tramadol has been researched along with Disease Models, Animal in 105 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 30 (28.57) | 29.6817 |
| 2010's | 61 (58.10) | 24.3611 |
| 2020's | 14 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Athavankar, S; Balwe, S; Barbhaiya, R; Begum, F; Bhosale, S; Bhuniya, D; De, S; Hajare, A; Joshi, D; Joshi, K; Kharul, RK; Madgula, V; Magdum, A; Meru, AV; Mookhtiar, KA; Raje, AA; Shaikh, N | 1 |
| Hwang, HJ; Jun, JH; Kim, KJ; Kim, MH; Lee, JR; Lee, W; Nam, SH; Oh, JE; Yoo, YC | 1 |
| Hagiwara, S; Inage, K; Kanno, K; Kawarai, Y; Nakamura, J; Ohtori, S; Orita, S; Suzuki, T; Suzuki-Narita, M; Yoh, S | 1 |
| Bucher, CH; Buttgereit, F; Hohlbaum, K; Huwyler, J; Jirkof, P; Klopfleisch, R; Konietschke, F; Kurmies, S; Lang, A; Löhning, M; Rapp, AE; Schreiner, V; Thöne-Reineke, C; Wolter, A | 1 |
| Atrott, K; Jirkof, P; Laimbacher, A; Niechcial, A; Scharl, M; Schwarzfischer, M; Spalinger, M | 1 |
| Benedet, PO; Callado de Oliveira, DMM; Lucena, F; Melleu, FF; Mujica, EMM; Norões, MM; Ribeiro, LFC; Stein, T; Tonussi, CR | 1 |
| Konno, SI; Sato, R; Sekiguchi, M | 1 |
| Beshel, FN; Mkpe, ID; Nwangwa, JN; Ofuru, OS; Sam-Ekpe, VG; Stephen, GI; Udefa, AL | 1 |
| Badawy, MA; El Omri, A; Hassan, NA; Hassan, NS; Massoud, AA; Metwally, FG; Minisy, FM; Oishi, H; Omara, EA; Shawki, HH | 1 |
| Chen, GD; Ji, CC; Jiang, HY; Liang, T; Liu, B; Luo, ZP; Shao, YJ | 1 |
| Fu, F; Li, T; Liu, R; Wang, L; Wang, T; Zhai, R; Zhang, L | 1 |
| Ahmadiani, A; Asadi, S; Ershad, A; Savaheli, S; Sherafati, F; Sorayya, M; Valian, N | 1 |
| Abdel Hamid, OI; Abdelfadeel, KF; Sabik, LME; Shaban, SF | 1 |
| Beling, A; Heuser, A; Kaya, Z; Kelm, N; Kespohl, M; Klingel, K; Pinkert, S | 1 |
| Gupta, GD; Raj, K; Singh, S | 1 |
| Battaglia, G; Bernabucci, M; Bruno, V; Cannella, M; Gradini, R; Imbriglio, T; Mascio, G; Nicoletti, F; Notartomaso, S; Scarselli, P; Zappulla, C | 1 |
| Ardakani, YH; Esmaeili, Z; Ghazi-Khansari, M; Lavasani, H; Mohammadi, S; Nezami, A; Rouini, MR | 1 |
| Blennerhassett, MG; Ghasemlou, N; Lourenssen, SR; Parlow, LRG; Winterborn, AN | 1 |
| Akbarian, R; Chamanara, M; Dehpour, AR; Ghasemi, M; Imran-Khan, M; Norouzi-Javidan, A; Ostadhadi, S | 1 |
| Cañizares, FJ; Cobos, EJ; Entrena, JM; Fernández-Segura, E; Montilla-García, Á; Perazzoli, G; Portillo-Salido, E; Tejada, MÁ | 1 |
| Achenbach, JC; Berrue, F; Ellis, LD; Hill, J; McDougall, JJ; Morash, M | 1 |
| Dhull, DK; Kumar, A | 1 |
| Bethapudi, B; Chandrasekaran, PR; Murugan, S; Purusothaman, D; Velusami, CC | 1 |
| Huang, Y; Qu, Y; Song, J; Wang, D; Wang, X; Zhang, G | 1 |
| Akkurt, A; Akkurt, I; Bakar, B; Cetin, C; Ceylan, AF; Dincel, GC; Erdogan, AM; Kisa, U; Ogden, M; Oppong, J | 1 |
| Abouzed, TK; El-Sayed, Y; Lebda, MA; Nasr, SM; Sadek, KM | 1 |
| Miranda, HF; Noriega, V; Poblete, P; Prieto, JC; Sierralta, F; Zepeda, RJ | 1 |
| Ibrahim, MA; Salah-Eldin, AE | 1 |
| Awaga, Y; Hama, A; Hayashi, I; Magata, Y; Natsume, T; Ogawa, S; Okamoto, S; Shidahara, Y; Takamatsu, H; Yamoto, K | 1 |
| Hong, GS; Kalff, J; Lysson, M; Stein, K; Wehner, S | 1 |
| Cheng, YT; Huang, YH; Lin, FS; Lin, WY; Sun, WZ; Yen, CT | 1 |
| Ahangar, N; Bameri, B; Fallah, M; Mohammadi, H; Samadi, M; Shaki, F | 1 |
| Antkowiak, B; Bartosiński, A; Bodera, P; Kalicki, B; Kieliszek, J; Paluch, M; Stankiewicz, W; Wawer, I; Zawada, K | 1 |
| Affaitati, G; Costantini, R; Fabrizio, A; Giamberardino, MA; Lapenna, D; Lopopolo, M; Massimini, F | 1 |
| El Husseiny, RM; Ghaffar, HM; Mohamed, TM | 1 |
| Arizpe, HM; Clifford, JL; Fowler, M; Garza, TH; Loyd, DR; Novak, J; Petz, LN; Slater, TM | 1 |
| Homan, T; Kaneko, K; Oka, M; Okamoto, K; Oyama, T; Umehara, M | 1 |
| Asakura, K; Isami, K; Kaneko, S; Maeda, S; Nakagawa, T; Sakakiyama, M; Shirakawa, H; So, K | 1 |
| Bolooki, A; Ranjbar, M; Sabbagh, A; Sazmand, A; Varzi, HN | 1 |
| Kögel, B; Schneider, J; Terlinden, R | 1 |
| Castagné, V; Le Cudennec, C | 1 |
| Calvillo, L; Casana, R; Ciuffreda, MC; Gnecchi, M; Roughan, J; Spazzolini, C; Tolva, V; Vanoli, E | 1 |
| Gholami, M; Roshan-Milani, S; Saboory, E | 1 |
| Ishikawa, G; Nagakura, Y; Shimizu, Y; Takeshita, N | 1 |
| Kanbara, T; Kanemasa, T; Minami, K; Nakamura, A; Ono, H; Sakaguchi, G; Shinohara, S | 1 |
