Hu, S; Hua, Z; Jia, Y; Li, S; Liu, J; Ran, J; Shi, J; Wang, R; Wang, X; Wang, Y; Yan, F; Yan, J; Yuan, S; Zhang, Y; Zhang, Z; Zhao, Y; Zheng, Z, 2019)
"Tranexamic acid reduces the risk of bleeding among patients undergoing cardiac surgery, but it is unclear whether this leads to improved outcomes."5.24Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery. ( Bussières, JS; Byrne, K; Chan, MT; Cooper, DJ; Forbes, A; Jayarajah, M; Landoni, G; Marasco, S; McGuinness, S; McNeil, J; Myles, PS; Painter, T; Silbert, B; Smith, JA; Wallace, S, 2017)
"Tranexamic acid (TXA) reduces surgical bleeding and reduces death from bleeding after trauma and childbirth."5.12Effect of tranexamic acid on thrombotic events and seizures in bleeding patients: a systematic review and meta-analysis. ( Murao, S; Nakata, H; Roberts, I; Yamakawa, K, 2021)
"This study aimed to evaluate the efficacy and safety of using high-dose intravenous tranexamic acid (TXA) to reduce blood loss in idiopathic scoliosis surgery."5.12The efficacy and safety of high-dose tranexamic acid in adolescent idiopathic scoliosis: a meta-analysis. ( Chen, JC; Lin, L; Na, XQ; Qu, QC; Ruan, TY; Shrestha, IK; Si, YY; Tan, M; Tao, JP, 2021)
"Tranexamic acid (TXA) is one of the measures indicated to reduce bleeding and the need for volume replacement."5.12Tranexamic acid in Neurosurgery: a controversy indication-review. ( Costa E Silva, LT; da Silva Brito, J; de Faria, JL; de Souza, NB; Figueiredo, EG; Kilesse, CTSM; Pereira, CU; Rabelo, NN, 2021)
"The aim of this meta-analysis was to assess whether tranexamic acid (TXA) therapy for adult cardiac surgery is associated with an increase in the risk of seizures, and we performed a meta-analysis of randomized controlled trials (RCTs) and non-randomized observational studies."4.95Seizures associated with tranexamic acid for cardiac surgery: a meta-analysis of randomized and non-randomized studies. ( Ando, T; Takagi, H; Umemoto, T, 2017)
"To investigate the incidence rate of tranexamic acid (TXA)-associated seizures."4.93Tranexamic acid-associated seizures: A meta-analysis. ( Lin, Z; Xiaoyi, Z, 2016)
" The most commonly used antifibrinolytic drug, tranexamic acid, is associated with an increased incidence of postoperative seizures."4.93Tranexamic acid-associated seizures: Causes and treatment. ( Avramescu, S; Lecker, I; Mazer, CD; Orser, BA; Wang, DS; Whissell, PD, 2016)
"This study described the outcomes of patients receiving topical, nebulized, endobronchial, or systemic tranexamic acid (TXA) for bleeding events while on extracorporeal membrane oxygenation (ECMO)."4.31Tranexamic Acid for Bleeding Management in Adult Patients on Extracorporeal Membrane Oxygenation. ( Jakowenko, ND; Kalvelage, EL; Macielak, RJ; Nabzdyk, CGS; Nei, SD; Seelhammer, TG; Wieruszewski, PM, 2023)
"To evaluate the effects of administering tranexamic acid (TXA) after cardiopulmonary bypass, instead of after anesthesia induction, on postoperative seizures and blood transfusion requirements."4.12Tranexamic acid after cardiopulmonary bypass does not increase risk of postoperative seizures: a retrospective study. ( Chen, C; Du, L; Liu, J, 2022)
"This multicenter international experience of pediatric craniofacial surgery reports no increase in seizures or thromboembolic events in those that received antifibrinolytics (tranexamic acid and epsilon-aminocaproic acid) versus those that did not."4.12Safety of antifibrinolytics in 6583 pediatric patients having craniosynostosis surgery: A decade of data reported from the multicenter Pediatric Craniofacial Collaborative Group. ( Benzon, HA; Goobie, SM; King, MR; Nelson, O; Pérez-Pradilla, C; Staffa, SJ; Stricker, PA, 2022)
"In cardiac surgery, use of the antifibrinolytic agent tranexamic acid (TXA) and acute perioperative stroke are both associated with convulsive seizures."4.02Associations of preoperative stroke and tranexamic acid administration with convulsive seizures in valvular open-heart surgery. ( Deutsch, MA; Gummert, JF; Hulde, N; Koster, A; von Dossow, V; Zittermann, A, 2021)
"High-dose tranexamic acid (TXA) can cause seizures in patients who have undergone pulmonary endarterectomy (PTE)."3.96Deprescribing practices for anticonvulsants after benign seizures secondary to high-dose tranexamic acid in a single, large UK cardiothoracic centre. ( Barrow, L; Jenkins, D; Ng, CY; Tan, Z; Valchanov, K, 2020)
"The present study aimed to examine the association between tranexamic acid use and adverse effects (seizures, thromboembolism, and renal dysfunction) in a pediatric trauma population using a national inpatient database in Japan."3.88Safety of Tranexamic Acid During Pediatric Trauma: A Nationwide Database Study. ( Maeda, T; Matsui, H; Michihata, N; Miyata, S; Ohnishi, Y; Sasabuchi, Y; Yasunaga, H, 2018)
"The incidence of postoperative nonischemic seizures associated with the use of tranexamic acid (TXA) and the possibility of prevention with a low-dose regimen of TXA were evaluated."3.85Low-Dose Versus High-Dose Tranexamic Acid Reduces the Risk of Nonischemic Seizures After Cardiac Surgery With Cardiopulmonary Bypass. ( Ayoub, C; Chamberland, MÈ; Cogan, J; Couture, P; Denault, A; Deschamps, A; Desjardins, G; Laliberté, É; Lebon, JS; Rochon, A, 2017)
"The present study aimed to examine the association between tranexamic acid (TXA) use and adverse effects (seizures, thromboembolism, and renal dysfunction) in a pediatric cardiac surgery population using a national inpatient database in Japan."3.85Safety of Tranexamic Acid in Pediatric Cardiac Surgery: A Nationwide Database Study. ( Maeda, T; Matsui, H; Miyata, S; Ohnishi, Y; Sasabuchi, Y; Yasunaga, H, 2017)
"Tranexamic acid (TXA) is an antifibrinolytic that is widely used to reduce surgical bleeding."3.83Intravenous tranexamic acid for intracerebral meningioma resections: A randomized, parallel-group, non-inferiority trial. ( Li, S; Liu, M; Peng, Y; Sessler, DI; Wu, Y; Yan, X; Yang, J; Zeng, M; Zhang, L; Zhou, D, 2024)
"A 68-year-old man was admitted and received tranexamic acid for persistent hemoptysis."3.77Generalized convulsion resulted in hyperammonemia during treatment with tranexamic acid for hemoptysis. ( Chen, HC; Chen, SC; Huang, MS; Wang, CS; Yang, CJ, 2011)
"To investigate the incidence of postoperative generalized seizures in patients undergoing aortic valve replacement (AVR) under extracorporeal circulation, who received either high-dose tranexamic acid (TXA) or epsilon aminocaproic acid (EACA) as an antifibrinolytic agent."3.77High-dose tranexamic acid is related to increased risk of generalized seizures after aortic valve replacement. ( Beyersdorf, F; Keyl, C; Lehane, C; Stampf, S; Trenk, D; Uhl, R; Wiesenack, C, 2011)
" Postoperatively, a higher incidence of seizures in the first 48 hours was seen with tranexamic acid compared with aprotinin (11% versus 4%, p = 0."3.76Safety and efficacy of aprotinin and tranexamic acid in pulmonary endarterectomy surgery with hypothermia: review of 200 patients. ( Berman, M; Cardone, D; Dunning, J; Gerrard, C; Jenkins, D; Klein, A; Sharples, L; Tsui, S; Vuylsteke, A, 2010)
"To compare the efficacy and adverse events of high-dose vs low-dose tranexamic acid in patients undergoing cardiac surgery with cardiopulmonary bypass."3.11Effect of High- vs Low-Dose Tranexamic Acid Infusion on Need for Red Blood Cell Transfusion and Adverse Events in Patients Undergoing Cardiac Surgery: The OPTIMAL Randomized Clinical Trial. ( Cheng, Z; Feng, W; Liu, S; Pan, W; Shi, J; Sun, H; Wang, W; Wang, Y; Zheng, Z; Zhou, C, 2022)
