tram-34 and Weight-Gain

Amyotrophic lateral sclerosis (ALS) patients exhibit dysfunctional energy metabolism and weight loss, which is negatively correlated with survival, together with neuroinflammation. However, the possible contribution of neuroinflammation to deregulations of feeding behaviour in ALS has not been studied in detail. We here investigated if microglial K. hSOD1. We found that treatment of hSOD1. Using ALS mouse models, we describe defects in the hypothalamic melanocortin system that affect appetite control. These results reveal a new regulatory role for K

Topics: Amyotrophic Lateral Sclerosis; Animals; Disease Models, Animal; Energy Metabolism; Feeding Behavior; Homeostasis; Melanocortins; Mice; Mice, Transgenic; Microglia; Potassium Channels, Calcium-Activated; Pyrazoles; Receptors, Cannabinoid; Spinal Cord; Superoxide Dismutase-1; Weight Gain