| El-Nahhas, T; Ezzeldin, E; Shahat, AA; Soudi, AN; Souror, WA | 1 |
| Asl, HA; Karimi, P; Mobarakeh, SZ; Takhtfooladi, HA; Takhtfooladi, MA | 1 |
| Fujimoto, Y; Funao, T; Mori, T; Nishikawa, K; Suehiro, K; Takahashi, R | 1 |
| Diaz, JA; Hawley, AE; Hish, GA; Lester, PA; Myers, DD | 1 |
| Beltrán-Villalobos, KL; Cruz, CA; Déciga-Campos, M; Ramírez-Marín, PM | 1 |
| Ide, S; Minami, M; Satoh, M; Satoyoshi, H | 1 |
| Doods, H; Gould, SA; Lamla, T; Pekcec, A | 1 |
| Duan, ML; Tong, JH; Wang, SH; Xia, M; Xu, JG; Zeng, HJ; Zhou, ZQ | 1 |
| Apan, A; Cuvas Apan, O; Ozer, MA; Sengul, D; Takir, S | 1 |
| Aranda, N; Castillo, R; Miranda, HF; Noriega, V; Prieto, JC; Sierralta, F; Zanetta, P | 1 |
| Antoniów, M; Grześkowiak, E; Kus, K; Nowakowska, E; Ratajczak, P; Szkutnik-Fiedler, D | 1 |
| Harada, S; Kageyama, E; Matsuura, W; Tokuyama, S | 1 |
| Puig, MM; Romero, A; Romero-Alejo, E | 1 |
| Corona-Ramos, JN; De la O-Arciniega, M; Déciga-Campos, M; Domínguez-Ramírez, AM; Espinosa-Juárez, JV; Jaramillo-Morales, OA; López-Muñoz, FJ; Medina-López, JR | 1 |
| Ballet, S; Chevillard, L; Guillemyn, K; Lagard, C; Laplanche, JL; Mégarbane, B; Risède, P; Spetea, M | 1 |
| Audi, EA; Fiaes, GCS; Maraschin, JC; Porcu, M; Roncon, CM; Sestile, CC; Souza, RLS | 1 |
| Belzung, C; Bodard, S; Chalon, S; Coubard, S; Yalcin, I | 1 |
| Bortolatto, CF; Jesse, CR; Nogueira, CW; Rocha, JB; Savegnago, L | 1 |
| Miranda, HF; Prieto, JC; Puig, MM; Romero, MA | 1 |
| Fox, MA; Jensen, CL; Murphy, DL | 1 |
| Berrocoso, E; Mico, JA | 1 |
| Kim, SH; Mun, H; Park, KU; Song, J | 1 |
| Guo, Z; Zhang, LZ | 1 |
| Jesse, CR; Nogueira, CW | 1 |
| Obara, I; Przewlocka, B; Wordliczek, J; Wrzosek, A | 1 |
| Asghari-Roodsari, A; Dehpour, AR; Javadi-Paydar, M; Khodadad, TK; Lesani, A; Norouzi, A; Shirkhodaei, M | 1 |
| Cha, DS; Jeon, H; Park, HJ | 1 |
| Miranda, HF; Puig, MM; Romero, MA | 1 |
| Ashmawi, HA; Costa, LS; Posso, IP; Slullitel, A; Sousa, AM | 1 |
| Homan, T; Kyotani, J; Oka, M; Oyama, T | 1 |
| Bankstahl, JP; Bankstahl, M; Bloms-Funke, P; Löscher, W | 1 |
| Alvarez, P; Brun, A; Constandil, L; Correa, A; Hernández, A; Labertrandie, A; Lopez, J; Pelissier, T | 1 |
| Ciruela, F; Fernández-Dueñas, V; Poveda, R; Sánchez, S | 1 |
| Assreuy, J; Bet, AC; Fernandes, D; Nardi, GM; Sordi, R | 1 |
| Kimura, M; Obata, H; Saito, S | 1 |
| Keyhanfar, F; Meymandi, MS | 1 |
| Alaçam, B; Aydin, ON; Ek, RO; Şen, S; Temoçin, S; Uğur, B | 1 |
| de Groat, WC; Mally, AD; Matsuta, Y; Roppolo, JR; Shen, B; Tai, C; Wang, J; Zhang, F | 1 |
| Bianchi, M; Gaspani, L; Limiroli, E; Panerai, AE; Sacerdote, P | 1 |
| Dogru, A; Onal, A; Soykan, N; Uyar, M | 1 |
| Planas, E; Pol, O; Poveda, R; Puig, MM; Romero, A; Sánchez, S | 1 |
| Dost, R; Rostock, A; Rundfeldt, C | 1 |
| Dongmo, AB; Lacaille-Dubois, MA; Nguelefack, T | 1 |
| Aksu, F; Belzung, C; Yalcin, I | 1 |
| Kulkarni, SK; Patil, CS; Singh, VP | 1 |
| Dürsteler, C; Fernandez, V; Mases, A; Pol, O; Puig, MM | 1 |
| Epstein, DH; Jasinski, DR; Preston, KL | 1 |
| Okuducu, H; Onal, SA | 1 |
| Aguirre-Bañuelos, P; Arellano-Guerrero, A; Castañeda-Hernández, G; Hoyo-Vadillo, C; Pérez-Urizar, J; Pozos-Guillén, AJ | 1 |
| Gibert-Rahola, J; Mico, JA; Rojas-Corrales, MO | 1 |
| Déciga-Campos, M; González-Trujano, ME; Guevara-Fefer, P; López-Muñoz, FJ; Martínez, AL; Moreno, J; Peña, EI | 1 |
| Christoph, T; Kögel, B; Schug, SA; Strassburger, W | 1 |
| Bianchi, M; Ferrario, P; Franchi, S; Martucci, C; Sacerdote, P | 1 |
| Berrocoso, E; De Benito, MD; Mico, JA | 1 |
| Kamerman, P; Koller, A; Loram, L | 1 |
| Bilir, A; Erkasap, N; Gulec, S; Kaygisiz, Z; Koken, T; Kurt, I; Tanriverdi, B | 1 |
| Dürsteler, C; Mases, A; Miranda, HF; Planas, E; Poveda, R; Puig, MM | 1 |
| Bauer, WR; Dong, ZQ; Ma, F; Wang, X; Wu, GC; Xie, H | 1 |
| Friderichs, E; Löscher, W; Potschka, H | 1 |
| Affaitati, G; De Laurentis, S; Giamberardino, MA; Lapenna, D; Lerza, R; Vecchiet, L | 1 |
1 review(s) available for tramadol and Disease Models, Animal
| Article | Year |
|---|---|
Abuse liability, behavioral pharmacology, and physical-dependence potential of opioids in humans and laboratory animals: lessons from tramadol.