"Tranexamic acid (TXA) is an anti-fibrinolytic effective in reducing blood loss in orthopedic surgery."3.11Randomized, controlled trial of two tranexamic acid dosing protocols in adult spinal deformity surgery. ( Clohisy, JCF; Dafrawy, MHE; Frazier, E; Kelly, MP; Lenke, LG; Wolfe, RC, 2022)
" However, in infants less than 1 year of age, the optimal dosing based on pharmacokinetic (PK) considerations is still under discussion."2.84Pharmacokinetics of tranexamic acid in neonates and infants undergoing cardiac surgery. ( Braun, S; Burg, S; Gertler, R; Grassin-Delyle, S; Gruber, M; Martin, K; Tassani-Prell, P; Urien, S; Wiesner, G, 2017)
"Usually, TXA-associated seizures persist for a few minutes with no progression into status epilepticus."2.82Tranexamic acid-associated fatal status epilepticus in a paediatric non-cardiac surgery: A case report and literature review. ( Aboul-Fotouh, S; Habib, MZ; Hassan, BEE; Magdy, SM, 2022)
"All three patients with seizures were ≥65 years old, had "open-chamber" procedures, and had cardiopulmonary bypass times >120 min."2.79A prospective observational study of seizures after cardiac surgery using continuous EEG monitoring. ( Chase, L; Chu, MW; Fox, SA; Gofton, TE; Murkin, JM; Norton, L; Young, GB, 2014)
" This meta-analysis aims to provide information on the optimal dosage and delivery method which is effective with the least adverse outcomes."2.61Different dose regimes and administration methods of tranexamic acid in cardiac surgery: a meta-analysis of randomized trials. ( Gao, X; Guo, J; Hu, W; Ji, H; Lv, H; Ma, Y; Shi, J; Wang, G; Zhang, S, 2019)
"Tranexamic acid is a well-known antifibrinolytic medication frequently prescribed to individuals with bleeding disorders."1.91Accidental intrathecal injection of tranexamic acid: a case report. ( Harby, SA; Kohaf, NA, 2023)
" However, concerns regarding potential adverse reactions, specifically postoperative seizures and thrombotic events, still exist."1.72Evaluation of the safety of tranexamic acid use in pediatric patients undergoing spinal fusion surgery: a retrospective comparative cohort study. ( Chang, PS; Chatterjee, A; Geiselmann, MT; Ivasyk, I; Jordan, C; Kamel, H; Khormaee, S, 2022)
"Tranexamic acid (TXA) has been used extensively to minimize blood loss in cardiac surgery and more recently in orthopedic surgery."1.56Tranexamic acid administration during total joint arthroplasty surgery is not associated with an increased risk of perioperative seizures: a national database analysis. ( Fiasconaro, M; Kirksey, MA; Liu, J; Memtsoudis, SG; Poeran, J; Wilson, LA, 2020)
"Tranexamic acid (TXA) is a common antifibrinolytic agent used to minimize bleeding in cardiac surgery."1.48Tranexamic Acid Dosing for Cardiac Surgical Patients With Chronic Renal Dysfunction: A New Dosing Regimen. ( Beattie, WS; Bojko, B; Jerath, A; Looby, N; Pang, KS; Pawliszyn, J; Reyes-Garces, N; Vasiljevic, T; Wąsowicz, M; Wijeysundera, D; Yang, QJ; Yau, TM, 2018)
" Therefore, the dosage of TA should be decreased judiciously in patients with chronic kidney disease especially on hemodialysis to prevent postoperative seizures."1.46[Two Cases of Convulsive Seizures after Cardiac Surgery Suspiciously Caused by Tranexamic Acid Administration in Patients on Chronic Hemodialysis]. ( Aoi, R; Kawashima, E; Kitagawa, H; Maehira, M; Soga, M; Takahashi, K; Yuasa, M, 2017)
"Tranexamic acid was introduced during these procedures in 2006."1.43Use of Tranexamic Acid Is Associated with Reduced Blood Product Transfusion in Complex Skull Base Neurosurgical Procedures: A Retrospective Cohort Study. ( Akagami, R; Flexman, AM; Mebel, D, 2016)
"She had no further episodes of convulsion till dis-charge and during the two months of follow-up."1.40Tranexamic acid overdosage-induced generalized seizure in renal failure. ( Agarwal, SK; Bhat, A; Bhowmik, DM; Dogra, M; Vibha, D, 2014)
"Convulsive seizures are a serious postoperative complication after cardiac surgery."1.40The association between tranexamic acid and convulsive seizures after cardiac surgery: a multivariate analysis in 11 529 patients. ( Carroll, J; Djaiani, G; Garrido-Olivares, L; Jerath, A; Katznelson, R; Rao, V; Sharma, V; Wasowicz, M, 2014)
"The seizures were likely due to a total dose of 8 g of tranexamic acid (TXA) administered intraoperatively."1.39[A case of postoperative convulsive seizure following tranexamic acid infusion during aortic valve replacement]. ( Ichikawa, J; Kodaka, M; Komori, M; Kubota, S; Nakano, K; Nishiyama, K; Sato, N, 2013)
"Convulsive seizures (CS) occur in ∼1% of the patients after cardiac surgery with cardiopulmonary bypass."1.39Moderate dosage of tranexamic acid during cardiac surgery with cardiopulmonary bypass and convulsive seizures: incidence and clinical outcome. ( Börgermann, J; Gillis-Januszewski, T; Koster, A; Lueth, JU; Schirmer, U; Zittermann, A, 2013)
" Future tranexamic acid trials should assess the blood-conserving effect of tranexamic acid at a lower dosage and specifically monitor for seizure occurrence."1.38High-dose tranexamic acid is an independent predictor of early seizure after cardiopulmonary bypass. ( Dagenais, F; Dionne, S; Kalavrouziotis, D; Mohammadi, S; Voisine, P, 2012)
"Compared to the non-seizure group, seizure patients had an increased rate of postoperative neurological complications, defined as delirium and/or stroke (3."1.38Seizures following cardiac surgery: the impact of tranexamic acid and other risk factors. ( Ariano, RE; Grocott, HP; Jacobsohn, E; Leake, J; Manji, JS; Manji, RA; Menkis, AH, 2012)
"Although the fourfold risk for seizures using TXA was not significant, we currently use EACA in paediatric cardiac surgery."1.37Tranexamic acid versus ɛ-aminocaproic acid: efficacy and safety in paediatric cardiac surgery. ( Breuer, T; Gertler, R; Hapfelmeier, A; Hess, J; Lange, R; Martin, K; Schreiber, C; Wiesner, G, 2011)
"Postoperative seizures occurred significantly more frequently in TXA patients (7."1.37Seizures after open heart surgery: comparison of ε-aminocaproic acid and tranexamic acid. ( Breuer, T; Gertler, R; Knorr, J; Lange, R; Macguill, M; Martin, K; Tassani, P; Wiesner, G, 2011)
"All patients with seizures did not have permanent neurological abnormalities."1.36High-dose tranexamic Acid is associated with nonischemic clinical seizures in cardiac surgical patients. ( Burt, C; Chu, M; Falter, F; Granton, J; Murkin, JM; Young, B, 2010)
"The exact mechanism of TxA-induced seizures is thought to be via inhibition of gamma-aminobutyric acid receptors in neurons."1.36Tranexamic Acid in cardiac surgery and postoperative seizures: a case report series. ( Almeida, A; Bell, D; Marasco, S; Rowland, M, 2010)
"Ten hours later, the patient developed myoclonus of his upper extremities and face."1.35Polymyoclonus seizure resulting from accidental injection of tranexamic acid in spinal anesthesia. ( Arami, A; Jafari, A; Mohseni, K; Nobahar, MR, 2009)
"Tranexamic acid may cause severe complications when used in the central nervous system."1.31Convulsive seizures following subdural application of fibrin sealant containing tranexamic acid in a rat model. ( Hopf, R; Redl, H; Schlag, MG, 2000)
"However, tAMCA has been shown to cause epileptic seizures."1.31Epileptic seizures following cortical application of fibrin sealants containing tranexamic acid in rats. ( Hopf, R; Redl, H; Schlag, MG; Zifko, U, 2002)

