trandolapril and Leukemia--Erythroblastic--Acute

trandolapril has been researched along with Leukemia--Erythroblastic--Acute* in 1 studies

Other Studies

1 other study(ies) available for trandolapril and Leukemia--Erythroblastic--Acute

Article	Year
Induction of apoptosis in leukemic cell lines treated with captopril, trandolapril and losartan: a new role in the treatment of leukaemia for these agents. Leukemia research, 2009, Volume: 33, Issue:6 Renin-angiotensin system (RAS) in the bone marrow is related to proliferation and cellular differentiation. We investigated the effect of ACE inhibitors (ACEI) captopril (>1mM) and trandolapril (>0.05 mM) and losartan (0.2 mM) on K562 cell line and K562 transfected with c-myc, bcl-x and bcl-2 (KmycB, Kbclx and Kbcl2 respectively). RAS components, proliferation, apoptosis and c-myc expression were analyzed. ACEI and losartan inhibited cell growth, decreased c-myc expression and increased apoptosis. These effects seem to be associated to angiotensin II-induced Smad activation. This work offers a new possible line of treatment for some acute myeloid leukemias and a new area of clinical research. Topics: Angiotensin-Converting Enzyme Inhibitors; Apoptosis; Blotting, Northern; Blotting, Western; Captopril; Cell Proliferation; Genes, myc; Humans; Indoles; K562 Cells; Leukemia, Erythroblastic, Acute; Losartan; Polymerase Chain Reaction	2009

Article

Year

Induction of apoptosis in leukemic cell lines treated with captopril, trandolapril and losartan: a new role in the treatment of leukaemia for these agents.

Leukemia research, 2009, Volume: 33, Issue:6

Renin-angiotensin system (RAS) in the bone marrow is related to proliferation and cellular differentiation. We investigated the effect of ACE inhibitors (ACEI) captopril (>1mM) and trandolapril (>0.05 mM) and losartan (0.2 mM) on K562 cell line and K562 transfected with c-myc, bcl-x and bcl-2 (KmycB, Kbclx and Kbcl2 respectively). RAS components, proliferation, apoptosis and c-myc expression were analyzed. ACEI and losartan inhibited cell growth, decreased c-myc expression and increased apoptosis. These effects seem to be associated to angiotensin II-induced Smad activation. This work offers a new possible line of treatment for some acute myeloid leukemias and a new area of clinical research.

Topics: Angiotensin-Converting Enzyme Inhibitors; Apoptosis; Blotting, Northern; Blotting, Western; Captopril; Cell Proliferation; Genes, myc; Humans; Indoles; K562 Cells; Leukemia, Erythroblastic, Acute; Losartan; Polymerase Chain Reaction

2009