Topics: Animals; Behavior, Animal; Brain; Disease Models, Animal; Humans; Narcotic Antagonists; Opioid-Related Disorders; Product Surveillance, Postmarketing; Receptors, Opioid; Self Administration; Species Specificity; Tramadol; United States; United States Food and Drug Administration | 2006 |
1 trial(s) available for tramadol and Disease Models, Animal
| Article | Year |
|---|---|
Characterisation of tramadol, morphine and tapentadol in an acute pain model in Beagle dogs.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dog Diseases; Dogs; Dose-Response Relationship, Drug; Male; Morphine; Pain; Pain Measurement; Phenols; Receptors, Opioid, mu; Tapentadol; Tramadol | 2014 |
103 other study(ies) available for tramadol and Disease Models, Animal
| Article | Year |
|---|---|
Discovery and evaluation of novel FAAH inhibitors in neuropathic pain model.
Topics: Amidohydrolases; Animals; Antineoplastic Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Molecular Structure; Neuralgia; Rats; Structure-Activity Relationship | 2019 |
Identification for antitumor effects of tramadol in a xenograft mouse model using orthotopic breast cancer cells.
Topics: Animals; Antineoplastic Agents; Breast; Breast Neoplasms; Cell Line, Tumor; Disease Models, Animal; Female; Heterografts; Humans; Killer Cells, Natural; MCF-7 Cells; Mice; Mice, Inbred BALB C; Mice, Nude; Morphine; Receptors, Estrogen; Receptors, Progesterone; Tramadol; Transplantation, Heterologous; TRPV Cation Channels | 2021 |
Analgesic effects and arthritic changes following tramadol administration in a rat hip osteoarthritis model.
Topics: Analgesics; Animals; Calcitonin Gene-Related Peptide; Disease Models, Animal; Iodoacetic Acid; Male; Osteoarthritis, Hip; Rats; Rats, Sprague-Dawley; Tramadol | 2022 |
A buprenorphine depot formulation provides effective sustained post-surgical analgesia for 72 h in mouse femoral fracture models.
Topics: Agnosia; Analgesia; Animals; Buprenorphine; Disease Models, Animal; Drinking Water; Female; Femoral Fractures; Male; Mice; Mice, Inbred C57BL; Pain; Pain Management; Tramadol | 2023 |
Evaluation of the effect of tramadol, paracetamol and metamizole on the severity of experimental colitis.
Topics: Acetaminophen; Analgesics; Animals; Colitis; Dextran Sulfate; Dipyrone; Disease Models, Animal; Drinking Water; Female; Mice; Mice, Inbred C57BL; Tramadol | 2023 |
Intrathecally injected tramadol reduces articular incapacitation and edema in a rat model of lipopolysaccharide (LPS)-induced reactive arthritis.
Topics: Analgesics, Opioid; Animals; Arthralgia; Arthritis, Experimental; Arthritis, Reactive; Disease Models, Animal; Edema; Injections, Spinal; Lipopolysaccharides; Male; Rats; Rats, Wistar; Tramadol | 2019 |
Acetaminophen combined with tramadol is more effective than acetaminophen or tramadol to reduce neuropathic root pain: an experimental study with application of nucleus pulposus in a rat model.
Topics: Acetaminophen; Animals; Behavior, Animal; Disease Models, Animal; Female; Neuralgia; Nucleus Pulposus; Rats; Rats, Sprague-Dawley; Tramadol | 2020 |
Vitamin E administration does not ameliorate tramadol-associated impairment of testicular function in Wistar rats.
Topics: Administration, Oral; Animals; Disease Models, Animal; Ejaculation; Epididymis; Humans; Infertility, Male; Male; Nigeria; Oxidative Stress; Rats; Rats, Wistar; Sperm Count; Sperm Motility; Spermatozoa; Substance-Related Disorders; Testis; Tramadol; Vitamin E | 2020 |
Pomegranate Seeds Extract Possesses a Protective Effect against Tramadol-Induced Testicular Toxicity in Experimental Rats.
Topics: Analgesics, Opioid; Animals; Antioxidants; Apoptosis; Disease Models, Animal; Male; Oxidative Stress; Plant Extracts; Pomegranate; Protective Agents; Rats; Rats, Wistar; Seeds; Spermatids; Spermatozoa; Testicular Diseases; Testis; Tramadol | 2020 |
Microstructure and mechanical properties of subchondral bone are negatively regulated by tramadol in osteoarthritis in mice.
Topics: Analgesics, Opioid; Animals; Bone and Bones; Bone Remodeling; Cartilage; Disease Models, Animal; Elastic Modulus; Male; Menisci, Tibial; Mice, Inbred C57BL; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Osteoarthritis, Knee; Synovitis; Tramadol; X-Ray Microtomography | 2020 |
Antinociceptive effects of rotigotine-loaded microspheres and its synergistic interactions with analgesics in inflammatory pain in rats.
Topics: Acetaminophen; Analgesics; Animals; Behavior, Animal; Carrageenan; Delayed-Action Preparations; Disease Models, Animal; Drug Compounding; Drug Synergism; Drug Therapy, Combination; Hyperalgesia; Locomotion; Male; Microspheres; Nociceptive Pain; Open Field Test; Pain Threshold; Rats, Sprague-Dawley; Tetrahydronaphthalenes; Thiophenes; Tramadol | 2021 |
Preconditioning by ultra-low dose of tramadol reduces the severity of tramadol-induced seizure: Contribution of glutamate receptors.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Brain; Calcium-Binding Proteins; Calponins; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Male; Microfilament Proteins; Neuropeptides; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Severity of Illness Index; Tramadol | 2021 |
Tramadol aggravates cardiovascular toxicity in a rat model of alcoholism: Involvement of intermediate microfilament proteins and immune-expressed osteopontin.
Topics: Alcoholism; Animals; Aorta; Cardiotoxicity; Disease Models, Animal; Gene Expression Regulation; Intermediate Filaments; Male; Myocardium; Osteopontin; Rats; Tramadol | 2021 |
Exploration of Analgesia with Tramadol in the Coxsackievirus B3 Myocarditis Mouse Model.
Topics: Analgesia; Animals; Coxsackievirus Infections; Disease Models, Animal; Enterovirus B, Human; Heart; Male; Mice; Mice, Inbred C57BL; Myocarditis; Tramadol; Viral Load; Virus Replication | 2021 |
l-Theanine ameliorates motor deficit, mitochondrial dysfunction, and neurodegeneration against chronic tramadol induced rats model of Parkinson's disease.
Topics: Animals; Antioxidants; Corpus Striatum; Disease Models, Animal; Dopamine; gamma-Aminobutyric Acid; Glutamates; Mitochondria; Neurodegenerative Diseases; Neuroprotective Agents; Neurotransmitter Agents; Oxidative Stress; Parkinson Disease; Rats; Rats, Wistar; Serotonin; Tramadol | 2022 |
Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic pain.
Topics: Acetylcarnitine; Amitriptyline; Analgesics; Animals; Chronic Disease; Disease Models, Animal; Epigenesis, Genetic; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Mice; Mice, Inbred C57BL; Neuralgia; Pain Management; Pregabalin; Receptors, Metabotropic Glutamate; Time Factors; Tramadol | 2017 |
A disposition kinetic study of Tramadol in bile duct ligated rats in perfused rat liver model.