Research

Studies (74)

TimeframeStudies, this research(%)All Research%
pre-19902 (2.70)18.7374
1990's0 (0.00)18.2507
2000's7 (9.46)29.6817
2010's47 (63.51)24.3611
2020's18 (24.32)2.80

Authors

AuthorsStudies
Chen, C1
Liu, J3
Du, L1
Murao, S1
Nakata, H1
Roberts, I1
Yamakawa, K1
Aboul-Fotouh, S1
Habib, MZ1
Magdy, SM1
Hassan, BEE1
Clohisy, JCF1
Lenke, LG1
Dafrawy, MHE1
Wolfe, RC1
Frazier, E1
Kelly, MP1
Ivasyk, I1
Chatterjee, A1
Jordan, C1
Geiselmann, MT1
Chang, PS1
Kamel, H1
Khormaee, S1
Shi, J3
Zhou, C1
Pan, W1
Sun, H1
Liu, S1
Feng, W1
Wang, W1
Cheng, Z1
Wang, Y2
Zheng, Z2
King, MR1
Staffa, SJ1
Stricker, PA1
Pérez-Pradilla, C1
Nelson, O1
Benzon, HA1
Goobie, SM1
Patel, S1
Harby, SA1
Kohaf, NA1
Li, S2
Liu, M1
Yang, J1
Yan, X1
Wu, Y1
Zhang, L1
Zeng, M1
Zhou, D1
Peng, Y1
Sessler, DI1
Jakowenko, ND1
Seelhammer, TG1
Nabzdyk, CGS1
Macielak, RJ1
Nei, SD1
Kalvelage, EL1
Wieruszewski, PM1
Hulde, N3
Zittermann, A6
Deutsch, MA3
von Dossow, V3
Gummert, JF3
Koster, A6
Zhang, Y1
Jia, Y1
Yuan, S1
Wang, R1
Zhang, Z1
Wang, X1
Ran, J1
Zhao, Y1
Hua, Z1
Yan, J1
Hu, S1
Yan, F1
Aflaki, K1
Bhuptani, P1
Aflaki, S1
Kirksey, MA1
Wilson, LA1
Fiasconaro, M1
Poeran, J1
Memtsoudis, SG1
de Faria, JL1
da Silva Brito, J1
Costa E Silva, LT1
Kilesse, CTSM1
de Souza, NB1
Pereira, CU1
Figueiredo, EG1
Rabelo, NN1
Tan, Z1
Ng, CY1
Jenkins, D2
Barrow, L1
Valchanov, K1
Shrestha, IK1
Ruan, TY1
Lin, L1
Tan, M1
Na, XQ1
Qu, QC1
Chen, JC1
Si, YY1
Tao, JP1
Couture, P1
Lebon, JS1
Laliberté, É1
Desjardins, G1
Chamberland, MÈ1
Ayoub, C1
Rochon, A1
Cogan, J1
Denault, A1
Deschamps, A1
Gerstein, NS1
Deriy, L1
Patel, PA1
Jerath, A2
Yang, QJ1
Pang, KS1
Looby, N1
Reyes-Garces, N1
Vasiljevic, T1
Bojko, B1
Pawliszyn, J1
Wijeysundera, D1
Beattie, WS1
Yau, TM1
Wąsowicz, M2
Maeda, T2
Michihata, N1
Sasabuchi, Y2
Matsui, H2
Ohnishi, Y2
Miyata, S2
Yasunaga, H2
Kawashima, E1
Yuasa, M1
Maehira, M1
Soga, M1
Aoi, R1
Takahashi, K1
Kitagawa, H1
Loi, MM1
Derderian, SC1
Bennett, TD1
Guo, J1
Gao, X1
Ma, Y1
Lv, H1
Hu, W1
Zhang, S1
Ji, H1
Wang, G1
Merriman, B1
Mayson, K1
Sawka, A1
Akagami, R2
Flexman, AM2
Ichikawa, J1
Kodaka, M1
Nishiyama, K1
Sato, N1
Kubota, S1
Nakano, K1
Komori, M1
Alston, RP1
McMullan, V1
Schirmer, U3
Kratzer, S1
Irl, H1
Mattusch, C1
Bürge, M1
Kurz, J1
Kochs, E1
Eder, M1
Rammes, G1
Haseneder, R1
Bhat, A1
Bhowmik, DM1
Vibha, D1
Dogra, M1
Agarwal, SK1
Sharma, V1
Katznelson, R1
Garrido-Olivares, L1
Carroll, J1
Rao, V1
Djaiani, G1
Gofton, TE1
Chu, MW1
Norton, L1
Fox, SA1
Chase, L1
Murkin, JM2
Young, GB1
Gertler, R4
Wiesner, G5
Tassani-Prell, P2
Martin, K5
Gruber, M2
Mebel, D1
Lecker, I3
Wang, DS2
Whissell, PD1
Avramescu, S1
Mazer, CD3
Orser, BA3
Idialisoa, R1
Jouffroy, R1
Philippe, P1
Lamhaut, L1
Baud, F1
Carli, P1
Vivien, B1
Lin, Z1
Xiaoyi, Z1
Myles, PS1
Smith, JA1
Forbes, A1
Silbert, B1
Jayarajah, M1
Painter, T1
Cooper, DJ1
Marasco, S2
McNeil, J1
Bussières, JS1
McGuinness, S1
Byrne, K1
Chan, MT1
Landoni, G1
Wallace, S1
Grassin-Delyle, S1
Urien, S1
Braun, S1
Burg, S1
Takagi, H1
Ando, T1
Umemoto, T1
Breuer, T3
Lange, R3
Tassani, P2
Mohseni, K1
Jafari, A1
Nobahar, MR1
Arami, A1
Wang, CS1
Yang, CJ1
Chen, SC1
Chen, HC1
Huang, MS1
Falter, F1
Granton, J1
Young, B1
Burt, C1
Chu, M1
Fox, MA1
Bell, D1
Almeida, A1
Rowland, M1
Casati, V1
Romano, A1
Novelli, E1
D'Angelo, A1
Berman, M1
Cardone, D1
Sharples, L1
Vuylsteke, A1
Klein, A1
Gerrard, C1
Dunning, J1
Tsui, S1
Hapfelmeier, A1
Schreiber, C1
Hess, J1
Knorr, J1
Macguill, M1
Keyl, C1
Uhl, R1
Beyersdorf, F1
Stampf, S1
Lehane, C1
Wiesenack, C1
Trenk, D1
Goldstone, AB1
Bronster, DJ1
Chikwe, J1
Kalavrouziotis, D1
Voisine, P1
Mohammadi, S1
Dionne, S1
Dagenais, F1
Manji, RA1
Grocott, HP1
Leake, J1
Ariano, RE1
Manji, JS1
Menkis, AH1
Jacobsohn, E1
Ferraris, VA1
Akay, MH1
Senay, S1
Karabulut, H1
Toraman, F1
Kocyiğit, M1
Alhan, HC1
Börgermann, J1
Lueth, JU1
Gillis-Januszewski, T1
Romaschin, AD1
Peterson, M1
Schwinn, DA1
Mackensen, GB1
Brown, EN1
Pusateri, AE1
Weiskopf, RB1
Bebarta, V1
Butler, F1
Cestero, RF1
Chaudry, IH1
Deal, V1
Dorlac, WC1
Gerhardt, RT1
Given, MB1
Hansen, DR1
Hoots, WK1
Klein, HG1
Macdonald, VW1
Mattox, KL1
Michael, RA1
Mogford, J1
Montcalm-Smith, EA1
Niemeyer, DM1
Prusaczyk, WK1
Rappold, JF1
Rassmussen, T1
Rentas, F1
Ross, J1
Thompson, C1
Tucker, LD1
Dehghani, E1
Trenfield, S1
Yeh, HM1
Lau, HP1
Lin, PL1
Sun, WZ1
Mok, MS1
Yamaura, A1
Nakamura, T1
Makino, H1
Hagihara, Y1
Pellegrini, A1
Giaretta, D1
Chemello, R1
Zanotto, L1
Testa, G1
Schlag, MG3
Hopf, R3
Redl, H3
Fodstad, H1
Zifko, U1
Furtmüller, R1
Berger, M1
Huck, S1
Sieghart, W1

Clinical Trials (13)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Low Versus High Dose Tranexamic Acid in Adult Spinal Deformity Surgery: A Randomized, Blinded, Controlled Trial[NCT02053363]Phase 2/Phase 364 participants (Actual)Interventional2014-03-31Completed
Outcome Impact of Different Tranexamic Acid Regimen in Cardiac Surgery With Cardiopulmonary Bypass (the OPTIMAL Study)[NCT03782350]Phase 43,079 participants (Actual)Interventional2018-12-26Completed
Pharmacokinetics of Tranexamic Acid in Patients With Varying Renal Function Undergoing Cardiac Surgery With the Use of Cardiopulmonary Bypass[NCT01609686]49 participants (Actual)Observational2012-01-31Completed
The Effect of Two Different Tranexamic Acid Dose Regimens on Intraoperative and Postoperative Bleeding in Coronary Artery Bypass Surgery[NCT05994989]60 participants (Anticipated)Observational2023-08-14Recruiting
Seizures After Cardiac Surgery -- A Prospective Study With Continuous EEG Monitoring[NCT01291992]100 participants (Actual)Observational2010-09-30Completed
Tranexamic Acid for Blood Loss Minimization in Endoscopic Pituitary Surgery: A Double-Blind Randomized Controlled Trial[NCT04863339]Phase 20 participants (Actual)Interventional2022-03-31Withdrawn (stopped due to Challenges in recruitment)
Tranexamic Acid Usage in Bilateral Mastectomy to Reduce Post-surgical Drainage[NCT05554211]Phase 230 participants (Anticipated)Interventional2022-07-12Recruiting
Tranexamic Acid to Prevent OpeRation in Chronic Subdural Hematoma. A Double-blind, Placebo-controlled, Multicentre, Randomized Controlled Clinical Trial[NCT03582293]Phase 3140 participants (Anticipated)Interventional2018-06-19Recruiting
The Effect of Local Tranexamic Acid on Post-operative Edema and Ecchymosis in Eyelid Surgery[NCT04951128]Phase 450 participants (Anticipated)Interventional2021-08-01Not yet recruiting
Tranexamic Acid for the Prevention of Obstetrical Hemorrhage After Cesarean Delivery: A Randomized Controlled Trial[NCT03364491]Phase 311,000 participants (Actual)Interventional2018-03-15Completed
DEPOSITION: Pilot Study Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery[NCT03376061]Phase 497 participants (Actual)Interventional2017-12-21Completed
Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery (DEPOSITION) Study[NCT03954314]Phase 33,242 participants (Actual)Interventional2019-09-17Terminated (stopped due to Upon the Data Safety Monitoring Board review of the interim analysis (75% of participants have finished their follow-up) on November 17, 2023, they made a recommendation to stop recruitment into the trial.)
The Effect of Tranexamic Acid on Blood Loss and Transfusion Rates in Major Oncologic Surgery[NCT01980355]76 participants (Actual)Interventional2012-06-12Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Blood Loss

"To compare the estimated blood loss in patients undergoing complex, reconstructive, spinal fusion surgeries receiving one of two dosing protocols for the anti-fibrinolytic, TXA.~Estimated blood loss was calculated by suction canister volume minus intraoperative irrigation fluid plus blood content in sponges as estimated by weight for all cases." (NCT02053363)
Timeframe: This outcome is measured during surgery, from exposure to wound closure, approximately 8 hours.

InterventionmL (Mean)
High Dose/Study Group2046
Standard of Care/Control1596

Number of Patients Sustaining Intraoperative or 90 Day Complications

To compare the rates of intraoperative complications and 90 day complications observed in the two groups. (NCT02053363)
Timeframe: Perioperative complications were defined as complications occurring within 90 days of surgery.

InterventionParticipants (Count of Participants)
High Dose/Study Group2
Standard of Care/Control3

Red Blood Cell Transfusions

To compare the mean volume (mL) of packed red blood cell (PRBC) transfusions given to the two groups. Volumes of RBC vary from bag to bag and real volumes will be recorded as provided by the blood bank. (NCT02053363)
Timeframe: Participants will be followed for the duration of their hospital stay measured from day of surgery to day of discharge from the hospital, approximately 7 days.

InterventionmL (Mean)
High Dose/Study Group1259
Standard of Care/Control935

Change in Hemoglobin

[Key secondary outcome] Change in hemoglobin from the most recent measured before delivery to lowest measured in the 48 hours after delivery (NCT03364491)
Timeframe: from 4 weeks before delivery to 48 hours postpartum

Interventiongrams per deciliter (Mean)
Tranexamic Acid-1.8
Placebo-1.9

Length of Stay

Mother's length of stay from delivery to discharge (NCT03364491)
Timeframe: Until hospital discharge, an average of 3 days

Interventiondays (Median)
Tranexamic Acid3
Placebo3

Number of Mothers Who Died or Had Thromboembolic Events (Venous or Arterial), Ischemic Stroke, Myocardial Infarction, New-onset Seizure Activity, or Were Admitted to the Intensive Care Unit for More Than 24 Hours

(NCT03364491)
Timeframe: within 6 weeks postpartum

InterventionParticipants (Count of Participants)
Tranexamic Acid35
Placebo32

Number of Participants Who Received Open Label TXA or Other Antifibrinolytic

This is the number of mothers who were treated with any amount of open-label TXA (not blinded study drug) or another antifibrinolytic (eg., Amicar) (NCT03364491)
Timeframe: within 7 days postpartum

InterventionParticipants (Count of Participants)
Tranexamic Acid108
Placebo109

Number of Participants Who Received Surgical or Radiologic Interventions to Control Bleeding and Related Complications

This is the number of mothers who required any of the following types of surgical procedures to control bleeding: laparotomy, evacuation of hematoma, hysterectomy, uterine packing, intrauterine balloon tamponade, interventional radiology (NCT03364491)
Timeframe: within 7 days postpartum

InterventionParticipants (Count of Participants)
Tranexamic Acid233
Placebo231

Number of Participants Who Received Treatments and Interventions in Response to Bleeding and Related Complications

[Key secondary outcome] This is the number of mothers who received treatments and interventions to control bleeding such as: uterotonics such as prostaglandins or methergine, but excluding oxytocin; open label TXA or other antifibrinolytics; transfusion of 1 or more units of fresh frozen plasma, cryoprecipitate, or platelets or administration of any factor concentrates; laparotomy, evacuation of hematoma, hysterectomy, uterine packing, intrauterine balloon tamponade, interventional radiology (NCT03364491)
Timeframe: within 7 days postpartum