Topics: Animals; Bile Ducts; Disease Models, Animal; Kinetics; Ligation; Liver; Male; Perfusion; Rats, Wistar; Tramadol | 2017 |
Analgesia and mouse strain influence neuromuscular plasticity in inflamed intestine.
Topics: Analgesia; Analgesics, Opioid; Animals; Buprenorphine; Colitis; Dextran Sulfate; Disease Models, Animal; Inflammation; Intestines; Mice; Mice, Inbred BALB C; Tramadol; Trinitrobenzenesulfonic Acid | 2017 |
Involvement of NMDA receptors in the antidepressant-like effect of tramadol in the mouse forced swimming test.
Topics: Animals; Antidepressive Agents; Depressive Disorder; Disease Models, Animal; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Agents; Ketamine; Magnesium Sulfate; Male; Mice; N-Methylaspartate; Receptors, N-Methyl-D-Aspartate; Swimming; Tramadol | 2017 |
Grip strength in mice with joint inflammation: A rheumatology function test sensitive to pain and analgesia.
Topics: Acetaminophen; Analgesics; Animals; Arthritis; Celecoxib; Disease Models, Animal; Diterpenes; Female; Freund's Adjuvant; Hand Strength; Hyperalgesia; Ibuprofen; Inflammation; Muscle Strength; Nociceptors; Oxycodone; Pain Measurement; Rheumatic Diseases; Ruthenium Red; Tarsus, Animal; Touch; Tramadol; TRPV Cation Channels | 2017 |
Comparison of cannabinoids with known analgesics using a novel high throughput zebrafish larval model of nociception.
Topics: Acetaminophen; Acetic Acid; Analgesics; Animals; Cannabinoid Receptor Agonists; Cannabinoids; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Ibuprofen; Larva; Locomotion; Nociception; Pain; Principal Component Analysis; Time Factors; Tramadol; Zebrafish | 2018 |
Tramadol ameliorates behavioural, biochemical, mitochondrial and histological alterations in ICV-STZ-induced sporadic dementia of Alzheimer's type in rats.
Topics: Alzheimer Disease; Animals; Behavior, Animal; Dementia; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Memantine; Mitochondria; Neuroprotective Agents; Oxidative Stress; Rats; Rats, Sprague-Dawley; Streptozocin; Tramadol | 2018 |
Antiarthritic Effect of Polar Extract of Curcuma longa on Monosodium Iodoacetate Induced Osteoarthritis in Rats.
Topics: Animals; Collagen Type II; Curcuma; Disease Models, Animal; Female; Humans; Iodoacetic Acid; Male; Matrix Metalloproteinase 3; Matrix Metalloproteinase 7; Osteoarthritis; Plant Extracts; Rats; Rats, Wistar; Tramadol | 2017 |
Analgesic effects of Marasmius androsaceus mycelia ethanol extract and possible mechanisms in mice.
Topics: Analgesics; Animals; Disease Models, Animal; Male; Marasmius; Mice; Pain; Pain Measurement; Plant Extracts; Tramadol | 2018 |
Cerebral ischaemia/reperfusion injury could be managed by using tramadol.
Topics: Acute Disease; Animals; Brain Edema; Caspase 3; Chronic Disease; Disease Models, Animal; Hippocampus; Inflammation; Male; Neuroprotective Agents; Parietal Lobe; Random Allocation; Rats, Wistar; Reperfusion Injury; Tramadol | 2018 |
The molecular and biochemical insight view of lycopene in ameliorating tramadol-induced liver toxicity in a rat model: implication of oxidative stress, apoptosis, and MAPK signaling pathways.
Topics: Animals; Antioxidants; Apoptosis; Chemical and Drug Induced Liver Injury; Disease Models, Animal; DNA Fragmentation; Lycopene; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Oxidative Stress; Rats; Tramadol | 2018 |
Interleukin-1beta in synergism gabapentin with tramadol in murine model of diabetic neuropathy.
Topics: Analgesics; Animals; Diabetic Neuropathies; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Gabapentin; Interleukin-1beta; Male; Mice; Neuralgia; Pain Measurement; Spinal Cord; Streptozocin; Tramadol | 2019 |
Chronic Addiction to Tramadol and Withdrawal Effect on the Spermatogenesis and Testicular Tissues in Adult Male Albino Rats.
Topics: Analgesics, Opioid; Animals; Apoptosis; Apoptosis Regulatory Proteins; Disease Models, Animal; Male; Opioid-Related Disorders; Oxidative Stress; Rats, Wistar; Spermatogenesis; Substance Withdrawal Syndrome; Testis; Tramadol | 2019 |
Distinguishing analgesic drugs from non-analgesic drugs based on brain activation in macaques with oxaliplatin-induced neuropathic pain.
Topics: Analgesics; Animals; Antineoplastic Agents; Brain; Cerebral Cortex; Cryopyrin-Associated Periodic Syndromes; Disease Models, Animal; Duloxetine Hydrochloride; Macaca fascicularis; Magnetic Resonance Imaging; Male; Neuralgia; Oxaliplatin; Pregabalin; Somatosensory Cortex; Tramadol | 2019 |
A comparative study about the immunomodulatory effects of tramadol and metamizole in a murine model of postoperative ileus.
Topics: Animals; Dipyrone; Disease Models, Animal; Ileus; Immunologic Factors; Male; Mice; Mice, Inbred C57BL; Postoperative Complications; Tramadol | 2019 |
Synergistic symptom-specific effects of ketorolac-tramadol and ketorolac-pregabalin in a rat model of peripheral neuropathy.
Topics: Animals; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Ketorolac; Male; Meloxicam; Neuralgia; Pregabalin; Rats; Rats, Sprague-Dawley; Tramadol | 2019 |
Caffeine attenuates seizure and brain mitochondrial disruption induced by Tramadol: the role of adenosinergic pathway.
Topics: Animals; Brain; Caffeine; Disease Models, Animal; Mice; Mitochondria; Protein Carbonylation; Seizures; Tramadol | 2021 |
Changes in antioxidant capacity of blood due to mutual action of electromagnetic field (1800 MHz) and opioid drug (tramadol) in animal model of persistent inflammatory state.
Topics: Analgesics, Opioid; Animals; Antioxidants; Disease Models, Animal; Electromagnetic Fields; Inflammation; Injections, Intraperitoneal; Male; Rats; Rats, Wistar; Reactive Oxygen Species; Tramadol | 2013 |
Effects of tramadol on viscero-visceral hyperalgesia in a rat model of endometriosis plus ureteral calculosis.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Endometriosis; Female; Hyperalgesia; Rats, Sprague-Dawley; Tramadol; Ureteral Calculi; Visceral Pain | 2014 |
Effects of tramadol, clonazepam, and their combination on brain mitochondrial complexes.
Topics: Analgesics, Opioid; Animals; Anticonvulsants; Brain; Clonazepam; Disease Models, Animal; Electron Transport Complex I; Electron Transport Complex II; Electron Transport Complex III; Electron Transport Complex IV; Male; Mitochondria; Nerve Tissue Proteins; Neurons; Neurotoxicity Syndromes; Opioid-Related Disorders; Qualitative Research; Random Allocation; Rats; Substance-Related Disorders; Tramadol; Weight Loss | 2015 |
A rat model of full thickness thermal injury characterized by thermal hyperalgesia, mechanical allodynia, pronociceptive peptide release and tramadol analgesia.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Burns; Calcitonin Gene-Related Peptide; Disease Models, Animal; Hyperalgesia; Male; Morphine; Nociception; Nociceptive Pain; Pain; Rats; Rats, Sprague-Dawley; Spinal Cord; Substance P; Tramadol | 2014 |
The analgesic effect of tramadol in animal models of neuropathic pain and fibromyalgia.
Topics: Analgesics, Opioid; Animals; Chronic Pain; Disease Models, Animal; Fibromyalgia; Male; Neuralgia; Pain Measurement; Rats; Rats, Sprague-Dawley; Tramadol | 2014 |
Preventive and alleviative effect of tramadol on neuropathic pain in rats: roles of α₂-adrenoceptors and spinal astrocytes.
Topics: Analgesics, Opioid; Animals; Astrocytes; Disease Models, Animal; Dopamine beta-Hydroxylase; Hyperalgesia; Male; Neuralgia; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Spinal Cord; Tramadol | 2014 |
Study on analgesic and anti-inflammatory properties of Cordia myxa fruit hydro-alcoholic extract.
Topics: Acetic Acid; Analgesics; Animals; Anti-Inflammatory Agents; Behavior, Animal; Cordia; Disease Models, Animal; Female; Formaldehyde; Fruit; Indomethacin; Inflammation; Male; Methanol; Mice; Pain; Phytotherapy; Plant Extracts; Plants, Medicinal; Solvents; Tramadol | 2013 |
Face-to-face comparison of the predictive validity of two models of neuropathic pain in the rat: analgesic activity of pregabalin, tramadol and duloxetine.
Topics: Analgesics; Animals; Cold Temperature; Disease Models, Animal; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Hot Temperature; Hyperalgesia; Male; Neuralgia; Physical Stimulation; Pregabalin; Rats, Wistar; Sciatic Nerve; Thiophenes; Tramadol | 2014 |
Rat experimental model of myocardial ischemia/reperfusion injury: an ethical approach to set up the analgesic management of acute post-surgical pain.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Carbazoles; Disease Models, Animal; Male; Myocardial Reperfusion Injury; Pain Management; Pain Measurement; Pain, Postoperative; Rats, Sprague-Dawley; Tramadol | 2014 |
Proconvulsant effects of tramadol and morphine on pentylenetetrazol-induced seizures in adult rats using different routes of administration.
Topics: Analgesics; Animals; Convulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Synergism; Female; Morphine; Pentylenetetrazole; Rats; Rats, Wistar; Seizures; Time Factors; Tramadol | 2014 |
Efficacy of drugs with different mechanisms of action in relieving spontaneous pain at rest and during movement in a rat model of osteoarthritis.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Duloxetine Hydrochloride; Gait; Iodoacetic Acid; Male; Morphine; Movement; Osteoarthritis; Pain; Rats; Rest; Thiophenes; Tramadol; Weight-Bearing | 2014 |
Effect of the norepinephrine transporter (NET) inhibition on μ-opioid receptor (MOR)-induced anti-nociception in a bone cancer pain model.
Topics: Analgesics, Opioid; Animals; Bone Neoplasms; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice, Inbred C3H; Morphine; Neoplasm Transplantation; Norepinephrine Plasma Membrane Transport Proteins; Oxycodone; Pain; Phenols; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Opioid, mu; Tapentadol; Tramadol; Tumor Cells, Cultured | 2014 |
Biochemical and neurotransmitters changes associated with tramadol in streptozotocin-induced diabetes in rats.
Topics: Animals; Brain; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Disease Models, Animal; Dopamine; Humans; Male; Neurotransmitter Agents; Norepinephrine; Rats; Rats, Sprague-Dawley; Serotonin; Streptozocin; Tramadol | 2014 |
Influence of tramadol on ischemia-reperfusion injury of rats' skeletal muscle.
Topics: Animals; Catalase; Creatine Kinase; Disease Models, Animal; Femoral Artery; Injections, Intravenous; L-Lactate Dehydrogenase; Male; Malondialdehyde; Muscle, Skeletal; Random Allocation; Rats; Rats, Wistar; Reperfusion Injury; Superoxide Dismutase; Tramadol | 2014 |
Brain serotonin content regulates the manifestation of tramadol-induced seizures in rats: disparity between tramadol-induced seizure and serotonin syndrome.
Topics: Animals; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Histamine; Male; Rats; Rats, Sprague-Dawley; Seizures; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Serotonin Syndrome; Tramadol | 2015 |
Effects of analgesic use on inflammation and hematology in a murine model of venous thrombosis.
Topics: Analgesics; Anesthetics, Local; Animals; Bupivacaine; Buprenorphine; Carbazoles; Disease Models, Animal; Inflammation; Ligation; Male; Mice; Mice, Inbred C57BL; Random Allocation; Tramadol; Vena Cava, Inferior; Venous Thrombosis | 2014 |
Coadministration of tramadol and tizanidine in an experimental acute pain model in rat.
Topics: Acute Pain; Analgesics; Animals; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Drug Therapy, Combination; Female; Humans; Rats; Rats, Wistar; Tramadol | 2014 |
Amelioration of the reduced antinociceptive effect of morphine in the unpredictable chronic mild stress model mice by noradrenalin but not serotonin reuptake inhibitors.
Topics: Analgesics; Animals; Chronic Disease; Citalopram; Disease Models, Animal; Male; Maprotiline; Mice, Inbred BALB C; Morphine; Norepinephrine; Selective Serotonin Reuptake Inhibitors; Stress, Physiological; Temperature; Tramadol | 2015 |
Pharmacological characterization of intraplantar Complete Freund's Adjuvant-induced burrowing deficits.
Topics: Amines; Analgesics; Animals; Antibodies; Behavior, Animal; Celecoxib; Cyclohexanecarboxylic Acids; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Freund's Adjuvant; Gabapentin; gamma-Aminobutyric Acid; Ibuprofen; Indomethacin; Inflammation; Male; Morphine; Motor Activity; Nerve Growth Factor; Pain; Rats, Wistar; Tramadol | 2016 |
Tramadol inhibits proliferation, migration and invasion via α2-adrenoceptor signaling in breast cancer cells.
Topics: Analgesics, Opioid; Animals; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Models, Animal; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Receptors, Adrenergic, alpha-2; Signal Transduction; Tramadol; Xenograft Model Antitumor Assays | 2016 |
Effect of topical administration of tramadol on corneal wound healing in rats.