InterventionParticipants (Count of Participants)
Tranexamic Acid892
Placebo986

Number of Participants Who Were Transfused With 4 or More Units of Packed Red Blood Cells

Participants were categorized according to the amount of packed red blood cells or whole blood transfused, either as 0 to 3 units, or 4 or more units (NCT03364491)
Timeframe: within 7 days postpartum

InterventionParticipants (Count of Participants)
Tranexamic Acid20
Placebo19

Number of Participants Who Were Transfused With Other Blood Products

This is the number of mothers who received during the first 7 days after delivery a transfusion of 1 or more units of fresh frozen plasma, cryoprecipitate, or platelets, or received any factor concentrates (NCT03364491)
Timeframe: within 7 days postpartum

InterventionParticipants (Count of Participants)
Tranexamic Acid29
Placebo31

Number of Participants Who Were Treated With Uterotonics Other Than Oxytocin

This is the number of mothers who were treated with uterotonics such as prostaglandins or methergine, but excluding oxytocin, from delivery through 48 hours after delivery. (NCT03364491)
Timeframe: within 48 hours postpartum

InterventionParticipants (Count of Participants)
Tranexamic Acid649
Placebo732

Number of Participants With a Thromboembolic Event (Venous or Arterial), Ischemic Stroke, or Myocardial Infarction

[Key secondary outcome] This is the number of mothers who experienced a thromboembolic event, ischemic stroke, or myocardial infarction during the 6 weeks after delivery. (NCT03364491)
Timeframe: within 6 weeks postpartum

InterventionParticipants (Count of Participants)
Tranexamic Acid12
Placebo13

Number of Participants With Estimated Blood Loss Greater Than 1 Liter During Delivery

[Major secondary outcome] The surgeon or anesthesiologist estimated the blood loss during the delivery in milliliters, which was recorded in the anesthesia record and/or operative report (NCT03364491)
Timeframe: From skin incision to transfer from operating room, average of 1 hour

InterventionParticipants (Count of Participants)
Tranexamic Acid339
Placebo368

Number of Participants With Maternal Death or Transfusion of Packed Red Blood Cells

Participants were monitored from delivery until hospital discharge or 7 days after delivery (postpartum), whichever is sooner. This is the number of mothers who died for any reason, or had a blood transfusion of 1 or more units (of packed red blood cells, including whole blood or cell saver). (NCT03364491)
Timeframe: by hospital discharge or by 7 days postpartum, whichever is sooner

InterventionParticipants (Count of Participants)
Tranexamic Acid201
Placebo233

Number of Participants With Postpartum Infectious Complications

[Key Secondary Outcome] This is the number of mothers who experienced any of the following infectious complications in the 6 weeks after delivery: endometritis, surgical site infection, pelvic abscess (NCT03364491)
Timeframe: within 6 weeks postpartum

InterventionParticipants (Count of Participants)
Tranexamic Acid162
Placebo125

Number of Participants With Seizure Activity That Was Not Seen Prior to Study Enrollment

This is the number of mothers who experienced seizure activity, confirmed by central review, whose onset is after enrollment (NCT03364491)
Timeframe: within 6 weeks postpartum

InterventionParticipants (Count of Participants)
Tranexamic Acid2
Placebo0

Mean Concentration of TxA in Plasma Collected From Participants

Plasma TxA concentrations measured from blood samples taken upon arrival in the ICU (NCT03376061)
Timeframe: on arrival in ICU within 3 hours

Interventionmicrogram per milliliter per kilogram (Mean)
Topical TxA (Intervention)0.58
Intravenous TxA (Control)1.10

Median Number of Hours Participants Spent in ICU

Number of hours participants spent in the intensive care unit (ICU) (NCT03376061)
Timeframe: Number of hours spent in ICU from arrival to exit (collected at the Post-Operative Visit).

Interventionhours (Median)
Topical TxA (Intervention)23
Intravenous TxA (Control)26

Median Volume of Mediastinal Fluid Collected From Participants

Cumulative volume (mL) of fluid collected from mediastinal drainage tubes 24 hours after the surgical procedure (NCT03376061)
Timeframe: Fluid collected in the first 24 hours after the surgical procedure

InterventionmL (Median)
Topical TxA (Intervention)500
Intravenous TxA (Control)540

Number of Participants With Mortality

The occurrence of death due to any cause (NCT03376061)
Timeframe: Patients will be followed post-operatively until hospital discharge

InterventionParticipants (Count of Participants)
Topical TxA (Intervention)1
Intravenous TxA (Control)1

Number of Participants With RBC Transfusion

Patients requiring a red blood cell transfusion (NCT03376061)
Timeframe: Intra-operative and post-operative RBC transfusions

InterventionParticipants (Count of Participants)
Topical TxA (Intervention)19
Intravenous TxA (Control)23

Number of Participants With Re-operation for Bleeding or Tamponade

Occurrence of re-operation for the purpose of bleeding or cardiac tamponade (NCT03376061)
Timeframe: Patients will be followed post-operatively until hospital discharge

InterventionParticipants (Count of Participants)
Topical TxA (Intervention)0
Intravenous TxA (Control)1

Number of Participants With Seizures

Patients experiencing a post-operative seizure (NCT03376061)
Timeframe: Patients will be followed post-operatively until hospital discharge

InterventionParticipants (Count of Participants)
Topical TxA (Intervention)0
Intravenous TxA (Control)1

Estimated Blood Loss

Surgical blood loss estimation (NCT01980355)
Timeframe: From time of surgery to 90 days post hospital discharge

InterventionmL (Median)
Tranexamic Acid450
Placebo365

Number of Participants Who Required Transfusion

To determine the impact of perioperative administration of tranexamic acid on blood loss and transfusion rates in major oncologic surgery (NCT01980355)
Timeframe: From time of surgery to 90 days post hospital discharge

InterventionParticipants (Count of Participants)
Tranexamic Acid8
Placebo5

Reviews

9 reviews available for tranexamic acid and Absence Seizure

ArticleYear
Effect of tranexamic acid on thrombotic events and seizures in bleeding patients: a systematic review and meta-analysis.
    Critical care (London, England), 2021, Nov-01, Volume: 25, Issue:1

    Topics: Acute Coronary Syndrome; Antifibrinolytic Agents; Hemorrhage; Humans; Risk Assessment; Seizures; Str

2021
Tranexamic acid-associated fatal status epilepticus in a paediatric non-cardiac surgery: A case report and literature review.
    British journal of clinical pharmacology, 2022, Volume: 88, Issue:9

    Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Child; Child, Preschool; Humans; Male; Propofol; Seiz

2022
Tranexamic acid in Neurosurgery: a controversy indication-review.
    Neurosurgical review, 2021, Volume: 44, Issue:3

    Topics: Adult; Antifibrinolytic Agents; Blood Loss, Surgical; Blood Transfusion; Brain Injuries, Traumatic;

2021
The efficacy and safety of high-dose tranexamic acid in adolescent idiopathic scoliosis: a meta-analysis.
    Journal of orthopaedic surgery and research, 2021, Jan-14, Volume: 16, Issue:1

    Topics: Adolescent; Blood Loss, Surgical; Female; Humans; Infusions, Intravenous; Intraoperative Complicatio

2021
Different dose regimes and administration methods of tranexamic acid in cardiac surgery: a meta-analysis of randomized trials.
    BMC anesthesiology, 2019, 07-15, Volume: 19, Issue:1

    Topics: Antifibrinolytic Agents; Blood Transfusion; Cardiac Surgical Procedures; Dose-Response Relationship,

2019
Tranexamic acid-associated seizures: Causes and treatment.
    Annals of neurology, 2016, Volume: 79, Issue:1

    Topics: Animals; Antifibrinolytic Agents; Humans; Seizures; Tranexamic Acid

2016
Tranexamic acid-associated seizures: A meta-analysis.
    Seizure, 2016, Volume: 36

    Topics: Antifibrinolytic Agents; Databases, Bibliographic; Dose-Response Relationship, Drug; Humans; Odds Ra

2016
Seizures associated with tranexamic acid for cardiac surgery: a meta-analysis of randomized and non-randomized studies.
    The Journal of cardiovascular surgery, 2017, Volume: 58, Issue:4

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antifibrinolytic Agents; Blood Loss, Surgical; Cardiac S

2017
Tranexamic acid and trauma: current status and knowledge gaps with recommended research priorities.
    Shock (Augusta, Ga.), 2013, Volume: 39, Issue:2

    Topics: Antifibrinolytic Agents; Hemorrhage; Humans; Postoperative Complications; Randomized Controlled Tria

2013

Trials

7 trials available for tranexamic acid and Absence Seizure

ArticleYear
Randomized, controlled trial of two tranexamic acid dosing protocols in adult spinal deformity surgery.
    Spine deformity, 2022, Volume: 10, Issue:6

    Topics: Adult; Antifibrinolytic Agents; Blood Loss, Surgical; Humans; Prospective Studies; Seizures; Tranexa

2022
Effect of High- vs Low-Dose Tranexamic Acid Infusion on Need for Red Blood Cell Transfusion and Adverse Events in Patients Undergoing Cardiac Surgery: The OPTIMAL Randomized Clinical Trial.
    JAMA, 2022, 07-26, Volume: 328, Issue:4

    Topics: Adult; Antifibrinolytic Agents; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Dose-Response R

2022
Intravenous tranexamic acid for intracerebral meningioma resections: A randomized, parallel-group, non-inferiority trial.
    Journal of clinical anesthesia, 2024, Volume: 92

    Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Double-Blind Method; Humans; Meningeal Neoplasms; Men

2024
Safety and efficacy of tranexamic acid in paediatric cardiac surgery: study protocol for a double-blind randomised controlled trial.
    BMJ open, 2019, 11-25, Volume: 9, Issue:11

    Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Blood Transfusion; Cardiac Surgical Procedures; Cardi

2019
A prospective observational study of seizures after cardiac surgery using continuous EEG monitoring.
    Neurocritical care, 2014, Volume: 21, Issue:2

    Topics: Aged; Antifibrinolytic Agents; Cardiac Surgical Procedures; Electroencephalography; Female; Follow-U

2014
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
    The New England journal of medicine, 2017, 01-12, Volume: 376, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Aspirin; Blood Transfusion; Coronary Artery Bypass

2017
Pharmacokinetics of tranexamic acid in neonates and infants undergoing cardiac surgery.
    British journal of clinical pharmacology, 2017, Volume: 83, Issue:8

    Topics: Administration, Intravenous; Antifibrinolytic Agents; Blood Loss, Surgical; Cardiac Surgical Procedu

2017

Other Studies

58 other studies available for tranexamic acid and Absence Seizure

ArticleYear
Tranexamic acid after cardiopulmonary bypass does not increase risk of postoperative seizures: a retrospective study.
    General thoracic and cardiovascular surgery, 2022, Volume: 70, Issue:4

    Topics: Adult; Antifibrinolytic Agents; Blood Loss, Surgical; Cardiopulmonary Bypass; Humans; Retrospective

2022
Evaluation of the safety of tranexamic acid use in pediatric patients undergoing spinal fusion surgery: a retrospective comparative cohort study.
    BMC musculoskeletal disorders, 2022, Jul-08, Volume: 23, Issue:1

    Topics: Adolescent; Antifibrinolytic Agents; Blood Loss, Surgical; Child; Cohort Studies; Humans; Pulmonary

2022
Safety of antifibrinolytics in 6583 pediatric patients having craniosynostosis surgery: A decade of data reported from the multicenter Pediatric Craniofacial Collaborative Group.
    Paediatric anaesthesia, 2022, Volume: 32, Issue:12

    Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Loss, Surgical; Child; Craniosynostoses; Humans; I

2022
Tranexamic acid-associated seizures in a paediatric patient.
    British journal of clinical pharmacology, 2022, Volume: 88, Issue:10

    Topics: Anticonvulsants; Child; Humans; Propofol; Seizures; Status Epilepticus; Tranexamic Acid

2022
Accidental intrathecal injection of tranexamic acid: a case report.
    Journal of medical case reports, 2023, Feb-16, Volume: 17, Issue:1

    Topics: Adult; Atracurium; Humans; Injections, Spinal; Male; Saline Solution; Seizures; Thiopental; Tranexam

2023
Tranexamic Acid for Bleeding Management in Adult Patients on Extracorporeal Membrane Oxygenation.
    ASAIO journal (American Society for Artificial Internal Organs : 1992), 2023, Dec-01, Volume: 69, Issue:12

    Topics: Adolescent; Adult; Extracorporeal Membrane Oxygenation; Hemorrhage; Hemostatics; Humans; Retrospecti

2023
Tranexamic acid and convulsive seizures after off-pump coronary artery bypass surgery: the role of renal insufficiency.
    Interactive cardiovascular and thoracic surgery, 2019, 12-01, Volume: 29, Issue:6

    Topics: Adult; Aged; Antifibrinolytic Agents; Coronary Artery Bypass, Off-Pump; Female; Glomerular Filtratio

2019
Phenytoin Pharmacokinetics and Cardiopulmonary Bypass: A Case of Seizures in the Postoperative Period.
    Journal of cardiothoracic and vascular anesthesia, 2020, Volume: 34, Issue:3

    Topics: Cardiopulmonary Bypass; Humans; Phenytoin; Postoperative Period; Seizures; Tranexamic Acid

2020
Tranexamic acid and convulsive seizures after isolated coronary artery bypass surgery: the role of cardiopulmonary bypass and renal function.
    Interactive cardiovascular and thoracic surgery, 2020, 04-01, Volume: 30, Issue:4

    Topics: Aged; Antifibrinolytic Agents; Cardiopulmonary Bypass; Coronary Artery Bypass; Female; Glomerular Fi

2020
Tranexamic acid administration during total joint arthroplasty surgery is not associated with an increased risk of perioperative seizures: a national database analysis.
    Regional anesthesia and pain medicine, 2020, Volume: 45, Issue:7

    Topics: Antifibrinolytic Agents; Arthroplasty, Replacement, Hip; Blood Loss, Surgical; Humans; Seizures; Tra

2020
Deprescribing practices for anticonvulsants after benign seizures secondary to high-dose tranexamic acid in a single, large UK cardiothoracic centre.
    European journal of hospital pharmacy : science and practice, 2020, Volume: 27, Issue:6

    Topics: Anticonvulsants; Antifibrinolytic Agents; Deprescriptions; Dose-Response Relationship, Drug; Endarte

2020
Associations of preoperative stroke and tranexamic acid administration with convulsive seizures in valvular open-heart surgery.
    Journal of anesthesia, 2021, Volume: 35, Issue:3

    Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Cardiac Surgical Procedures; Humans; Retrospective St

2021
Low-Dose Versus High-Dose Tranexamic Acid Reduces the Risk of Nonischemic Seizures After Cardiac Surgery With Cardiopulmonary Bypass.
    Journal of cardiothoracic and vascular anesthesia, 2017, Volume: 31, Issue:5

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Cardiac Surgical Procedures; Cardiopulmonary Bypas

2017
Tranexamic Acid Use in Cardiac Surgery: Hemostasis, Seizures, or a Little of Both.
    Journal of cardiothoracic and vascular anesthesia, 2018, Volume: 32, Issue:4

    Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Cardiac Surgical Procedures; Hemostasis; Humans; Seiz