Topics: Administration, Topical; Analgesics, Opioid; Animals; Blepharospasm; Blinking; Corneal Injuries; Disease Models, Animal; Fluorophotometry; Intraocular Pressure; Male; Ophthalmic Solutions; Rats; Rats, Wistar; Slit Lamp; Tonometry, Ocular; Tramadol; Wound Healing | 2016 |
Antinociceptive Interaction of Tramadol with Gabapentin in Experimental Mononeuropathic Pain.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Gabapentin; gamma-Aminobutyric Acid; Interleukin-1beta; Linear Models; Male; Mice; Mononeuropathies; Neuralgia; Tramadol | 2016 |
Coadministration of tramadol with aripiprazole and venlafaxine--The effect on spatial memory functions in male rats.
Topics: Animals; Antidepressive Agents; Antipsychotic Agents; Aripiprazole; Behavior, Animal; Chronic Pain; Depression; Disease Models, Animal; Male; Maze Learning; Memory Disorders; Rats; Rats, Wistar; Spatial Memory; Tramadol; Venlafaxine Hydrochloride | 2016 |
Unique action mechanisms of tramadol in global cerebral ischemia-induced mechanical allodynia.
Topics: Analgesics, Opioid; Animals; Brain Ischemia; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Male; Mice; Naltrexone; Narcotic Antagonists; Pain Measurement; Pain Threshold; Tramadol | 2016 |
Antihyperalgesic effects of dexketoprofen and tramadol in a model of postoperative pain in mice - effects on glial cell activation.
Topics: Analgesics; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Drug Combinations; Hyperalgesia; Ketoprofen; Male; Mice; Naloxone; Neuroglia; Pain Threshold; Pain, Postoperative; Tramadol | 2016 |
The Antinociceptive Effects of Tramadol and/or Gabapentin on Rat Neuropathic Pain Induced by a Chronic Constriction Injury.
Topics: Amines; Analgesics; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Gabapentin; gamma-Aminobutyric Acid; Lethal Dose 50; Male; Mice; Neuralgia; Rats; Rats, Wistar; Tramadol | 2016 |
Bifunctional peptide-based opioid agonist/nociceptin antagonist ligand for dual treatment of nociceptive and neuropathic pain.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Indoles; Ligands; Male; Narcotic Antagonists; Neuralgia; Nociceptin; Nociceptive Pain; Oligopeptides; Opioid Peptides; Pain Measurement; Peptides; Phenalenes; Plethysmography; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Respiration; Time Factors; Tramadol | 2017 |
Panicolytic-like effect of tramadol is mediated by opioid receptors in the dorsal periaqueductal grey.
Topics: Analgesics, Opioid; Animals; Anxiety; Behavior, Animal; Disease Models, Animal; Male; Naloxone; Narcotic Antagonists; Panic; Periaqueductal Gray; Piperazines; Pyridines; Rats; Rats, Wistar; Receptors, Opioid, mu; Serotonin 5-HT1 Receptor Antagonists; Serotonin and Noradrenaline Reuptake Inhibitors; Tramadol | 2017 |
Effects of 5,7-dihydroxytryptamine lesion of the dorsal raphe nucleus on the antidepressant-like action of tramadol in the unpredictable chronic mild stress in mice.
Topics: 5,7-Dihydroxytryptamine; Animals; Antidepressive Agents; Behavior, Animal; Brain; Chromatography, High Pressure Liquid; Depression; Disease Models, Animal; Male; Mice; Mice, Inbred BALB C; Raphe Nuclei; Serotonin; Stress, Psychological; Tramadol | 2008 |
Involvement of L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of tramadol in the rat forced swimming test.
Topics: Analysis of Variance; Animals; Antidepressive Agents; Arginine; Behavior, Animal; Cyclic GMP; Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Exploratory Behavior; Male; Nitric Oxide; Rats; Rats, Wistar; Signal Transduction; Swimming; Tramadol | 2008 |
Effects of tramadol and dexketoprofen on analgesia and gastrointestinal transit in mice.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Charcoal; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Gastrointestinal Transit; Ketoprofen; Male; Mice; Pain; Pain Measurement; Tramadol; Tromethamine | 2009 |
Tramadol and another atypical opioid meperidine have exaggerated serotonin syndrome behavioural effects, but decreased analgesic effects, in genetically deficient serotonin transporter (SERT) mice.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Behavior, Animal; Behavioral Symptoms; Disease Models, Animal; Drug Interactions; Drug Synergism; Female; Meperidine; Mice; Mice, Inbred C57BL; Mice, Knockout; Pain Measurement; Piperazines; Pyridines; Serotonin Antagonists; Serotonin Plasma Membrane Transport Proteins; Tramadol | 2009 |
Cooperative opioid and serotonergic mechanisms generate superior antidepressant-like effects in a mice model of depression.
Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Behavior, Animal; Codeine; Depression; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Duloxetine Hydrochloride; Enzyme Inhibitors; Hindlimb Suspension; Male; Mice; Motor Activity; Selective Serotonin Reuptake Inhibitors; Serotonin; Thiophenes; Tramadol | 2009 |
Effect of the combined use of tramadol and milnacipran on pain threshold in an animal model of fibromyalgia.
Topics: Analgesics, Opioid; Animals; Antidepressive Agents; Behavior, Animal; Cyclopropanes; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Fibromyalgia; Hydrogen-Ion Concentration; Hyperalgesia; Injections, Intraperitoneal; Male; Milnacipran; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Sodium Chloride; Time Factors; Tramadol | 2009 |
Tramadol reduces myocardial infarct size and expression and activation of nuclear factor kappa B in acute myocardial infarction in rats.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Intercellular Adhesion Molecule-1; Male; Myocardial Infarction; NF-kappa B; Random Allocation; Rats; Rats, Sprague-Dawley; Tramadol; Treatment Outcome | 2009 |
Evidence for the involvement of glutamatergic and neurokinin 1 receptors in the antinociception elicited by tramadol in mice.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Bites and Stings; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Mice; Pain; Pain Measurement; Receptors, Glutamate; Receptors, Neurokinin-1; Spinal Cord; Tramadol | 2010 |
Efficacy of tramadol in combination with doxepin or venlafaxine in inhibition of nociceptive process in the rat model of neuropathic pain: an isobolographic analysis.
Topics: Analgesics, Opioid; Animals; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Cyclohexanols; Disease Models, Animal; Dose-Response Relationship, Drug; Doxepin; Drug Interactions; Drug Therapy, Combination; Hyperalgesia; Male; Neuralgia; Pain Measurement; Rats; Rats, Wistar; Statistics as Topic; Tramadol; Venlafaxine Hydrochloride | 2009 |
Involvement of the nitric oxide pathway in the anticonvulsant effect of tramadol on pentylenetetrazole-induced seizures in mice.
Topics: Analysis of Variance; Animals; Anticonvulsants; Arginine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Male; Mice; Mice, Inbred Strains; Naloxone; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentylenetetrazole; Seizures; Signal Transduction; Time Factors; Tramadol | 2010 |
Antinociceptive and hypnotic properties of Celastrus orbiculatus.