2018
Tranexamic Acid Dosing for Cardiac Surgical Patients With Chronic Renal Dysfunction: A New Dosing Regimen.
    Anesthesia and analgesia, 2018, Volume: 127, Issue:6

    Topics: Aged; Antifibrinolytic Agents; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Drug Administrat

2018
Safety of Tranexamic Acid During Pediatric Trauma: A Nationwide Database Study.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2018, Volume: 19, Issue:12

    Topics: Acute Kidney Injury; Antifibrinolytic Agents; Case-Control Studies; Child; Child, Preschool; Databas

2018
[Two Cases of Convulsive Seizures after Cardiac Surgery Suspiciously Caused by Tranexamic Acid Administration in Patients on Chronic Hemodialysis].
    Masui. The Japanese journal of anesthesiology, 2017, Volume: 66, Issue:3

    Topics: Aged; Antifibrinolytic Agents; Aortic Valve; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Hu

2017
Tranexamic Acid and Seizures in Pediatric Trauma.
    Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2018, Volume: 19, Issue:12

    Topics: Child; Humans; Seizures; Tranexamic Acid

2018
Postoperative seizure in a neurosurgical patient: Should tranexamic acid be on the differential?
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2013, Volume: 60, Issue:5

    Topics: Cardiac Surgical Procedures; Female; Humans; Male; Postoperative Complications; Seizures; Tranexamic

2013
[A case of postoperative convulsive seizure following tranexamic acid infusion during aortic valve replacement].
    Masui. The Japanese journal of anesthesiology, 2013, Volume: 62, Issue:2

    Topics: Aged, 80 and over; Aortic Valve; Humans; Male; Postoperative Complications; Seizures; Tranexamic Aci

2013
Observational studies are not reliable enough when making decisions about individual patient care.
    British journal of anaesthesia, 2013, Volume: 110, Issue:6

    Topics: Antifibrinolytic Agents; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Female; Humans; Male;

2013
Safety of antifibrinolytic therapy during cardiac surgery and randomized controlled trials.
    British journal of anaesthesia, 2013, Volume: 110, Issue:6

    Topics: Antifibrinolytic Agents; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Female; Humans; Male;

2013
Tranexamic acid impairs γ-aminobutyric acid receptor type A-mediated synaptic transmission in the murine amygdala: a potential mechanism for drug-induced seizures?
    Anesthesiology, 2014, Volume: 120, Issue:3

    Topics: Amygdala; Animals; Antifibrinolytic Agents; Disease Models, Animal; Electric Stimulation; Male; Mice

2014
Tranexamic acid overdosage-induced generalized seizure in renal failure.
    Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia, 2014, Volume: 25, Issue:1

    Topics: Anticonvulsants; Antifibrinolytic Agents; Drug Overdose; Female; Humans; Kidney; Menorrhagia; Middle

2014
The association between tranexamic acid and convulsive seizures after cardiac surgery: a multivariate analysis in 11 529 patients.
    Anaesthesia, 2014, Volume: 69, Issue:2

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Cardiac Surgical Procedures; Cardiopulmonary Bypas

2014
Measurement of tranexamic acid serum concentrations in a 7-month-old infant with clinical seizures after open heart surgery.
    Pediatric neurology, 2014, Volume: 51, Issue:2

    Topics: Antifibrinolytic Agents; Cardiac Surgical Procedures; Humans; Infant; Postoperative Complications; S

2014
Use of Tranexamic Acid Is Associated with Reduced Blood Product Transfusion in Complex Skull Base Neurosurgical Procedures: A Retrospective Cohort Study.
    Anesthesia and analgesia, 2016, Volume: 122, Issue:2

    Topics: Antifibrinolytic Agents; Blood Transfusion; Cohort Studies; Erythrocyte Transfusion; Female; Hemoglo

2016
Beware of using tranexamic acid in parturients with eclampsia.
    Anaesthesia, critical care & pain medicine, 2016, Volume: 35, Issue:3

    Topics: Adult; Antifibrinolytic Agents; Blood Loss, Surgical; Cesarean Section; Critical Care; Eclampsia; Fe

2016
Safety of Tranexamic Acid in Pediatric Cardiac Surgery: A Nationwide Database Study.
    Journal of cardiothoracic and vascular anesthesia, 2017, Volume: 31, Issue:2

    Topics: Antifibrinolytic Agents; Cardiac Surgical Procedures; Child, Preschool; Cohort Studies; Databases, F

2017
The risks of aprotinin and tranexamic acid in cardiac surgery: a one-year follow-up of 1188 consecutive patients.
    Anesthesia and analgesia, 2008, Volume: 107, Issue:6

    Topics: Adult; Aged; Antifibrinolytic Agents; Aprotinin; Cardiac Surgical Procedures; Coronary Artery Bypass

2008
Polymyoclonus seizure resulting from accidental injection of tranexamic acid in spinal anesthesia.
    Anesthesia and analgesia, 2009, Volume: 108, Issue:6

    Topics: Anesthesia, General; Anesthesia, Spinal; Anticonvulsants; Antifibrinolytic Agents; Critical Care; Hu

2009
Generalized convulsion resulted in hyperammonemia during treatment with tranexamic acid for hemoptysis.
    Irish journal of medical science, 2011, Volume: 180, Issue:3

    Topics: Aged; Antifibrinolytic Agents; Hemoptysis; Humans; Hyperammonemia; Male; Seizures; Tranexamic Acid

2011
High-dose tranexamic Acid is associated with nonischemic clinical seizures in cardiac surgical patients.
    Anesthesia and analgesia, 2010, Feb-01, Volume: 110, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antifibrinolytic Agents; Blood Loss, Surgical; Cardiac Surgical Proc

2010
High-dose tranexamic Acid is associated with nonischemic clinical seizures in cardiac surgical patients.
    Anesthesia and analgesia, 2010, Feb-01, Volume: 110, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antifibrinolytic Agents; Blood Loss, Surgical; Cardiac Surgical Proc

2010
High-dose tranexamic Acid is associated with nonischemic clinical seizures in cardiac surgical patients.
    Anesthesia and analgesia, 2010, Feb-01, Volume: 110, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antifibrinolytic Agents; Blood Loss, Surgical; Cardiac Surgical Proc

2010
High-dose tranexamic Acid is associated with nonischemic clinical seizures in cardiac surgical patients.
    Anesthesia and analgesia, 2010, Feb-01, Volume: 110, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Antifibrinolytic Agents; Blood Loss, Surgical; Cardiac Surgical Proc

2010
Tranexamic acid: how much is enough?
    Anesthesia and analgesia, 2010, Volume: 111, Issue:2

    Topics: Antifibrinolytic Agents; Blood Loss, Surgical; Cardiac Surgical Procedures; Dose-Response Relationsh

2010
Tranexamic Acid in cardiac surgery and postoperative seizures: a case report series.
    The heart surgery forum, 2010, Volume: 13, Issue:4

    Topics: Aged; Aged, 80 and over; Antifibrinolytic Agents; Cardiac Surgical Procedures; Cohort Studies; Coron

2010
Tranexamic acid for trauma.
    Lancet (London, England), 2010, Sep-25, Volume: 376, Issue:9746

    Topics: Antifibrinolytic Agents; Hemorrhage; Humans; Nervous System Diseases; Randomized Controlled Trials a

2010
Safety and efficacy of aprotinin and tranexamic acid in pulmonary endarterectomy surgery with hypothermia: review of 200 patients.
    The Annals of thoracic surgery, 2010, Volume: 90, Issue:5

    Topics: Adult; Aged; Antifibrinolytic Agents; Aprotinin; Blood Loss, Surgical; Endarterectomy; Female; Hemos

2010
Tranexamic acid versus ɛ-aminocaproic acid: efficacy and safety in paediatric cardiac surgery.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2011, Volume: 39, Issue:6

    Topics: Aminocaproic Acid; Antifibrinolytic Agents; Blood Transfusion; Cardiac Surgical Procedures; Cardiopu