Topics: Acetic Acid; Animals; Celastrus; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Formaldehyde; Hypnotics and Sedatives; Indomethacin; Male; Mice; Mice, Inbred ICR; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Pain Threshold; Phenobarbital; Plant Extracts; Plants, Medicinal; Reaction Time; Sleep; Time Factors; Tramadol | 2011 |
Antinociceptive and anti-exudative synergism between dexketoprofen and tramadol in a model of inflammatory pain in mice.
Topics: Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Drug Combinations; Drug Synergism; Inflammation; Ketoprofen; Male; Mice; Pain; Pain Measurement; Tramadol; Tromethamine | 2012 |
Percutaneous sciatic nerve block with tramadol induces analgesia and motor blockade in two animal pain models.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Male; Nerve Block; Pain Measurement; Rats; Rats, Wistar; Sciatic Nerve; Tramadol | 2012 |
Effect of tramadol on pain-related behaviors and bladder overactivity in rodent cystitis models.
Topics: Analgesics; Animals; Behavior, Animal; Cyclophosphamide; Cystitis; Disease Models, Animal; Female; In Vitro Techniques; Male; Mice; Organ Size; Pain; Rats; Tramadol; Urinary Bladder; Urinary Bladder, Overactive | 2012 |
Striking differences in proconvulsant-induced alterations of seizure threshold in two rat models.
Topics: Animals; Anticonvulsants; Caffeine; Central Nervous System Stimulants; Chlorpromazine; Convulsants; Dextroamphetamine; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Electroshock; Male; Pentylenetetrazole; Phenobarbital; Phosphodiesterase Inhibitors; Rats; Rats, Wistar; Reaction Time; Seizures; Theophylline; Time Factors; Tramadol | 2012 |
Antihyperalgesic effects of clomipramine and tramadol in a model of posttraumatic trigeminal neuropathic pain in mice.
Topics: Acetone; Analgesics, Opioid; Animals; Capsaicin; Clomipramine; Disease Models, Animal; Formaldehyde; Hyperalgesia; Irritants; Male; Mice; Nociceptors; Orbit; Pruritus; Selective Serotonin Reuptake Inhibitors; Sensory System Agents; Tramadol; Transient Receptor Potential Channels; Trigeminal Nerve Injuries; Trigeminal Neuralgia; TRPA1 Cation Channel; TRPV Cation Channels; Vibrissae | 2011 |
Synergistic interaction between fentanyl and a tramadol: paracetamol combination on the inhibition of nociception in mice.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Disease Models, Animal; Drug Synergism; Fentanyl; Male; Mice; Narcotic Antagonists; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tramadol; Visceral Pain | 2012 |
Opioid analgesics in experimental sepsis: effects on physiological, biochemical, and haemodynamic parameters.
Topics: Analgesics, Opioid; Animals; Biochemical Phenomena; Body Temperature; Body Weight; Cardiovascular System; Disease Models, Animal; Eating; Female; Fentanyl; Hemodynamics; Rats; Sepsis; Tramadol; Water | 2013 |
Antihypersensitivity effects of tramadol hydrochloride in a rat model of postoperative pain.
Topics: Adrenergic Antagonists; Analgesics, Opioid; Animals; Behavior, Animal; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Male; Microdialysis; Motor Activity; Narcotic Antagonists; Norepinephrine; Pain Measurement; Pain Threshold; Pain, Postoperative; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Serotonin; Serotonin Antagonists; Spinal Cord; Time Factors; Tramadol | 2012 |
Pregabalin antinociception and its interaction with tramadol in acute model of pain.
Topics: Acute Pain; Analgesics; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Drug Therapy, Combination; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Male; Mice; Pain; Pregabalin; Time Factors; Tramadol | 2012 |
The antinociceptive effects of systemic administration of tramadol, gabapentin and their combination on mice model of acute pain.
Topics: Acute Pain; Amines; Analgesics; Analgesics, Opioid; Animals; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Gabapentin; gamma-Aminobutyric Acid; Hot Temperature; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Nociception; Pain Measurement; Random Allocation; Tramadol | 2012 |
Combination of foot stimulation and tramadol treatment reverses irritation induced bladder overactivity in cats.
Topics: Acetic Acid; Analgesics, Opioid; Animals; Cats; Combined Modality Therapy; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Electric Stimulation; Female; Foot; Infusions, Intravenous; Male; Random Allocation; Reference Values; Tramadol; Treatment Outcome; Urinary Bladder, Overactive | 2012 |
The analgesic drug tramadol prevents the effect of surgery on natural killer cell activity and metastatic colonization in rats.
Topics: Adjuvants, Anesthesia; Analgesics, Opioid; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Down-Regulation; Killer Cells, Natural; Laparotomy; Lung Neoplasms; Male; Morphine; Neoplasm Metastasis; Pentobarbital; Rats; Rats, Inbred F344; Spleen; Stress, Physiological; Tramadol; Tumor Cells, Cultured | 2002 |
The antinociceptive effect of tramadol-venlafaxine combination on the paw withdrawal threshold in a rat model of neuropathic pain.
Topics: Analgesics; Animals; Cyclohexanols; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Male; Pain Threshold; Pressure; Rats; Rats, Sprague-Dawley; Sciatic Neuropathy; Tramadol; Venlafaxine Hydrochloride | 2003 |
Interaction between metamizol and tramadol in a model of acute visceral pain in rats.
Topics: Abdominal Pain; Acute Disease; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Dipyrone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Antagonism; Drug Interactions; Drug Synergism; Ethacrynic Acid; Male; Naloxone; Narcotic Antagonists; Pain Measurement; Rats; Rats, Sprague-Dawley; Tramadol; Visceral Afferents | 2003 |
The anti-hyperalgesic activity of retigabine is mediated by KCNQ potassium channel activation.
Topics: Acute Disease; Amines; Analgesics, Opioid; Animals; Carbamates; Cyclohexanecarboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Indoles; Ion Channel Gating; KCNQ2 Potassium Channel; KCNQ3 Potassium Channel; Male; Mice; Peripheral Nervous System Diseases; Phenylenediamines; Physical Stimulation; Potassium Channel Blockers; Potassium Channels, Voltage-Gated; Pyridines; Rats; Rats, Wistar; Spinal Nerves; Touch; Tramadol | 2004 |
Antinociceptive and anti-inflammatory activities of Acacia pennata wild (Mimosaceae).
Topics: Acetic Acid; Administration, Oral; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butanols; Carrageenan; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Edema; Female; Flavonoids; Formaldehyde; Hindlimb; Male; Mice; Mimosa; Pain; Plant Extracts; Plant Leaves; Pressure; Rats; Rats, Wistar; Stimulation, Chemical; Tramadol | 2005 |
Effects of desipramine and tramadol in a chronic mild stress model in mice are altered by yohimbine but not by pindolol.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Analgesics, Opioid; Animals; Antidepressive Agents, Tricyclic; Behavior, Animal; Body Weight; Chronic Disease; Desipramine; Disease Models, Animal; Male; Mice; Mice, Inbred BALB C; Motor Activity; Pindolol; Stress, Physiological; Tramadol; Yohimbine | 2005 |
Analysis of interaction between etoricoxib and tramadol against mechanical hyperalgesia of spinal cord injury in rats.
Topics: Animals; Disease Models, Animal; Drug Synergism; Drug Therapy, Combination; Etoricoxib; Female; Hyperalgesia; Pain Threshold; Pyridines; Rats; Rats, Wistar; Spinal Cord Injuries; Sulfones; Tramadol | 2006 |
Interaction between tramadol and two anti-emetics on nociception and gastrointestinal transit in mice.
Topics: Analgesics, Opioid; Animals; Antiemetics; Disease Models, Animal; Dose-Response Relationship, Drug; Droperidol; Drug Interactions; Female; Gastrointestinal Transit; Mice; Ondansetron; Pain; Pain Measurement; Postoperative Nausea and Vomiting; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Antagonists; Serotonin Antagonists; Tramadol | 2006 |
Is nitric oxide involved in the antinociceptive activity of tramadol? Findings in a rat model of neuropathic pain.
Topics: Analgesics; Animals; Arginine; Disease Models, Animal; Injections, Intraperitoneal; Male; Nerve Compression Syndromes; Neuralgia; Nitric Oxide; Nitric Oxide Donors; Nitroarginine; Nociceptors; Rats; Rats, Wistar; Tramadol | 2005 |
Isobolographic analysis of the dual-site synergism in the antinociceptive response of tramadol in the formalin test in rats.
Topics: Analgesics, Opioid; Animals; Disease Models, Animal; Drug Administration Routes; Drug Synergism; Hindlimb; Male; Pain Measurement; Rats; Rats, Wistar; Tramadol | 2006 |
Role of atypical opiates in OCD. Experimental approach through the study of 5-HT(2A/C) receptor-mediated behavior.
Topics: 5-Hydroxytryptophan; Analgesics, Opioid; Animals; Clozapine; Desipramine; Disease Models, Animal; Dose-Response Relationship, Drug; Fluvoxamine; Indophenol; Levorphanol; Male; Methadone; Mice; Morphine; Naloxone; Narcotic Antagonists; Obsessive-Compulsive Disorder; Piperazines; Receptor, Serotonin, 5-HT2A; Receptor, Serotonin, 5-HT2C; Stereotyped Behavior; Tics; Tourette Syndrome; Tramadol; Triazoles | 2007 |
Evaluation of the antinociceptive effect of Rosmarinus officinalis L. using three different experimental models in rodents.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Aspirin; Disease Models, Animal; Dose-Response Relationship, Drug; Inflammation; Male; Mice; Pain; Pain Measurement; Plant Components, Aerial; Plant Extracts; Plants, Medicinal; Rats; Rats, Wistar; Rosmarinus; Tramadol | 2007 |
Tramadol has a better potency ratio relative to morphine in neuropathic than in nociceptive pain models.
Topics: Analgesics, Opioid; Animals; Cold Temperature; Disease Models, Animal; Dose-Response Relationship, Drug; Hot Temperature; Hyperalgesia; Injections, Intravenous; Male; Morphine; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Sciatic Nerve; Sciatic Neuropathy; Time Factors; Tramadol | 2007 |
Increased tumor necrosis factor-alpha and prostaglandin E2 concentrations in the cerebrospinal fluid of rats with inflammatory hyperalgesia: the effects of analgesic drugs.
Topics: Acetaminophen; Administration, Oral; Analgesics; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Behavior, Animal; Cyclooxygenase Inhibitors; Dinoprostone; Disease Models, Animal; Drug Combinations; Freund's Adjuvant; Hyperalgesia; Inflammation; Male; Pain; Pain Measurement; Pain Threshold; Rats; Rats, Sprague-Dawley; Sulfonamides; Touch; Tramadol; Tumor Necrosis Factor-alpha | 2007 |
Role of serotonin 5-HT1A and opioid receptors in the antiallodynic effect of tramadol in the chronic constriction injury model of neuropathic pain in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesics, Opioid; Animals; Chronic Disease; Disease Models, Animal; Drug Interactions; Male; Naloxone; Narcotic Antagonists; Pain; Pain Threshold; Piperazines; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT1A; Receptors, Opioid; Sciatic Nerve; Sciatic Neuropathy; Serotonin 5-HT1 Receptor Agonists; Tramadol | 2007 |
Postoperative administration of the analgesic tramadol, but not the selective cyclooxygenase-2 inhibitor parecoxib, abolishes postoperative hyperalgesia in a new model of postoperative pain in rats.
Topics: Analgesics, Opioid; Animals; Cyclooxygenase 2 Inhibitors; Disease Models, Animal; Hyperalgesia; Isoxazoles; Pain, Postoperative; Rats; Rats, Sprague-Dawley; Tramadol | 2007 |
Effects of tramadol on myocardial ischemia-reperfusion injury.
Topics: Animals; Cardiotonic Agents; Disease Models, Animal; Heart; In Vitro Techniques; Male; Myocardial Reperfusion Injury; Oxidative Stress; Rats; Rats, Sprague-Dawley; Tramadol | 2007 |
Synergistic interaction between dexamethasone and tramadol in a murine model of acute visceral pain.
Topics: Analgesics, Opioid; Animals; Antiemetics; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Synergism; Female; Glucocorticoids; Humans; Mice; Models, Biological; Pain; Pain Measurement; Tramadol | 2007 |
Involvement of serotonin 2A receptors in the analgesic effect of tramadol in mono-arthritic rats.
Topics: Analgesics, Opioid; Animals; Arthralgia; Arthritis; Brain; Disease Models, Animal; Dose-Response Relationship, Drug; Injections, Intraperitoneal; Ketanserin; Male; Neural Pathways; Pain Measurement; Pain Threshold; Posterior Horn Cells; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Serotonin, 5-HT2A; RNA, Messenger; Serotonin; Serotonin Antagonists; Synaptic Transmission; Tramadol; Up-Regulation | 2008 |
Anticonvulsant and proconvulsant effects of tramadol, its enantiomers and its M1 metabolite in the rat kindling model of epilepsy.
Topics: Animals; Anticonvulsants; Convulsants; Disease Models, Animal; Electric Stimulation; Epilepsy; Kindling, Neurologic; Male; Rats; Rats, Wistar; Stereoisomerism; Tramadol | 2000 |
Effects of tramadol on behavioural indicators of colic pain in a rat model of ureteral calculosis.
Topics: Analgesics, Opioid; Animals; Behavior, Animal; Body Weight; Colic; Disease Models, Animal; Dose-Response Relationship, Drug; Estrous Cycle; Female; Hyperalgesia; Injections, Intraperitoneal; Muscle, Skeletal; Pain; Pain Measurement; Rats; Rats, Sprague-Dawley; Tramadol; Ureteral Calculi | 2002 |