2011
Seizures after open heart surgery: comparison of ε-aminocaproic acid and tranexamic acid.
    Journal of cardiothoracic and vascular anesthesia, 2011, Volume: 25, Issue:1

    Topics: Aged; Aminocaproic Acid; Anesthesia; Antifibrinolytic Agents; Blood Loss, Surgical; Cardiac Surgical

2011
High-dose tranexamic acid is related to increased risk of generalized seizures after aortic valve replacement.
    European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, 2011, Volume: 39, Issue:5

    Topics: Aged; Aged, 80 and over; Aminocaproic Acid; Antifibrinolytic Agents; Aortic Valve; Drug Administrati

2011
Seizures after adult cardiac surgery.
    Journal of cardiothoracic and vascular anesthesia, 2011, Volume: 25, Issue:4

    Topics: Aminocaproic Acid; Antifibrinolytic Agents; Cardiac Surgical Procedures; Female; Humans; Male; Posto

2011
"Seizing" the opportunity to understand antifibrinolytic drugs.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2012, Volume: 59, Issue:1

    Topics: Cardiac Surgical Procedures; Female; Humans; Male; Postoperative Complications; Seizures; Tranexamic

2012
High-dose tranexamic acid is an independent predictor of early seizure after cardiopulmonary bypass.
    The Annals of thoracic surgery, 2012, Volume: 93, Issue:1

    Topics: Aged; Antifibrinolytic Agents; Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Electroence

2012
High-dose tranexamic acid is an independent predictor of early seizure after cardiopulmonary bypass.
    The Annals of thoracic surgery, 2012, Volume: 93, Issue:1

    Topics: Aged; Antifibrinolytic Agents; Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Electroence

2012
High-dose tranexamic acid is an independent predictor of early seizure after cardiopulmonary bypass.
    The Annals of thoracic surgery, 2012, Volume: 93, Issue:1

    Topics: Aged; Antifibrinolytic Agents; Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Electroence

2012
High-dose tranexamic acid is an independent predictor of early seizure after cardiopulmonary bypass.
    The Annals of thoracic surgery, 2012, Volume: 93, Issue:1

    Topics: Aged; Antifibrinolytic Agents; Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Electroence

2012
High-dose tranexamic acid is an independent predictor of early seizure after cardiopulmonary bypass.
    The Annals of thoracic surgery, 2012, Volume: 93, Issue:1

    Topics: Aged; Antifibrinolytic Agents; Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Electroence

2012
High-dose tranexamic acid is an independent predictor of early seizure after cardiopulmonary bypass.
    The Annals of thoracic surgery, 2012, Volume: 93, Issue:1

    Topics: Aged; Antifibrinolytic Agents; Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Electroence

2012
High-dose tranexamic acid is an independent predictor of early seizure after cardiopulmonary bypass.
    The Annals of thoracic surgery, 2012, Volume: 93, Issue:1

    Topics: Aged; Antifibrinolytic Agents; Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Electroence

2012
High-dose tranexamic acid is an independent predictor of early seizure after cardiopulmonary bypass.
    The Annals of thoracic surgery, 2012, Volume: 93, Issue:1

    Topics: Aged; Antifibrinolytic Agents; Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Electroence

2012
High-dose tranexamic acid is an independent predictor of early seizure after cardiopulmonary bypass.
    The Annals of thoracic surgery, 2012, Volume: 93, Issue:1

    Topics: Aged; Antifibrinolytic Agents; Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Electroence

2012
Seizures following cardiac surgery: the impact of tranexamic acid and other risk factors.
    Canadian journal of anaesthesia = Journal canadien d'anesthesie, 2012, Volume: 59, Issue:1

    Topics: Aged; Aged, 80 and over; Anticonvulsants; Antifibrinolytic Agents; Cardiac Surgical Procedures; Coho

2012
Invited commentary.
    The Annals of thoracic surgery, 2012, Volume: 93, Issue:1

    Topics: Cardiopulmonary Bypass; Female; Heart Diseases; Humans; Male; Seizures; Tranexamic Acid

2012
Low-dose tranexamic acid use in isolated coronary artery bypass surgery.
    The Annals of thoracic surgery, 2012, Volume: 94, Issue:3

    Topics: Cardiopulmonary Bypass; Female; Heart Diseases; Humans; Male; Seizures; Tranexamic Acid

2012
Moderate dosage of tranexamic acid during cardiac surgery with cardiopulmonary bypass and convulsive seizures: incidence and clinical outcome.
    British journal of anaesthesia, 2013, Volume: 110, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anesthesia; Antifibrinolytic Agents; Cardiac Surgical Pr

2013
Tranexamic acid concentrations associated with human seizures inhibit glycine receptors.
    The Journal of clinical investigation, 2012, Volume: 122, Issue:12

    Topics: Adult; Aged; Aged, 80 and over; Aminocaproic Acid; Animals; Anticonvulsants; Aprotinin; Binding, Com

2012
Understanding the TXA seizure connection.
    The Journal of clinical investigation, 2012, Volume: 122, Issue:12

    Topics: Animals; GABA-A Receptor Antagonists; Humans; Receptors, Glycine; Seizures; Tranexamic Acid

2012
Tranexamic acid in open cardiac surgery with cardiopulmonary bypass, convulsive seizures, and in-hospital mortality.
    British journal of anaesthesia, 2013, Volume: 110, Issue:2

    Topics: Antifibrinolytic Agents; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Female; Humans; Male;

2013
Reply from the authors.
    British journal of anaesthesia, 2013, Volume: 110, Issue:2

    Topics: Antifibrinolytic Agents; Cardiac Surgical Procedures; Cardiopulmonary Bypass; Female; Humans; Male;

2013
Convulsions and refractory ventricular fibrillation after intrathecal injection of a massive dose of tranexamic acid.
    Anesthesiology, 2003, Volume: 98, Issue:1

    Topics: Adenocarcinoma; Aged; Antifibrinolytic Agents; Cardiopulmonary Resuscitation; Drug Overdose; Fatal O

2003
Cerebral complication of antifibrinolytic therapy in the treatment of ruptured intracranial aneurysm. Animal experiment and a review of literature.
    European neurology, 1980, Volume: 19, Issue:2

    Topics: Aminocaproates; Aminocaproic Acid; Animals; Blood Pressure; Cerebral Cortex; Cisterna Magna; Cyclohe

1980
Feline generalized epilepsy induced by tranexamic acid (AMCA).
    Epilepsia, 1982, Volume: 23, Issue:1

    Topics: Administration, Topical; Animals; Cats; Cerebral Cortex; Cyclohexanecarboxylic Acids; Dose-Response

1982
Convulsive seizures following subdural application of fibrin sealant containing tranexamic acid in a rat model.
    Neurosurgery, 2000, Volume: 47, Issue:6

    Topics: Animals; Antifibrinolytic Agents; Aprotinin; Drug Combinations; Fibrin Tissue Adhesive; Gait; Male;

2000
Convulsive seizures following subdural application of fibrin sealant containing tranexamic acid in a rat model.
    Neurosurgery, 2001, Volume: 49, Issue:2

    Topics: Animals; Antifibrinolytic Agents; Fibrin Tissue Adhesive; Humans; Rats; Seizures; Subdural Space; Ti

2001
Epileptic seizures following cortical application of fibrin sealants containing tranexamic acid in rats.
    Acta neurochirurgica, 2002, Volume: 144, Issue:1

    Topics: Animals; Antifibrinolytic Agents; Cerebral Cortex; Electroencephalography; Fibrin Tissue Adhesive; M

2002
Tranexamic acid, a widely used antifibrinolytic agent, causes convulsions by a gamma-aminobutyric acid(A) receptor antagonistic effect.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 301, Issue:1

    Topics: Animals; Antifibrinolytic Agents; Binding, Competitive; Brain Chemistry; Cell Line; Dizocilpine Male

2002
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